UA60296C2 - Циклопептидные производные и способ их получения, фармацевтическая композиция и способ ее получения - Google Patents
Циклопептидные производные и способ их получения, фармацевтическая композиция и способ ее получения Download PDFInfo
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- UA60296C2 UA60296C2 UA98052413A UA98052413A UA60296C2 UA 60296 C2 UA60296 C2 UA 60296C2 UA 98052413 A UA98052413 A UA 98052413A UA 98052413 A UA98052413 A UA 98052413A UA 60296 C2 UA60296 C2 UA 60296C2
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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Abstract
Соединения формулы (І) R1-Q1-X1-Q2-R2, в которых Q1, Q1 независимы друг от друга, или отсутствуют, или представляют собой -NH-(CH2)n-CO-; R1, R2 независимы друг от друга, или отсутствуют, или представляют собой цикло-(Arg-Gly-Asp-Z), где Z связан в боковой цепи с Q1 или Q2, или, если Q1 и/или Q2 отсутствуют(ет), связан с Х и, где по крайней мере один из радикалов R1 или R2 всегда должен присутствовать; Х представляет собой -CO-R18-CO-, и, если R1-Q1- или R2-Q2- отсутствуют, R10, R13, R16, Het-CO- или флуоресцентно окрашенный остаток, который связывается через -CONH-, -COO-, -NH-C(=S)-NH-, -NH-C(=О)-NH-, -SO2NH- или -NHCO-связи; и Z, R10, R13, R16, R18, Het и n принимают значения, указанные в п. 1. Изобретение также относится к солям этих соединений. Эти соединения и их соли, могут применяться как ингибиторы интегрина, в частности, для профилактики и лечения заболеваний кровообращения, тромбозов, сердечного инфаркта, коронарных заболеваний сердца, артериосклероза и заболеваний, связанных с патологическим развитием сосудов, а также в терапии опухолей.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19538741A DE19538741A1 (de) | 1995-10-18 | 1995-10-18 | Cyclopeptidderivate |
| PCT/EP1996/004462 WO1997014716A1 (de) | 1995-10-18 | 1996-10-14 | Cyclopeptidderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA60296C2 true UA60296C2 (ru) | 2003-10-15 |
Family
ID=7775137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA98052413A UA60296C2 (ru) | 1995-10-18 | 1996-10-14 | Циклопептидные производные и способ их получения, фармацевтическая композиция и способ ее получения |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6566491B2 (ru) |
| EP (1) | EP0856007B1 (ru) |
| JP (1) | JP2000500432A (ru) |
| KR (1) | KR100475397B1 (ru) |
| CN (1) | CN1118475C (ru) |
| AR (1) | AR008983A1 (ru) |
| AT (1) | ATE264874T1 (ru) |
| AU (1) | AU716847B2 (ru) |
| BR (1) | BR9611358A (ru) |
| CA (1) | CA2234980C (ru) |
| CZ (1) | CZ288379B6 (ru) |
| DE (2) | DE19538741A1 (ru) |
| DK (1) | DK0856007T3 (ru) |
| ES (1) | ES2220992T3 (ru) |
| HU (1) | HU226594B1 (ru) |
| NO (1) | NO981752L (ru) |
| PL (1) | PL186914B1 (ru) |
| PT (1) | PT856007E (ru) |
| RU (1) | RU2174520C2 (ru) |
| SK (1) | SK284752B6 (ru) |
| TW (1) | TW570928B (ru) |
| UA (1) | UA60296C2 (ru) |
| WO (1) | WO1997014716A1 (ru) |
| ZA (1) | ZA968770B (ru) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2477601C1 (ru) * | 2011-08-09 | 2013-03-20 | Лев Петрович Петренко | Способ формирования структуры кроны виноградника (вариант русской логики - версия 5) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5753230A (en) | 1994-03-18 | 1998-05-19 | The Scripps Research Institute | Methods and compositions useful for inhibition of angiogenesis |
| US7053041B1 (en) | 1996-05-31 | 2006-05-30 | The Scripps Research Institute | Methods and compositions useful for inhibition of αvβ5mediated angiogenesis |
| AU733303C (en) | 1996-05-31 | 2002-08-08 | Scripps Research Institute, The | Methods and compositions useful for inhibition of angiogenesis |
| PL330240A1 (en) * | 1996-05-31 | 1999-05-10 | Scripps Research Inst | Methods and compositions useful in inhibiting angiogenesis in which alphavbeta5 acts as intermediary |
| DE19755800A1 (de) * | 1997-12-16 | 1999-06-17 | Merck Patent Gmbh | Cyclopeptidderivate |
| UA71608C2 (en) | 1999-03-11 | 2004-12-15 | Merck Patent Gmbh | A method for producing the cyclic pentapeptide |
| DE19933173A1 (de) | 1999-07-15 | 2001-01-18 | Merck Patent Gmbh | Cyclische Peptidderivate als Inhibitoren des Integrins alpha¶v¶beta¶6¶ |
| WO2002040073A1 (en) | 2000-11-20 | 2002-05-23 | Université De Genève | Endosseous implant |
| MXPA04000839A (es) | 2001-08-01 | 2004-05-14 | Merck Patent Gesellscahft Mit | Metodos y composiciones para el tratamiento de enfermedades oftalmicas. |
| RU2360686C1 (ru) * | 2008-02-14 | 2009-07-10 | Михаил Владимирович Кутушов | Лекарственное средство для лечения онкологических заболеваний |
| CN110128490B (zh) | 2018-02-09 | 2021-03-16 | 厦门诺康得生物科技有限公司 | 一种用于免疫细胞表面修饰的糖类衍生物及其应用 |
| US10494403B2 (en) * | 2018-03-06 | 2019-12-03 | Ciphore Biomed Technology Limited Company | Cyclopeptide, pharmaceutical or cosmetic composition comprising the same and method for preparing the same |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4310643A1 (de) * | 1993-04-01 | 1994-10-06 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren |
-
1995
- 1995-10-18 DE DE19538741A patent/DE19538741A1/de not_active Withdrawn
-
1996
- 1996-10-04 US US09/051,603 patent/US6566491B2/en not_active Expired - Lifetime
- 1996-10-14 SK SK473-98A patent/SK284752B6/sk not_active IP Right Cessation
- 1996-10-14 UA UA98052413A patent/UA60296C2/ru unknown
- 1996-10-14 CA CA002234980A patent/CA2234980C/en not_active Expired - Fee Related
- 1996-10-14 CZ CZ19981111A patent/CZ288379B6/cs not_active IP Right Cessation
- 1996-10-14 PL PL96327238A patent/PL186914B1/pl not_active IP Right Cessation
- 1996-10-14 PT PT96934675T patent/PT856007E/pt unknown
- 1996-10-14 HU HU9803000A patent/HU226594B1/hu not_active IP Right Cessation
- 1996-10-14 RU RU98109791/04A patent/RU2174520C2/ru not_active IP Right Cessation
- 1996-10-14 ES ES96934675T patent/ES2220992T3/es not_active Expired - Lifetime
- 1996-10-14 AT AT96934675T patent/ATE264874T1/de active
- 1996-10-14 JP JP9515508A patent/JP2000500432A/ja active Pending
- 1996-10-14 BR BR9611358A patent/BR9611358A/pt not_active IP Right Cessation
- 1996-10-14 DK DK96934675T patent/DK0856007T3/da active
- 1996-10-14 KR KR10-1998-0702835A patent/KR100475397B1/ko not_active IP Right Cessation
- 1996-10-14 WO PCT/EP1996/004462 patent/WO1997014716A1/de active IP Right Grant
- 1996-10-14 AU AU72921/96A patent/AU716847B2/en not_active Expired
- 1996-10-14 EP EP96934675A patent/EP0856007B1/de not_active Expired - Lifetime
- 1996-10-14 CN CN96198432A patent/CN1118475C/zh not_active Expired - Lifetime
- 1996-10-14 DE DE59610991T patent/DE59610991D1/de not_active Expired - Lifetime
- 1996-10-17 ZA ZA968770A patent/ZA968770B/xx unknown
- 1996-10-18 AR ARP960104798A patent/AR008983A1/es not_active Application Discontinuation
- 1996-10-24 TW TW085113332A patent/TW570928B/zh active
-
1998
- 1998-04-17 NO NO981752A patent/NO981752L/no not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2477601C1 (ru) * | 2011-08-09 | 2013-03-20 | Лев Петрович Петренко | Способ формирования структуры кроны виноградника (вариант русской логики - версия 5) |
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