UA5954A1 - Спосіб отримання (+)-4-ді-(н-пропіл)-аміно-6-карбамоіл-1,3,4,5-тетрагідробенз (с,д) індола або його фармацевтично придатної солі - Google Patents
Спосіб отримання (+)-4-ді-(н-пропіл)-аміно-6-карбамоіл-1,3,4,5-тетрагідробенз (с,д) індола або його фармацевтично придатної соліInfo
- Publication number
- UA5954A1 UA5954A1 UA3856855A UA3856855A UA5954A1 UA 5954 A1 UA5954 A1 UA 5954A1 UA 3856855 A UA3856855 A UA 3856855A UA 3856855 A UA3856855 A UA 3856855A UA 5954 A1 UA5954 A1 UA 5954A1
- Authority
- UA
- Ukraine
- Prior art keywords
- teterahydrobenzo
- indol
- propyl
- amino
- carbamoyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Спосіб отримання (±)-4-ди-(н-пропіл)-аміно-6-карбамоїл-1,3,4,5-тетрагідробенз (с,d) індолу формули І або його фармацевтично прийнятної солі. (±)-4-ди-(н-пропіл)-аміно-6-ціано-1,3,4,5-тетрагідробенз (с,d) індол піддають гідролізу гідрооксидом калію в середовищі трет-бутанолу в атмосфері азоту в присутності диметилсульфоксиду з виділенням цільового продукту хроматографічним розділенням и в разі необхідності продукт переводять у фармацевтично прийнятну сіль кислоти.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57709684A | 1984-02-06 | 1984-02-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
UA5954A1 true UA5954A1 (uk) | 1994-12-29 |
Family
ID=24307259
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA3856855A UA5954A1 (uk) | 1984-02-06 | 1985-02-04 | Спосіб отримання (+)-4-ді-(н-пропіл)-аміно-6-карбамоіл-1,3,4,5-тетрагідробенз (с,д) індола або його фармацевтично придатної солі |
Country Status (24)
Country | Link |
---|---|
EP (1) | EP0153083B1 (uk) |
JP (2) | JPH0699388B2 (uk) |
KR (1) | KR860001892B1 (uk) |
AR (1) | AR240641A1 (uk) |
AT (1) | ATE53021T1 (uk) |
AU (1) | AU572258B2 (uk) |
CA (1) | CA1291484C (uk) |
CY (1) | CY1657A (uk) |
DE (1) | DE3577848D1 (uk) |
DK (1) | DK167572B1 (uk) |
ES (2) | ES8605236A1 (uk) |
GR (1) | GR850313B (uk) |
HK (1) | HK63792A (uk) |
HU (1) | HU193941B (uk) |
IE (1) | IE57916B1 (uk) |
IL (1) | IL74222A (uk) |
MY (1) | MY102763A (uk) |
NZ (1) | NZ211031A (uk) |
PH (1) | PH20490A (uk) |
PT (1) | PT79925B (uk) |
SG (1) | SG66992G (uk) |
SU (1) | SU1375128A3 (uk) |
UA (1) | UA5954A1 (uk) |
ZA (1) | ZA85916B (uk) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3346573A1 (de) * | 1983-12-23 | 1985-07-04 | Troponwerke GmbH & Co KG, 5000 Köln | 1,3,4,5-tetrahydrobenz(c,d)indole, ein verfahren zu ihrer herstellung und ihre verwendung |
CA1266482A1 (en) * | 1984-05-24 | 1990-03-06 | Carl Kaiser | 6-oxygenated-1,3,4,5-tetrahydrobenz(cd)indol-4-amines |
DE3525564A1 (de) * | 1985-07-15 | 1987-02-05 | Schering Ag | Tricyclische verbindungen mit indolstruktur, verfahren zu ihrer herstellung und deren verwendung als arzneimittel |
US4745126A (en) * | 1987-03-12 | 1988-05-17 | Eli Lilly And Company | Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides |
DE3809155A1 (de) * | 1988-03-18 | 1989-09-28 | Bayer Ag | 1,3,4,5-tetrahydrobenz-(c,d)-indole |
US4999382A (en) * | 1988-10-26 | 1991-03-12 | Massachusetts Institute Of Technology | Compositions for treating tobacco withdrawal symptoms and methods for their use |
US5204340A (en) * | 1989-04-11 | 1993-04-20 | Eli Lilly And Company | Tetrahydrobenz(c,d)indole serotonin agonists |
US5273975A (en) * | 1989-06-09 | 1993-12-28 | The Upjohn Company | Heterocyclic amines having central nervous system activity |
US5302612A (en) * | 1990-02-26 | 1994-04-12 | Eli Lilly And Company | 6-substituted-hexahydrobenz[cd]indoles |
US5039820A (en) * | 1990-02-26 | 1991-08-13 | Eli Lilly And Company | 4-amino-6-iodo-hexahydrobenz(cd)indoles |
IL97309A (en) * | 1990-02-26 | 1996-11-14 | Lilly Co Eli | Intermediates for hexahydrobenz] [DC indoles and a process for making their pure enantiomers |
IL97308A (en) * | 1990-02-26 | 1996-10-31 | Lilly Co Eli | Xahydrobenz [DC] Induced indoles in position 6, their preparation process and pharmaceutical preparations containing them |
US5096908A (en) * | 1990-05-04 | 1992-03-17 | Eli Lilly And Company | Method of inhibiting gastric acid secretion |
US5340838A (en) * | 1990-05-04 | 1994-08-23 | Eli Lilly And Company | Method of inhibiting gastric acid secretion with 2-phenylcyclopropylamines |
US5258379A (en) * | 1990-05-04 | 1993-11-02 | Eli Lilly And Company | Method of inhibiting gastric acid secretion with n-arylpiperazines |
US5229409A (en) * | 1990-08-15 | 1993-07-20 | Eli Lilly And Company | 6-substituted-tetrahydrobenz[cd]indoles |
US5229410A (en) * | 1990-08-15 | 1993-07-20 | Eli Lilly And Company | 6-substituted-hexahydrobenz[cd]indoles |
US5364856A (en) * | 1991-03-28 | 1994-11-15 | Eli Lilly And Company | 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles |
US5633273A (en) * | 1991-03-28 | 1997-05-27 | Eli Lilly And Company | 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd] indoles |
US5244911A (en) * | 1991-03-28 | 1993-09-14 | Eli Lilly And Company | 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz(cd)indoles and pharmaceutical use thereof |
US5244912A (en) * | 1991-03-28 | 1993-09-14 | Eli Lilly And Company | 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz(cd)indoles and pharmaceutical use thereof |
US5347013A (en) * | 1991-03-28 | 1994-09-13 | Eli Lilly And Company | 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles |
JP3433804B2 (ja) | 1993-07-27 | 2003-08-04 | ファルマシア・アンド・アップジョン・カンパニー | 中枢神経系活性を有する複素環アミン類 |
US5385928A (en) * | 1994-05-18 | 1995-01-31 | Eli Lilly And Company | Tetrahydrobenz [CD] indazoles, compositions and use |
FR2732964B1 (fr) * | 1995-04-14 | 1997-05-16 | Adir | Nouveaux amides tricycliques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
US6242473B1 (en) * | 1999-01-08 | 2001-06-05 | Maxim Pharmaceuticals, Inc. | Treatment and prevention of reactive oxygen metabolite-mediated cellular damage |
US7074927B2 (en) | 1999-05-13 | 2006-07-11 | Pharmacia & Upjohn Company | Heterocyclic amines having central nervous system activity |
TW200732302A (en) * | 2005-12-13 | 2007-09-01 | Daicel Chem | Indoline derivative |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3194811A (en) * | 1963-09-05 | 1965-07-13 | Merck & Co Inc | Aroyl-benzindolyl acids |
US4282240A (en) * | 1979-11-23 | 1981-08-04 | Merck & Co., Inc. | Amino substituted tetrahydrobenzindoles |
DE3346573A1 (de) * | 1983-12-23 | 1985-07-04 | Troponwerke GmbH & Co KG, 5000 Köln | 1,3,4,5-tetrahydrobenz(c,d)indole, ein verfahren zu ihrer herstellung und ihre verwendung |
CA1266482A1 (en) * | 1984-05-24 | 1990-03-06 | Carl Kaiser | 6-oxygenated-1,3,4,5-tetrahydrobenz(cd)indol-4-amines |
-
1985
- 1985-02-03 IL IL74222A patent/IL74222A/xx not_active IP Right Cessation
- 1985-02-04 GR GR850313A patent/GR850313B/el unknown
- 1985-02-04 PT PT79925A patent/PT79925B/pt not_active IP Right Cessation
- 1985-02-04 NZ NZ211031A patent/NZ211031A/xx unknown
- 1985-02-04 PH PH31815A patent/PH20490A/en unknown
- 1985-02-04 DK DK048785A patent/DK167572B1/da not_active IP Right Cessation
- 1985-02-04 HU HU85413A patent/HU193941B/hu not_active IP Right Cessation
- 1985-02-04 IE IE263/85A patent/IE57916B1/en not_active IP Right Cessation
- 1985-02-04 AU AU38419/85A patent/AU572258B2/en not_active Ceased
- 1985-02-04 SU SU853856855A patent/SU1375128A3/ru active
- 1985-02-04 UA UA3856855A patent/UA5954A1/uk unknown
- 1985-02-05 KR KR1019850000715A patent/KR860001892B1/ko not_active IP Right Cessation
- 1985-02-05 CA CA000473579A patent/CA1291484C/en not_active Expired - Lifetime
- 1985-02-05 ES ES540151A patent/ES8605236A1/es not_active Expired
- 1985-02-05 JP JP60021590A patent/JPH0699388B2/ja not_active Expired - Lifetime
- 1985-02-05 AR AR29941385A patent/AR240641A1/es active
- 1985-02-06 DE DE8585300779T patent/DE3577848D1/de not_active Expired - Lifetime
- 1985-02-06 ZA ZA85916A patent/ZA85916B/xx unknown
- 1985-02-06 EP EP85300779A patent/EP0153083B1/en not_active Expired - Lifetime
- 1985-02-06 AT AT85300779T patent/ATE53021T1/de not_active IP Right Cessation
- 1985-11-15 ES ES548942A patent/ES8704894A1/es not_active Expired
-
1987
- 1987-09-22 MY MYPI87001863A patent/MY102763A/en unknown
-
1992
- 1992-07-01 SG SG669/92A patent/SG66992G/en unknown
- 1992-08-20 HK HK637/92A patent/HK63792A/xx not_active IP Right Cessation
-
1993
- 1993-05-14 CY CY1657A patent/CY1657A/xx unknown
- 1993-12-15 JP JP5315469A patent/JPH0745470B2/ja not_active Expired - Lifetime
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