ES8605236A1 - Un procedimiento para la preparacion de nuevos 4-dialquilaminotetrahidrobenzol (c,d) indoles 6-sustituidos. - Google Patents

Un procedimiento para la preparacion de nuevos 4-dialquilaminotetrahidrobenzol (c,d) indoles 6-sustituidos.

Info

Publication number
ES8605236A1
ES8605236A1 ES540151A ES540151A ES8605236A1 ES 8605236 A1 ES8605236 A1 ES 8605236A1 ES 540151 A ES540151 A ES 540151A ES 540151 A ES540151 A ES 540151A ES 8605236 A1 ES8605236 A1 ES 8605236A1
Authority
ES
Spain
Prior art keywords
substituted
dialkylaminotetrahydrobenz
indoles
tetrahydrobenz
ino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES540151A
Other languages
English (en)
Other versions
ES540151A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES8605236A1 publication Critical patent/ES8605236A1/es
Publication of ES540151A0 publication Critical patent/ES540151A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 4-DIALQUILAMINOTETRAHIDROBENZO C,D INDOLES 6-SUSTITUIDOS, DE FORMULA GENERAL (I), EN LA QUE R1 Y R2 SON INDIVIDUALMENTE, ETILO, N-PROPILO O ALILO; Y X ES CONH2, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN SOMETER UN COMPUESTO DE FORMULA GENERAL (II) A HIDROLISIS, PREFERIBLEMENTE UTILIZANDO UNA BASE DEL TIPO DE HIDROXILO, EN UN ALCANOL C1-4. DE APLICACION COMO AGENTES CONTRA LA OBESIDAD, CONTRA EL ALCOHOLISMO, CONTRA LA DEMENCIA SENIL Y CONTRA EL HABITO DE FUMAR.
ES540151A 1984-02-06 1985-02-05 Un procedimiento para la preparacion de nuevos 4-dialquilaminotetrahidrobenzol (c,d) indoles 6-sustituidos. Expired ES8605236A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57709684A 1984-02-06 1984-02-06

Publications (2)

Publication Number Publication Date
ES8605236A1 true ES8605236A1 (es) 1986-03-16
ES540151A0 ES540151A0 (es) 1986-03-16

Family

ID=24307259

Family Applications (2)

Application Number Title Priority Date Filing Date
ES540151A Expired ES8605236A1 (es) 1984-02-06 1985-02-05 Un procedimiento para la preparacion de nuevos 4-dialquilaminotetrahidrobenzol (c,d) indoles 6-sustituidos.
ES548942A Expired ES8704894A1 (es) 1984-02-06 1985-11-15 Un procedimiento para la preparacion de nuevos 4-dialquila- minotetrahidrobenzo (c,d)indoles 6-sustituidos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES548942A Expired ES8704894A1 (es) 1984-02-06 1985-11-15 Un procedimiento para la preparacion de nuevos 4-dialquila- minotetrahidrobenzo (c,d)indoles 6-sustituidos

Country Status (24)

Country Link
EP (1) EP0153083B1 (es)
JP (2) JPH0699388B2 (es)
KR (1) KR860001892B1 (es)
AR (1) AR240641A1 (es)
AT (1) ATE53021T1 (es)
AU (1) AU572258B2 (es)
CA (1) CA1291484C (es)
CY (1) CY1657A (es)
DE (1) DE3577848D1 (es)
DK (1) DK167572B1 (es)
ES (2) ES8605236A1 (es)
GR (1) GR850313B (es)
HK (1) HK63792A (es)
HU (1) HU193941B (es)
IE (1) IE57916B1 (es)
IL (1) IL74222A (es)
MY (1) MY102763A (es)
NZ (1) NZ211031A (es)
PH (1) PH20490A (es)
PT (1) PT79925B (es)
SG (1) SG66992G (es)
SU (1) SU1375128A3 (es)
UA (1) UA5954A1 (es)
ZA (1) ZA85916B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3346573A1 (de) * 1983-12-23 1985-07-04 Troponwerke GmbH & Co KG, 5000 Köln 1,3,4,5-tetrahydrobenz(c,d)indole, ein verfahren zu ihrer herstellung und ihre verwendung
CA1266482A1 (en) * 1984-05-24 1990-03-06 Carl Kaiser 6-oxygenated-1,3,4,5-tetrahydrobenz(cd)indol-4-amines
DE3525564A1 (de) * 1985-07-15 1987-02-05 Schering Ag Tricyclische verbindungen mit indolstruktur, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
US4745126A (en) * 1987-03-12 1988-05-17 Eli Lilly And Company Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides
DE3809155A1 (de) * 1988-03-18 1989-09-28 Bayer Ag 1,3,4,5-tetrahydrobenz-(c,d)-indole
US4999382A (en) * 1988-10-26 1991-03-12 Massachusetts Institute Of Technology Compositions for treating tobacco withdrawal symptoms and methods for their use
US5204340A (en) * 1989-04-11 1993-04-20 Eli Lilly And Company Tetrahydrobenz(c,d)indole serotonin agonists
US5273975A (en) * 1989-06-09 1993-12-28 The Upjohn Company Heterocyclic amines having central nervous system activity
IL97308A (en) * 1990-02-26 1996-10-31 Lilly Co Eli Xahydrobenz [DC] Induced indoles in position 6, their preparation process and pharmaceutical preparations containing them
IL97309A (en) * 1990-02-26 1996-11-14 Lilly Co Eli Intermediates for hexahydrobenz] [DC indoles and a process for making their pure enantiomers
US5039820A (en) * 1990-02-26 1991-08-13 Eli Lilly And Company 4-amino-6-iodo-hexahydrobenz(cd)indoles
US5302612A (en) * 1990-02-26 1994-04-12 Eli Lilly And Company 6-substituted-hexahydrobenz[cd]indoles
US5096908A (en) * 1990-05-04 1992-03-17 Eli Lilly And Company Method of inhibiting gastric acid secretion
US5258379A (en) * 1990-05-04 1993-11-02 Eli Lilly And Company Method of inhibiting gastric acid secretion with n-arylpiperazines
US5340838A (en) * 1990-05-04 1994-08-23 Eli Lilly And Company Method of inhibiting gastric acid secretion with 2-phenylcyclopropylamines
US5229409A (en) * 1990-08-15 1993-07-20 Eli Lilly And Company 6-substituted-tetrahydrobenz[cd]indoles
US5229410A (en) * 1990-08-15 1993-07-20 Eli Lilly And Company 6-substituted-hexahydrobenz[cd]indoles
US5656653A (en) * 1991-03-28 1997-08-12 Eli Lilly And Company 6-heterocyclic-4-amino-1,2,2A,3,4,5-hexahydrobenz[cd]indoles
US5347013A (en) * 1991-03-28 1994-09-13 Eli Lilly And Company 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles
US5244911A (en) * 1991-03-28 1993-09-14 Eli Lilly And Company 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz(cd)indoles and pharmaceutical use thereof
US5364856A (en) * 1991-03-28 1994-11-15 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles
US5244912A (en) * 1991-03-28 1993-09-14 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz(cd)indoles and pharmaceutical use thereof
CN1043574C (zh) 1993-07-27 1999-06-09 法玛西雅厄普约翰美国公司 具有中枢神经系统活性的杂环胺
US5385928A (en) * 1994-05-18 1995-01-31 Eli Lilly And Company Tetrahydrobenz [CD] indazoles, compositions and use
FR2732964B1 (fr) * 1995-04-14 1997-05-16 Adir Nouveaux amides tricycliques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
US6242473B1 (en) * 1999-01-08 2001-06-05 Maxim Pharmaceuticals, Inc. Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
US7074927B2 (en) 1999-05-13 2006-07-11 Pharmacia & Upjohn Company Heterocyclic amines having central nervous system activity
TW200732302A (en) * 2005-12-13 2007-09-01 Daicel Chem Indoline derivative

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3194811A (en) * 1963-09-05 1965-07-13 Merck & Co Inc Aroyl-benzindolyl acids
US4282240A (en) * 1979-11-23 1981-08-04 Merck & Co., Inc. Amino substituted tetrahydrobenzindoles
DE3346573A1 (de) * 1983-12-23 1985-07-04 Troponwerke GmbH & Co KG, 5000 Köln 1,3,4,5-tetrahydrobenz(c,d)indole, ein verfahren zu ihrer herstellung und ihre verwendung
CA1266482A1 (en) * 1984-05-24 1990-03-06 Carl Kaiser 6-oxygenated-1,3,4,5-tetrahydrobenz(cd)indol-4-amines

Also Published As

Publication number Publication date
HU193941B (en) 1987-12-28
IL74222A (en) 1988-07-31
EP0153083A2 (en) 1985-08-28
MY102763A (en) 1992-10-31
GR850313B (es) 1985-06-05
PT79925A (en) 1985-03-01
HK63792A (en) 1992-08-28
CA1291484C (en) 1991-10-29
JPH0699388B2 (ja) 1994-12-07
IL74222A0 (en) 1985-05-31
PH20490A (en) 1987-01-21
IE850263L (en) 1985-08-06
SG66992G (en) 1992-09-04
HUT37121A (en) 1985-11-28
CY1657A (en) 1993-05-14
ZA85916B (en) 1986-09-24
DE3577848D1 (de) 1990-06-28
DK48785D0 (da) 1985-02-04
SU1375128A3 (ru) 1988-02-15
ES8704894A1 (es) 1987-04-16
KR850005825A (ko) 1985-09-26
DK167572B1 (da) 1993-11-22
DK48785A (da) 1985-09-03
ATE53021T1 (de) 1990-06-15
EP0153083B1 (en) 1990-05-23
ES540151A0 (es) 1986-03-16
AU572258B2 (en) 1988-05-05
EP0153083A3 (en) 1987-01-14
KR860001892B1 (ko) 1986-10-24
IE57916B1 (en) 1993-05-19
AR240641A1 (es) 1990-07-31
ES548942A0 (es) 1987-04-16
UA5954A1 (uk) 1994-12-29
JPH06279406A (ja) 1994-10-04
JPH0745470B2 (ja) 1995-05-17
JPS60208959A (ja) 1985-10-21
AU3841985A (en) 1985-08-15
NZ211031A (en) 1989-08-29
PT79925B (en) 1987-02-05

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20051130