UA52607C2 - Похідні біфенілів, фармацевтична композиція на їх основі та спосіб інгібування (варіанти) - Google Patents

Похідні біфенілів, фармацевтична композиція на їх основі та спосіб інгібування (варіанти) Download PDF

Info

Publication number
UA52607C2
UA52607C2 UA97126359A UA97126359A UA52607C2 UA 52607 C2 UA52607 C2 UA 52607C2 UA 97126359 A UA97126359 A UA 97126359A UA 97126359 A UA97126359 A UA 97126359A UA 52607 C2 UA52607 C2 UA 52607C2
Authority
UA
Ukraine
Prior art keywords
сно
bis
carboxymethylphenyl
mannopyranosyloxy
phenyl
Prior art date
Application number
UA97126359A
Other languages
English (en)
Russian (ru)
Ukrainian (uk)
Inventor
Тімоті Коган
Брайан Дюпре
Іан Л. Скотт
Хуонг Бьюі
Каті Л. Уілер
Карін М. Келлер
Джасмал М. Кассір
Original Assignee
Тексіс Байотекнолоджі Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Тексіс Байотекнолоджі Корпорейшн filed Critical Тексіс Байотекнолоджі Корпорейшн
Publication of UA52607C2 publication Critical patent/UA52607C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • External Artificial Organs (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
UA97126359A 1995-06-29 1996-06-26 Похідні біфенілів, фармацевтична композиція на їх основі та спосіб інгібування (варіанти) UA52607C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US278495P 1995-06-29 1995-06-29
US53395P 1995-06-29 1995-06-29
PCT/US1996/011032 WO1997001335A1 (en) 1995-06-29 1996-06-26 Di- and trivalent small molecule selectin inhibitors

Publications (1)

Publication Number Publication Date
UA52607C2 true UA52607C2 (uk) 2003-01-15

Family

ID=26667782

Family Applications (1)

Application Number Title Priority Date Filing Date
UA97126359A UA52607C2 (uk) 1995-06-29 1996-06-26 Похідні біфенілів, фармацевтична композиція на їх основі та спосіб інгібування (варіанти)

Country Status (21)

Country Link
EP (1) EP0840606B1 (index.php)
JP (1) JP4046351B2 (index.php)
KR (1) KR100438136B1 (index.php)
CN (1) CN1149082C (index.php)
AT (1) ATE193647T1 (index.php)
AU (1) AU704596B2 (index.php)
BR (1) BR9608873A (index.php)
CA (1) CA2221991C (index.php)
CZ (1) CZ290072B6 (index.php)
DE (1) DE69608804T2 (index.php)
DK (1) DK0840606T3 (index.php)
ES (1) ES2146886T3 (index.php)
FI (1) FI974618L (index.php)
GR (1) GR3034289T3 (index.php)
HU (1) HU224590B1 (index.php)
NO (1) NO310623B1 (index.php)
PL (1) PL185372B1 (index.php)
PT (1) PT840606E (index.php)
RU (1) RU2165931C2 (index.php)
UA (1) UA52607C2 (index.php)
WO (1) WO1997001335A1 (index.php)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1020944C (zh) * 1990-01-30 1993-05-26 阿图尔-费希尔股份公司费希尔厂 紧固件
AU6024998A (en) * 1997-01-15 1998-08-07 Glycomed Incorporated Aryl c-glycoside compounds and sulfated esters thereof
AU1903699A (en) * 1997-12-08 1999-06-28 Glycomed Incorporated Disalicylate analog based sialyl lewisx mimetics
CA2342855A1 (en) * 1998-09-04 2000-03-16 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel pyranoses
PH12000002657B1 (en) 1999-10-12 2006-02-21 Bristol Myers Squibb Co C-aryl glucoside SGLT2 inhibitors
GB9924990D0 (en) * 1999-10-21 1999-12-22 Glaxo Group Ltd Medicaments
US6555519B2 (en) 2000-03-30 2003-04-29 Bristol-Myers Squibb Company O-glucosylated benzamide SGLT2 inhibitors and method
US6683056B2 (en) 2000-03-30 2004-01-27 Bristol-Myers Squibb Company O-aryl glucoside SGLT2 inhibitors and method
US6936590B2 (en) 2001-03-13 2005-08-30 Bristol Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
CA2486106C (en) 2002-05-16 2013-07-16 Glycomimetics, Inc. Compounds and methods for inhibiting selectin-mediated function
DE602004011272T2 (de) 2003-11-19 2008-12-24 Glycomimetics, Inc. Spezifischer antagonist sowohl für e- als auch p-selektine
EP1577289A1 (en) 2004-03-18 2005-09-21 Revotar Biopharmaceuticals AG Non-glycosylated/-glycosidic/-peptidic small molecule selectin inhibitors for the treament of inflammatory disorders
EP1928892B1 (en) 2005-08-09 2011-10-12 GlycoMimetics, Inc. Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas
ES2651929T3 (es) 2005-09-02 2018-01-30 Glycomimetics, Inc. Inhibidores de pan-selectina heterobifuncionales
EP1764095A1 (en) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel nitrocatechol derivatives having selectin ligand activity
EP1764096A1 (en) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel phloroglucinol derivatives having selectin ligand activity
EP1764093A1 (en) 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel aromatic compounds and their use in medical applications
KR100827674B1 (ko) * 2006-05-23 2008-05-07 (주)한빛테크 자동트립 장치와 그 제어방법
EP1897533A1 (en) * 2006-09-08 2008-03-12 Revotar Biopharmaceuticals AG Use of 1,6-Bis [3-(3-carboxymethylphenyl)-4-(2-alpha -D-mannopyranosyl-oxy)-phenyl] hexane for the preparation of cosmetic compositions
EP1903049A1 (en) 2006-09-08 2008-03-26 Revotar Biopharmaceuticals AG Crystalline forms of 1,6-Bis [3-(3-carboxymethylphenyl)-4-(2-alpha -D-mannopyranosyloxy)-phenyl] hexane
EP1958637A1 (en) * 2007-02-14 2008-08-20 Revotar Biopharmaceuticals AG Pharmaceutical composition for the treatment of IL-8 mediated diseases
RU2527177C2 (ru) 2007-12-20 2014-08-27 Энвиво Фармасьютикалз, Инк. Четырехзамещенные бензолы
US8895510B2 (en) 2008-04-08 2014-11-25 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
RU2012152633A (ru) * 2010-05-07 2014-06-20 Ревотар Биофармасьютикалз Аг Способ получения бимосиамозы
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
PL2794626T6 (pl) 2011-12-22 2020-11-02 Glycomimetics, Inc. Związki antagonistyczne E-selektyny
US9867841B2 (en) 2012-12-07 2018-01-16 Glycomimetics, Inc. Compounds, compositions and methods using E-selectin antagonists for mobilization of hematopoietic cells
EP3569609A1 (en) 2014-12-03 2019-11-20 GlycoMimetics, Inc. Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors
EP3497131B1 (en) 2016-08-08 2022-03-09 GlycoMimetics, Inc. Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4.
WO2018169853A1 (en) 2017-03-15 2018-09-20 Glycomimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH19293A (en) * 1982-11-15 1986-03-04 Pfizer Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof
NZ224501A (en) * 1987-05-06 1990-01-29 Adir Tylosin and carbomycin oxime derivatives and pharmaceutical compositions
US5075289A (en) * 1988-06-07 1991-12-24 Abbott Laboratories 9-r-azacyclic erythromycin antibiotics
CA2064985A1 (en) * 1991-04-05 1992-10-06 Robert R. Wilkening 8a-aza-8a-homoertyhromycin cyclic lactams
EP0627442A4 (en) * 1992-01-31 1995-01-11 Nippon Shinyaku Co Ltd DERIVATIVE OF A LEWIS TYPE SUGAR CHAIN.
US5444050A (en) * 1994-04-29 1995-08-22 Texas Biotechnology Corporation Binding of E-selectin or P-selectin to sialyl Lewisx or sialyl-Lewisa
US5498775A (en) * 1994-11-07 1996-03-12 American Home Products Corporation Polyanionic benzylglycosides as inhibitors of smooth muscle cell proliferation

Also Published As

Publication number Publication date
ES2146886T3 (es) 2000-08-16
AU704596B2 (en) 1999-04-29
AU6292396A (en) 1997-01-30
HU224590B1 (hu) 2005-11-28
JP4046351B2 (ja) 2008-02-13
HUP9802602A2 (hu) 1999-02-01
PL185372B1 (pl) 2003-04-30
DE69608804T2 (de) 2000-11-02
DE69608804D1 (de) 2000-07-13
GR3034289T3 (en) 2000-12-29
CZ407597A3 (cs) 1998-07-15
NO310623B1 (no) 2001-07-30
CA2221991C (en) 2007-09-18
NO976074D0 (no) 1997-12-23
FI974618A7 (fi) 1997-12-23
CZ290072B6 (cs) 2002-05-15
PL324330A1 (en) 1998-05-25
DK0840606T3 (da) 2000-08-07
JPH11508885A (ja) 1999-08-03
EP0840606A4 (index.php) 1998-05-13
NO976074L (no) 1998-03-02
EP0840606B1 (en) 2000-06-07
FI974618A0 (fi) 1997-12-23
HUP9802602A3 (en) 1999-08-30
CN1149082C (zh) 2004-05-12
PT840606E (pt) 2000-11-30
FI974618L (fi) 1997-12-23
WO1997001335A1 (en) 1997-01-16
EP0840606A1 (en) 1998-05-13
ATE193647T1 (de) 2000-06-15
CA2221991A1 (en) 1997-01-16
RU2165931C2 (ru) 2001-04-27
BR9608873A (pt) 1999-07-06
KR100438136B1 (ko) 2004-08-25
CN1196678A (zh) 1998-10-21
KR19990028441A (ko) 1999-04-15

Similar Documents

Publication Publication Date Title
UA52607C2 (uk) Похідні біфенілів, фармацевтична композиція на їх основі та спосіб інгібування (варіанти)
US5919768A (en) Di- and trivalent small molecule selectin inhibitors
AU691920B2 (en) Biphenyl Mannopyranoside Compounds
AU707160B2 (en) Tetrahydronaphthalene derivatives and their therapeutic use
AU637822B2 (en) Bile acid derivatives, processes for their preparation, and use as pharmaceuticals
JP5209476B2 (ja) ヘテロ二官能性全セレクチン阻害剤
HUT77345A (hu) E-szelektin, P-szelektin vagy L-szelektin szialil-Lewis x-hez vagy szialil-Lewis a-hoz kapcsolódását gátló mannopiranoziloxi-bifenil származékok és ezeket tartalmazó gyógyszerkészítmények
JP2001354666A (ja) 新規糖脂質誘導体
ES2362940T3 (es) Compuesto de trehalosa y producto farmacéutico que comprende dicho compuesto.
CN103168035A (zh) 4-异丙基苯基山梨醇化合物的晶型及其制备方法
JPH01125394A (ja) シアロシルグリセロリピッド類及びその製造方法
AU726935B2 (en) Fluoro labelled anthracyclinone and anthracycline derivatives
CN106608893A (zh) 磷酰甘露五糖及其衍生物，及其制备方法和应用
EP0048613A1 (en) 4-0-Substituted -2-deoxystreptamine aminoglycoside derivatives, their preparation and formulations containing them
CN1930180B (zh) 左侧葡萄糖脂a类似物
GB2034707A (en) Anthracycline glycosides
DK149818B (da) Analogifremgangsmaade til fremstilling af 5-fluoruracil-derivater
CN101238140A (zh) 脂质a类似物的制造方法
JPH0798832B2 (ja) イミダゾジアゼピン誘導体
PT86882A (pt) Processo para a preparacao de derivados dissacaridos
JPS615089A (ja) 新規アミノグリコシド誘導体
HK1131622A (zh) 抗凝血化合物