UA48006A1 - Methyl ethers of heteryloxamic acids exhibiting anti-inflammatory, analgesic and antipyretic activity - Google Patents
Methyl ethers of heteryloxamic acids exhibiting anti-inflammatory, analgesic and antipyretic activity Download PDFInfo
- Publication number
- UA48006A1 UA48006A1 UA3934190A UA3934190A UA48006A1 UA 48006 A1 UA48006 A1 UA 48006A1 UA 3934190 A UA3934190 A UA 3934190A UA 3934190 A UA3934190 A UA 3934190A UA 48006 A1 UA48006 A1 UA 48006A1
- Authority
- UA
- Ukraine
- Prior art keywords
- substances
- analgesic
- inflammatory
- heteryloxamic
- substance
- Prior art date
Links
- 239000002253 acid Substances 0.000 title claims abstract 3
- 150000007513 acids Chemical class 0.000 title claims abstract 3
- 230000000202 analgesic effect Effects 0.000 title claims abstract 3
- 230000003110 anti-inflammatory effect Effects 0.000 title claims abstract 3
- 230000001754 anti-pyretic effect Effects 0.000 title claims abstract 3
- 230000001747 exhibiting effect Effects 0.000 title abstract 2
- 150000005217 methyl ethers Chemical class 0.000 title abstract 2
- 238000012876 topography Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 abstract 8
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 2
- CPKISUMKCULUNR-UHFFFAOYSA-N 2-methoxy-2-oxoacetic acid Chemical compound COC(=O)C(O)=O CPKISUMKCULUNR-UHFFFAOYSA-N 0.000 abstract 1
- RMMXTBMQSGEXHJ-UHFFFAOYSA-N Aminophenazone Chemical compound O=C1C(N(C)C)=C(C)N(C)N1C1=CC=CC=C1 RMMXTBMQSGEXHJ-UHFFFAOYSA-N 0.000 abstract 1
- 229960000583 acetic acid Drugs 0.000 abstract 1
- 229960000212 aminophenazone Drugs 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000012362 glacial acetic acid Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 231100001231 less toxic Toxicity 0.000 abstract 1
- DJGAAPFSPWAYTJ-UHFFFAOYSA-M metamizole sodium Chemical compound [Na+].O=C1C(N(CS([O-])(=O)=O)C)=C(C)N(C)N1C1=CC=CC=C1 DJGAAPFSPWAYTJ-UHFFFAOYSA-M 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to derivatives of the heterocyclic substances in particular methyl ethers of heteryloxamic acids of the general formula HetNHCOCOOCH3 (I), where Het - 5-СН3-1,3,4-thyodiasolyl-2; 5-NH2SO2 thyodiasolyl-2 or thyasolyl-2, exhibiting the anti-inflammatory, analgesic and antipyretic activity. The substances may be used in medicine. In searching for pharmacological activity the novel substance were obtained. The substances (I) are obtained from monomethyloxalate chloroanhydride and the respective 2-amino heterocyclic substance in the presence of triethylamine on cooling in the medium of the glacial acetic acid. The yield amounts to 78-92%. The end products (I) represent the crystal substances. The novel substances (I) are more active and less toxic as against butadion, analgin and amidopyrin. (LD50 7250 mg/kg of live weight when the substance is administered intragastrically).
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UA3934190A UA48006A1 (en) | 1985-05-20 | 1985-05-20 | Methyl ethers of heteryloxamic acids exhibiting anti-inflammatory, analgesic and antipyretic activity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UA3934190A UA48006A1 (en) | 1985-05-20 | 1985-05-20 | Methyl ethers of heteryloxamic acids exhibiting anti-inflammatory, analgesic and antipyretic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA48006A1 true UA48006A1 (en) | 2002-08-15 |
Family
ID=74216337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA3934190A UA48006A1 (en) | 1985-05-20 | 1985-05-20 | Methyl ethers of heteryloxamic acids exhibiting anti-inflammatory, analgesic and antipyretic activity |
Country Status (1)
| Country | Link |
|---|---|
| UA (1) | UA48006A1 (en) |
-
1985
- 1985-05-20 UA UA3934190A patent/UA48006A1/en unknown
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