UA48023A1 - N-IMIDE OF p-(CYCLOHEXYLOXAMIDOSULFONYL)-SUCCINEANILIC ACID EXHIBITING ANTI-INFLAMMATORY ACTIVITY - Google Patents
N-IMIDE OF p-(CYCLOHEXYLOXAMIDOSULFONYL)-SUCCINEANILIC ACID EXHIBITING ANTI-INFLAMMATORY ACTIVITY Download PDFInfo
- Publication number
- UA48023A1 UA48023A1 UA4264404A UA4264404A UA48023A1 UA 48023 A1 UA48023 A1 UA 48023A1 UA 4264404 A UA4264404 A UA 4264404A UA 4264404 A UA4264404 A UA 4264404A UA 48023 A1 UA48023 A1 UA 48023A1
- Authority
- UA
- Ukraine
- Prior art keywords
- cyclohexyloxamidosulfonyl
- imide
- inflammatory activity
- succineanilic
- acid
- Prior art date
Links
- 230000003110 anti-inflammatory effect Effects 0.000 title claims abstract 3
- 239000002253 acid Substances 0.000 title abstract 3
- 230000001747 exhibiting effect Effects 0.000 title abstract 2
- 238000012876 topography Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 abstract 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- 206010030113 Oedema Diseases 0.000 abstract 1
- 150000004075 acetic anhydrides Chemical class 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- PAFZNILMFXTMIY-UHFFFAOYSA-N cyclohexylamine Chemical compound NC1CCCCC1 PAFZNILMFXTMIY-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
The invention relates to the heterocyclic substances, in particular to N-imide of p-(cyclohexyloxamidosulfonyl)-succineanilic acid exhibiting anti-inflammatory activity. The substances may be used in medicine. The aim consists in developing novel more active substances of such a group. The end products are synthesized in a reaction of cyclohexylamide of p-aminobenzenesulfoniloxamic acid with succinic and acetic anhydrides in the medium of the acetic acid on heating for 1 h. The yield amounts to 91%, the melting point is 218-220°С, the gross formula is C18H21N3O6S. The substance synthesized decrease the edema by 30% at a dose of 4.5 mg/kg. The toxicity of the substance is 5500 mg/kg. The corresponding values for the substance used for comparison are 100 mg/kg, 26-38% і 1000-3700 mg/kg.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UA4264404A UA48023A1 (en) | 1987-04-29 | 1987-04-29 | N-IMIDE OF p-(CYCLOHEXYLOXAMIDOSULFONYL)-SUCCINEANILIC ACID EXHIBITING ANTI-INFLAMMATORY ACTIVITY |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UA4264404A UA48023A1 (en) | 1987-04-29 | 1987-04-29 | N-IMIDE OF p-(CYCLOHEXYLOXAMIDOSULFONYL)-SUCCINEANILIC ACID EXHIBITING ANTI-INFLAMMATORY ACTIVITY |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA48023A1 true UA48023A1 (en) | 2002-08-15 |
Family
ID=74216252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA4264404A UA48023A1 (en) | 1987-04-29 | 1987-04-29 | N-IMIDE OF p-(CYCLOHEXYLOXAMIDOSULFONYL)-SUCCINEANILIC ACID EXHIBITING ANTI-INFLAMMATORY ACTIVITY |
Country Status (1)
| Country | Link |
|---|---|
| UA (1) | UA48023A1 (en) |
-
1987
- 1987-04-29 UA UA4264404A patent/UA48023A1/en unknown
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