UA48015A1 - 3-(2-nitrosuccine aniloylhydrazon) isatine exhibiting anti-inflammatory activity - Google Patents

3-(2-nitrosuccine aniloylhydrazon) isatine exhibiting anti-inflammatory activity Download PDF

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Publication number
UA48015A1
UA48015A1 UA4183330A UA4183330A UA48015A1 UA 48015 A1 UA48015 A1 UA 48015A1 UA 4183330 A UA4183330 A UA 4183330A UA 4183330 A UA4183330 A UA 4183330A UA 48015 A1 UA48015 A1 UA 48015A1
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UA
Ukraine
Prior art keywords
isatine
inflammatory activity
nitrosuccine
aniloylhydrazon
exhibiting anti
Prior art date
Application number
UA4183330A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Валентин Петрович Черних
Валентин Петрович Черных
Олександр Вікторович Чувурін
Александр Викторович Чувурин
Владислав Володимирович Страшний
Валерій Валентинович Дроговоз
Валерий Валентинович Дроговоз
Лариса Василівна Яковлєва
Лариса Васильевна Яковлева
Валентина Франківна Беднарчук
Лідія Іванівна Самохіна
Лидия Ивановна Самохина
Галина Григорівна Кононенко
Original Assignee
Національна Фармацевтична Академія України
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Publication date
Application filed by Національна Фармацевтична Академія України filed Critical Національна Фармацевтична Академія України
Priority to UA4183330A priority Critical patent/UA48015A1/en
Publication of UA48015A1 publication Critical patent/UA48015A1/en

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Abstract

The invention relates to the heterocyclic substances in particular to 3-(2-nitrosuccine aniloylhydrazon) isatine exhibiting the anti-inflammatory activity. The substance synthesized may be used in medicine. The aim consists in developing novel more active and less toxic substances of such a group. The end substances are synthesized in a reaction of hydrazine-o-nitrosuccineanylic acid with isatine in ethanol medium on heating for 2 h. The yield amounts to 92%. The gross formula is С18H15N5O5. The anti-inflammatory activity of the novel substance is 1.8-fold as high as that of indometacin. LD50 of the novel substance is 4390 mg/kg versus 47 mg/kg in indometacin.

Claims (1)

Формула винаходу 3-(2-Нитросукцинанилоилгидразон)изатина формуль! ше М 70 (о)The formula of the invention 3-(2-Nitrosuccinaniloylhydrazone)isatin formulas! she M 70 (o) О.М н проявляющий противовоспалительную активность. Офіційний бюлетень "Промислоава власність". Книга 1 "Винаходи, корисні моделі, топографії інтегральних мікросхем", 2002, М 8, 15.08.2002. Державний департамент інтелектуальної власності Міністерства освіти і науки України. «- « ІС) «- «в) с « ші с ;» щ» (ее) («в) - 50 сл - 60 б5O.M. showing anti-inflammatory activity. Official bulletin "Industrial Property". Book 1 "Inventions, useful models, topographies of integrated microcircuits", 2002, M 8, 15.08.2002. State Department of Intellectual Property of the Ministry of Education and Science of Ukraine. "- " IS) "- "c) s " shi s ;" sh" (ee) ("c) - 50 sl - 60 b5
UA4183330A 1987-01-19 1987-01-19 3-(2-nitrosuccine aniloylhydrazon) isatine exhibiting anti-inflammatory activity UA48015A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
UA4183330A UA48015A1 (en) 1987-01-19 1987-01-19 3-(2-nitrosuccine aniloylhydrazon) isatine exhibiting anti-inflammatory activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
UA4183330A UA48015A1 (en) 1987-01-19 1987-01-19 3-(2-nitrosuccine aniloylhydrazon) isatine exhibiting anti-inflammatory activity

Publications (1)

Publication Number Publication Date
UA48015A1 true UA48015A1 (en) 2002-08-15

Family

ID=74216220

Family Applications (1)

Application Number Title Priority Date Filing Date
UA4183330A UA48015A1 (en) 1987-01-19 1987-01-19 3-(2-nitrosuccine aniloylhydrazon) isatine exhibiting anti-inflammatory activity

Country Status (1)

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UA (1) UA48015A1 (en)

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