UA42024C2 - Спосіб біоконверсії для синтезу транс-гідроксисульфону - Google Patents
Спосіб біоконверсії для синтезу транс-гідроксисульфонуInfo
- Publication number
- UA42024C2 UA42024C2 UA97041700A UA97041700A UA42024C2 UA 42024 C2 UA42024 C2 UA 42024C2 UA 97041700 A UA97041700 A UA 97041700A UA 97041700 A UA97041700 A UA 97041700A UA 42024 C2 UA42024 C2 UA 42024C2
- Authority
- UA
- Ukraine
- Prior art keywords
- trans
- synthesis
- hydroxysulfone
- biological conversion
- tcai
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/185—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Новий мікробіологічний спосіб біоконверсії проміжної сполуки сульфокетону в проміжну сполуку транс-гідроксисульфону, який є попередником кінцевого продукту, інгібітору карбонатдегідрогенази. Кінцевий продукт має місцеву дію при лікуванні очної гіпертензії та глаукоми. Спосіб включає ферментацію субстрату сульфокетону в присутності мікроорганізму Rhodotorula rubra, або Rhodotorula pіlіmіnae. Отриманий аналог транс-гідроксисульфону виявляє діастереомірний надлишок більш ніж 95%.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/305,110 US5474919A (en) | 1994-09-13 | 1994-09-13 | Bioconversion process for the synthesis of transhydroxy sulfone by Rhodotorula rubra or Rhodotorula piliminae |
PCT/US1995/011243 WO1996008577A1 (en) | 1994-09-13 | 1995-09-08 | Bioconversion process for the synthesis of trans-hydroxy sulfone |
Publications (1)
Publication Number | Publication Date |
---|---|
UA42024C2 true UA42024C2 (uk) | 2001-10-15 |
Family
ID=23179375
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA97041700A UA42024C2 (uk) | 1994-09-13 | 1995-09-08 | Спосіб біоконверсії для синтезу транс-гідроксисульфону |
Country Status (11)
Country | Link |
---|---|
US (1) | US5474919A (uk) |
CN (1) | CN1057796C (uk) |
AU (1) | AU3464195A (uk) |
BR (1) | BR9508921A (uk) |
CZ (1) | CZ289030B6 (uk) |
FI (1) | FI971035A (uk) |
RU (1) | RU2134296C1 (uk) |
SK (1) | SK283028B6 (uk) |
TW (1) | TW384310B (uk) |
UA (1) | UA42024C2 (uk) |
WO (1) | WO1996008577A1 (uk) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0658211T4 (da) * | 1992-08-28 | 2004-04-13 | Avecia Ltd | Enzymatisk, asymmetrisk reduktionsfremgangsmåde til fremstilling af 4H-thieno(2,3-6)thiopyranderivater |
JP3777408B2 (ja) * | 1994-12-28 | 2006-05-24 | 株式会社カネカ | カルボン酸誘導体の製造法 |
ATE200283T1 (de) * | 1994-12-28 | 2001-04-15 | Kanegafuchi Chemical Ind | Verfahren zur herstellung eines carbonsäurederivates |
US5900368A (en) * | 1996-09-17 | 1999-05-04 | Merck & Co., Inc. | Process for bioreduction of bisaryl ketone to bisaryl alcohol |
ES2177415B1 (es) * | 2000-09-04 | 2004-10-16 | Ragactives, S.L. | Procedimiento para la obtencion de 4-alquilamino-5, 6-dihidro-4h-tieno-(2,3b)-tiopiran-2-sulfonamida-7-dioxidos, e intermedios. |
US20050059583A1 (en) | 2003-09-15 | 2005-03-17 | Allergan, Inc. | Methods of providing therapeutic effects using cyclosporin components |
WO2006074230A2 (en) * | 2005-01-06 | 2006-07-13 | Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Method of making dorzolamide hydrochloride |
WO2006078731A2 (en) * | 2005-01-18 | 2006-07-27 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Amorphous and crystalline forms of dorzolamide hydrochloride and processes of making same |
KR20100031571A (ko) * | 2007-05-07 | 2010-03-23 | 시플라 리미티드 | 도르졸라미드의 제조방법 |
HUE027183T2 (en) | 2011-03-10 | 2016-08-29 | Zach System Spa | Asymmetric reduction process |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4797413A (en) * | 1986-05-14 | 1989-01-10 | Merck & Co., Inc. | Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use |
US5371014A (en) * | 1988-02-12 | 1994-12-06 | Daicel Chemical Industries, Ltd. | Process for the production of optically active 2-hydroxy acid esters using microbes to reduce the 2-oxo precursor |
US4968815A (en) * | 1990-04-16 | 1990-11-06 | Merck & Co., Inc. | Synthesis of (S)-3-(thien-2-ylthio)butyric acid analogs |
US4968814A (en) * | 1990-04-18 | 1990-11-06 | Merck & Co., Inc. | (S)-Alkyl 3-(thien-2-ylthio)butyrate and analogs and synthesis thereof |
US5157129A (en) * | 1990-04-18 | 1992-10-20 | Merck & Co., Inc. | Enantiospecific synthesis of s-(+)-5,6-dihydro-4-(r-amino)-4h-thieno(2,3-b)thiopyran-2-sulfonamide-7,7-dioxide |
US5091409A (en) * | 1990-05-17 | 1992-02-25 | Merck & Co., Inc. | 4-alkylamino-6-(C3-5 -hydrocarbyl)thieno[2,3-B]thiopyran-2-sulfonamide-7,7-dioxides |
DE69123041T2 (de) * | 1990-08-10 | 1997-04-03 | Daicel Chem | Herstellungsverfahren für optisch aktiven 3-phenyl-1,3-propandiol |
US5352579A (en) * | 1991-06-28 | 1994-10-04 | Gen Probe, Inc. | Nucleic acid probes to histoplasma capsulatum |
DK0658211T4 (da) * | 1992-08-28 | 2004-04-13 | Avecia Ltd | Enzymatisk, asymmetrisk reduktionsfremgangsmåde til fremstilling af 4H-thieno(2,3-6)thiopyranderivater |
JP3279671B2 (ja) * | 1992-09-28 | 2002-04-30 | 鐘淵化学工業株式会社 | チエノチオピラン誘導体の製造方法 |
-
1994
- 1994-09-13 US US08/305,110 patent/US5474919A/en not_active Expired - Lifetime
-
1995
- 1995-09-08 BR BR9508921A patent/BR9508921A/pt not_active Application Discontinuation
- 1995-09-08 SK SK315-97A patent/SK283028B6/sk unknown
- 1995-09-08 CN CN95196145A patent/CN1057796C/zh not_active Expired - Fee Related
- 1995-09-08 WO PCT/US1995/011243 patent/WO1996008577A1/en active IP Right Grant
- 1995-09-08 AU AU34641/95A patent/AU3464195A/en not_active Abandoned
- 1995-09-08 CZ CZ1997774A patent/CZ289030B6/cs not_active IP Right Cessation
- 1995-09-08 RU RU97105763A patent/RU2134296C1/ru not_active IP Right Cessation
- 1995-09-08 UA UA97041700A patent/UA42024C2/uk unknown
- 1995-09-12 TW TW084109539A patent/TW384310B/zh not_active IP Right Cessation
-
1997
- 1997-03-12 FI FI971035A patent/FI971035A/fi not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CZ77497A3 (en) | 1997-07-16 |
RU2134296C1 (ru) | 1999-08-10 |
CZ289030B6 (cs) | 2001-10-17 |
TW384310B (en) | 2000-03-11 |
CN1162980A (zh) | 1997-10-22 |
CN1057796C (zh) | 2000-10-25 |
FI971035A0 (fi) | 1997-03-12 |
SK31597A3 (en) | 1997-10-08 |
SK283028B6 (sk) | 2003-02-04 |
WO1996008577A1 (en) | 1996-03-21 |
AU3464195A (en) | 1996-03-29 |
US5474919A (en) | 1995-12-12 |
FI971035A (fi) | 1997-03-12 |
BR9508921A (pt) | 1997-09-30 |
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