UA127380C2 - Співкристали, фармацевтичні композиції на їх основі та способи лікування, які передбачають їх застосування - Google Patents

Співкристали, фармацевтичні композиції на їх основі та способи лікування, які передбачають їх застосування Download PDF

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Publication number
UA127380C2
UA127380C2 UAA202003279A UAA202003279A UA127380C2 UA 127380 C2 UA127380 C2 UA 127380C2 UA A202003279 A UAA202003279 A UA A202003279A UA A202003279 A UAA202003279 A UA A202003279A UA 127380 C2 UA127380 C2 UA 127380C2
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UA
Ukraine
Prior art keywords
compound
formula
crystal
cancer
mutation
Prior art date
Application number
UAA202003279A
Other languages
English (en)
Ukrainian (uk)
Inventor
Бенджамін С. Лейн
Бенджамин С. Лейн
Чун-Хой Ґу
Чун-Хой ГУ
Original Assignee
Ле Лаборатуар Сервье
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ле Лаборатуар Сервье filed Critical Ле Лаборатуар Сервье
Publication of UA127380C2 publication Critical patent/UA127380C2/uk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/265—Citric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
UAA202003279A 2017-11-02 2018-11-02 Співкристали, фармацевтичні композиції на їх основі та способи лікування, які передбачають їх застосування UA127380C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762580501P 2017-11-02 2017-11-02
PCT/US2018/058930 WO2019090059A1 (en) 2017-11-02 2018-11-02 Cocrystals, pharmaceutical compositions thereof, and methods of treatment involving same

Publications (1)

Publication Number Publication Date
UA127380C2 true UA127380C2 (uk) 2023-08-02

Family

ID=64572453

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA202003279A UA127380C2 (uk) 2017-11-02 2018-11-02 Співкристали, фармацевтичні композиції на їх основі та способи лікування, які передбачають їх застосування

Country Status (25)

Country Link
US (3) US11345677B2 (enExample)
EP (1) EP3704101B1 (enExample)
JP (3) JP7335877B2 (enExample)
KR (1) KR102731624B1 (enExample)
CN (2) CN118359585A (enExample)
AU (3) AU2018360827B2 (enExample)
CA (1) CA3081535A1 (enExample)
DK (1) DK3704101T3 (enExample)
EA (1) EA202091112A1 (enExample)
ES (1) ES3075257T3 (enExample)
FI (1) FI3704101T3 (enExample)
HR (1) HRP20260783T1 (enExample)
IL (2) IL274123B2 (enExample)
LT (1) LT3704101T (enExample)
MA (1) MA50526B1 (enExample)
MX (2) MX2020004513A (enExample)
PH (1) PH12020550462A1 (enExample)
PT (1) PT3704101T (enExample)
RS (1) RS68236B1 (enExample)
SG (1) SG11202003612VA (enExample)
SI (1) SI3704101T1 (enExample)
SM (1) SMT202600262T1 (enExample)
TW (2) TWI796377B (enExample)
UA (1) UA127380C2 (enExample)
WO (1) WO2019090059A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200085832A1 (en) * 2019-11-22 2020-03-19 Agios Pharmaceuticals, Inc. Deuterated analogs of an organic compound
TW202227446A (zh) 2020-08-12 2022-07-16 美商施維雅製藥有限公司 有機化合物之固態形式
US20230346789A1 (en) * 2022-03-31 2023-11-02 Msd International Gmbh Methods of treating enhancing brain tumors using combination therapy
AR133332A1 (es) 2023-07-25 2025-09-17 Servier Lab Sales, cocristales, composiciones farmacéuticas de los mismos, y métodos de tratamiento que implican los mismos
CN121843929A (zh) * 2023-09-18 2026-04-10 贝达药业股份有限公司 突变型idh抑制剂化合物及其盐的固体形式
EP4538262A1 (en) 2023-10-12 2025-04-16 Sandoz Ag Cocrystals of vorasidenib
US20250257050A1 (en) 2024-02-09 2025-08-14 Les Laboratoires Servier Process for the preparation of vorasidenib

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013010564B1 (pt) * 2010-11-01 2021-09-21 Celgene Car Llc Compostos heterocíclicos e composições compreendendo os mesmos
SMT201800334T1 (it) 2012-01-06 2018-09-13 Agios Pharmaceuticals Inc Composti terapeuticamente attivi e loro metodi di utilizzo
WO2015003360A2 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use

Also Published As

Publication number Publication date
MX2020004513A (es) 2020-09-17
BR112020008598A2 (pt) 2021-01-26
EP3704101B1 (en) 2026-05-06
CN111527076A (zh) 2020-08-11
IL274123B1 (en) 2023-09-01
IL305426B1 (en) 2024-06-01
MX2022014792A (es) 2023-01-16
JP7335877B2 (ja) 2023-08-30
HRP20260783T1 (hr) 2026-08-14
TWI796377B (zh) 2023-03-21
AU2026205552A1 (en) 2026-07-30
EP3704101A1 (en) 2020-09-09
KR102731624B1 (ko) 2024-11-19
US12679820B2 (en) 2026-07-14
CA3081535A1 (en) 2019-05-09
PT3704101T (pt) 2026-06-24
US11345677B2 (en) 2022-05-31
US20220363661A1 (en) 2022-11-17
CN111527076B (zh) 2024-03-12
FI3704101T3 (fi) 2026-06-12
US11851417B2 (en) 2023-12-26
IL274123B2 (en) 2024-01-01
TW202337885A (zh) 2023-10-01
MA50526B1 (fr) 2026-06-30
AU2018360827A1 (en) 2020-05-14
JP2021501766A (ja) 2021-01-21
ES3075257T3 (en) 2026-07-29
IL305426A (en) 2023-10-01
SG11202003612VA (en) 2020-05-28
CN118359585A (zh) 2024-07-19
MA50526A (fr) 2020-09-09
JP2023093666A (ja) 2023-07-04
EA202091112A1 (ru) 2020-07-23
KR20240166601A (ko) 2024-11-26
US20240343705A1 (en) 2024-10-17
PH12020550462A1 (en) 2021-03-22
IL305426B2 (en) 2024-10-01
WO2019090059A1 (en) 2019-05-09
IL274123A (en) 2020-06-30
LT3704101T (lt) 2026-06-25
JP7780576B2 (ja) 2025-12-04
TW201930285A (zh) 2019-08-01
RS68236B1 (en) 2026-07-31
DK3704101T3 (da) 2026-06-15
AU2024203186A1 (en) 2024-05-30
JP2024113028A (ja) 2024-08-21
SI3704101T1 (sl) 2026-07-31
US20210198234A1 (en) 2021-07-01
JP7499377B2 (ja) 2024-06-13
AU2024203186B2 (en) 2026-04-16
SMT202600262T1 (it) 2026-07-16
AU2018360827B2 (en) 2024-02-22
TWI839131B (zh) 2024-04-11
KR20200095480A (ko) 2020-08-10

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