JP7335877B2 - 共結晶、その医薬組成物、およびそれを伴う治療方法 - Google Patents

共結晶、その医薬組成物、およびそれを伴う治療方法 Download PDF

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JP7335877B2
JP7335877B2 JP2020524501A JP2020524501A JP7335877B2 JP 7335877 B2 JP7335877 B2 JP 7335877B2 JP 2020524501 A JP2020524501 A JP 2020524501A JP 2020524501 A JP2020524501 A JP 2020524501A JP 7335877 B2 JP7335877 B2 JP 7335877B2
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compound
pharmaceutical composition
crystal
formula
cancer
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JP2021501766A5 (enExample
JP2021501766A (ja
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ベンジャミン エス． レーン，
チョン－フイ グ，
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Laboratoires Servier SAS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/265—Citric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2020524501A 2017-11-02 2018-11-02 共結晶、その医薬組成物、およびそれを伴う治療方法 Active JP7335877B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023070786A JP7499377B2 (ja) 2017-11-02 2023-04-24 共結晶、その医薬組成物、およびそれを伴う治療方法
JP2024090124A JP7780576B2 (ja) 2017-11-02 2024-06-03 共結晶、その医薬組成物、およびそれを伴う治療方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762580501P 2017-11-02 2017-11-02
US62/580,501 2017-11-02
PCT/US2018/058930 WO2019090059A1 (en) 2017-11-02 2018-11-02 Cocrystals, pharmaceutical compositions thereof, and methods of treatment involving same

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JP2023070786A Division JP7499377B2 (ja) 2017-11-02 2023-04-24 共結晶、その医薬組成物、およびそれを伴う治療方法

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JP2021501766A JP2021501766A (ja) 2021-01-21
JP2021501766A5 JP2021501766A5 (enExample) 2021-12-16
JP7335877B2 true JP7335877B2 (ja) 2023-08-30

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JP2020524501A Active JP7335877B2 (ja) 2017-11-02 2018-11-02 共結晶、その医薬組成物、およびそれを伴う治療方法
JP2023070786A Active JP7499377B2 (ja) 2017-11-02 2023-04-24 共結晶、その医薬組成物、およびそれを伴う治療方法
JP2024090124A Active JP7780576B2 (ja) 2017-11-02 2024-06-03 共結晶、その医薬組成物、およびそれを伴う治療方法

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JP2023070786A Active JP7499377B2 (ja) 2017-11-02 2023-04-24 共結晶、その医薬組成物、およびそれを伴う治療方法
JP2024090124A Active JP7780576B2 (ja) 2017-11-02 2024-06-03 共結晶、その医薬組成物、およびそれを伴う治療方法

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US (3) US11345677B2 (enExample)
EP (1) EP3704101A1 (enExample)
JP (3) JP7335877B2 (enExample)
KR (2) KR20240166601A (enExample)
CN (2) CN118359585A (enExample)
AU (2) AU2018360827B2 (enExample)
BR (1) BR112020008598A2 (enExample)
CA (1) CA3081535A1 (enExample)
EA (1) EA202091112A1 (enExample)
IL (2) IL274123B2 (enExample)
MA (1) MA50526A (enExample)
MX (2) MX2020004513A (enExample)
PH (1) PH12020550462A1 (enExample)
SG (1) SG11202003612VA (enExample)
TW (2) TWI839131B (enExample)
UA (1) UA127380C2 (enExample)
WO (1) WO2019090059A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200085832A1 (en) * 2019-11-22 2020-03-19 Agios Pharmaceuticals, Inc. Deuterated analogs of an organic compound
TW202227446A (zh) 2020-08-12 2022-07-16 美商施維雅製藥有限公司 有機化合物之固態形式
US20230346789A1 (en) 2022-03-31 2023-11-02 Msd International Gmbh Methods of treating enhancing brain tumors using combination therapy
AR133332A1 (es) 2023-07-25 2025-09-17 Servier Lab Sales, cocristales, composiciones farmacéuticas de los mismos, y métodos de tratamiento que implican los mismos
WO2025060940A1 (zh) * 2023-09-18 2025-03-27 贝达药业股份有限公司 突变型idh抑制剂化合物及其盐的固体形式
EP4538262A1 (en) 2023-10-12 2025-04-16 Sandoz Ag Cocrystals of vorasidenib
US20250257050A1 (en) 2024-02-09 2025-08-14 Les Laboratoires Servier Process for the preparation of vorasidenib

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016526561A (ja) 2013-07-11 2016-09-05 アジオス ファーマシューティカルズ， インコーポレイテッド 治療活性化合物およびそれらの使用方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012061299A1 (en) * 2010-11-01 2012-05-10 Avila Therapeutics, Inc. Heterocyclic compounds and uses thereof
US9579324B2 (en) * 2013-07-11 2017-02-28 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016526561A (ja) 2013-07-11 2016-09-05 アジオス ファーマシューティカルズ， インコーポレイテッド 治療活性化合物およびそれらの使用方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Pharm Tech Japan，2009年，Vol. 25, No.12，p.155-166
日本薬理学雑誌，2017年，Vol. 150，pp. 36-40

Also Published As

Publication number Publication date
JP2023093666A (ja) 2023-07-04
IL305426B2 (en) 2024-10-01
US20220363661A1 (en) 2022-11-17
SG11202003612VA (en) 2020-05-28
US20210198234A1 (en) 2021-07-01
KR102731624B1 (ko) 2024-11-19
MX2020004513A (es) 2020-09-17
TWI839131B (zh) 2024-04-11
IL305426A (en) 2023-10-01
UA127380C2 (uk) 2023-08-02
JP7780576B2 (ja) 2025-12-04
AU2024203186A1 (en) 2024-05-30
TW201930285A (zh) 2019-08-01
TWI796377B (zh) 2023-03-21
EP3704101A1 (en) 2020-09-09
IL274123A (en) 2020-06-30
US11851417B2 (en) 2023-12-26
TW202337885A (zh) 2023-10-01
AU2018360827A1 (en) 2020-05-14
MA50526A (fr) 2020-09-09
IL305426B1 (en) 2024-06-01
IL274123B1 (en) 2023-09-01
WO2019090059A1 (en) 2019-05-09
US11345677B2 (en) 2022-05-31
CN111527076A (zh) 2020-08-11
US20240343705A1 (en) 2024-10-17
PH12020550462A1 (en) 2021-03-22
JP2024113028A (ja) 2024-08-21
CN118359585A (zh) 2024-07-19
JP7499377B2 (ja) 2024-06-13
CN111527076B (zh) 2024-03-12
MX2022014792A (es) 2023-01-16
KR20240166601A (ko) 2024-11-26
BR112020008598A2 (pt) 2021-01-26
EA202091112A1 (ru) 2020-07-23
KR20200095480A (ko) 2020-08-10
AU2018360827B2 (en) 2024-02-22
JP2021501766A (ja) 2021-01-21
CA3081535A1 (en) 2019-05-09
IL274123B2 (en) 2024-01-01

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