UA123385C2 - Рекомбінантний модифікований вірус вісповакцини анкара (mva) та спосіб лікування або попередження інфекцій вірусу rsv - Google Patents
Рекомбінантний модифікований вірус вісповакцини анкара (mva) та спосіб лікування або попередження інфекцій вірусу rsv Download PDFInfo
- Publication number
- UA123385C2 UA123385C2 UAA201501765A UAA201501765A UA123385C2 UA 123385 C2 UA123385 C2 UA 123385C2 UA A201501765 A UAA201501765 A UA A201501765A UA A201501765 A UAA201501765 A UA A201501765A UA 123385 C2 UA123385 C2 UA 123385C2
- Authority
- UA
- Ukraine
- Prior art keywords
- mma
- recombinant
- virus
- protein
- shi
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title claims abstract description 64
- 241000725643 Respiratory syncytial virus Species 0.000 title claims abstract description 8
- 241001183012 Modified Vaccinia Ankara virus Species 0.000 title abstract description 7
- 238000000034 method Methods 0.000 claims abstract description 163
- 125000003729 nucleotide group Chemical group 0.000 claims abstract description 122
- 239000002773 nucleotide Substances 0.000 claims abstract description 121
- 108010090054 Membrane Glycoproteins Proteins 0.000 claims abstract description 112
- 102000012750 Membrane Glycoproteins Human genes 0.000 claims abstract description 112
- 208000015181 infectious disease Diseases 0.000 claims abstract description 75
- 108090001074 Nucleocapsid Proteins Proteins 0.000 claims abstract description 69
- 241000700605 Viruses Species 0.000 claims description 109
- 230000003053 immunization Effects 0.000 claims description 66
- 238000002649 immunization Methods 0.000 claims description 59
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 40
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 36
- 108060003393 Granulin Proteins 0.000 claims description 29
- 239000008194 pharmaceutical composition Substances 0.000 claims description 27
- 241000282414 Homo sapiens Species 0.000 claims description 25
- 108700026244 Open Reading Frames Proteins 0.000 claims description 16
- 208000027697 autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency Diseases 0.000 claims description 15
- 101710085938 Matrix protein Proteins 0.000 claims description 13
- 235000013305 food Nutrition 0.000 claims description 13
- 239000012634 fragment Substances 0.000 claims description 13
- 108091005804 Peptidases Proteins 0.000 claims description 12
- 238000004519 manufacturing process Methods 0.000 claims description 12
- 101710127721 Membrane protein Proteins 0.000 claims description 10
- 239000004365 Protease Substances 0.000 claims description 10
- 229940083538 smallpox vaccine Drugs 0.000 claims description 10
- 238000011282 treatment Methods 0.000 claims description 9
- 238000007918 intramuscular administration Methods 0.000 claims description 7
- 230000002265 prevention Effects 0.000 claims description 7
- 241000710198 Foot-and-mouth disease virus Species 0.000 claims description 6
- 235000010469 Glycine max Nutrition 0.000 claims description 6
- 238000004113 cell culture Methods 0.000 claims description 6
- 230000002829 reductive effect Effects 0.000 claims description 6
- 230000009385 viral infection Effects 0.000 claims description 5
- 101800001494 Protease 2A Proteins 0.000 claims description 4
- 108091081024 Start codon Proteins 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 244000068988 Glycine max Species 0.000 claims description 3
- 208000001203 Smallpox Diseases 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- 230000035939 shock Effects 0.000 claims description 3
- 206010073261 Ovarian theca cell tumour Diseases 0.000 claims description 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 2
- 229930182817 methionine Natural products 0.000 claims 2
- 101100314454 Caenorhabditis elegans tra-1 gene Proteins 0.000 claims 1
- 244000301682 Heliotropium curassavicum Species 0.000 claims 1
- 235000015854 Heliotropium curassavicum Nutrition 0.000 claims 1
- 241001397173 Kali <angiosperm> Species 0.000 claims 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims 1
- 238000005242 forging Methods 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 abstract description 257
- 230000028993 immune response Effects 0.000 abstract description 13
- 239000013598 vector Substances 0.000 abstract description 9
- 230000000306 recurrent effect Effects 0.000 abstract description 4
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 description 156
- 241000699670 Mus sp. Species 0.000 description 136
- 102000004169 proteins and genes Human genes 0.000 description 86
- 235000018102 proteins Nutrition 0.000 description 84
- 210000004027 cell Anatomy 0.000 description 73
- 210000004072 lung Anatomy 0.000 description 63
- 238000010561 standard procedure Methods 0.000 description 48
- 230000004044 response Effects 0.000 description 42
- 210000002966 serum Anatomy 0.000 description 41
- 230000036039 immunity Effects 0.000 description 39
- 241001465754 Metazoa Species 0.000 description 37
- 238000004458 analytical method Methods 0.000 description 36
- 210000004988 splenocyte Anatomy 0.000 description 29
- 108090000765 processed proteins & peptides Proteins 0.000 description 28
- 230000005867 T cell response Effects 0.000 description 25
- 238000007920 subcutaneous administration Methods 0.000 description 24
- 239000007924 injection Substances 0.000 description 23
- 238000002347 injection Methods 0.000 description 23
- 239000003814 drug Substances 0.000 description 22
- 239000012071 phase Substances 0.000 description 22
- 210000004369 blood Anatomy 0.000 description 21
- 239000008280 blood Substances 0.000 description 21
- 241000699666 Mus <mouse, genus> Species 0.000 description 20
- 238000002255 vaccination Methods 0.000 description 20
- 101710204837 Envelope small membrane protein Proteins 0.000 description 19
- 239000000427 antigen Substances 0.000 description 18
- 238000011160 research Methods 0.000 description 18
- 235000001014 amino acid Nutrition 0.000 description 17
- 108091007433 antigens Proteins 0.000 description 17
- 102000036639 antigens Human genes 0.000 description 17
- 230000003612 virological effect Effects 0.000 description 17
- 150000001413 amino acids Chemical class 0.000 description 16
- 201000010099 disease Diseases 0.000 description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 16
- 229940079593 drug Drugs 0.000 description 16
- 230000010354 integration Effects 0.000 description 15
- 238000012545 processing Methods 0.000 description 15
- 108020004414 DNA Proteins 0.000 description 14
- 230000037396 body weight Effects 0.000 description 14
- 238000002360 preparation method Methods 0.000 description 14
- 102000004196 processed proteins & peptides Human genes 0.000 description 14
- 239000000523 sample Substances 0.000 description 14
- 101710088839 Replication initiation protein Proteins 0.000 description 13
- 230000001086 cytosolic effect Effects 0.000 description 13
- 210000000952 spleen Anatomy 0.000 description 13
- 229960001600 xylazine Drugs 0.000 description 12
- 108090000288 Glycoproteins Proteins 0.000 description 11
- 238000006243 chemical reaction Methods 0.000 description 11
- 239000007788 liquid Substances 0.000 description 11
- 229960000856 protein c Drugs 0.000 description 11
- 230000000638 stimulation Effects 0.000 description 11
- 238000013518 transcription Methods 0.000 description 11
- 230000035897 transcription Effects 0.000 description 11
- 238000003199 nucleic acid amplification method Methods 0.000 description 10
- 102100038132 Endogenous retrovirus group K member 6 Pro protein Human genes 0.000 description 9
- 102000003886 Glycoproteins Human genes 0.000 description 9
- 230000003321 amplification Effects 0.000 description 9
- 238000012217 deletion Methods 0.000 description 9
- 230000037430 deletion Effects 0.000 description 9
- 230000007717 exclusion Effects 0.000 description 9
- 230000001815 facial effect Effects 0.000 description 9
- 239000012530 fluid Substances 0.000 description 9
- 230000001939 inductive effect Effects 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 230000010076 replication Effects 0.000 description 9
- 230000002238 attenuated effect Effects 0.000 description 8
- 238000011161 development Methods 0.000 description 8
- 230000001717 pathogenic effect Effects 0.000 description 8
- 239000013612 plasmid Substances 0.000 description 8
- 229920001184 polypeptide Polymers 0.000 description 8
- 235000019419 proteases Nutrition 0.000 description 8
- 102000004127 Cytokines Human genes 0.000 description 7
- 108090000695 Cytokines Proteins 0.000 description 7
- 101800003332 Metamorphosin A Proteins 0.000 description 7
- 101800004937 Protein C Proteins 0.000 description 7
- 210000001744 T-lymphocyte Anatomy 0.000 description 7
- 230000005875 antibody response Effects 0.000 description 7
- 230000001413 cellular effect Effects 0.000 description 7
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 7
- 244000052769 pathogen Species 0.000 description 7
- 239000002953 phosphate buffered saline Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 210000003462 vein Anatomy 0.000 description 7
- 206010011906 Death Diseases 0.000 description 6
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
- 101710145006 Lysis protein Proteins 0.000 description 6
- 102000017975 Protein C Human genes 0.000 description 6
- 101800001700 Saposin-D Proteins 0.000 description 6
- 241000700618 Vaccinia virus Species 0.000 description 6
- 230000009471 action Effects 0.000 description 6
- 238000010367 cloning Methods 0.000 description 6
- 230000002354 daily effect Effects 0.000 description 6
- 238000010586 diagram Methods 0.000 description 6
- 235000005911 diet Nutrition 0.000 description 6
- 230000037213 diet Effects 0.000 description 6
- 108020001507 fusion proteins Proteins 0.000 description 6
- 102000037865 fusion proteins Human genes 0.000 description 6
- 210000005260 human cell Anatomy 0.000 description 6
- 238000002955 isolation Methods 0.000 description 6
- 230000002147 killing effect Effects 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 230000003472 neutralizing effect Effects 0.000 description 6
- 150000007523 nucleic acids Chemical class 0.000 description 6
- 239000013600 plasmid vector Substances 0.000 description 6
- 230000028327 secretion Effects 0.000 description 6
- 229940125575 vaccine candidate Drugs 0.000 description 6
- 238000005406 washing Methods 0.000 description 6
- IJJWOSAXNHWBPR-HUBLWGQQSA-N 5-[(3as,4s,6ar)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-n-(6-hydrazinyl-6-oxohexyl)pentanamide Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)NCCCCCC(=O)NN)SC[C@@H]21 IJJWOSAXNHWBPR-HUBLWGQQSA-N 0.000 description 5
- 206010015548 Euthanasia Diseases 0.000 description 5
- 241000282412 Homo Species 0.000 description 5
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 description 5
- 241000124008 Mammalia Species 0.000 description 5
- 101100018424 Mus musculus Ids gene Proteins 0.000 description 5
- 230000024932 T cell mediated immunity Effects 0.000 description 5
- 239000008186 active pharmaceutical agent Substances 0.000 description 5
- 238000004422 calculation algorithm Methods 0.000 description 5
- 244000309466 calf Species 0.000 description 5
- 238000010790 dilution Methods 0.000 description 5
- 239000012895 dilution Substances 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 210000002950 fibroblast Anatomy 0.000 description 5
- 230000028996 humoral immune response Effects 0.000 description 5
- 230000005847 immunogenicity Effects 0.000 description 5
- 230000008595 infiltration Effects 0.000 description 5
- 238000001764 infiltration Methods 0.000 description 5
- 238000003780 insertion Methods 0.000 description 5
- 230000037431 insertion Effects 0.000 description 5
- 238000007912 intraperitoneal administration Methods 0.000 description 5
- 229960003299 ketamine Drugs 0.000 description 5
- 108020004707 nucleic acids Proteins 0.000 description 5
- 102000039446 nucleic acids Human genes 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 230000003248 secreting effect Effects 0.000 description 5
- 238000013207 serial dilution Methods 0.000 description 5
- 239000006228 supernatant Substances 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 230000004580 weight loss Effects 0.000 description 5
- 239000012224 working solution Substances 0.000 description 5
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 5
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 4
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 4
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 4
- 206010002091 Anaesthesia Diseases 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 4
- 229920000742 Cotton Polymers 0.000 description 4
- 241000699800 Cricetinae Species 0.000 description 4
- 101800000342 Glycoprotein C Proteins 0.000 description 4
- 208000035415 Reinfection Diseases 0.000 description 4
- 101001039853 Sonchus yellow net virus Matrix protein Proteins 0.000 description 4
- 206010046865 Vaccinia virus infection Diseases 0.000 description 4
- 241000700647 Variola virus Species 0.000 description 4
- 239000003708 ampul Substances 0.000 description 4
- 230000037005 anaesthesia Effects 0.000 description 4
- -1 and P is cofactor G Proteins 0.000 description 4
- 238000010171 animal model Methods 0.000 description 4
- 238000011088 calibration curve Methods 0.000 description 4
- 230000036755 cellular response Effects 0.000 description 4
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 4
- 239000002299 complementary DNA Substances 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 230000002327 eosinophilic effect Effects 0.000 description 4
- 239000012894 fetal calf serum Substances 0.000 description 4
- 230000004927 fusion Effects 0.000 description 4
- 230000006801 homologous recombination Effects 0.000 description 4
- 238000002744 homologous recombination Methods 0.000 description 4
- 230000008105 immune reaction Effects 0.000 description 4
- 210000000987 immune system Anatomy 0.000 description 4
- 230000006698 induction Effects 0.000 description 4
- 239000003550 marker Substances 0.000 description 4
- 239000013642 negative control Substances 0.000 description 4
- 230000002685 pulmonary effect Effects 0.000 description 4
- 230000006798 recombination Effects 0.000 description 4
- 238000005215 recombination Methods 0.000 description 4
- 230000003362 replicative effect Effects 0.000 description 4
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 4
- 238000001890 transfection Methods 0.000 description 4
- 208000007089 vaccinia Diseases 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 241000283707 Capra Species 0.000 description 3
- 108091026890 Coding region Proteins 0.000 description 3
- 108020004705 Codon Proteins 0.000 description 3
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 3
- 238000002965 ELISA Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 241000287828 Gallus gallus Species 0.000 description 3
- 101000756628 Mus musculus Actin, cytoplasmic 1 Proteins 0.000 description 3
- 241001494479 Pecora Species 0.000 description 3
- 101710132653 Protein M2 Proteins 0.000 description 3
- 238000002123 RNA extraction Methods 0.000 description 3
- 102100023935 Transmembrane glycoprotein NMB Human genes 0.000 description 3
- 108020000999 Viral RNA Proteins 0.000 description 3
- 208000036142 Viral infection Diseases 0.000 description 3
- 210000000683 abdominal cavity Anatomy 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 210000000709 aorta Anatomy 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 210000003719 b-lymphocyte Anatomy 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 101150116749 chuk gene Proteins 0.000 description 3
- 201000003740 cowpox Diseases 0.000 description 3
- 230000034994 death Effects 0.000 description 3
- 231100000517 death Toxicity 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 210000003979 eosinophil Anatomy 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 239000006166 lysate Substances 0.000 description 3
- 238000012423 maintenance Methods 0.000 description 3
- 230000002906 microbiologic effect Effects 0.000 description 3
- 210000000440 neutrophil Anatomy 0.000 description 3
- 230000007170 pathology Effects 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 230000000241 respiratory effect Effects 0.000 description 3
- 239000007929 subcutaneous injection Substances 0.000 description 3
- 238000010254 subcutaneous injection Methods 0.000 description 3
- 238000006467 substitution reaction Methods 0.000 description 3
- 108091007466 transmembrane glycoproteins Proteins 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- 210000003501 vero cell Anatomy 0.000 description 3
- 241000726103 Atta Species 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 2
- 244000025361 Ficus carica Species 0.000 description 2
- 235000008730 Ficus carica Nutrition 0.000 description 2
- 241001547860 Gaya Species 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 108091006905 Human Serum Albumin Proteins 0.000 description 2
- 102000008100 Human Serum Albumin Human genes 0.000 description 2
- 101000807236 Human cytomegalovirus (strain AD169) Membrane glycoprotein US3 Proteins 0.000 description 2
- 206010061598 Immunodeficiency Diseases 0.000 description 2
- 102000004388 Interleukin-4 Human genes 0.000 description 2
- 108090000978 Interleukin-4 Proteins 0.000 description 2
- 241000282553 Macaca Species 0.000 description 2
- 241001436793 Meru Species 0.000 description 2
- 206010065764 Mucosal infection Diseases 0.000 description 2
- 229930182555 Penicillin Natural products 0.000 description 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 102000002508 Peptide Elongation Factors Human genes 0.000 description 2
- 108010068204 Peptide Elongation Factors Proteins 0.000 description 2
- 108010076504 Protein Sorting Signals Proteins 0.000 description 2
- 108020004511 Recombinant DNA Proteins 0.000 description 2
- 241000159610 Roya <green alga> Species 0.000 description 2
- 101710200413 Small hydrophobic protein Proteins 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 241000587120 Vaccinia virus Ankara Species 0.000 description 2
- 108700005077 Viral Genes Proteins 0.000 description 2
- 101150044453 Y gene Proteins 0.000 description 2
- 238000007792 addition Methods 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 125000000539 amino acid group Chemical group 0.000 description 2
- 210000004102 animal cell Anatomy 0.000 description 2
- 210000004436 artificial bacterial chromosome Anatomy 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000012472 biological sample Substances 0.000 description 2
- 238000010241 blood sampling Methods 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 210000003837 chick embryo Anatomy 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 102000035122 glycosylated proteins Human genes 0.000 description 2
- 108091005608 glycosylated proteins Proteins 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 230000002163 immunogen Effects 0.000 description 2
- 239000012678 infectious agent Substances 0.000 description 2
- 230000002458 infectious effect Effects 0.000 description 2
- 229940028885 interleukin-4 Drugs 0.000 description 2
- 231100000636 lethal dose Toxicity 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 210000004962 mammalian cell Anatomy 0.000 description 2
- 210000001161 mammalian embryo Anatomy 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- PGSADBUBUOPOJS-UHFFFAOYSA-N neutral red Chemical compound Cl.C1=C(C)C(N)=CC2=NC3=CC(N(C)C)=CC=C3N=C21 PGSADBUBUOPOJS-UHFFFAOYSA-N 0.000 description 2
- 230000003448 neutrophilic effect Effects 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229940049954 penicillin Drugs 0.000 description 2
- 238000002203 pretreatment Methods 0.000 description 2
- 235000019833 protease Nutrition 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000001850 reproductive effect Effects 0.000 description 2
- 210000002345 respiratory system Anatomy 0.000 description 2
- 238000010839 reverse transcription Methods 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 235000015067 sauces Nutrition 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 229960005322 streptomycin Drugs 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229940031626 subunit vaccine Drugs 0.000 description 2
- 235000013616 tea Nutrition 0.000 description 2
- 230000001018 virulence Effects 0.000 description 2
- 102000007469 Actins Human genes 0.000 description 1
- 108010085238 Actins Proteins 0.000 description 1
- 206010001197 Adenocarcinoma of the cervix Diseases 0.000 description 1
- 208000034246 Adenocarcinoma of the cervix uteri Diseases 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 244000005894 Albizia lebbeck Species 0.000 description 1
- 240000003825 Allium akaka Species 0.000 description 1
- 235000000201 Allium akaka Nutrition 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 244000099147 Ananas comosus Species 0.000 description 1
- 235000007119 Ananas comosus Nutrition 0.000 description 1
- 241000182988 Assa Species 0.000 description 1
- 240000005220 Bischofia javanica Species 0.000 description 1
- 235000010893 Bischofia javanica Nutrition 0.000 description 1
- 241000283726 Bison Species 0.000 description 1
- 241000283725 Bos Species 0.000 description 1
- 241000566113 Branta sandvicensis Species 0.000 description 1
- OWNRRUFOJXFKCU-UHFFFAOYSA-N Bromadiolone Chemical compound C=1C=C(C=2C=CC(Br)=CC=2)C=CC=1C(O)CC(C=1C(OC2=CC=CC=C2C=1O)=O)C1=CC=CC=C1 OWNRRUFOJXFKCU-UHFFFAOYSA-N 0.000 description 1
- 101150111062 C gene Proteins 0.000 description 1
- 101710117545 C protein Proteins 0.000 description 1
- 108010040864 CERE Proteins 0.000 description 1
- 101100495256 Caenorhabditis elegans mat-3 gene Proteins 0.000 description 1
- 101100227826 Caenorhabditis elegans mks-5 gene Proteins 0.000 description 1
- 101100153505 Caenorhabditis elegans tni-1 gene Proteins 0.000 description 1
- 102000019034 Chemokines Human genes 0.000 description 1
- 108010012236 Chemokines Proteins 0.000 description 1
- 241000511343 Chondrostoma nasus Species 0.000 description 1
- 208000028399 Critical Illness Diseases 0.000 description 1
- 235000017788 Cydonia oblonga Nutrition 0.000 description 1
- 206010011831 Cytomegalovirus infection Diseases 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 238000007399 DNA isolation Methods 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 101100234002 Drosophila melanogaster Shal gene Proteins 0.000 description 1
- 101150013191 E gene Proteins 0.000 description 1
- 101710091045 Envelope protein Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010014950 Eosinophilia Diseases 0.000 description 1
- 240000008187 Erythrina edulis Species 0.000 description 1
- 235000002757 Erythrina edulis Nutrition 0.000 description 1
- 101000978703 Escherichia virus Qbeta Maturation protein A2 Proteins 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 241000219146 Gossypium Species 0.000 description 1
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 1
- 102000004144 Green Fluorescent Proteins Human genes 0.000 description 1
- 101001024566 Homo sapiens Ecto-ADP-ribosyltransferase 4 Proteins 0.000 description 1
- 101000840540 Homo sapiens Iduronate 2-sulfatase Proteins 0.000 description 1
- 244000025221 Humulus lupulus Species 0.000 description 1
- 235000008694 Humulus lupulus Nutrition 0.000 description 1
- 101100533874 Hypocrea jecorina (strain QM6a) sor5 gene Proteins 0.000 description 1
- 208000029462 Immunodeficiency disease Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000008070 Interferon-gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 102000013462 Interleukin-12 Human genes 0.000 description 1
- 108010065805 Interleukin-12 Proteins 0.000 description 1
- 102000000743 Interleukin-5 Human genes 0.000 description 1
- 108010002616 Interleukin-5 Proteins 0.000 description 1
- 102000015335 Ku Autoantigen Human genes 0.000 description 1
- 108010025026 Ku Autoantigen Proteins 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 101150046652 M2 gene Proteins 0.000 description 1
- 241000604742 Machilus thunbergii Species 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 241001139947 Mida Species 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 101100498160 Mus musculus Dach1 gene Proteins 0.000 description 1
- 240000007817 Olea europaea Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000531207 Oxera splendida Species 0.000 description 1
- 102100034574 P protein Human genes 0.000 description 1
- 101710181008 P protein Proteins 0.000 description 1
- 239000012807 PCR reagent Substances 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 241000269799 Perca fluviatilis Species 0.000 description 1
- 101710177166 Phosphoprotein Proteins 0.000 description 1
- 108010089430 Phosphoproteins Proteins 0.000 description 1
- 102000007982 Phosphoproteins Human genes 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 240000005546 Piper methysticum Species 0.000 description 1
- 235000016787 Piper methysticum Nutrition 0.000 description 1
- 229920000954 Polyglycolide Polymers 0.000 description 1
- 241000549435 Pria Species 0.000 description 1
- 108010001267 Protein Subunits Proteins 0.000 description 1
- 102000002067 Protein Subunits Human genes 0.000 description 1
- 101710188315 Protein X Proteins 0.000 description 1
- 208000029464 Pulmonary infiltrates Diseases 0.000 description 1
- 240000001987 Pyrus communis Species 0.000 description 1
- 241000219492 Quercus Species 0.000 description 1
- 108010010225 RA VII Proteins 0.000 description 1
- 238000011529 RT qPCR Methods 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
- 208000002200 Respiratory Hypersensitivity Diseases 0.000 description 1
- 235000011449 Rosa Nutrition 0.000 description 1
- YASAKCUCGLMORW-UHFFFAOYSA-N Rosiglitazone Chemical compound C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O YASAKCUCGLMORW-UHFFFAOYSA-N 0.000 description 1
- MBQKTLYFUYNAPZ-UHFFFAOYSA-N Rubia akane RA-VII Natural products C1=CC(OC)=CC=C1CC(N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(N(C1=O)C)C2)C(=O)NC(C)C(=O)N(C)C1CC(C=C1)=CC=C1OC1=CC2=CC=C1OC MBQKTLYFUYNAPZ-UHFFFAOYSA-N 0.000 description 1
- 241000801924 Sena Species 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 244000166071 Shorea robusta Species 0.000 description 1
- 235000015076 Shorea robusta Nutrition 0.000 description 1
- 101710172711 Structural protein Proteins 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 108010008038 Synthetic Vaccines Proteins 0.000 description 1
- 241001424341 Tara spinosa Species 0.000 description 1
- 241000019011 Tasa Species 0.000 description 1
- 108020005038 Terminator Codon Proteins 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 241000656145 Thyrsites atun Species 0.000 description 1
- 108700019146 Transgenes Proteins 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 244000042038 Tropaeolum tuberosum Species 0.000 description 1
- 241000767700 Tyche Species 0.000 description 1
- 206010046861 Vaccination complication Diseases 0.000 description 1
- 108010003533 Viral Envelope Proteins Proteins 0.000 description 1
- 101150068402 Wipf1 gene Proteins 0.000 description 1
- 241001377938 Yara Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- YQNQNVDNTFHQSW-UHFFFAOYSA-N acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester Chemical compound CC(=O)OC1=CC=CC=C1C(=O)NC1=NC=C([N+]([O-])=O)S1 YQNQNVDNTFHQSW-UHFFFAOYSA-N 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000002730 additional effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000010085 airway hyperresponsiveness Effects 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000000680 avirulence Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 101150044992 bchB gene Proteins 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 201000008873 bone osteosarcoma Diseases 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 210000000234 capsid Anatomy 0.000 description 1
- 210000004903 cardiac system Anatomy 0.000 description 1
- 230000002612 cardiopulmonary effect Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000007969 cellular immunity Effects 0.000 description 1
- 201000006662 cervical adenocarcinoma Diseases 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000015111 chews Nutrition 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 244000309457 enveloped RNA virus Species 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 230000008029 eradication Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 102000054767 gene variant Human genes 0.000 description 1
- 238000012252 genetic analysis Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000005090 green fluorescent protein Substances 0.000 description 1
- 230000007773 growth pattern Effects 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 230000005745 host immune response Effects 0.000 description 1
- 102000054886 human ART4 Human genes 0.000 description 1
- 102000057422 human IDS Human genes 0.000 description 1
- 230000004727 humoral immunity Effects 0.000 description 1
- 230000008348 humoral response Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 230000007813 immunodeficiency Effects 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 210000003000 inclusion body Anatomy 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 229960003130 interferon gamma Drugs 0.000 description 1
- 229940117681 interleukin-12 Drugs 0.000 description 1
- 229940100602 interleukin-5 Drugs 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 210000003292 kidney cell Anatomy 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 208000030500 lower respiratory tract disease Diseases 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 235000009973 maize Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 230000016379 mucosal immune response Effects 0.000 description 1
- 210000003739 neck Anatomy 0.000 description 1
- VTRAEEWXHOVJFV-UHFFFAOYSA-N olmesartan Chemical compound CCCC1=NC(C(C)(C)O)=C(C(O)=O)N1CC1=CC=C(C=2C(=CC=CC=2)C=2NN=NN=2)C=C1 VTRAEEWXHOVJFV-UHFFFAOYSA-N 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000006179 pH buffering agent Substances 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 238000002161 passivation Methods 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 244000144985 peep Species 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 235000013550 pizza Nutrition 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 108010025221 plasma protein Z Proteins 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 229940024231 poxvirus vaccine Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 108010071967 protein K Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- MBQKTLYFUYNAPZ-FEZMQHRXSA-N ra vii Chemical compound C1=CC(OC)=CC=C1C[C@H](N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)NC(=O)[C@@H](N(C1=O)C)C2)C(=O)N[C@@H](C)C(=O)N(C)[C@H]1CC(C=C1)=CC=C1OC1=CC2=CC=C1OC MBQKTLYFUYNAPZ-FEZMQHRXSA-N 0.000 description 1
- 238000003753 real-time PCR Methods 0.000 description 1
- 229940124551 recombinant vaccine Drugs 0.000 description 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 238000011896 sensitive detection Methods 0.000 description 1
- 238000002864 sequence alignment Methods 0.000 description 1
- 238000013376 serial cultivation Methods 0.000 description 1
- 108091006024 signal transducing proteins Proteins 0.000 description 1
- 102000034285 signal transducing proteins Human genes 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 101150041594 soti gene Proteins 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 210000001179 synovial fluid Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 235000008521 threonine Nutrition 0.000 description 1
- 230000005029 transcription elongation Effects 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 230000017613 viral reproduction Effects 0.000 description 1
- 230000006490 viral transcription Effects 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 229910000859 α-Fe Inorganic materials 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261678367P | 2012-08-01 | 2012-08-01 | |
EP12005594 | 2012-08-01 | ||
PCT/EP2013/055483 WO2014019718A1 (en) | 2012-08-01 | 2013-03-15 | Recombinant modified vaccinia virus ankara (mva) respiratory syncytial virus (rsv) vaccine |
Publications (1)
Publication Number | Publication Date |
---|---|
UA123385C2 true UA123385C2 (uk) | 2021-03-31 |
Family
ID=66440168
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201501765A UA123385C2 (uk) | 2012-08-01 | 2013-03-15 | Рекомбінантний модифікований вірус вісповакцини анкара (mva) та спосіб лікування або попередження інфекцій вірусу rsv |
Country Status (8)
Country | Link |
---|---|
JP (2) | JP6895944B2 (ja) |
DK (1) | DK2879702T3 (ja) |
ES (1) | ES2767324T3 (ja) |
HU (1) | HUE047102T2 (ja) |
LT (1) | LT2879702T (ja) |
PT (1) | PT2879702T (ja) |
UA (1) | UA123385C2 (ja) |
ZA (1) | ZA201500606B (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2879702T3 (da) * | 2012-08-01 | 2020-02-24 | Bavarian Nordic As | Rekombinant modificeret vacciniavirus ankara (mva)-vaccine mod respiratorisk syncytialvirus (rsv) |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008114149A2 (en) * | 2007-03-21 | 2008-09-25 | Id Biomedical Corporation Of Quebec | Chimeric antigens |
CA2770304C (en) * | 2009-08-04 | 2019-11-26 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, Centers For Disease Control And Prevention | Anti-rsv immunogens and methods of immunization |
US9173933B2 (en) * | 2010-10-15 | 2015-11-03 | Bavarian Nordic A/S | Recombinant modified vaccinia virus Ankara influenza vaccine |
WO2012085936A2 (en) * | 2010-12-20 | 2012-06-28 | Panacea Biotech Ltd | Recombinant respiratory syncytial virus plasmids and vaccines |
WO2012089231A1 (en) * | 2010-12-30 | 2012-07-05 | Okairòs Ag | Paramyxovirus vaccines |
KR20220119527A (ko) * | 2012-08-01 | 2022-08-29 | 버베리안 노딕 에이/에스 | 재조합 변형된 백시니아 바이러스 앙카라(ankara) (mva) 호흡기 신시티알 바이러스(rsv) 백신 |
DK2879702T3 (da) * | 2012-08-01 | 2020-02-24 | Bavarian Nordic As | Rekombinant modificeret vacciniavirus ankara (mva)-vaccine mod respiratorisk syncytialvirus (rsv) |
-
2013
- 2013-03-15 DK DK13717721.8T patent/DK2879702T3/da active
- 2013-03-15 ES ES13717721T patent/ES2767324T3/es active Active
- 2013-03-15 UA UAA201501765A patent/UA123385C2/uk unknown
- 2013-03-15 LT LTEP13717721.8T patent/LT2879702T/lt unknown
- 2013-03-15 PT PT137177218T patent/PT2879702T/pt unknown
- 2013-03-15 HU HUE13717721A patent/HUE047102T2/hu unknown
-
2015
- 2015-01-27 ZA ZA2015/00606A patent/ZA201500606B/en unknown
-
2018
- 2018-12-26 JP JP2018242562A patent/JP6895944B2/ja active Active
-
2021
- 2021-06-04 JP JP2021094027A patent/JP7317896B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
DK2879702T3 (da) | 2020-02-24 |
LT2879702T (lt) | 2020-02-10 |
HUE047102T2 (hu) | 2020-04-28 |
ES2767324T3 (es) | 2020-06-17 |
PT2879702T (pt) | 2020-02-04 |
JP2019068833A (ja) | 2019-05-09 |
ZA201500606B (en) | 2020-05-27 |
JP2021137023A (ja) | 2021-09-16 |
JP7317896B2 (ja) | 2023-07-31 |
JP6895944B2 (ja) | 2021-06-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP7113924B2 (ja) | 組み換え改変ワクシニアウイルスアンカラ(mva)フィロウイルスワクチン | |
US20210196814A1 (en) | Recombinant Modified Vaccinia Virus Ankara (MVA) Respiratory Syncytial Virus (RSV) Vaccine | |
Enjuanes et al. | Molecular basis of coronavirus virulence and vaccine development | |
US11571471B2 (en) | Recombinant modified vaccinia virus ankara (MVA) equine encephalitis virus vaccine | |
US20090214587A1 (en) | Recombinant virus and use thereof | |
US11896658B2 (en) | RSV vaccines and methods of production and use thereof | |
UA123385C2 (uk) | Рекомбінантний модифікований вірус вісповакцини анкара (mva) та спосіб лікування або попередження інфекцій вірусу rsv | |
WO2024079285A9 (en) | Treatment using a one-to-stop attenuated sars-cov-2 virus | |
CN113227360A (zh) | 具有新型流感病毒来源的血凝素蛋白基因的DIs株来源的重组牛痘病毒 |