UA122090U - METHOD OF DIAGNOSTICS OF ATHEROSCLEROSIS DEVELOPMENT - Google Patents

Abstract

A method of diagnosing the development of atherosclerosis includes clinical examination, examination of low and high density lipoprotein cholesterol levels, arteriography. MTHFR C677T, eNOS T786C gene polymorphism, thrombomodulin content, folic acid, GAG, homocysteine and homozygous carrier 677-TT, 786-SS, thrombomodulin levels of ml <5 ml, 5 µl / 5 ml, 5 µl / 5 mL, 5 µm / ml levels, 5 µm / ml, 5 µm / ml levels, 5 µg / ml, 5 th / th levels / 6 ml GAG> 28 μmol / l, homocysteine> 20 μmol / l diagnose the development of atherosclerosis.

Description

A useful model belongs to medicine, in particular to therapy and rheumatology. It is prescribed and can be used in the treatment and examination of patients.

Ways of diagnosing the development of atherosclerosis are known. These include determination of cholesterol levels of low and high density lipoproteins, arteriography of Ts|A.N. Okorokov

Diagnosis of diseases of internal organs. - Vol. 6 - pp. 75-85).

However, the known method is not effective enough and does not allow diagnosing the development of atherosclerosis at the beginning of the disease. Accordingly, there is no possibility to prevent atherosclerosis.

The basis of a useful model is the task of developing a method that would allow diagnosing the onset of atherosclerosis at an early stage.

The task is solved by the fact that together with a clinical examination, a study of low and high-density lipoprotein cholesterol levels, arteriography, according to a useful model, polymorphisms of the methylenetetrahydrofolate reductase (MTNEK C677T), nitric oxide synthase (emo T786C), thrombomodulin content are determined in the patient's blood serum , folic acid, glycosaminoglycans (GAG), homocysteine. With homozygous carriers of 677-TT, 786-SS, levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, GAG 228 μmol/l, homocysteine 220 μmol/l, the development of atherosclerosis is diagnosed.

Application of the method. During hospitalization, the patient is examined, low- and high-density lipoprotein cholesterol levels are examined, and arteriography is performed. Polymorphism of MTNEK C677tT, emo T786C genes, thrombomodulin, folic acid, GAG, homocysteine content are determined in blood serum by immunoenzymatic method. With homozygous carrier 677-TT, 786-

SS, levels of thrombomodulin 25 ng/ml, folic acid "6 ng/ml, GAG "28 μmol/l, homocysteine "20 μmol/l diagnose the development of atherosclerosis.

A specific example of using the method.

Patient A., 58 years old, was hospitalized with a diagnosis of rheumatoid arthritis.

Examined Low and high density lipoprotein cholesterol levels were studied. An arteriography of vessels was performed. There are no signs of atherosclerosis. The polymorphism of MTNEK Sb677y and emo5 T786C genes was determined in blood serum. The content of thrombomodulin, folic acid, GAG, homocysteine was determined by immunoenzymatic method. Established homozygous carrier 677-

TT and 786-SS. Levels of thrombomodulin - 10.4 ng/ml, folic acid - 2.8 ng/ml, GAG - 34 μmol/l, homocysteine - 32 μmol/l. The development of atherosclerosis was diagnosed. Arteriographic signs of the latter were detected only after 14 months.

Thus, the proposed method allows diagnosing atherosclerosis in the early stages.

Claims (1)

USEFUL MODEL FORMULA A method of diagnosing the development of atherosclerosis, which includes a clinical examination, a study of low and high-density lipoprotein cholesterol levels, arteriography, which is distinguished by which additionally determine the polymorphism of the MINEV C677T, eMmoO5 T7860 genes in the blood serum, the content of thrombomodulin, folic acid, GAG, homocysteine, and with homozygous carriers of 677-TT, 786-SS, levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml , GAG »28 μmol/l, homocysteine 220 μmol/l diagnose the development of atherosclerosis.