UA122052U - METHOD OF DIAGNOSTICS OF ATHEROSCLEROSIS DEVELOPMENT - Google Patents

Abstract

A method of diagnosing the development of atherosclerosis includes clinical examination, examination of low and high density lipoprotein cholesterol levels, arteriography. In the serum determine the polymorphism of the eNOS T786C gene, the content of thrombomodulin, folic acid, COMP, PSA. When homozygous carrier 786-SS, thrombomodulin levels> 5 ng / ml, folic acid <6 ng / ml, COMP> 595 ng / ml, SRP> 6 mg / l diagnose the development of atherosclerosis.

Description

The useful model belongs to the field of medicine, in particular to therapy and rheumatology, and is intended and can be used in the treatment and examination of patients.

A well-known analogue is the method of determining cholesterol levels of low and high density lipoproteins, arteriography (A.N. Okorokov. Diagnosis of diseases of internal organs. -Vol. 6-S. 75-85).

However, the analog is insufficiently effective and does not allow diagnosing the development of atherosclerosis even at the onset of the disease. Accordingly, there is no possibility to prevent atherosclerosis.

The basis of a useful model is the task of developing a method that would allow diagnosing the onset of atherosclerosis at an early stage.

The task is solved by conducting a clinical examination with a study of low and high-density lipoprotein cholesterol levels, arteriography, according to a useful model, in the blood serum of the patient to determine the polymorphism of the nitric oxide synthase gene (eMO5 t786C), the content of thrombomodulin, folic acid, cartilage oligomeric matrix protein (COMP), C-reactive protein (CRP). With homozygous carrier 786-SS, levels of thrombomodulin "5 ng/ml, folic acid "b ng/ml, SOMR "595 ng/ml, PSA "6b mg/l, the development of atherosclerosis is diagnosed.

A useful model is performed as follows.

During hospitalization, the patient is examined, low- and high-density lipoprotein cholesterol levels are examined, and arteriography is performed. In the patient's blood serum, the polymorphism of the eMmOo5 17860 gene is determined, the content of thrombomodulin, folic acid,

SOMR, SRP. With homozygous carrier 786-SS, levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, SOMR "595 ng/ml, PSA "6 mg/l, the development of atherosclerosis is diagnosed.

A specific example of using the method.

Patient V., 56 years old, was hospitalized with a diagnosis of rheumatoid arthritis. Inspected.

Low and high density lipoprotein cholesterol levels were studied. Arteriography was performed.

There are no signs of atherosclerosis. Polymorphism of the eMO5 T7860 gene was determined in blood serum.

The content of thrombomodulin, folic acid, SOMP, SRP was determined by immunoenzymatic method.

Homozygous carrier 786-SS was established. Levels of thrombomodulin -10.4 ng/ml, folic acid

Zo - 4.4 ng/ml, SMP - 670 ng/ml, SRP - 20 mg/l. The development of atherosclerosis was diagnosed.

Arteriographic signs of the process were detected only after 13 months.

Thus, a useful model allows establishing a diagnosis in the early stages of the development of atherosclerosis.

Claims (1)

USEFUL MODEL FORMULA A method of diagnosing the development of atherosclerosis, which includes a clinical examination, a study of low and high-density lipoprotein cholesterol levels, arteriography, which is distinguished by the fact that the eMMO5 T786C gene polymorphism, thrombomodulin content, folic acid, SOMR, SRP, with homozygous carrier 786-SS, thrombomodulin levels 25 ng/ml, folic acid "6 ng/ml, SOMR "595 ng/ml, SRP "b mg/l diagnose the development of atherosclerosis.