UA121123U - METHOD OF DIAGNOSTICS OF ATHEROSCLEROSIS DEVELOPMENT - Google Patents

Abstract

A method of diagnosing the development of atherosclerosis includes clinical examination, studies of low and high density lipoprotein cholesterol levels, arteriography, determination of MTHFR C677T, eNOS T786C gene polymorphism in the serum, thrombodulin content, GAG, IL-6. With homozygous carrier 677-TT, 786-CC, thrombomodulin levels> 5 ng / ml, GAG> 28 μmol / l, IL-6> 10 ng / l, homocysteine> 20 μmol / l diagnose the development of atherosclerosis.

Description

The proposed method of diagnosing the development of atherosclerosis belongs to medicine, in particular to therapy and rheumatology. It is prescribed and can be used in the treatment and examination of patients.

Ways of diagnosing the development of atherosclerosis are known. These include determination of cholesterol levels of low and high density lipoproteins, arteriography (Okorokov A.N. Diagnostics of diseases of internal organs. - M.: Med. lit., 2003. - Vol. 6. - P. 75-85).

However, the known method is not effective enough and does not allow diagnosing the development of atherosclerosis even at the onset of the disease. Accordingly, there is no possibility to prevent atherosclerosis.

The basis of a useful model is the task of developing a method that would allow diagnosing the onset of atherosclerosis at an early stage.

The task is solved by the fact that, along with the study of low and high-density lipoprotein cholesterol levels, arteriography in the patient's blood serum determines the polymorphism of the genes methylenetetrahydrofolate reductase (MITNEV Сб677Т), nitric oxide synthase (emoОо5 17860), the content of thrombomodulin, glycosaminoglycans (GAG), interleukin b ( IL-b), homocysteine. With homozygous carriers of 677-TT, 786-SS, thrombomodulin levels »5 ng/ml,

GAG 528 μmol/l, IL-b6 210 ng/l, homocysteine 220 μmol/l diagnose the development of atherosclerosis.

Application of the method. During hospitalization, the patient is examined, low- and high-density lipoprotein cholesterol levels are examined, and arteriography is performed. Polymorphism of MTNEV 677, emMmO5 1786C genes, thrombomodulin, GAG, IL-6, and homocysteine content are determined in serum. With homozygous carriers of 677-1T, 786-SS, levels of thrombomodulin »5 ng/ml, GAG »28 μmol/l, IL-b6 »10 ng/l, homocysteine »20 μmol/l, the development of atherosclerosis is diagnosed.

A specific example of using the method

Patient M., 50 years old, hospitalized in the clinic with a diagnosis of rheumatoid arthritis. Examined

Low and high density lipoprotein cholesterol levels were studied. An arteriography of vessels was performed. There are no signs of atherosclerosis. Polymorphism of MTNEV genes was determined in blood serum

C677T and eMmo5 T7860. The content of thrombomodulin, GAG, IL-6,

From homocysteine. Homozygous carriers of 677-TT and 786-SS were established. Levels of thrombomodulin - 12 ng/ml, GAG - 34 μmol/l, IL-6-14 ng/l, homocysteine - 38 μmol/l. The development of atherosclerosis was diagnosed. Arteriographic signs of the latter were detected only after 12 months.

Thus, the proposed method allows diagnosing atherosclerosis in the early stages of the process.

Claims (1)

USEFUL MODEL FORMULA A method of diagnosing the development of atherosclerosis, which includes a clinical examination, examination of the levels of low and high-density lipoprotein cholesterol, arteriography, determination of the MTNEV C677T, eMmO5 1786C gene polymorphism, the content of thrombomodulin, GAG, IL-b, and homocysteine in blood serum, which is distinguished by , that with homozygous carriers of 677-TT, 786-SS, levels of thrombomodulin »5 ng/ml, GAG »28 μmol/l, IL-b6 »10 ng/l, homocysteine »20 μmol/l diagnose the development of atherosclerosis.