UA118658C2 - СПОСІБ ДІАГНОСТИКИ ПРОГНОЗУ ВІДПОВІДІ НА ІНГІБІТОР TNFα - Google Patents
СПОСІБ ДІАГНОСТИКИ ПРОГНОЗУ ВІДПОВІДІ НА ІНГІБІТОР TNFαInfo
- Publication number
- UA118658C2 UA118658C2 UAA201504849A UAA201504849A UA118658C2 UA 118658 C2 UA118658 C2 UA 118658C2 UA A201504849 A UAA201504849 A UA A201504849A UA A201504849 A UAA201504849 A UA A201504849A UA 118658 C2 UA118658 C2 UA 118658C2
- Authority
- UA
- Ukraine
- Prior art keywords
- tnf
- inhibitor
- diagnostic method
- predicting response
- treatment
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 238000002405 diagnostic procedure Methods 0.000 title abstract 2
- 230000014509 gene expression Effects 0.000 abstract 1
- 238000011223 gene expression profiling Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Cell Biology (AREA)
- Rehabilitation Therapy (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Винахід стосується способу in vitro прогнозування того, чи відповідатиме пацієнт, який має ревматоїдний артрит, на лікування інгібітором TNF(, при цьому спосіб включає визначення рівня експресії генів CNTNAP3, CYP4F3, GZMB, ММЕ, МХ1, RAVER2, SERPINB10 та TNFAIP6 або рівня експресії генів CNTNAP3, CYP4F3, EPSTІ1, ММЕ, RGS1, SERP1NB10 та TNFAIP6, або рівня експресії генів FCGR3A, GPAM, GZMB, IFI35, ММЕ, PTGS2, RAVER2, RFC1 та RSAD2, в зразку крові згаданого пацієнта.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU1200607A HU230680B1 (hu) | 2012-10-19 | 2012-10-19 | Diagnosztikai eljárás |
PCT/HU2013/000101 WO2014060785A2 (en) | 2012-10-19 | 2013-10-18 | DIAGNOSTIC METHOD FOR PREDICTING RESPONSE TO TNFα INHIBITOR |
Publications (1)
Publication Number | Publication Date |
---|---|
UA118658C2 true UA118658C2 (uk) | 2019-02-25 |
Family
ID=89990915
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201504849A UA118658C2 (uk) | 2012-10-19 | 2013-10-18 | СПОСІБ ДІАГНОСТИКИ ПРОГНОЗУ ВІДПОВІДІ НА ІНГІБІТОР TNFα |
Country Status (12)
Country | Link |
---|---|
US (1) | US20160194709A1 (uk) |
EP (1) | EP2909340B1 (uk) |
JP (1) | JP2016502400A (uk) |
CA (1) | CA2889087C (uk) |
DK (1) | DK2909340T3 (uk) |
EA (1) | EA037105B1 (uk) |
ES (1) | ES2645972T3 (uk) |
HU (1) | HU230680B1 (uk) |
NO (1) | NO2909340T3 (uk) |
PL (1) | PL2909340T3 (uk) |
UA (1) | UA118658C2 (uk) |
WO (1) | WO2014060785A2 (uk) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016179469A1 (en) * | 2015-05-07 | 2016-11-10 | Abbvie Inc. | Methods and compositions for diagnosing and treating inflammatory bowel disease |
JP2018527895A (ja) | 2015-06-29 | 2018-09-27 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | 抗−apobec3抗体並びにその製造及び使用方法 |
GB2547406A (en) * | 2015-11-20 | 2017-08-23 | Folkersen Lasse | Apparatus and methods of using of biomarkers for predicting TNF-inhibitor response |
GB201521357D0 (en) * | 2015-12-03 | 2016-01-20 | Univ Liverpool | Methods for predicting response to anti-TNF therapy |
EP3433271A4 (en) * | 2016-03-23 | 2019-11-27 | Regents of the University of Minnesota | PROCEDURE FOR DETECTING APOBEC3 EXPRESSION AND PREDICTING CLINICAL RESULTS |
US20200399698A1 (en) * | 2018-02-19 | 2020-12-24 | Genefron Ltd. | Methods of determining response to tnf alpha blockers |
EP3765634A4 (en) | 2018-03-16 | 2021-12-01 | Scipher Medicine Corporation | METHODS AND SYSTEMS FOR PREDICTING THE RESPONSE TO ANTI-TNF THERAPIES |
WO2020111887A1 (ko) * | 2018-11-30 | 2020-06-04 | 차의과학대학교 산학협력단 | 뇌 유래 소포체 특이적 마커 및 이를 이용한 뇌 질병 진단 방법 |
US20220073988A1 (en) * | 2018-12-07 | 2022-03-10 | Dna Chip Research Inc. | Method for predicting efficacy of rheumatoid arthritis therapeutic agent and biomarker used therein |
WO2020264426A1 (en) | 2019-06-27 | 2020-12-30 | Scipher Medicine Corporation | Developing classifiers for stratifying patients |
KR102429261B1 (ko) * | 2020-08-25 | 2022-08-03 | 충북대학교 산학협력단 | 한국인의 tnf 저해제 약물 반응성 예측을 위한 바이오마커 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000058362A1 (en) * | 1999-03-26 | 2000-10-05 | Human Genome Sciences, Inc. | Neutrokine-alpha binding proteins and methods based thereon |
ES2322267T3 (es) * | 2003-04-09 | 2009-06-18 | Genentech, Inc. | Terapia de una enfermedad autoinmunologica en un paciente que presenta una respuesta inadecuada a un inhibidor de tnf-alfa. |
EP1857559A1 (en) * | 2006-05-16 | 2007-11-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A method for predicting responsiveness to TNF alpha blocking agents |
WO2008122007A1 (en) * | 2007-04-02 | 2008-10-09 | Genentech, Inc. | Biological markers predictive of rheumatoid arthritis response to b-cell antagonists |
WO2008132176A2 (en) * | 2007-04-27 | 2008-11-06 | Universite Catholique De Louvain | Method for evaluating the response of an individual to tnf blocking therapy |
US8092998B2 (en) * | 2007-05-31 | 2012-01-10 | Abbott Laboratories | Biomarkers predictive of the responsiveness to TNFα inhibitors in autoimmune disorders |
CN102171365B (zh) * | 2008-08-25 | 2014-01-29 | 森托科尔奥索生物科技公司 | 用于溃疡性结肠炎和相关疾病的抗tnf治疗的生物标记物 |
JP2011004743A (ja) * | 2009-06-26 | 2011-01-13 | Dna Chip Research Inc | 関節リウマチ患者におけるインフリキシマブ薬効の有効性を判別する方法 |
WO2012061620A1 (en) * | 2010-11-04 | 2012-05-10 | Genentech, Inc. | Methods for treating, diagnosing, and monitoring rheumatoid arthritis |
-
2012
- 2012-10-19 HU HU1200607A patent/HU230680B1/hu not_active IP Right Cessation
-
2013
- 2013-10-18 PL PL13789899T patent/PL2909340T3/pl unknown
- 2013-10-18 EA EA201590773A patent/EA037105B1/ru unknown
- 2013-10-18 EP EP13789899.5A patent/EP2909340B1/en active Active
- 2013-10-18 CA CA2889087A patent/CA2889087C/en not_active Expired - Fee Related
- 2013-10-18 DK DK13789899.5T patent/DK2909340T3/da active
- 2013-10-18 UA UAA201504849A patent/UA118658C2/uk unknown
- 2013-10-18 US US14/436,705 patent/US20160194709A1/en not_active Abandoned
- 2013-10-18 JP JP2015537363A patent/JP2016502400A/ja active Pending
- 2013-10-18 NO NO13789899A patent/NO2909340T3/no unknown
- 2013-10-18 ES ES13789899.5T patent/ES2645972T3/es active Active
- 2013-10-18 WO PCT/HU2013/000101 patent/WO2014060785A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2014060785A3 (en) | 2014-06-12 |
DK2909340T3 (da) | 2017-11-13 |
CA2889087A1 (en) | 2014-04-24 |
ES2645972T3 (es) | 2017-12-11 |
WO2014060785A2 (en) | 2014-04-24 |
EP2909340B1 (en) | 2017-08-02 |
EA037105B1 (ru) | 2021-02-05 |
EA201590773A1 (ru) | 2015-09-30 |
JP2016502400A (ja) | 2016-01-28 |
US20160194709A1 (en) | 2016-07-07 |
PL2909340T3 (pl) | 2018-01-31 |
CA2889087C (en) | 2021-11-16 |
NO2909340T3 (uk) | 2017-12-30 |
HU230680B1 (hu) | 2017-08-28 |
HUP1200607A2 (en) | 2014-04-28 |
EP2909340A2 (en) | 2015-08-26 |
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