UA117221C2 - Сполука триазинону та інгібітор кальцієвих каналів т-типу - Google Patents

Сполука триазинону та інгібітор кальцієвих каналів т-типу

Info

Publication number
UA117221C2
UA117221C2 UAA201411691A UAA201411691A UA117221C2 UA 117221 C2 UA117221 C2 UA 117221C2 UA A201411691 A UAA201411691 A UA A201411691A UA A201411691 A UAA201411691 A UA A201411691A UA 117221 C2 UA117221 C2 UA 117221C2
Authority
UA
Ukraine
Prior art keywords
compound
group
calcium channel
type calcium
channel inhibitor
Prior art date
Application number
UAA201411691A
Other languages
English (en)
Inventor
Норіко Саїто
Дзун Єгі
Хіросі Нагаї
Мегумі Уено
Юсуке Сінтані
Юсуке Інаба
Мітіакі Адаті
Юїті Хіраї
Такесі Кавадзу
Коїті Ясутаке
Даїкі Такахасі
Original Assignee
Ніссан Кемікал Індастріз, Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ніссан Кемікал Індастріз, Лтд. filed Critical Ніссан Кемікал Індастріз, Лтд.
Publication of UA117221C2 publication Critical patent/UA117221C2/uk

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    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/30—Only oxygen atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/42—One nitrogen atom
    • C07D251/46—One nitrogen atom with oxygen or sulfur atoms attached to the two other ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Запропоновано нову сполуку триазинону, яка має чудову інгібуючу активність потенціалзалежних кальцієвих каналів Т-типу і, зокрема, може бути використана для лікування болю. Сполука формули (І), таутомер сполуки, її фармацевтично прийнятна сіль або сольват: EMBED ISISServer , (I) де кожен замісник докладно описаний у описі або у формулі винаходу, наприклад R1 являє собою Н або С1-6алкокси і т. п., кожен з L1 і L2, незалежно, являє собою одинарний зв'язок або NR і т. п., L являє собою С1-6алкілен і т. п., А являє собою С6-14арил або від 5- до 10-членний гетероарил, який необов'язково заміщений і т. п., В являє собою С3-11циклоалкілен і т. п., D являє собою С6-14арил або від 5- до 10-членний гетероарил, який необов'язково заміщений, і т. п.
UAA201411691A 2012-03-30 2013-03-29 Сполука триазинону та інгібітор кальцієвих каналів т-типу UA117221C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012081163 2012-03-30
JP2013039267 2013-02-28
PCT/JP2013/059589 WO2013147183A1 (ja) 2012-03-30 2013-03-29 トリアジノン化合物及びｔ型カルシウムチャネル阻害剤

Publications (1)

Publication Number Publication Date
UA117221C2 true UA117221C2 (uk) 2018-07-10

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US (1) US9403798B2 (uk)
EP (1) EP2832728B8 (uk)
JP (1) JP6304492B2 (uk)
KR (1) KR102104469B1 (uk)
CN (1) CN104203928B (uk)
AU (1) AU2013241050B2 (uk)
BR (1) BR112014023919A8 (uk)
CA (1) CA2869127C (uk)
DK (1) DK2832728T3 (uk)
ES (1) ES2691082T3 (uk)
HK (1) HK1203962A1 (uk)
IL (1) IL234874B (uk)
MX (1) MX353470B (uk)
NZ (1) NZ626112A (uk)
PH (1) PH12014502066B1 (uk)
RU (1) RU2645158C2 (uk)
SG (1) SG11201406013PA (uk)
TW (1) TWI597271B (uk)
UA (1) UA117221C2 (uk)
WO (1) WO2013147183A1 (uk)

Families Citing this family (3)

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Publication number Priority date Publication date Assignee Title
US20160237071A1 (en) * 2013-10-02 2016-08-18 Nissan Chemical Industries, Ltd. T-type calcium channel inhibitor
US20160340322A1 (en) * 2013-12-17 2016-11-24 Nissan Chemical Industries, Ltd. Substituted triazinone compound and t-type calcium channel inhibitor
JP7279637B2 (ja) * 2017-08-23 2023-05-23 日産化学株式会社 新規重合体及びジアミン化合物

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JPS57144268A (en) * 1981-03-03 1982-09-06 Taiho Yakuhin Kogyo Kk Triazine compound and its preparation
JPS57144269A (en) * 1981-03-03 1982-09-06 Taiho Yakuhin Kogyo Kk Triazine derivative and its preparation
AU2004259346A1 (en) * 2003-07-22 2005-02-03 Neurogen Corporation Substituted pyridin-2-ylamine analogues
EP1866290B1 (en) * 2005-03-24 2013-05-01 Janssen Pharmaceutica N.V. Prokineticin 1 receptor antagonists
US8377968B2 (en) 2008-06-02 2013-02-19 Zalicus Pharmaceuticals, Ltd. N-piperidinyl acetamide derivatives as calcium channel blockers
EP2138488A1 (en) * 2008-06-26 2009-12-30 sanofi-aventis 4-(pyridin-4-yl)-1H-[1,3,5]triazin-2-one derivatives as GSK3-beta inhibitors for the treatment of neurodegenerative diseases
CN102395571B (zh) * 2009-02-13 2015-12-16 盐野义制药株式会社 三嗪衍生物及含有该三嗪衍生物的药物组合物
EP2477963A4 (en) 2009-09-18 2013-02-27 Zalicus Pharmaceuticals Ltd ARYLSULFON DERIVATIVES AS CALCIUM CHANNEL BLOCKERS
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DK2604595T3 (en) * 2010-08-10 2016-05-23 Shionogi & Co TRIAZINE DERIVATIVES AND PHARMACEUTICAL RELATIONSHIP CONTAINING THIS AND PROVIDING ANALGETIC ACTIVITY

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IL234874B (en) 2018-02-28
KR20140138654A (ko) 2014-12-04
US9403798B2 (en) 2016-08-02
HK1203962A1 (en) 2015-11-06
EP2832728B8 (en) 2018-10-31
JPWO2013147183A1 (ja) 2015-12-14
BR112014023919A8 (pt) 2018-01-16
PH12014502066A1 (en) 2015-02-09
EP2832728A1 (en) 2015-02-04
MX353470B (es) 2018-01-15
BR112014023919A2 (pt) 2017-06-20
RU2645158C2 (ru) 2018-02-16
MX2014011721A (es) 2015-02-04
JP6304492B2 (ja) 2018-04-04
CN104203928A (zh) 2014-12-10
AU2013241050B2 (en) 2017-07-13
KR102104469B1 (ko) 2020-04-24
TW201350471A (zh) 2013-12-16
PH12014502066B1 (en) 2015-02-09
RU2014143777A (ru) 2016-05-27
CA2869127C (en) 2020-06-09
TWI597271B (zh) 2017-09-01
US20150065705A1 (en) 2015-03-05
EP2832728B1 (en) 2018-09-05
NZ626112A (en) 2016-04-29
AU2013241050A1 (en) 2014-10-16
CA2869127A1 (en) 2013-10-03
ES2691082T3 (es) 2018-11-23
EP2832728A4 (en) 2015-11-04
CN104203928B (zh) 2017-06-06
DK2832728T3 (en) 2018-10-22
WO2013147183A1 (ja) 2013-10-03
SG11201406013PA (en) 2014-11-27

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