UA107818C2 - Alkyl amino pyrimidine derivatives as antagonists district h4-histamine receptors - Google Patents
Alkyl amino pyrimidine derivatives as antagonists district h4-histamine receptors Download PDFInfo
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- UA107818C2 UA107818C2 UAA201207986A UAA201207986A UA107818C2 UA 107818 C2 UA107818 C2 UA 107818C2 UA A201207986 A UAA201207986 A UA A201207986A UA A201207986 A UAA201207986 A UA A201207986A UA 107818 C2 UA107818 C2 UA 107818C2
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- alkyl
- formula
- compounds
- methyl
- group
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- 125000003282 alkyl amino group Chemical group 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 description 418
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- 125000004568 thiomorpholinyl group Chemical group 0.000 description 1
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
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- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- 125000006250 trifluoro ethyl amino group Chemical group [H]N(*)C([H])([H])C(F)(F)F 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
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- 229910052725 zinc Inorganic materials 0.000 description 1
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- GTLDTDOJJJZVBW-UHFFFAOYSA-N zinc cyanide Chemical compound [Zn+2].N#[C-].N#[C-] GTLDTDOJJJZVBW-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09382302 | 2009-12-23 | ||
| PCT/EP2010/070562 WO2011076878A1 (en) | 2009-12-23 | 2010-12-22 | Aminoalkylpyrimidine derivatives as histamine h4 receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA107818C2 true UA107818C2 (en) | 2015-02-25 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201207986A UA107818C2 (en) | 2009-12-23 | 2010-12-22 | Alkyl amino pyrimidine derivatives as antagonists district h4-histamine receptors |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8901146B2 (https=) |
| EP (1) | EP2516420B8 (https=) |
| JP (1) | JP5781537B2 (https=) |
| KR (1) | KR101740085B1 (https=) |
| CN (1) | CN102803248B (https=) |
| AR (1) | AR079725A1 (https=) |
| AU (1) | AU2010334804B2 (https=) |
| BR (1) | BR112012017126A2 (https=) |
| CA (1) | CA2785353C (https=) |
| IL (1) | IL220554A (https=) |
| MX (1) | MX345142B (https=) |
| NZ (1) | NZ601021A (https=) |
| PE (1) | PE20121505A1 (https=) |
| RU (1) | RU2573828C2 (https=) |
| TW (1) | TWI487697B (https=) |
| UA (1) | UA107818C2 (https=) |
| WO (1) | WO2011076878A1 (https=) |
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| UA109775C2 (xx) | 2009-10-29 | 2015-10-12 | N-вмісні гетероарильні похідні як інгібітори jak3-кінази | |
| KR102507287B1 (ko) * | 2011-09-02 | 2023-03-07 | 인사이트 홀딩스 코포레이션 | Ｐｉ３ｋ 억제제로서 헤테로시클릴아민 |
| TWI797176B (zh) | 2017-10-17 | 2023-04-01 | 西班牙商帕羅製藥有限公司 | ４-胺基嘧啶化合物之合成 |
| GB201817047D0 (en) | 2018-10-19 | 2018-12-05 | Heptares Therapeutics Ltd | H4 antagonist compounds |
| JP2022165429A (ja) * | 2019-10-02 | 2022-11-01 | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | ヒスタミンｈ４受容体調節作用を有する新規トリアジン誘導体 |
| CN117018194B (zh) * | 2023-07-26 | 2026-04-17 | 同济大学 | 毒蕈碱型受体5型受体拮抗剂的用途 |
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| WO1999023076A1 (en) * | 1997-11-04 | 1999-05-14 | Pfizer Products Inc. | Therapeutically active compounds based on indazole bioisostere replacement of catechol in pde4 inhibitors |
| ES2273047T3 (es) | 2002-10-28 | 2007-05-01 | Bayer Healthcare Ag | Fenilaminopirimidinas sustituidas con heteroariloxi como inhibidores de rho-cinasa. |
| JP4544999B2 (ja) * | 2002-11-25 | 2010-09-15 | 持田製薬株式会社 | ４−ヒドロキシピペリジン誘導体を有効成分とする呼吸器疾患治療剤 |
| EP1505064A1 (en) * | 2003-08-05 | 2005-02-09 | Bayer HealthCare AG | 2-Aminopyrimidine derivatives |
| WO2005054239A1 (en) | 2003-12-05 | 2005-06-16 | Bayer Healthcare Ag | 2-aminopyrimidine derivatives |
| KR20080004585A (ko) * | 2005-04-08 | 2008-01-09 | 바이엘 파마슈티칼스 코포레이션 | 피리미딘 유도체 및 암의 치료에서의 이의 용도 |
| US20090306038A1 (en) | 2005-09-13 | 2009-12-10 | Carceller Gonzalez Elena | 2-Aminopyrimidine derivatives as modulators of the histamine H4 receptor activity |
| CN103626742B (zh) * | 2005-11-01 | 2017-04-26 | 塔格根公司 | 激酶的联-芳基间-嘧啶抑制剂 |
| NL2000323C2 (nl) | 2005-12-20 | 2007-11-20 | Pfizer Ltd | Pyrimidine-derivaten. |
| WO2008031556A2 (en) | 2006-09-12 | 2008-03-20 | Ucb Pharma, S.A. | 2 amino-pyrimidine derivatives as h4 receptor antagonists, processes for preparing them and their use in pharmaceutical compositions |
| US7985745B2 (en) | 2006-10-02 | 2011-07-26 | Abbott Laboratories | Method for pain treatment |
| CL2008000467A1 (es) | 2007-02-14 | 2008-08-22 | Janssen Pharmaceutica Nv | Compuestos derivados de 2-aminopirimidina, moduladores del receptor histamina h4; su procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar un trastorno inflamatorio seleccionado de alegia, asma |
| WO2009068512A1 (en) * | 2007-11-30 | 2009-06-04 | Palau Pharma, S. A. | 2 -amino-pyrimidine derivatives as histamine h4 antagonists |
| WO2009077608A1 (en) | 2007-12-19 | 2009-06-25 | Palau Pharma, S. A. | 2 -aminopyrimidine derivatives as histamine h4 antagonists |
| SI2235012T1 (sl) * | 2007-12-21 | 2013-11-29 | Palau Pharma, S.A. | 4-aminopirimidinski derivati kot antagonisti histaminskega receptorja H4 |
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Also Published As
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| CA2785353C (en) | 2017-10-31 |
| JP5781537B2 (ja) | 2015-09-24 |
| US20130018031A1 (en) | 2013-01-17 |
| CA2785353A1 (en) | 2011-06-30 |
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| IL220554A (en) | 2016-08-31 |
| AR079725A1 (es) | 2012-02-15 |
| MX345142B (es) | 2017-01-18 |
| WO2011076878A1 (en) | 2011-06-30 |
| CN102803248A (zh) | 2012-11-28 |
| EP2516420A1 (en) | 2012-10-31 |
| AU2010334804A1 (en) | 2012-07-19 |
| RU2573828C2 (ru) | 2016-01-27 |
| AU2010334804B2 (en) | 2015-04-02 |
| PE20121505A1 (es) | 2012-11-05 |
| NZ601021A (en) | 2014-09-26 |
| JP2013515698A (ja) | 2013-05-09 |
| BR112012017126A2 (pt) | 2017-10-31 |
| EP2516420B1 (en) | 2018-08-22 |
| MX2012007385A (es) | 2012-08-15 |
| US8901146B2 (en) | 2014-12-02 |
| TWI487697B (zh) | 2015-06-11 |
| CN102803248B (zh) | 2015-09-16 |
| TW201141840A (en) | 2011-12-01 |
| RU2012131223A (ru) | 2014-02-10 |
| EP2516420B8 (en) | 2018-10-17 |
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