UA106992C2 - Похідні 2-аміно-2-фенілалканолу, їх одержання та фармацевтична композиція, що їх містить - Google Patents
Похідні 2-аміно-2-фенілалканолу, їх одержання та фармацевтична композиція, що їх міститьInfo
- Publication number
- UA106992C2 UA106992C2 UAA201202431A UAA201202431A UA106992C2 UA 106992 C2 UA106992 C2 UA 106992C2 UA A201202431 A UAA201202431 A UA A201202431A UA A201202431 A UAA201202431 A UA A201202431A UA 106992 C2 UA106992 C2 UA 106992C2
- Authority
- UA
- Ukraine
- Prior art keywords
- alkyl
- straight
- ris
- branched
- amino
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
Abstract
Складноефірні похідні 2-аміно-2-фенілалканолу загальної формули (І), де: Rутворює з Rта атомами азоту й вуглецю, до яких вони відповідно приєднані, гетероцикл з 4-7 членами, за необхідності заміщений в α-положенні атома азоту одним або двома Rта Rрадикалами, що можуть незалежно один від одного означати водень або лінійний або розгалужений алкіл (1-4С), та Rозначає Η чи радикал -CO-O-CHR-OCOR, для якого Rозначає Η або лінійний чи розгалужений алкіл (1-4С), та Rозначає алкіл, за необхідності заміщений бензилоксикарбоніламіно, ациламіно або залишком амінокислоти, або означає гетероцикл, або Rозначає лінійний чи розгалужений алкіл (1-4С), алкіл (2-4С), заміщений ОН, алкокси, алкілтіо, NH, алкіламіно, діалкіламіно, що за необхідності утворюють з атомом азоту, до якого вони приєднані, гетероцикл з 5 чи 6 членами, причому зрозуміло, що згаданий заміщений алкільний радикал лінійний або розгалужений та містить принаймні 2С між >N-Rта замісником, якщо тільки не зазначене інше, алкіл та ацил лінійні або розгалужені (1-7С), в їхніх R- чи S-формах або їх сумішах, а також їхні фармацевтично прийнятні солі.(I)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0903750A FR2948660B1 (fr) | 2009-07-30 | 2009-07-30 | Derives de 2-amino-2-phenyl-alkanol, leur preparation et les compositions pharmaceutiques qui les contiennent |
| PCT/FR2010/051598 WO2011012810A1 (fr) | 2009-07-30 | 2010-07-28 | Derives de 2-amino-2-phényl-alkanol, leur preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA106992C2 true UA106992C2 (uk) | 2014-11-10 |
Family
ID=41600791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201202431A UA106992C2 (uk) | 2009-07-30 | 2010-07-28 | Похідні 2-аміно-2-фенілалканолу, їх одержання та фармацевтична композиція, що їх містить |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8436192B2 (uk) |
| EP (1) | EP2459530B1 (uk) |
| JP (1) | JP2013500320A (uk) |
| KR (1) | KR20120052256A (uk) |
| CN (1) | CN102471259A (uk) |
| AU (1) | AU2010277400B2 (uk) |
| BR (1) | BR112012002042A2 (uk) |
| CA (1) | CA2767285A1 (uk) |
| FR (1) | FR2948660B1 (uk) |
| IL (1) | IL217351A (uk) |
| MA (1) | MA33458B1 (uk) |
| MX (1) | MX2012001378A (uk) |
| MY (1) | MY156335A (uk) |
| NZ (1) | NZ597861A (uk) |
| RU (1) | RU2012107465A (uk) |
| TW (1) | TW201105630A (uk) |
| UA (1) | UA106992C2 (uk) |
| WO (1) | WO2011012810A1 (uk) |
| ZA (1) | ZA201200165B (uk) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102012007439A1 (de) | 2012-04-13 | 2013-10-17 | Compositence Gmbh | Legekopf und Vorrichtung und Verfahren zum Aufbau eines dreidimensionalen Vorformlings für ein Bauteil aus einem Faserverbundwerkstoff |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1434826A (en) * | 1973-11-14 | 1976-05-05 | Gallardo Antonio Sa | Esters and carbamates of aminoalkanols |
| FR2669333B1 (fr) | 1990-11-16 | 1993-03-19 | Univ Rouen | Procede de separation des enantiomeres des 5-aryl-5-alkylhydantouines. |
| PT551034E (pt) | 1991-12-12 | 2001-01-31 | Hoechst Marion Roussel Inc | Antibioticos cefalosporinas com um radical benziloxiimino substituido na posicao 7 |
| FR2684994B1 (fr) | 1991-12-12 | 1995-03-03 | Roussel Uclaf | Nouvelles cephalosporines comportant en position 7, un radical benzyloxyimino substitue, leur procede de preparation et leur application comme medicaments. |
| US5587372A (en) | 1991-12-12 | 1996-12-24 | Roussel Uclaf | Cephalosporins |
| EP0628562A1 (fr) | 1993-06-10 | 1994-12-14 | Roussel Uclaf | Céphalosporines comportant en position 7 un radical oxymino substitué, leurs intermédiaires, leurs procédé de préparation et leur application comme médicaments |
| FR2765218B1 (fr) | 1997-06-30 | 1999-08-13 | Jouveinal Inst Rech | Le (s) 3,4,5-trimethoxybenzoate de 2-methylamino-2-phenyl-n- butyle, son application au traitement des douleurs chroniques |
| EP1110549A1 (en) | 1999-12-23 | 2001-06-27 | Warner-Lambert Company | Use of trimebutine for treating pain |
| AU2001261219B2 (en) * | 2000-05-05 | 2005-08-25 | University Of Virginia Patent Foundation | Felbamate derived compounds |
| TW200524868A (en) * | 2003-07-31 | 2005-08-01 | Zeria Pharm Co Ltd | Benzylamine derivatives |
| TWI354664B (en) * | 2003-08-21 | 2011-12-21 | Bristol Myers Squibb Co | Cyclic derivatives as modulators of chemokine rece |
| EA200601461A1 (ru) * | 2004-03-17 | 2007-02-27 | Пфайзер Продактс, Инк. | Новые производные бензил(иден)лактама |
| US7696234B2 (en) * | 2004-06-02 | 2010-04-13 | Eli Lilly And Company | Histamine H3 receptor agents, preparation and therapeutic uses |
| NZ563639A (en) | 2005-06-29 | 2009-12-24 | Compumedics Ltd | Sensor assembly with conductive bridge |
| FR2927076B1 (fr) * | 2008-01-31 | 2010-03-26 | Oroxcell | Derives de 2-amino-2-phenyl-alkanol, leur preparation et les compositions pharmaceutiques qui les contiennent |
-
2009
- 2009-07-30 FR FR0903750A patent/FR2948660B1/fr not_active Expired - Fee Related
-
2010
- 2010-07-26 TW TW099124488A patent/TW201105630A/zh unknown
- 2010-07-28 MY MYPI2012000014A patent/MY156335A/en unknown
- 2010-07-28 BR BR112012002042-0A patent/BR112012002042A2/pt not_active IP Right Cessation
- 2010-07-28 MA MA34570A patent/MA33458B1/fr unknown
- 2010-07-28 CA CA2767285A patent/CA2767285A1/fr not_active Abandoned
- 2010-07-28 AU AU2010277400A patent/AU2010277400B2/en not_active Expired - Fee Related
- 2010-07-28 KR KR1020127002562A patent/KR20120052256A/ko not_active Application Discontinuation
- 2010-07-28 US US13/387,462 patent/US8436192B2/en not_active Expired - Fee Related
- 2010-07-28 RU RU2012107465/04A patent/RU2012107465A/ru not_active Application Discontinuation
- 2010-07-28 UA UAA201202431A patent/UA106992C2/uk unknown
- 2010-07-28 MX MX2012001378A patent/MX2012001378A/es active IP Right Grant
- 2010-07-28 WO PCT/FR2010/051598 patent/WO2011012810A1/fr active Application Filing
- 2010-07-28 NZ NZ597861A patent/NZ597861A/xx not_active IP Right Cessation
- 2010-07-28 EP EP10752885.3A patent/EP2459530B1/fr not_active Not-in-force
- 2010-07-28 JP JP2012522224A patent/JP2013500320A/ja active Pending
- 2010-07-28 CN CN2010800339523A patent/CN102471259A/zh active Pending
-
2012
- 2012-01-03 IL IL217351A patent/IL217351A/en not_active IP Right Cessation
- 2012-01-09 ZA ZA2012/00165A patent/ZA201200165B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN102471259A (zh) | 2012-05-23 |
| FR2948660A1 (fr) | 2011-02-04 |
| IL217351A0 (en) | 2012-02-29 |
| CA2767285A1 (fr) | 2011-02-03 |
| MX2012001378A (es) | 2012-03-14 |
| TW201105630A (en) | 2011-02-16 |
| MA33458B1 (fr) | 2012-07-03 |
| FR2948660B1 (fr) | 2011-08-19 |
| WO2011012810A1 (fr) | 2011-02-03 |
| US8436192B2 (en) | 2013-05-07 |
| AU2010277400A1 (en) | 2012-02-02 |
| US20120129909A1 (en) | 2012-05-24 |
| MY156335A (en) | 2016-02-15 |
| ZA201200165B (en) | 2013-04-24 |
| EP2459530B1 (fr) | 2013-06-26 |
| BR112012002042A2 (pt) | 2018-04-10 |
| JP2013500320A (ja) | 2013-01-07 |
| IL217351A (en) | 2014-01-30 |
| AU2010277400B2 (en) | 2014-11-27 |
| KR20120052256A (ko) | 2012-05-23 |
| EP2459530A1 (fr) | 2012-06-06 |
| RU2012107465A (ru) | 2013-09-10 |
| NZ597861A (en) | 2013-08-30 |
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| UA106992C2 (uk) | Похідні 2-аміно-2-фенілалканолу, їх одержання та фармацевтична композиція, що їх містить |