TWM584197U - Health care product with core-shell structure - Google Patents

Abstract

A health care product with a core-shell structure includes a core and an outer layer formed on an outer surface of the core, wherein the core includes Taiwan lemon and at least one probiotic, and the outer layer includes at least one probiotic .

Description

Health product with core-shell structure

This novel relates to health products having a core-shell structure, particularly to a lime fragrance to protect Taiwan (Citrus reticulata var. Depressa) active ingredient in gastric acid and bile salt without destruction, and can effectively exert its antioxidant and Anti-inflammatory health supplement.

Taiwan lemon (Latin scientific name: Citrus reticulata var. Depressa ; Chinese alias: flat lemon) is an evergreen shrub of the genus Citrus of the Rutaceae family; the fruit is oblate, about 3-5 cm in diameter and weighs about 25-35 g, with a greenish-yellow pericarp and yellow-orange color after ripening, characterized by sour taste and strong aroma, mainly distributed in low-altitude forest areas in Taiwan, Okinawa, Japan and Kyushu.

It is currently known that the peel of Taiwan lemon fruit is rich in flavonoids [such as hesperidin, neo-hesperidin, etc.], and flavonoids have been proven to have antioxidant properties (anti-oxidation), anti-inflammation, anti-bacterial and anti-viral, anti-tumor, immune stimulating, and prevention of cardiovascular diseases Physiological and pharmacological activity. In particular, polymethoxyflavones (PMFs) [for example, nobiletin and tangeretin] have been found to be anti-inflammatory, anti-cancer, and prevent atherosclerosis ) Has excellent efficacy.

In addition, TW I541016 B reveals that the juice or extract of Taiwan lemon fruit is rich in sinensetin, isosinensetin, and hesperidin, and has been found to be excellent in vitro experiments. Xanthine oxidase inhibits activity and is therefore expected to be useful in the prevention or treatment of hyperuricemia or gout.

Based on the above beneficial effects, Taiwan lemon and its juice or extract have been widely used in food and health products. However, the active ingredients in commercially available healthy foods containing Taiwan lemon may be destroyed by gastric acid and bile salts in the stomach or intestines, resulting in a decrease in their antioxidant or anti-inflammatory activity. Therefore, how to protect the active ingredient of Taiwan lemon in foods or health products so that it can be effectively absorbed by the human body and exert its effects has become the goal of researchers in this field.

Probiotics are a microbial food ingredient that is beneficial to health and can selectively stimulate the growth of native bacteria in the intestine and change the composition of the intestinal microflora , Quantity, or nature, to promote the intestinal health of the host, and then improve the host's immune response (immune response). Known probiotic microorganisms may be used as comprising Lactobacillus (Lactobacillus), the genus Bifidus (Bifidobacterium), Bacillus (Bacillus), Lactococcus (Lactococcus), Enterococcus genus (Enterococcus), Saccharomyces (Saccharomyces), Streptococcus (Streptococcus) and other species.

After research, the applicant unexpectedly found that using probiotics to coat the layered structure of Taiwan lemon can protect Taiwan lemon and its active ingredients from being damaged by gastric acid or bile salts, and thus effectively improve its antioxidant and anti-inflammatory properties. efficacy.

Therefore, the object of the present invention is to provide a body that can effectively absorb Taiwan lemon ( Citrus reticulata var. Depressa ) and its active ingredients, thereby achieving anti-oxidation and anti-inflammation effects. Health products.

Therefore, the new health care product includes a core and an outer layer body formed on an outer surface of the core, wherein the core includes Taiwan lemon ( Citrus reticulata var. Depressa ) and at least one Prebiotics, the outer layer contains at least one probiotic.

The function of the new type is that through the layered coating structure of the health product, the human body can enhance the absorption of Taiwan lemon and its active ingredients, and can effectively achieve the anti-oxidation and anti-inflammatory effects.

Referring to FIG. 1, a preferred embodiment of the novel health care product includes a core 1 and an outer layer body 2 formed on an outer surface of the core 1.

The core 1 includes Taiwan lemon ( Citrus reticulata var. Depressa ) and at least one prebiotic.

According to the present invention, the Taiwan lemon may be a fruit juice or fruit extract of a Taiwan lemon. The preparation of fruit juices or fruit extracts of Taiwan lemon can be carried out using techniques that are well known and used by those skilled in the art. In this regard, reference can be made to TW I541016 B.

In the embodiment of the present invention, the Taiwan lemon is a fruit juice obtained by subjecting the fruit of Taiwan lemon [including peel, pulp, and seeds] to an extrusion process.

Preferably, the probiotic is selected from the group consisting of corn starch, maltodextrin, resistant maltodextrin, and fructooligosaccharides ( fructooligosaccharides, isomaltooligosaccharides, cellulose, inulin, galactooligosaccharides, arabinogalactan, xylooligosaccharides, and their The combination. In a preferred embodiment of the present invention, the probiotic is a combination of fructooligosaccharide and isomalto-oligosaccharide.

Preferably, based on the total weight of the health product, the Taiwan lemon has a content ranging from 2 to 10 wt%. In a preferred embodiment of the present invention, the Taiwan lemon has a content of 6 wt%.

Preferably, based on the total weight of the health product, the probiotic has a content ranging from 1 to 10 wt% . In a preferred embodiment of the present invention, the probiotic has a content of 6 wt%.

In a preferred embodiment of the present invention, the core 1 may further include a pharmaceutically acceptable carrier that is widely used in pharmaceutical manufacturing technology. For example, the pharmaceutically acceptable carrier may include one or more agents selected from the group consisting of solvents [eg, alcohols], buffers, emulsifiers, and suspending agents (suspending agent), decomposer, disintegrating agent, dispersing agent, binding agent [for example, gelatin and arabic gum], excipients Excipient [e.g., starch], stabilizing agent, chelating agent, diluent, gelling agent, preservative, filler ( filler), wetting agent, lubricant, absorption delaying agent, liposome, sweetening agent [for example, powdered sugar], flavoring agent] [for example, yogurt powder], a coloring agent, and the like. The selection and quantity of these reagents fall within the professionalism and routine skills of those familiar with the technology.

In a preferred embodiment of the present invention, the pharmaceutically acceptable carrier contains the following agents: starch, yogurt powder, and powdered sugar.

According to the present invention, the core 1 is formed by firstly mixing Taiwan lemon, fructooligosaccharide, isomalt oligosaccharide, starch, yogurt powder, and powdered sugar, and then performing a forming treatment [eg, granulation molding ( granulation molding), and then dried at a temperature of 50 to 80 ° C to prevent the active ingredients contained in Taiwan lemon from being destroyed by high temperatures.

The outer layer body 2 contains at least one probiotic. Preferably, the probiotic is selected from the group consisting of: Lactobacillus acidophilus , Lactobacillus casei , Lactobacillus delbrueckii subsp . Lactis ), Lactobacillus fermentum , Lactobacillus gasseri , Lactobacillus helveticus , Lactobacillus johnsonii , Lactobacillus paracasei , Lactobacillus plantarum ), Lactobacillus reuteri , Lactobacillus rhamnosus , Lactobacillus salivarius , Bifidobacterium animalis subsp . lactis Bifidobacterium bifidum , Bifidobacterium breve , Bifidobacterium infantis , Bifidobacterium longum , Lactococcus lactis subsp. Cremoris , Lactococcus lactis Diacetyl subspecies variants (Lactococcus lactis subsp. Lactis biovardiacetylactis) , Lactococcus lactis subsp (Lactococcus lactis subsp. Lactis), Streptococcus thermophilus (Streptococcus thermophilus), Bacillus coagulans (Bacillus coagulans), Kluyveromyces marxianus Yeast ( Kluyveromyces marxianus ), and combinations thereof. In a preferred embodiment of the present invention, the probiotic is Lactobacillus acidophilus, Bifidobacterium longum, Lactobacillus rhamnosus, Lactobacillus paracasei, Lactobacillus fermentum, Lactobacillus helveticus, Streptococcus thermophilus, coagulation Combination of Bacillus and Kluyveromyces marx.

Preferably, based on the total weight of the health product, the probiotic has a content ranging from 3 to 10 wt%. In a preferred embodiment of the present invention, the probiotic has a content of 7 wt%.

In a preferred embodiment of the present invention, the outer layer 2 can be formed on the outer surface of the core 1 by using techniques well known and used by those skilled in the art to protect the Taiwan fragrance in the core 1. Lemon to prevent it from being damaged by stomach acid or bile salts.

In a preferred embodiment of the present invention, the health care product further includes an acid and alkali resistant layer formed on an outer surface of the probiotic bacteria. Regarding the composition of the acid and alkali resistant layer, please refer to TW M407754 U1.

The health products according to the new type can be manufactured in various sizes and shapes using techniques well known to those skilled in the art. Suitable shapes include, but are not limited to, rectangular, circular, oval, cylindrical, and polygonal shapes. In a preferred embodiment of the present invention, the health care product is made rectangular (see FIG. 1). In another preferred embodiment of the present invention, the health care product is made into a circle (see FIG. 2).

Due to the layered coating structure of the new health product, after oral administration by the human body, the outer layer 2 containing the probiotic bacteria can protect the core 1 from the Taiwan lemon and its active ingredients in the core 1 Stomach acid and bile salts are destroyed, and they can be released in the intestine smoothly. Therefore, the new health care product can effectively improve the anti-oxidation and anti-inflammation effects of the lemon and its active ingredients.

In summary, the new type can effectively protect the Taiwan lemon and its active ingredients in the core 1 from being damaged by gastric acid and bile salts, and smoothly enter the intestine and be absorbed by the human body, thereby exerting its antioxidant and anti-inflammatory properties. Effect, it can indeed achieve the purpose of new cost.

However, the above are only examples of the new model. When the scope of implementation of the new model cannot be limited by this, any simple equivalent changes and modifications made in accordance with the scope of the patent application of the new model and the content of the patent specification are still Within the scope of this new patent.

1‧‧‧core

2‧‧‧ Outer body

Other features and effects of the present invention will be clearly presented in the embodiments with reference to the drawings, among which:
FIG. 1 is a cross-sectional side view illustrating a preferred embodiment of the new health product; and FIG. 2 is a cross-sectional side view illustrating another preferred embodiment of the new health product.

Claims (10)

A health product with a core-shell structure includes:
A core includes Taiwan lemon and at least one probiotic; and an outer layer formed on the outer surface of the core includes at least one probiotic. The health product according to claim 1, wherein the probiotic is selected from the group consisting of Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus deuterii Lactobacillus subsp. Lactis, Lactobacillus fermentum, Lactobacillus gasseri , Lactobacillus helveticus, Lactobacillus yojei, Lactobacillus paracasei, Lactobacillus sphaeroides, Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus salivarius, Bifidobacterium lactis subspecies, Bifidobacterium bifidus Bifidobacterium breve, Bifidobacterium infantis, Bifidobacterium longum, Lactococcus lactis subsp. Lactis, Lactococcus lactis subsp. Lactis, Lactococcus lactis subsp. Lactadione variant, Streptococcus thermophilus, Bacillus coagulans, Max Kluyveromyces, and their combinations. The health product of claim 2, wherein the probiotic is Lactobacillus acidophilus, Bifidobacterium longum, Lactobacillus rhamnosus, Lactobacillus paracasei, Lactobacillus fermentum, Lactobacillus helveticus, Streptococcus thermophilus, coagulating spores Combination of Bacillus and Max Kluyveromyces. The health product of claim 1, wherein the probiotic is selected from the group consisting of corn starch, maltodextrin, indigestible maltodextrin, fructooligosaccharide, isomalt, Cellulose, inulin, galactooligosaccharide, arabinogalactan, xylooligosaccharide, and combinations thereof. The health product of claim 4, wherein the probiotic is a combination of isomaltooligosaccharide and fructooligosaccharide. As in the health product of claim 1, wherein the Taiwan lemon has a content ranging from 2 to 10 wt% based on the total weight of the health product. The health product of claim 1, wherein the probiotic has a content ranging from 1 to 10 wt% based on the total weight of the health product. The health product of claim 1, wherein the probiotic has a content ranging from 3 to 10 wt% based on the total weight of the health product. The health supplement of claim 1, further comprising an acid- and alkali-resistant layer formed on an outer surface of the probiotic. The health product of claim 1, further comprising a pharmaceutically acceptable carrier.