TWI912388B - Ｇｌｐ-１ｒ促效劑的晶型及其用途 - Google Patents

Ｇｌｐ-１ｒ促效劑的晶型及其用途

Info

Publication number
TWI912388B
TWI912388B TW110138006A TW110138006A TWI912388B TW I912388 B TWI912388 B TW I912388B TW 110138006 A TW110138006 A TW 110138006A TW 110138006 A TW110138006 A TW 110138006A TW I912388 B TWI912388 B TW I912388B
Authority
TW
Taiwan
Prior art keywords
crystal form
disease
compound
ray powder
powder diffraction
Prior art date
Application number
TW110138006A
Other languages
English (en)
Chinese (zh)
Other versions
TW202227421A (zh
Inventor
鐘文革
郭巍
征 李
姜夏偉
陳鵬源
Original Assignee
大陸商上海齊魯銳格醫藥研發有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 大陸商上海齊魯銳格醫藥研發有限公司 filed Critical 大陸商上海齊魯銳格醫藥研發有限公司
Publication of TW202227421A publication Critical patent/TW202227421A/zh
Application granted granted Critical
Publication of TWI912388B publication Critical patent/TWI912388B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
TW110138006A 2020-10-14 2021-10-13 Ｇｌｐ-１ｒ促效劑的晶型及其用途 TWI912388B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2020120814 2020-10-14
WOPCT/CN2020/120814 2020-10-14

Publications (2)

Publication Number Publication Date
TW202227421A TW202227421A (zh) 2022-07-16
TWI912388B true TWI912388B (zh) 2026-01-21

Family

ID=78401981

Family Applications (1)

Application Number Title Priority Date Filing Date
TW110138006A TWI912388B (zh) 2020-10-14 2021-10-13 Ｇｌｐ-１ｒ促效劑的晶型及其用途

Country Status (9)

Country Link
US (1) US12516041B2 (https=)
EP (1) EP4228753B1 (https=)
JP (1) JP7769695B2 (https=)
CN (1) CN116710446B (https=)
AU (1) AU2021359493A1 (https=)
CA (1) CA3195264A1 (https=)
ES (1) ES3041328T3 (https=)
TW (1) TWI912388B (https=)
WO (1) WO2022078352A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114761395B (zh) * 2019-12-02 2024-11-15 现代药品株式会社 Glp-1受体激动剂
PT4408840T (pt) 2021-09-27 2025-10-07 Terns Pharmaceuticals Inc Ácidos benzimidazolocarboxílicos como agonistas de glp-1r
CN118401519A (zh) 2021-10-25 2024-07-26 拓臻制药公司 作为glp-1r激动剂的化合物
CN119095843A (zh) 2022-02-23 2024-12-06 拓臻制药公司 作为glp-1r激动剂的化合物
CN117362282B (zh) * 2022-07-07 2026-04-21 杭州德睿智药科技有限公司 Glp-1r激动剂的盐及其制备方法和应用
US20260028332A1 (en) * 2022-07-18 2026-01-29 Mindrank Therapeutics (Suzhou) New Drug Research And Development Co., Ltd Polymorphic form of glp-1r agonist, preparation method therefor and use thereof
EP4568664B1 (en) 2023-04-07 2026-04-01 Terns Pharmaceuticals, Inc. Combination comprising a thr-beta agonist and a glp-1r agonist for use in treating obesity
CN120981457A (zh) 2023-09-14 2025-11-18 歌礼制药(中国)有限公司 Glp-1r激动剂及其治疗方法
TW202521534A (zh) 2023-11-24 2025-06-01 香港商歌禮製藥(中國)有限公司 Glp-1r 激動劑及其治療方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018109607A1 (en) * 2016-12-16 2018-06-21 Pfizer Inc. Glp-1 receptor agonists and uses thereof
WO2020103815A1 (en) * 2018-11-22 2020-05-28 Qilu Regor Therapeutics Inc. Glp-1r agonists and uses thereof

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
EA018225B1 (ru) 2008-03-07 2013-06-28 Транстек Фарма, Инк. Соединения оксадиазоантрацена для лечения диабета
AR083878A1 (es) * 2010-11-15 2013-03-27 Boehringer Ingelheim Int Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
DK3806855T5 (da) * 2018-06-15 2023-05-22 Pfizer GLP-1-receptoragonister og anvendelser deraf
EP3953344A4 (en) * 2019-04-12 2023-08-09 Qilu Regor Therapeutics Inc. GLP-IR AGONISTS AND THEIR USES

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018109607A1 (en) * 2016-12-16 2018-06-21 Pfizer Inc. Glp-1 receptor agonists and uses thereof
WO2020103815A1 (en) * 2018-11-22 2020-05-28 Qilu Regor Therapeutics Inc. Glp-1r agonists and uses thereof

Also Published As

Publication number Publication date
JP7769695B2 (ja) 2025-11-13
CN116710446B (zh) 2024-10-18
ES3041328T3 (en) 2025-11-11
TW202227421A (zh) 2022-07-16
EP4228753B1 (en) 2025-07-30
EP4228753C0 (en) 2025-07-30
AU2021359493A1 (en) 2023-06-15
WO2022078352A1 (en) 2022-04-21
EP4228753A1 (en) 2023-08-23
CA3195264A1 (en) 2022-04-21
US20230382899A1 (en) 2023-11-30
JP2023546125A (ja) 2023-11-01
US12516041B2 (en) 2026-01-06
AU2021359493A9 (en) 2025-01-09
CN116710446A (zh) 2023-09-05

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