TWI905235B - 抗cd93之構築體及其用途 - Google Patents

抗cd93之構築體及其用途

Info

Publication number
TWI905235B
TWI905235B TW110127974A TW110127974A TWI905235B TW I905235 B TWI905235 B TW I905235B TW 110127974 A TW110127974 A TW 110127974A TW 110127974 A TW110127974 A TW 110127974A TW I905235 B TWI905235 B TW I905235B
Authority
TW
Taiwan
Prior art keywords
amino acid
acid sequence
seq
antibody
cdr3
Prior art date
Application number
TW110127974A
Other languages
English (en)
Chinese (zh)
Other versions
TW202221029A (zh
Inventor
陳梓榕
羅克珊 蓋雷特
格雷戈里 瓊斯
駒場繁
健 李
安吉拉 諾頓
黎華 吳
志南 夏
Original Assignee
美商當康生物科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2021/035542 external-priority patent/WO2021247769A1/en
Application filed by 美商當康生物科技有限公司 filed Critical 美商當康生物科技有限公司
Publication of TW202221029A publication Critical patent/TW202221029A/zh
Application granted granted Critical
Publication of TWI905235B publication Critical patent/TWI905235B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
TW110127974A 2020-07-29 2021-07-29 抗cd93之構築體及其用途 TWI905235B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US202063058359P 2020-07-29 2020-07-29
US63/058,359 2020-07-29
US202063084474P 2020-09-28 2020-09-28
US63/084,474 2020-09-28
WOPCT/US21/35542 2021-06-02
PCT/US2021/035542 WO2021247769A1 (en) 2020-06-02 2021-06-02 Anti-cd93 constructs and uses thereof

Publications (2)

Publication Number Publication Date
TW202221029A TW202221029A (zh) 2022-06-01
TWI905235B true TWI905235B (zh) 2025-11-21

Family

ID=80036794

Family Applications (1)

Application Number Title Priority Date Filing Date
TW110127974A TWI905235B (zh) 2020-07-29 2021-07-29 抗cd93之構築體及其用途

Country Status (12)

Country Link
US (1) US20230322935A1 (https=)
EP (1) EP4188550A1 (https=)
JP (2) JP7818570B2 (https=)
KR (1) KR20230133832A (https=)
CN (1) CN116783215A (https=)
AU (1) AU2021315665A1 (https=)
CA (1) CA3190328A1 (https=)
CO (1) CO2023001767A2 (https=)
IL (1) IL300121A (https=)
MX (1) MX2023001083A (https=)
TW (1) TWI905235B (https=)
WO (1) WO2022026763A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111201030B (zh) 2017-07-25 2024-11-01 真和制药有限公司 通过阻断tim-3和其配体的相互作用治疗癌症
WO2020160156A2 (en) 2019-01-30 2020-08-06 Immutics, Inc. Anti-gal3 antibodies and uses thereof
EP4157338A4 (en) 2020-05-26 2024-11-13 TrueBinding, Inc. METHOD FOR TREATING INFLAMMATORY DISEASES BY GALECTIN-3 BLOCKING
CN116529260A (zh) * 2020-06-02 2023-08-01 当康生物技术有限责任公司 抗cd93构建体及其用途
WO2025035451A1 (zh) * 2023-08-17 2025-02-20 上海君实生物医药科技股份有限公司 抗cd93抗体、其组合物及用途
WO2025130666A1 (zh) * 2023-12-19 2025-06-26 广东菲鹏制药股份有限公司 抗cd93抗体或其抗原结合片段及其应用
CN120757641A (zh) * 2024-03-29 2025-10-10 奥创新药(杭州)医药技术有限公司 抗cd93抗体、其抗原结合片段及其应用

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US20120039911A1 (en) * 2009-01-28 2012-02-16 Korea Research Institute Of Bioscience And Biotech Cd93 or use of soluble fragment thereof
US20190389960A1 (en) * 2018-06-25 2019-12-26 The Research Foundation For The State University Of New York Compositions and methods for c1q targeted therapy

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Also Published As

Publication number Publication date
MX2023001083A (es) 2023-04-10
CN116783215A (zh) 2023-09-19
CA3190328A1 (en) 2022-02-03
KR20230133832A (ko) 2023-09-19
US20230322935A1 (en) 2023-10-12
WO2022026763A1 (en) 2022-02-03
AU2021315665A1 (en) 2023-03-16
EP4188550A1 (en) 2023-06-07
TW202221029A (zh) 2022-06-01
JP2026026155A (ja) 2026-02-16
IL300121A (en) 2023-03-01
JP2023536461A (ja) 2023-08-25
JP7818570B2 (ja) 2026-02-20
CO2023001767A2 (es) 2023-06-09

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