JP7818570B2 - 抗ｃｄ９３構築物およびその使用 - Google Patents

抗ｃｄ９３構築物およびその使用

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Publication number
JP7818570B2
JP7818570B2 JP2023505921A JP2023505921A JP7818570B2 JP 7818570 B2 JP7818570 B2 JP 7818570B2 JP 2023505921 A JP2023505921 A JP 2023505921A JP 2023505921 A JP2023505921 A JP 2023505921A JP 7818570 B2 JP7818570 B2 JP 7818570B2
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JP
Japan
Prior art keywords
amino acid
acid sequence
seq
variant
cdr3
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JP2023505921A
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English (en)
Japanese (ja)
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JP2023536461A5 (https=
JP2023536461A (ja
Inventor
ジロン チェン，
ロクサン ゲレット，
グレゴリー ジョーンズ，
繁 駒場
ジアン リー，
アンジェラ ノートン，
リフア ウー，
ジナン シャ，
Original Assignee
ダイナミキュア バイオテクノロジー エルエルシー
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Priority claimed from PCT/US2021/035542 external-priority patent/WO2021247769A1/en
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Publication of JP2023536461A publication Critical patent/JP2023536461A/ja
Publication of JP2023536461A5 publication Critical patent/JP2023536461A5/ja
Priority to JP2025202939A priority Critical patent/JP2026026155A/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
JP2023505921A 2020-07-29 2021-07-29 抗ｃｄ９３構築物およびその使用 Active JP7818570B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025202939A JP2026026155A (ja) 2020-07-29 2025-11-25 抗ｃｄ９３構築物およびその使用

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202063058359P 2020-07-29 2020-07-29
US63/058,359 2020-07-29
US202063084474P 2020-09-28 2020-09-28
US63/084,474 2020-09-28
USPCT/US2021/035542 2021-06-02
PCT/US2021/035542 WO2021247769A1 (en) 2020-06-02 2021-06-02 Anti-cd93 constructs and uses thereof
PCT/US2021/043784 WO2022026763A1 (en) 2020-07-29 2021-07-29 Anti-cd93 constructs and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025202939A Division JP2026026155A (ja) 2020-07-29 2025-11-25 抗ｃｄ９３構築物およびその使用

Publications (3)

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JP2023536461A JP2023536461A (ja) 2023-08-25
JP2023536461A5 JP2023536461A5 (https=) 2024-08-05
JP7818570B2 true JP7818570B2 (ja) 2026-02-20

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JP2025202939A Pending JP2026026155A (ja) 2020-07-29 2025-11-25 抗ｃｄ９３構築物およびその使用

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Country Status (12)

Country Link
US (1) US20230322935A1 (https=)
EP (1) EP4188550A1 (https=)
JP (2) JP7818570B2 (https=)
KR (1) KR20230133832A (https=)
CN (1) CN116783215A (https=)
AU (1) AU2021315665A1 (https=)
CA (1) CA3190328A1 (https=)
CO (1) CO2023001767A2 (https=)
IL (1) IL300121A (https=)
MX (1) MX2023001083A (https=)
TW (1) TWI905235B (https=)
WO (1) WO2022026763A1 (https=)

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CN111201030B (zh) 2017-07-25 2024-11-01 真和制药有限公司 通过阻断tim-3和其配体的相互作用治疗癌症
WO2020160156A2 (en) 2019-01-30 2020-08-06 Immutics, Inc. Anti-gal3 antibodies and uses thereof
EP4157338A4 (en) 2020-05-26 2024-11-13 TrueBinding, Inc. METHOD FOR TREATING INFLAMMATORY DISEASES BY GALECTIN-3 BLOCKING
CN116529260A (zh) * 2020-06-02 2023-08-01 当康生物技术有限责任公司 抗cd93构建体及其用途
WO2025035451A1 (zh) * 2023-08-17 2025-02-20 上海君实生物医药科技股份有限公司 抗cd93抗体、其组合物及用途
WO2025130666A1 (zh) * 2023-12-19 2025-06-26 广东菲鹏制药股份有限公司 抗cd93抗体或其抗原结合片段及其应用
CN120757641A (zh) * 2024-03-29 2025-10-10 奥创新药(杭州)医药技术有限公司 抗cd93抗体、其抗原结合片段及其应用

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MX2023001083A (es) 2023-04-10
CN116783215A (zh) 2023-09-19
CA3190328A1 (en) 2022-02-03
TWI905235B (zh) 2025-11-21
KR20230133832A (ko) 2023-09-19
US20230322935A1 (en) 2023-10-12
WO2022026763A1 (en) 2022-02-03
AU2021315665A1 (en) 2023-03-16
EP4188550A1 (en) 2023-06-07
TW202221029A (zh) 2022-06-01
JP2026026155A (ja) 2026-02-16
IL300121A (en) 2023-03-01
JP2023536461A (ja) 2023-08-25
CO2023001767A2 (es) 2023-06-09

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