TWI886312B - 磷脂肌醇3-激酶抑制劑的調配物 - Google Patents

磷脂肌醇3-激酶抑制劑的調配物 Download PDF

Info

Publication number
TWI886312B
TWI886312B TW110128732A TW110128732A TWI886312B TW I886312 B TWI886312 B TW I886312B TW 110128732 A TW110128732 A TW 110128732A TW 110128732 A TW110128732 A TW 110128732A TW I886312 B TWI886312 B TW I886312B
Authority
TW
Taiwan
Prior art keywords
weight
formulation
amount
base formulation
present
Prior art date
Application number
TW110128732A
Other languages
English (en)
Chinese (zh)
Other versions
TW202220662A (zh
Inventor
艾吉斯 凱多紐斯
湯瑪士 羅西
福成 陳
Original Assignee
美商凡賽拉公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 美商凡賽拉公司 filed Critical 美商凡賽拉公司
Publication of TW202220662A publication Critical patent/TW202220662A/zh
Application granted granted Critical
Publication of TWI886312B publication Critical patent/TWI886312B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
TW110128732A 2020-08-04 2021-08-04 磷脂肌醇3-激酶抑制劑的調配物 TWI886312B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202063060843P 2020-08-04 2020-08-04
US202063060856P 2020-08-04 2020-08-04
US63/060,843 2020-08-04
US63/060,856 2020-08-04

Publications (2)

Publication Number Publication Date
TW202220662A TW202220662A (zh) 2022-06-01
TWI886312B true TWI886312B (zh) 2025-06-11

Family

ID=77519798

Family Applications (1)

Application Number Title Priority Date Filing Date
TW110128732A TWI886312B (zh) 2020-08-04 2021-08-04 磷脂肌醇3-激酶抑制劑的調配物

Country Status (6)

Country Link
US (1) US20220040193A1 (https=)
EP (1) EP4192431A1 (https=)
JP (1) JP2023538265A (https=)
CA (1) CA3187759A1 (https=)
TW (1) TWI886312B (https=)
WO (1) WO2022031729A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210124310A (ko) 2019-02-06 2021-10-14 벤테라, 인코포레이티드 국소 포스포이노시티드 3-키나제 억제제

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040009978A1 (en) * 2000-04-27 2004-01-15 Masahiko Hayakawa Fused heteroaryl derivatives
WO2006046040A1 (en) * 2004-10-25 2006-05-04 Piramed Limited Pharmaceutical compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100774855B1 (ko) * 2000-04-27 2007-11-08 아스텔라스세이야쿠 가부시키가이샤 축합 헤테로아릴 유도체
US6468989B1 (en) 2000-07-13 2002-10-22 Dow Pharmaceutical Sciences Gel compositions containing metronidazole
US6387383B1 (en) 2000-08-03 2002-05-14 Dow Pharmaceutical Sciences Topical low-viscosity gel composition
CN102268014B (zh) * 2010-06-03 2015-06-03 上海艾力斯医药科技有限公司 一类稠合杂芳基衍生物、制备方法及其应用
GB201011771D0 (en) * 2010-07-13 2010-08-25 Bioinvent Int Ab Biological material and particular uses thereof
BR112013008615B1 (pt) * 2010-10-13 2021-05-11 Medivir Ab composição farmacêutica
US20170340649A1 (en) * 2016-05-30 2017-11-30 Sun Pharmaceutical Industries Limited Topical aqueous spray compositions of halobetasol
KR102358377B1 (ko) * 2016-12-28 2022-02-03 히사미쓰 세이야꾸 가부시키가이샤 첩부제
KR20210124310A (ko) * 2019-02-06 2021-10-14 벤테라, 인코포레이티드 국소 포스포이노시티드 3-키나제 억제제

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040009978A1 (en) * 2000-04-27 2004-01-15 Masahiko Hayakawa Fused heteroaryl derivatives
WO2006046040A1 (en) * 2004-10-25 2006-05-04 Piramed Limited Pharmaceutical compounds

Also Published As

Publication number Publication date
TW202220662A (zh) 2022-06-01
CA3187759A1 (en) 2022-02-10
WO2022031729A1 (en) 2022-02-10
US20220040193A1 (en) 2022-02-10
JP2023538265A (ja) 2023-09-07
EP4192431A1 (en) 2023-06-14

Similar Documents

Publication Publication Date Title
AU2019213835B2 (en) Topical formulations comprising tofacitinib
US10758502B2 (en) High concentration local anesthetic formulations
EP2859892B1 (en) Patch
US10722493B2 (en) Methods for treating fibroproliferative disorders in a mammal
TWI862548B (zh) 外用的磷脂肌醇3-激酶抑制劑
BR112020025884A2 (pt) composição para aplicação tópica, embalagem, e, método para a fabricação de uma composição
TWI886312B (zh) 磷脂肌醇3-激酶抑制劑的調配物
CN103347498B (zh) 组蛋白脱乙酰酶抑制剂药物配方
WO2013081014A1 (ja) 貼付剤
US20230190755A1 (en) Topical formulations of PI3K-delta inhibitors
US20050158371A1 (en) Novel external agent
TWI903311B (zh) 局部藥物組合物、其製備方法及其在醫藥上的用途
AU2022398467A1 (en) Formulations of pyrrolopyridine-aniline compounds
US20070254887A1 (en) Pharmaceutical Composition for Transdermal Administration of Perospirone
CN117157080A (zh) 用于治疗皮肤病的含维生素d类似物的jak抑制剂
JP6625208B2 (ja) 経皮製剤
US12310950B2 (en) Formulations of pyrrolopyridine-aniline compounds
RU2757275C2 (ru) Композиции ректальной пены
CN115397398A (zh) 环状酯肽的局部药物制剂