TWI857071B - 2,3,5-三取代吡唑并[1,5-a]嘧啶化合物 - Google Patents

2,3,5-三取代吡唑并[1,5-a]嘧啶化合物 Download PDF

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Publication number
TWI857071B
TWI857071B TW109118850A TW109118850A TWI857071B TW I857071 B TWI857071 B TW I857071B TW 109118850 A TW109118850 A TW 109118850A TW 109118850 A TW109118850 A TW 109118850A TW I857071 B TWI857071 B TW I857071B
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alkyl
cancer
hydroxyalkyl
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TW109118850A
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TW202110850A (zh
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喬伊爾 華里 比提
山謬 勞瑞 卓爾
傑瑞米 湯瑪士 安德烈 佛尼爾
珍那 梨 傑佛瑞
肯尼斯 維克特 勞森
曼摩漢 瑞迪 賴勒提
雅圖 喀連那維卡 梅蓮恩
吉勞米 瑪塔
迪倫 哈汀 邁爾斯
傑 派翠克 包爾斯
荷森 厄爾 莎瑞菲
崔恩 瑞亞納恩 湯馬士
雪蕾 閆
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美商阿克思生物科學有限公司
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/0635Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0636Irradiating the whole body

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW109118850A 2019-06-04 2020-06-04 2,3,5-三取代吡唑并[1,5-a]嘧啶化合物 TWI857071B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962857148P 2019-06-04 2019-06-04
US62/857,148 2019-06-04

Publications (2)

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TW202110850A TW202110850A (zh) 2021-03-16
TWI857071B true TWI857071B (zh) 2024-10-01

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Country Link
US (1) US12410170B2 (https=)
EP (1) EP3980010A4 (https=)
JP (1) JP7665534B2 (https=)
KR (1) KR20220047247A (https=)
CN (1) CN114206332B (https=)
AR (1) AR119088A1 (https=)
AU (1) AU2020288610A1 (https=)
CA (1) CA3142712A1 (https=)
TW (1) TWI857071B (https=)
UY (1) UY38742A (https=)
WO (1) WO2020247496A1 (https=)

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JP2024521712A (ja) 2021-05-21 2024-06-04 アーカス バイオサイエンシーズ,インコーポレーテッド Axl阻害化合物
WO2023077046A1 (en) 2021-10-29 2023-05-04 Arcus Biosciences, Inc. Inhibitors of hif-2alpha and methods of use thereof
CN119072476A (zh) * 2022-03-02 2024-12-03 上海海雁医药科技有限公司 六元芳环并吡咯酮衍生物、其药物组合物及应用
CA3256561A1 (en) 2022-05-02 2023-11-09 Arcus Biosciences, Inc. Anti-tigit antibodies and their uses
EP4554680A1 (en) 2022-07-15 2025-05-21 Arcus Biosciences, Inc. Inhibitors of hpk1 and methods of use thereof
US20260028336A1 (en) 2022-07-20 2026-01-29 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
WO2024046454A1 (zh) * 2022-09-01 2024-03-07 上海海雁医药科技有限公司 杂芳基取代的吡啶并吡咯酮衍生物、其药物组合物及应用
CN119768155A (zh) 2022-09-14 2025-04-04 艾库斯生物科学有限公司 依曲地南的分散体
WO2024081385A1 (en) 2022-10-14 2024-04-18 Arcus Biosciences, Inc. Hpk1 inhibitors and methods of use thereof
EP4604920A1 (en) 2022-10-20 2025-08-27 Arcus Biosciences, Inc. Lyophilized formulations of cd73 compounds
EP4705292A1 (en) 2023-05-05 2026-03-11 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
US20250011318A1 (en) 2023-05-25 2025-01-09 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
WO2025076299A1 (en) 2023-10-06 2025-04-10 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
WO2025146216A1 (zh) * 2024-01-05 2025-07-10 成都赜灵生物医药科技有限公司 六并五氮杂环酰胺类化合物及其用途
WO2025193759A1 (en) 2024-03-12 2025-09-18 Gilead Sciences, Inc. Solid forms of an azolopyrimidine compound

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Also Published As

Publication number Publication date
EP3980010A1 (en) 2022-04-13
CN114206332B (zh) 2024-08-23
CA3142712A1 (en) 2020-12-10
JP2022535120A (ja) 2022-08-04
US20230024302A1 (en) 2023-01-26
US12410170B2 (en) 2025-09-09
WO2020247496A1 (en) 2020-12-10
AR119088A1 (es) 2021-11-24
JP7665534B2 (ja) 2025-04-21
AU2020288610A1 (en) 2022-01-27
CN114206332A (zh) 2022-03-18
TW202110850A (zh) 2021-03-16
UY38742A (es) 2020-12-31
KR20220047247A (ko) 2022-04-15
EP3980010A4 (en) 2023-06-07

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