TWI856048B - 多聚體ｔ細胞調節多肽及其使用方法 - Google Patents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20033—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
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- Oncology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Gynecology & Obstetrics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reproductive Health (AREA)
- Pregnancy & Childbirth (AREA)
- Wood Science & Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
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| US201862782205P | 2018-12-19 | 2018-12-19 | |
| US62/782,205 | 2018-12-19 | ||
| US201962814707P | 2019-03-06 | 2019-03-06 | |
| US62/814,707 | 2019-03-06 |
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| TW202031680A TW202031680A (zh) | 2020-09-01 |
| TWI856048B true TWI856048B (zh) | 2024-09-21 |
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| TW108146527A TWI856048B (zh) | 2018-12-19 | 2019-12-18 | 多聚體ｔ細胞調節多肽及其使用方法 |
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| US (2) | US20220389079A1 (https=) |
| EP (1) | EP3897746A4 (https=) |
| JP (2) | JP7481342B2 (https=) |
| KR (1) | KR20210104700A (https=) |
| CN (1) | CN113286621A (https=) |
| AU (1) | AU2019401183A1 (https=) |
| BR (1) | BR112021011838A2 (https=) |
| CA (1) | CA3113096A1 (https=) |
| IL (1) | IL282250A (https=) |
| MX (1) | MX2021007479A (https=) |
| TW (1) | TWI856048B (https=) |
| WO (1) | WO2020132138A1 (https=) |
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| CN116970059A (zh) | 2016-12-22 | 2023-10-31 | 库尔生物制药有限公司 | T细胞调节性多聚体多肽及其使用方法 |
| IL269000B2 (en) | 2017-03-15 | 2024-06-01 | Cue Biopharma Inc | Methods for modulating an immune response |
| TW201920249A (zh) | 2017-09-07 | 2019-06-01 | 美商信號生物製藥公司 | 具有結合位點之t細胞調節多聚體多肽及其使用方法 |
| AU2019401183A1 (en) * | 2018-12-19 | 2021-08-12 | Cue Biopharma, Inc. | Multimeric T-cell modulatory polypeptides and methods of use thereof |
| BR112022012112A2 (pt) | 2019-12-20 | 2022-09-06 | Regeneron Pharma | Agonistas de il2 e métodos de uso dos mesmos |
| TW202208395A (zh) | 2020-05-12 | 2022-03-01 | 美商信號生物製藥公司 | 多聚體ｔ細胞調節多肽及其使用方法 |
| WO2022056015A1 (en) * | 2020-09-09 | 2022-03-17 | Cue Biopharma, Inc. | Mhc class ii t-cell modulatory multimeric polypeptides and methods of use thereof |
| EP4211149A4 (en) * | 2020-09-09 | 2024-10-09 | Cue Biopharma, Inc. | MULTIMERIC POLYPEPTIDES MODULATING MHC CLASS II T CELLS FOR THE TREATMENT OF TYPE 1 DIABETES MELLITUS (T1D) AND METHODS OF USE THEREOF |
| TW202317623A (zh) | 2021-06-14 | 2023-05-01 | 美商再生元醫藥公司 | 基於il2之治療劑及其使用方法 |
| WO2024072958A1 (en) * | 2022-09-30 | 2024-04-04 | The Children's Hospital Of Philadelphia | Systems, formulations and methods for generating universal peptide/mhc complexes with engineered disulfide connecting the heavy and light chains |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015195531A2 (en) * | 2014-06-18 | 2015-12-23 | Albert Einstein College Of Medicine, Inc. | Syntac polypeptides and uses thereof |
| WO2017008844A1 (en) * | 2015-07-14 | 2017-01-19 | Biontech Ag | Peptide mimotopes of the cd3 t-cell co-receptor epsilon chain and uses thereof |
| WO2017201210A1 (en) * | 2016-05-18 | 2017-11-23 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY193723A (en) * | 2014-08-29 | 2022-10-27 | Hoffmann La Roche | Combination therapy of tumor-targeted il-2 variant immunocytokines and antibodies against human pd-l1 |
| CN116970059A (zh) * | 2016-12-22 | 2023-10-31 | 库尔生物制药有限公司 | T细胞调节性多聚体多肽及其使用方法 |
| AU2019401183A1 (en) * | 2018-12-19 | 2021-08-12 | Cue Biopharma, Inc. | Multimeric T-cell modulatory polypeptides and methods of use thereof |
| CN118852456A (zh) * | 2019-05-29 | 2024-10-29 | Cue生物制药股份有限公司 | 多聚体t细胞调节多肽及其使用方法 |
| JP2022536581A (ja) * | 2019-06-19 | 2022-08-18 | キュー バイオファーマ， インコーポレイテッド | 多量体ｔ細胞調節性ポリペプチド及びその使用方法 |
| WO2021081239A1 (en) * | 2019-10-23 | 2021-04-29 | Cue Biopharma, Inc. | T-cell modulatory chimeric molecules and methods of use thereof |
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2019
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- 2019-12-18 CA CA3113096A patent/CA3113096A1/en active Pending
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- 2019-12-18 BR BR112021011838-1A patent/BR112021011838A2/pt unknown
- 2019-12-18 KR KR1020217017809A patent/KR20210104700A/ko not_active Ceased
- 2019-12-18 EP EP19899240.6A patent/EP3897746A4/en active Pending
- 2019-12-18 WO PCT/US2019/067280 patent/WO2020132138A1/en not_active Ceased
- 2019-12-18 MX MX2021007479A patent/MX2021007479A/es unknown
- 2019-12-18 TW TW108146527A patent/TWI856048B/zh active
- 2019-12-18 CN CN201980080704.5A patent/CN113286621A/zh active Pending
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2021
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- 2021-05-21 US US17/327,171 patent/US20220389079A1/en not_active Abandoned
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2024
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015195531A2 (en) * | 2014-06-18 | 2015-12-23 | Albert Einstein College Of Medicine, Inc. | Syntac polypeptides and uses thereof |
| WO2017008844A1 (en) * | 2015-07-14 | 2017-01-19 | Biontech Ag | Peptide mimotopes of the cd3 t-cell co-receptor epsilon chain and uses thereof |
| WO2017201210A1 (en) * | 2016-05-18 | 2017-11-23 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
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| AU2019401183A1 (en) | 2021-08-12 |
| US20250092113A1 (en) | 2025-03-20 |
| JP2022515331A (ja) | 2022-02-18 |
| TW202031680A (zh) | 2020-09-01 |
| MX2021007479A (es) | 2021-09-23 |
| US20220389079A1 (en) | 2022-12-08 |
| IL282250A (en) | 2021-05-31 |
| BR112021011838A2 (pt) | 2021-08-31 |
| JP2024105344A (ja) | 2024-08-06 |
| CA3113096A1 (en) | 2020-06-25 |
| EP3897746A4 (en) | 2022-10-26 |
| KR20210104700A (ko) | 2021-08-25 |
| EP3897746A1 (en) | 2021-10-27 |
| WO2020132138A1 (en) | 2020-06-25 |
| CN113286621A (zh) | 2021-08-20 |
| JP7481342B2 (ja) | 2024-05-10 |
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