TWI848141B - 及其用途 - Google Patents

及其用途 Download PDF

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Publication number
TWI848141B
TWI848141B TW109122260A TW109122260A TWI848141B TW I848141 B TWI848141 B TW I848141B TW 109122260 A TW109122260 A TW 109122260A TW 109122260 A TW109122260 A TW 109122260A TW I848141 B TWI848141 B TW I848141B
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TW
Taiwan
Prior art keywords
alkyl
methyl
pyrrolo
compound
pyrrolidone
Prior art date
Application number
TW109122260A
Other languages
English (en)
Chinese (zh)
Other versions
TW202116773A (zh
Inventor
李菁
志偉 王
徐三甲
Original Assignee
英屬開曼群島商百濟神州有限公司
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Publication of TW202116773A publication Critical patent/TW202116773A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
TW109122260A 2019-07-04 2020-07-01 及其用途 TWI848141B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CN2019094749 2019-07-04
WOPCT/CN2019/094749 2019-07-04
WOPCT/CN2019/123268 2019-12-05
CN2019123268 2019-12-05
CN2020089498 2020-05-09
WOPCT/CN2020/089498 2020-05-09

Publications (2)

Publication Number Publication Date
TW202116773A TW202116773A (zh) 2021-05-01
TWI848141B true TWI848141B (zh) 2024-07-11

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
TW109122260A TWI848141B (zh) 2019-07-04 2020-07-01 及其用途

Country Status (14)

Country Link
US (1) US12454534B2 (https=)
EP (1) EP3994136A4 (https=)
JP (1) JP7579816B2 (https=)
KR (1) KR20220029690A (https=)
CN (3) CN114096536A (https=)
AU (1) AU2020299892A1 (https=)
BR (1) BR112022000019A2 (https=)
CA (1) CA3145751A1 (https=)
CO (1) CO2022001094A2 (https=)
IL (1) IL289553A (https=)
MX (1) MX2022000244A (https=)
TW (1) TWI848141B (https=)
WO (1) WO2021000925A1 (https=)
ZA (1) ZA202110732B (https=)

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CN114685490B (zh) * 2020-12-31 2025-03-28 南京再明医药有限公司 吡咯并吡啶类化合物及其应用
WO2022184152A1 (zh) * 2021-03-03 2022-09-09 劲方医药科技(上海)有限公司 稠环取代的六元杂环化合物及其制法和用途
CN115073472A (zh) * 2021-03-16 2022-09-20 江苏恒瑞医药股份有限公司 稠合二环类化合物、其制备方法及其在医药上的应用
WO2022199676A1 (zh) * 2021-03-26 2022-09-29 江苏恒瑞医药股份有限公司 稠合四环类化合物、其制备方法及其在医药上的应用
EP4341261A1 (en) * 2021-05-21 2024-03-27 Arcus Biosciences, Inc. Axl compounds
WO2022246179A1 (en) * 2021-05-21 2022-11-24 Arcus Biosciences, Inc. Axl inhibitor compounds
TW202321239A (zh) 2021-07-20 2023-06-01 瑞典商阿斯特捷利康公司 作為ｈｐｋ１抑制劑用於治療癌症之經取代的吡𠯤—２—甲醯胺
JP2024528722A (ja) * 2021-07-30 2024-07-30 ベイジーン リミテッド ＨＰＫ１分解誘導薬としてのピロロ［２，３－ｂ］ピラジン系の二官能性化合物及びその使用
WO2023151559A1 (zh) * 2022-02-08 2023-08-17 和径医药科技（上海）有限公司 杂环化合物、包含其的药物组合物及其抗肿瘤应用
CN116731029B (zh) * 2022-03-11 2026-01-02 石药集团中奇制药技术（石家庄）有限公司 一类并环化合物及其制备和应用
CN116925082A (zh) * 2022-04-24 2023-10-24 百济神州(苏州)生物科技有限公司 5H-吡咯并[2,3-b]吡嗪衍生物的多晶型形式，制备方法及其用途
WO2023207911A1 (zh) * 2022-04-24 2023-11-02 上海医药集团股份有限公司 一种双环杂环化合物、药物组合物和应用
WO2023207894A1 (en) * 2022-04-24 2023-11-02 Beigene , Ltd. POLYMORPH FORMS OF A 5H-PYRROLO [2, 3-b] PYRAZINE DERIVATIVE, METHODS OF PREPARATION, AND USES THEREFORE
AR129722A1 (es) 2022-06-28 2024-09-18 Arcus Biosciences Inc Compuestos inhibidores de axl

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Also Published As

Publication number Publication date
CN115073474B (zh) 2024-10-18
EP3994136A4 (en) 2023-06-28
US20220267333A1 (en) 2022-08-25
AU2020299892A1 (en) 2022-01-27
KR20220029690A (ko) 2022-03-08
CN114096536A (zh) 2022-02-25
EP3994136A1 (en) 2022-05-11
CN115028639A (zh) 2022-09-09
JP2022538019A (ja) 2022-08-31
CA3145751A1 (en) 2021-01-07
IL289553A (en) 2022-03-01
CO2022001094A2 (es) 2022-04-29
TW202116773A (zh) 2021-05-01
JP7579816B2 (ja) 2024-11-08
MX2022000244A (es) 2022-02-03
WO2021000925A1 (en) 2021-01-07
CN115073474A (zh) 2022-09-20
ZA202110732B (en) 2022-09-28
BR112022000019A2 (pt) 2022-02-22
US12454534B2 (en) 2025-10-28

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