TWI843806B - 作為nrf2活化劑之羥基吡啶并氧氮呯 - Google Patents

作為nrf2活化劑之羥基吡啶并氧氮呯 Download PDF

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Publication number
TWI843806B
TWI843806B TW109104455A TW109104455A TWI843806B TW I843806 B TWI843806 B TW I843806B TW 109104455 A TW109104455 A TW 109104455A TW 109104455 A TW109104455 A TW 109104455A TW I843806 B TWI843806 B TW I843806B
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Taiwan
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compound
disease
methyl
pharmaceutically acceptable
hydrate
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TW109104455A
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Chinese (zh)
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TW202045514A (zh
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馬克 艾朋
麥卡 葛羅古斯基
麥可 寇汀
布萊恩 羅弘
杰 馬修
潔科林 帕特森
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英商葛蘭素史克智慧財產發展有限公司
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
TW109104455A 2019-02-15 2020-02-13 作為nrf2活化劑之羥基吡啶并氧氮呯 TWI843806B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962806201P 2019-02-15 2019-02-15
US62/806,201 2019-02-15
US201962931877P 2019-11-07 2019-11-07
US62/931,877 2019-11-07

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TW202045514A TW202045514A (zh) 2020-12-16
TWI843806B true TWI843806B (zh) 2024-06-01

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TW113112455A TWI880702B (zh) 2019-02-15 2020-02-13 作為nrf2活化劑之羥基吡啶并氧氮呯

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US (3) US11945826B2 (https=)
EP (1) EP3924356A1 (https=)
JP (1) JP7602469B2 (https=)
KR (1) KR102932313B1 (https=)
CN (2) CN113474349B (https=)
AU (1) AU2020222080C1 (https=)
BR (1) BR112021016042A2 (https=)
CA (1) CA3129955A1 (https=)
CL (1) CL2021002110A1 (https=)
CO (1) CO2021010930A2 (https=)
IL (2) IL313950A (https=)
MA (1) MA54939A (https=)
MX (1) MX2021009659A (https=)
MY (1) MY209603A (https=)
PH (1) PH12021551873A1 (https=)
SG (1) SG11202108257TA (https=)
TW (2) TWI843806B (https=)
WO (1) WO2020165776A1 (https=)

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TWI880702B (zh) * 2019-02-15 2025-04-11 英商葛蘭素史克智慧財產發展有限公司 作為nrf2活化劑之羥基吡啶并氧氮呯

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EP3833662B1 (en) 2018-08-20 2024-01-17 Janssen Pharmaceutica NV Inhibitors of keap1-nrf2 protein-protein interaction
AR118050A1 (es) 2019-02-15 2021-09-15 Bristol Myers Squibb Co Compuestos bicíclicos sustituidos como moduladores del receptor farnesoide x
AU2020283361B2 (en) * 2019-05-31 2025-11-27 Ube Corporation Benzotriazole derivative
CN118488944A (zh) 2022-01-07 2024-08-13 中外制药株式会社 具有Nrf2活化作用的含氮杂环化合物
US20250282724A1 (en) 2022-04-28 2025-09-11 Daiichi Sankyo Company, Limited Benzotriazole compound
JPWO2023210740A1 (https=) 2022-04-28 2023-11-02
EP4580612A1 (en) * 2022-09-02 2025-07-09 Institut National de la Santé et de la Recherche Médicale Use of nrf2 activators for the treatment of cerebral small vessel disease
CN121152792A (zh) 2023-06-19 2025-12-16 中外制药株式会社 具有Nrf2活化作用的含氮杂环化合物的晶体

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TWI880702B (zh) * 2019-02-15 2025-04-11 英商葛蘭素史克智慧財產發展有限公司 作為nrf2活化劑之羥基吡啶并氧氮呯

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KR102932313B1 (ko) 2026-02-26
CL2021002110A1 (es) 2022-02-11
MY209603A (en) 2025-07-24
MA54939A (fr) 2021-12-22
CA3129955A1 (en) 2020-08-20
CO2021010930A2 (es) 2021-09-09
TW202045514A (zh) 2020-12-16
US20250313573A1 (en) 2025-10-09
CN113474349A (zh) 2021-10-01
JP2022520442A (ja) 2022-03-30
WO2020165776A1 (en) 2020-08-20
MX2021009659A (es) 2021-09-08
CN118206566A (zh) 2024-06-18
TWI880702B (zh) 2025-04-11
CN113474349B (zh) 2024-03-01
US20240352034A1 (en) 2024-10-24
US11945826B2 (en) 2024-04-02
AU2020222080C1 (en) 2022-09-29
IL313950A (en) 2024-08-01
IL285438B2 (en) 2024-12-01
US20220204526A1 (en) 2022-06-30
AU2020222080B2 (en) 2022-05-19
TW202440593A (zh) 2024-10-16
IL285438B1 (en) 2024-08-01
PH12021551873A1 (en) 2022-05-23
BR112021016042A2 (pt) 2021-10-05
EP3924356A1 (en) 2021-12-22
JP7602469B2 (ja) 2024-12-18
KR20210126676A (ko) 2021-10-20
SG11202108257TA (en) 2021-08-30
IL285438A (en) 2021-09-30
AU2020222080A1 (en) 2021-09-02

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