TWI839343B - 染髮劑 - Google Patents
染髮劑 Download PDFInfo
- Publication number
- TWI839343B TWI839343B TW108104536A TW108104536A TWI839343B TW I839343 B TWI839343 B TW I839343B TW 108104536 A TW108104536 A TW 108104536A TW 108104536 A TW108104536 A TW 108104536A TW I839343 B TWI839343 B TW I839343B
- Authority
- TW
- Taiwan
- Prior art keywords
- hair
- composition
- solution
- acid
- component
- Prior art date
Links
- 238000004043 dyeing Methods 0.000 claims abstract description 69
- 239000000118 hair dye Substances 0.000 claims abstract description 37
- 238000000034 method Methods 0.000 claims abstract description 27
- 150000003609 titanium compounds Chemical class 0.000 claims abstract description 18
- 150000003755 zirconium compounds Chemical class 0.000 claims abstract description 14
- 150000001875 compounds Chemical class 0.000 claims description 30
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 18
- 239000010936 titanium Substances 0.000 claims description 18
- 229910052719 titanium Inorganic materials 0.000 claims description 18
- NEZONWMXZKDMKF-JTQLQIEISA-N Alkannin Chemical compound C1=CC(O)=C2C(=O)C([C@@H](O)CC=C(C)C)=CC(=O)C2=C1O NEZONWMXZKDMKF-JTQLQIEISA-N 0.000 claims description 12
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 claims description 12
- 229910052726 zirconium Inorganic materials 0.000 claims description 12
- 241001071917 Lithospermum Species 0.000 claims description 10
- UNNKKUDWEASWDN-UHFFFAOYSA-N alkannin Natural products CC(=CCC(O)c1cc(O)c2C(=O)C=CC(=O)c2c1O)C UNNKKUDWEASWDN-UHFFFAOYSA-N 0.000 claims description 9
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 5
- 239000004615 ingredient Substances 0.000 claims description 4
- 239000000049 pigment Substances 0.000 abstract description 81
- 239000000975 dye Substances 0.000 abstract description 20
- 239000002243 precursor Substances 0.000 abstract description 14
- 210000004761 scalp Anatomy 0.000 abstract description 9
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical group OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 abstract description 4
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallyl group Chemical group C1(=C(C(=CC=C1)O)O)O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 abstract description 4
- 239000000203 mixture Substances 0.000 description 127
- 239000000243 solution Substances 0.000 description 108
- -1 iron ions Chemical class 0.000 description 45
- 238000002360 preparation method Methods 0.000 description 35
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 24
- 241000196324 Embryophyta Species 0.000 description 18
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 18
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 16
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 15
- 239000003446 ligand Substances 0.000 description 15
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 12
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 12
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 description 12
- 239000002453 shampoo Substances 0.000 description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 11
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 11
- 230000002829 reductive effect Effects 0.000 description 11
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 10
- 239000000284 extract Substances 0.000 description 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
- 239000000872 buffer Substances 0.000 description 9
- 239000002904 solvent Substances 0.000 description 9
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 8
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 8
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 8
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 8
- 239000002253 acid Substances 0.000 description 8
- 238000001816 cooling Methods 0.000 description 8
- 239000004310 lactic acid Substances 0.000 description 8
- 235000014655 lactic acid Nutrition 0.000 description 8
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 7
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 7
- 239000007864 aqueous solution Substances 0.000 description 7
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 7
- 230000001143 conditioned effect Effects 0.000 description 7
- 239000000706 filtrate Substances 0.000 description 7
- 229930003935 flavonoid Natural products 0.000 description 7
- 235000017173 flavonoids Nutrition 0.000 description 7
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 7
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 7
- 238000002156 mixing Methods 0.000 description 7
- 230000001590 oxidative effect Effects 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 7
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 6
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 6
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 6
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 6
- 235000001014 amino acid Nutrition 0.000 description 6
- 229940024606 amino acid Drugs 0.000 description 6
- 150000001413 amino acids Chemical class 0.000 description 6
- 235000015165 citric acid Nutrition 0.000 description 6
- 235000012754 curcumin Nutrition 0.000 description 6
- 229940109262 curcumin Drugs 0.000 description 6
- 239000004148 curcumin Substances 0.000 description 6
- 235000014113 dietary fatty acids Nutrition 0.000 description 6
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 description 6
- 239000000194 fatty acid Substances 0.000 description 6
- 229930195729 fatty acid Natural products 0.000 description 6
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 6
- 229910052742 iron Inorganic materials 0.000 description 6
- 229920001864 tannin Polymers 0.000 description 6
- 235000018553 tannin Nutrition 0.000 description 6
- 239000001648 tannin Substances 0.000 description 6
- QAIPRVGONGVQAS-DUXPYHPUSA-N trans-caffeic acid Chemical class OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-DUXPYHPUSA-N 0.000 description 6
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 5
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 5
- 235000011054 acetic acid Nutrition 0.000 description 5
- 239000003513 alkali Substances 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 229910021645 metal ion Inorganic materials 0.000 description 5
- 239000003002 pH adjusting agent Substances 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- 229920001451 polypropylene glycol Polymers 0.000 description 5
- 239000002244 precipitate Substances 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 239000011975 tartaric acid Substances 0.000 description 5
- 235000002906 tartaric acid Nutrition 0.000 description 5
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 4
- GQEZCXVZFLOKMC-UHFFFAOYSA-N 1-hexadecene Chemical compound CCCCCCCCCCCCCCC=C GQEZCXVZFLOKMC-UHFFFAOYSA-N 0.000 description 4
- RGCKGOZRHPZPFP-UHFFFAOYSA-N Alizarin Natural products C1=CC=C2C(=O)C3=C(O)C(O)=CC=C3C(=O)C2=C1 RGCKGOZRHPZPFP-UHFFFAOYSA-N 0.000 description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- 206010020751 Hypersensitivity Diseases 0.000 description 4
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 4
- HFVAFDPGUJEFBQ-UHFFFAOYSA-M alizarin red S Chemical compound [Na+].O=C1C2=CC=CC=C2C(=O)C2=C1C=C(S([O-])(=O)=O)C(O)=C2O HFVAFDPGUJEFBQ-UHFFFAOYSA-M 0.000 description 4
- 230000007815 allergy Effects 0.000 description 4
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 4
- 235000012730 carminic acid Nutrition 0.000 description 4
- 229920002678 cellulose Polymers 0.000 description 4
- 239000001913 cellulose Substances 0.000 description 4
- 235000010980 cellulose Nutrition 0.000 description 4
- 235000019646 color tone Nutrition 0.000 description 4
- 230000006837 decompression Effects 0.000 description 4
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical class OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 4
- CSFWPUWCSPOLJW-UHFFFAOYSA-N hydroxynaphthoquinone Natural products C1=CC=C2C(=O)C(O)=CC(=O)C2=C1 CSFWPUWCSPOLJW-UHFFFAOYSA-N 0.000 description 4
- KQPYUDDGWXQXHS-UHFFFAOYSA-N juglone Chemical compound O=C1C=CC(=O)C2=C1C=CC=C2O KQPYUDDGWXQXHS-UHFFFAOYSA-N 0.000 description 4
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 4
- 239000011976 maleic acid Substances 0.000 description 4
- 229920005862 polyol Polymers 0.000 description 4
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 4
- NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- 239000002562 thickening agent Substances 0.000 description 4
- QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 description 3
- CBCKQZAAMUWICA-UHFFFAOYSA-N 1,4-phenylenediamine Chemical compound NC1=CC=C(N)C=C1 CBCKQZAAMUWICA-UHFFFAOYSA-N 0.000 description 3
- FECNOIODIVNEKI-UHFFFAOYSA-N 2-[(2-aminobenzoyl)amino]benzoic acid Chemical class NC1=CC=CC=C1C(=O)NC1=CC=CC=C1C(O)=O FECNOIODIVNEKI-UHFFFAOYSA-N 0.000 description 3
- CLAHOZSYMRNIPY-UHFFFAOYSA-N 2-hydroxyethylurea Chemical compound NC(=O)NCCO CLAHOZSYMRNIPY-UHFFFAOYSA-N 0.000 description 3
- AIFLGMNWQFPTAJ-UHFFFAOYSA-J 2-hydroxypropanoate;titanium(4+) Chemical compound [Ti+4].CC(O)C([O-])=O.CC(O)C([O-])=O.CC(O)C([O-])=O.CC(O)C([O-])=O AIFLGMNWQFPTAJ-UHFFFAOYSA-J 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 3
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 3
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 description 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 3
- 235000010208 anthocyanin Nutrition 0.000 description 3
- 239000004410 anthocyanin Substances 0.000 description 3
- 229930002877 anthocyanin Natural products 0.000 description 3
- 235000003704 aspartic acid Nutrition 0.000 description 3
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 150000002215 flavonoids Chemical class 0.000 description 3
- 239000001530 fumaric acid Substances 0.000 description 3
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 3
- 229920000591 gum Polymers 0.000 description 3
- 229940031575 hydroxyethyl urea Drugs 0.000 description 3
- SXQCTESRRZBPHJ-UHFFFAOYSA-M lissamine rhodamine Chemical compound [Na+].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=C(S([O-])(=O)=O)C=C1S([O-])(=O)=O SXQCTESRRZBPHJ-UHFFFAOYSA-M 0.000 description 3
- 229960002510 mandelic acid Drugs 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 239000002736 nonionic surfactant Substances 0.000 description 3
- GUEIZVNYDFNHJU-UHFFFAOYSA-N quinizarin Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C(O)=CC=C2O GUEIZVNYDFNHJU-UHFFFAOYSA-N 0.000 description 3
- 229920001285 xanthan gum Polymers 0.000 description 3
- 235000010493 xanthan gum Nutrition 0.000 description 3
- 239000000230 xanthan gum Substances 0.000 description 3
- 229940082509 xanthan gum Drugs 0.000 description 3
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 2
- DOUMFZQKYFQNTF-WUTVXBCWSA-N (R)-rosmarinic acid Chemical compound C([C@H](C(=O)O)OC(=O)\C=C\C=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 DOUMFZQKYFQNTF-WUTVXBCWSA-N 0.000 description 2
- 229940058015 1,3-butylene glycol Drugs 0.000 description 2
- BTLXPCBPYBNQNR-UHFFFAOYSA-N 1-hydroxyanthraquinone Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C=CC=C2O BTLXPCBPYBNQNR-UHFFFAOYSA-N 0.000 description 2
- 229940075142 2,5-diaminotoluene Drugs 0.000 description 2
- GHCZTIFQWKKGSB-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;phosphoric acid Chemical compound OP(O)(O)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O GHCZTIFQWKKGSB-UHFFFAOYSA-N 0.000 description 2
- OBCSAIDCZQSFQH-UHFFFAOYSA-N 2-methyl-1,4-phenylenediamine Chemical compound CC1=CC(N)=CC=C1N OBCSAIDCZQSFQH-UHFFFAOYSA-N 0.000 description 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 2
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 2
- JOOXCMJARBKPKM-UHFFFAOYSA-N 4-oxopentanoic acid Chemical compound CC(=O)CCC(O)=O JOOXCMJARBKPKM-UHFFFAOYSA-N 0.000 description 2
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 2
- 244000215068 Acacia senegal Species 0.000 description 2
- 241000271309 Aquilaria crassna Species 0.000 description 2
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 2
- WDKYDMULARNCIS-GQCTYLIASA-N Caffeic acid ethyl ester Chemical compound CCOC(=O)\C=C\C1=CC=C(O)C(O)=C1 WDKYDMULARNCIS-GQCTYLIASA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 2
- 244000163122 Curcuma domestica Species 0.000 description 2
- 235000003392 Curcuma domestica Nutrition 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 2
- 229920002907 Guar gum Polymers 0.000 description 2
- 229920000084 Gum arabic Polymers 0.000 description 2
- 240000007829 Haematoxylum campechianum Species 0.000 description 2
- 241000238631 Hexapoda Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 108010076876 Keratins Proteins 0.000 description 2
- 102000011782 Keratins Human genes 0.000 description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 2
- 244000208060 Lawsonia inermis Species 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000123069 Ocyurus chrysurus Species 0.000 description 2
- 241000972673 Phellodendron amurense Species 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 2
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 2
- GHPSCBAZRWEYJT-UHFFFAOYSA-N Sappanin Natural products OC1=CC(O)=CC=C1C1=CC=C(O)C(O)=C1 GHPSCBAZRWEYJT-UHFFFAOYSA-N 0.000 description 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 235000010489 acacia gum Nutrition 0.000 description 2
- 239000000205 acacia gum Substances 0.000 description 2
- YRKCREAYFQTBPV-UHFFFAOYSA-N acetylacetone Chemical compound CC(=O)CC(C)=O YRKCREAYFQTBPV-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 239000001361 adipic acid Substances 0.000 description 2
- 235000011037 adipic acid Nutrition 0.000 description 2
- 150000001346 alkyl aryl ethers Chemical class 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 229920006318 anionic polymer Chemical class 0.000 description 2
- BCTILSWHJRTUIE-UHFFFAOYSA-N azanium;4-[4-[bis[4-(dimethylamino)phenyl]-hydroxymethyl]-3-methyl-5-oxo-4h-pyrazol-1-yl]benzenesulfonate Chemical compound [NH4+].C1=CC(N(C)C)=CC=C1C(O)(C=1C=CC(=CC=1)N(C)C)C1C(=O)N(C=2C=CC(=CC=2)S([O-])(=O)=O)N=C1C BCTILSWHJRTUIE-UHFFFAOYSA-N 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 235000021028 berry Nutrition 0.000 description 2
- VYTBDSUNRJYVHL-UHFFFAOYSA-N beta-Hydrojuglone Natural products O=C1CCC(=O)C2=C1C=CC=C2O VYTBDSUNRJYVHL-UHFFFAOYSA-N 0.000 description 2
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 description 2
- 235000019437 butane-1,3-diol Nutrition 0.000 description 2
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 2
- 235000005487 catechin Nutrition 0.000 description 2
- 229920006317 cationic polymer Polymers 0.000 description 2
- 239000003638 chemical reducing agent Substances 0.000 description 2
- 238000004040 coloring Methods 0.000 description 2
- 229910001431 copper ion Inorganic materials 0.000 description 2
- 235000003373 curcuma longa Nutrition 0.000 description 2
- COVFEVWNJUOYRL-UHFFFAOYSA-N digallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)=C1 COVFEVWNJUOYRL-UHFFFAOYSA-N 0.000 description 2
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- XMOCLSLCDHWDHP-IUODEOHRSA-N epi-Gallocatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-IUODEOHRSA-N 0.000 description 2
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 2
- VFPFQHQNJCMNBZ-UHFFFAOYSA-N ethyl gallate Chemical compound CCOC(=O)C1=CC(O)=C(O)C(O)=C1 VFPFQHQNJCMNBZ-UHFFFAOYSA-N 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 235000003891 ferrous sulphate Nutrition 0.000 description 2
- 239000011790 ferrous sulphate Substances 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 235000010417 guar gum Nutrition 0.000 description 2
- 239000000665 guar gum Substances 0.000 description 2
- 229960002154 guar gum Drugs 0.000 description 2
- 229940093915 gynecological organic acid Drugs 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 229920000831 ionic polymer Polymers 0.000 description 2
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 2
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 2
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 2
- 150000002605 large molecules Chemical class 0.000 description 2
- NUJOXMJBOLGQSY-UHFFFAOYSA-N manganese dioxide Chemical compound O=[Mn]=O NUJOXMJBOLGQSY-UHFFFAOYSA-N 0.000 description 2
- 239000012046 mixed solvent Substances 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 235000005985 organic acids Nutrition 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 235000006408 oxalic acid Nutrition 0.000 description 2
- 239000007800 oxidant agent Substances 0.000 description 2
- 239000006174 pH buffer Substances 0.000 description 2
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- SIOXPEMLGUPBBT-UHFFFAOYSA-N picolinic acid Chemical compound OC(=O)C1=CC=CC=N1 SIOXPEMLGUPBBT-UHFFFAOYSA-N 0.000 description 2
- 229920000058 polyacrylate Polymers 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- RLJWTAURUFQFJP-UHFFFAOYSA-N propan-2-ol;titanium Chemical compound [Ti].CC(C)O.CC(C)O.CC(C)O.CC(C)O RLJWTAURUFQFJP-UHFFFAOYSA-N 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 235000005875 quercetin Nutrition 0.000 description 2
- 229960001285 quercetin Drugs 0.000 description 2
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 2
- 235000005493 rutin Nutrition 0.000 description 2
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 2
- 229960004555 rutoside Drugs 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 229910001923 silver oxide Inorganic materials 0.000 description 2
- JHJLBTNAGRQEKS-UHFFFAOYSA-M sodium bromide Chemical compound [Na+].[Br-] JHJLBTNAGRQEKS-UHFFFAOYSA-M 0.000 description 2
- 239000001540 sodium lactate Substances 0.000 description 2
- 235000011088 sodium lactate Nutrition 0.000 description 2
- 229940005581 sodium lactate Drugs 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000001384 succinic acid Substances 0.000 description 2
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 2
- WGTYBPLFGIVFAS-UHFFFAOYSA-M tetramethylammonium hydroxide Chemical compound [OH-].C[N+](C)(C)C WGTYBPLFGIVFAS-UHFFFAOYSA-M 0.000 description 2
- 150000003573 thiols Chemical class 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- 235000013976 turmeric Nutrition 0.000 description 2
- 239000001052 yellow pigment Substances 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- ACEAELOMUCBPJP-UHFFFAOYSA-N (E)-3,4,5-trihydroxycinnamic acid Natural products OC(=O)C=CC1=CC(O)=C(O)C(O)=C1 ACEAELOMUCBPJP-UHFFFAOYSA-N 0.000 description 1
- GEYOCULIXLDCMW-UHFFFAOYSA-N 1,2-phenylenediamine Chemical group NC1=CC=CC=C1N GEYOCULIXLDCMW-UHFFFAOYSA-N 0.000 description 1
- SOGCSKLTQHBFLP-UHFFFAOYSA-N 1,4,5,8-tetrahydroxyanthraquinone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(O)=CC=C2O SOGCSKLTQHBFLP-UHFFFAOYSA-N 0.000 description 1
- PXGZQGDTEZPERC-UHFFFAOYSA-N 1,4-cyclohexanedicarboxylic acid Chemical compound OC(=O)C1CCC(C(O)=O)CC1 PXGZQGDTEZPERC-UHFFFAOYSA-N 0.000 description 1
- FBMQNRKSAWNXBT-UHFFFAOYSA-N 1,4-diaminoanthracene-9,10-dione Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C(N)=CC=C2N FBMQNRKSAWNXBT-UHFFFAOYSA-N 0.000 description 1
- NLXFWUZKOOWWFD-UHFFFAOYSA-N 1-(2-hydroxyethylamino)-4-(methylamino)anthracene-9,10-dione Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C(NCCO)=CC=C2NC NLXFWUZKOOWWFD-UHFFFAOYSA-N 0.000 description 1
- ZFPGARUNNKGOBB-UHFFFAOYSA-N 1-Ethyl-2-pyrrolidinone Chemical compound CCN1CCCC1=O ZFPGARUNNKGOBB-UHFFFAOYSA-N 0.000 description 1
- RRQYJINTUHWNHW-UHFFFAOYSA-N 1-ethoxy-2-(2-ethoxyethoxy)ethane Chemical compound CCOCCOCCOCC RRQYJINTUHWNHW-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- CVBUKMMMRLOKQR-UHFFFAOYSA-N 1-phenylbutane-1,3-dione Chemical compound CC(=O)CC(=O)C1=CC=CC=C1 CVBUKMMMRLOKQR-UHFFFAOYSA-N 0.000 description 1
- RECMXJOGNNTEBG-UHFFFAOYSA-N 1-phenylmethoxyethanol Chemical compound CC(O)OCC1=CC=CC=C1 RECMXJOGNNTEBG-UHFFFAOYSA-N 0.000 description 1
- NKWCGTOZTHZDHB-UHFFFAOYSA-N 1h-imidazol-1-ium-4-carboxylate Chemical compound OC(=O)C1=CNC=N1 NKWCGTOZTHZDHB-UHFFFAOYSA-N 0.000 description 1
- KYWMCFOWDYFYLV-UHFFFAOYSA-N 1h-imidazole-2-carboxylic acid Chemical compound OC(=O)C1=NC=CN1 KYWMCFOWDYFYLV-UHFFFAOYSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- GNCOVOVCHIHPHP-UHFFFAOYSA-N 2-[[4-[4-[(1-anilino-1,3-dioxobutan-2-yl)diazenyl]-3-chlorophenyl]-2-chlorophenyl]diazenyl]-3-oxo-n-phenylbutanamide Chemical compound C=1C=CC=CC=1NC(=O)C(C(=O)C)N=NC(C(=C1)Cl)=CC=C1C(C=C1Cl)=CC=C1N=NC(C(C)=O)C(=O)NC1=CC=CC=C1 GNCOVOVCHIHPHP-UHFFFAOYSA-N 0.000 description 1
- WXHLLJAMBQLULT-UHFFFAOYSA-N 2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-n-(2-methyl-6-sulfanylphenyl)-1,3-thiazole-5-carboxamide;hydrate Chemical compound O.C=1C(N2CCN(CCO)CC2)=NC(C)=NC=1NC(S1)=NC=C1C(=O)NC1=C(C)C=CC=C1S WXHLLJAMBQLULT-UHFFFAOYSA-N 0.000 description 1
- YNVZDODIHZTHOZ-UHFFFAOYSA-K 2-hydroxypropanoate;iron(3+) Chemical compound [Fe+3].CC(O)C([O-])=O.CC(O)C([O-])=O.CC(O)C([O-])=O YNVZDODIHZTHOZ-UHFFFAOYSA-K 0.000 description 1
- LYPJRFIBDHNQLY-UHFFFAOYSA-J 2-hydroxypropanoate;zirconium(4+) Chemical compound [Zr+4].CC(O)C([O-])=O.CC(O)C([O-])=O.CC(O)C([O-])=O.CC(O)C([O-])=O LYPJRFIBDHNQLY-UHFFFAOYSA-J 0.000 description 1
- DEQJBORXLQWRGV-UHFFFAOYSA-N 2-hydroxypropanoic acid;iron Chemical compound [Fe].CC(O)C(O)=O.CC(O)C(O)=O DEQJBORXLQWRGV-UHFFFAOYSA-N 0.000 description 1
- DSVUBXQDJGJGIC-UHFFFAOYSA-N 3',6'-dihydroxy-4',5'-diiodospiro[2-benzofuran-3,9'-xanthene]-1-one Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C(I)=C1OC1=C(I)C(O)=CC=C21 DSVUBXQDJGJGIC-UHFFFAOYSA-N 0.000 description 1
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 1
- HSDSBIUUVWRHTM-UHFFFAOYSA-N 4-(2-nitroanilino)phenol Chemical compound C1=CC(O)=CC=C1NC1=CC=CC=C1[N+]([O-])=O HSDSBIUUVWRHTM-UHFFFAOYSA-N 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-M 4-hydroxybenzoate Chemical compound OC1=CC=C(C([O-])=O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-M 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 235000003261 Artemisia vulgaris Nutrition 0.000 description 1
- 240000006891 Artemisia vulgaris Species 0.000 description 1
- 240000002900 Arthrospira platensis Species 0.000 description 1
- 235000016425 Arthrospira platensis Nutrition 0.000 description 1
- SGHZXLIDFTYFHQ-UHFFFAOYSA-L Brilliant Blue Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 SGHZXLIDFTYFHQ-UHFFFAOYSA-L 0.000 description 1
- 235000007627 Caesalpinia Nutrition 0.000 description 1
- 241000522234 Caesalpinia Species 0.000 description 1
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 244000020518 Carthamus tinctorius Species 0.000 description 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 description 1
- 241001517197 Cattleya Species 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 235000017788 Cydonia oblonga Nutrition 0.000 description 1
- 244000285955 Cyrtosperma chamissonis Species 0.000 description 1
- 235000005885 Cyrtosperma chamissonis Nutrition 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- CIWBSHSKHKDKBQ-DUZGATOHSA-N D-isoascorbic acid Chemical compound OC[C@@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-DUZGATOHSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 229920002707 Digallic acid Polymers 0.000 description 1
- 235000011511 Diospyros Nutrition 0.000 description 1
- 244000236655 Diospyros kaki Species 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- AFSDNFLWKVMVRB-UHFFFAOYSA-N Ellagic acid Chemical compound OC1=C(O)C(OC2=O)=C3C4=C2C=C(O)C(O)=C4OC(=O)C3=C1 AFSDNFLWKVMVRB-UHFFFAOYSA-N 0.000 description 1
- ATJXMQHAMYVHRX-CPCISQLKSA-N Ellagic acid Natural products OC1=C(O)[C@H]2OC(=O)c3cc(O)c(O)c4OC(=O)C(=C1)[C@H]2c34 ATJXMQHAMYVHRX-CPCISQLKSA-N 0.000 description 1
- 229920002079 Ellagic acid Polymers 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 239000004262 Ethyl gallate Substances 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 108010022355 Fibroins Proteins 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- NVXLIZQNSVLKPO-UHFFFAOYSA-N Glucosereductone Chemical compound O=CC(O)C=O NVXLIZQNSVLKPO-UHFFFAOYSA-N 0.000 description 1
- MIWUTEVJIISHCP-UHFFFAOYSA-N HC Blue No. 2 Chemical compound OCCNC1=CC=C(N(CCO)CCO)C=C1[N+]([O-])=O MIWUTEVJIISHCP-UHFFFAOYSA-N 0.000 description 1
- MWJSMPQOVHQYTE-UHFFFAOYSA-N HC Blue No.1 Chemical compound CNC1=CC=C(N(CCO)CCO)C=C1[N+]([O-])=O MWJSMPQOVHQYTE-UHFFFAOYSA-N 0.000 description 1
- GZGZVOLBULPDFD-UHFFFAOYSA-N HC Red No. 3 Chemical compound NC1=CC=C(NCCO)C([N+]([O-])=O)=C1 GZGZVOLBULPDFD-UHFFFAOYSA-N 0.000 description 1
- PNENOUKIPPERMY-UHFFFAOYSA-N HC Yellow No. 4 Chemical compound OCCNC1=CC=C([N+]([O-])=O)C=C1OCCO PNENOUKIPPERMY-UHFFFAOYSA-N 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 241000872190 Hypelate trifoliata Species 0.000 description 1
- QQILFGKZUJYXGS-UHFFFAOYSA-N Indigo dye Chemical compound C1=CC=C2C(=O)C(C3=C(C4=CC=CC=C4N3)O)=NC2=C1 QQILFGKZUJYXGS-UHFFFAOYSA-N 0.000 description 1
- 235000000177 Indigofera tinctoria Nutrition 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 244000017020 Ipomoea batatas Species 0.000 description 1
- 235000002678 Ipomoea batatas Nutrition 0.000 description 1
- 229910021578 Iron(III) chloride Inorganic materials 0.000 description 1
- 244000184861 Juglans nigra Species 0.000 description 1
- 235000013740 Juglans nigra Nutrition 0.000 description 1
- XMOCLSLCDHWDHP-UHFFFAOYSA-N L-Epigallocatechin Natural products OC1CC2=C(O)C=C(O)C=C2OC1C1=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-UHFFFAOYSA-N 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 240000004035 Lithospermum officinale Species 0.000 description 1
- 235000011030 Lithospermum officinale Nutrition 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 1
- 229920000057 Mannan Polymers 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 1
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- VEQPNABPJHWNSG-UHFFFAOYSA-N Nickel(2+) Chemical compound [Ni+2] VEQPNABPJHWNSG-UHFFFAOYSA-N 0.000 description 1
- 241000233855 Orchidaceae Species 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- 235000017343 Quebracho blanco Nutrition 0.000 description 1
- ZZAFFYPNLYCDEP-HNNXBMFYSA-N Rosmarinsaeure Natural products OC(=O)[C@H](Cc1cccc(O)c1O)OC(=O)C=Cc2ccc(O)c(O)c2 ZZAFFYPNLYCDEP-HNNXBMFYSA-N 0.000 description 1
- 241000065615 Schinopsis balansae Species 0.000 description 1
- 102000019307 Sclerostin Human genes 0.000 description 1
- 108050006698 Sclerostin Proteins 0.000 description 1
- 241000533293 Sesbania emerus Species 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 240000004584 Tamarindus indica Species 0.000 description 1
- 235000004298 Tamarindus indica Nutrition 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 241001506047 Tremella Species 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- GOKIPOOTKLLKDI-UHFFFAOYSA-N acetic acid;iron Chemical compound [Fe].CC(O)=O.CC(O)=O.CC(O)=O GOKIPOOTKLLKDI-UHFFFAOYSA-N 0.000 description 1
- MCDLETWIOVSGJT-UHFFFAOYSA-N acetic acid;iron Chemical compound [Fe].CC(O)=O.CC(O)=O MCDLETWIOVSGJT-UHFFFAOYSA-N 0.000 description 1
- HDYRYUINDGQKMC-UHFFFAOYSA-M acetyloxyaluminum;dihydrate Chemical compound O.O.CC(=O)O[Al] HDYRYUINDGQKMC-UHFFFAOYSA-M 0.000 description 1
- CQPFMGBJSMSXLP-UHFFFAOYSA-M acid orange 7 Chemical compound [Na+].OC1=CC=C2C=CC=CC2=C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 CQPFMGBJSMSXLP-UHFFFAOYSA-M 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 description 1
- 229910001508 alkali metal halide Inorganic materials 0.000 description 1
- 150000008045 alkali metal halides Chemical class 0.000 description 1
- 229910052936 alkali metal sulfate Inorganic materials 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 229940037003 alum Drugs 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 description 1
- 229940009827 aluminum acetate Drugs 0.000 description 1
- 229940010048 aluminum sulfate Drugs 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 239000000305 astragalus gummifer gum Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- LFZDEAVRTJKYAF-UHFFFAOYSA-L barium(2+) 2-[(2-hydroxynaphthalen-1-yl)diazenyl]naphthalene-1-sulfonate Chemical compound [Ba+2].C1=CC=CC2=C(S([O-])(=O)=O)C(N=NC3=C4C=CC=CC4=CC=C3O)=CC=C21.C1=CC=CC2=C(S([O-])(=O)=O)C(N=NC3=C4C=CC=CC4=CC=C3O)=CC=C21 LFZDEAVRTJKYAF-UHFFFAOYSA-L 0.000 description 1
- POJOORKDYOPQLS-UHFFFAOYSA-L barium(2+) 5-chloro-2-[(2-hydroxynaphthalen-1-yl)diazenyl]-4-methylbenzenesulfonate Chemical compound [Ba+2].C1=C(Cl)C(C)=CC(N=NC=2C3=CC=CC=C3C=CC=2O)=C1S([O-])(=O)=O.C1=C(Cl)C(C)=CC(N=NC=2C3=CC=CC=C3C=CC=2O)=C1S([O-])(=O)=O POJOORKDYOPQLS-UHFFFAOYSA-L 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 description 1
- 229940093265 berberine Drugs 0.000 description 1
- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 description 1
- 229940000635 beta-alanine Drugs 0.000 description 1
- 239000001055 blue pigment Substances 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 239000001058 brown pigment Substances 0.000 description 1
- 235000004883 caffeic acid Nutrition 0.000 description 1
- 229940074360 caffeic acid Drugs 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 150000001765 catechin Chemical class 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- BVQUETZBXIMAFZ-UHFFFAOYSA-N chembl1328567 Chemical compound C1=CC=C2C(=O)C(O)=C(O)C(=O)C2=C1 BVQUETZBXIMAFZ-UHFFFAOYSA-N 0.000 description 1
- HBHZKFOUIUMKHV-UHFFFAOYSA-N chembl1982121 Chemical compound OC1=CC=C2C=CC=CC2=C1N=NC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O HBHZKFOUIUMKHV-UHFFFAOYSA-N 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 1
- 229940074393 chlorogenic acid Drugs 0.000 description 1
- 235000001368 chlorogenic acid Nutrition 0.000 description 1
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 1
- 229930002875 chlorophyll Natural products 0.000 description 1
- 235000019804 chlorophyll Nutrition 0.000 description 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
- 229910001430 chromium ion Inorganic materials 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 1
- QAIPRVGONGVQAS-UHFFFAOYSA-N cis-caffeic acid Natural products OC(=O)C=CC1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-UHFFFAOYSA-N 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 150000001879 copper Chemical class 0.000 description 1
- OPQARKPSCNTWTJ-UHFFFAOYSA-L copper(ii) acetate Chemical compound [Cu+2].CC([O-])=O.CC([O-])=O OPQARKPSCNTWTJ-UHFFFAOYSA-L 0.000 description 1
- DYROSKSLMAPFBZ-UHFFFAOYSA-L copper;2-hydroxypropanoate Chemical compound [Cu+2].CC(O)C([O-])=O.CC(O)C([O-])=O DYROSKSLMAPFBZ-UHFFFAOYSA-L 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 150000001983 dialkylethers Chemical class 0.000 description 1
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 description 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 1
- 229940120503 dihydroxyacetone Drugs 0.000 description 1
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical class C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 description 1
- CZZYITDELCSZES-UHFFFAOYSA-N diphenylmethane Chemical compound C=1C=CC=CC=1CC1=CC=CC=C1 CZZYITDELCSZES-UHFFFAOYSA-N 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 239000000982 direct dye Substances 0.000 description 1
- IVKWXPBUMQZFCW-UHFFFAOYSA-L disodium;2-(2,4,5,7-tetraiodo-3-oxido-6-oxoxanthen-9-yl)benzoate;hydrate Chemical compound O.[Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=C(I)C(=O)C(I)=C2OC2=C(I)C([O-])=C(I)C=C21 IVKWXPBUMQZFCW-UHFFFAOYSA-L 0.000 description 1
- FHRUGNCCGSEPPE-UHFFFAOYSA-L disodium;2-(4,5-dibromo-3,6-dioxido-9h-xanthen-9-yl)benzoate;hydron Chemical compound [H+].[Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1C2=CC=C([O-])C(Br)=C2OC2=C(Br)C([O-])=CC=C21 FHRUGNCCGSEPPE-UHFFFAOYSA-L 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 229960002852 ellagic acid Drugs 0.000 description 1
- 235000004132 ellagic acid Nutrition 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- DZYNKLUGCOSVKS-UHFFFAOYSA-N epigallocatechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3cc(O)c(O)c(O)c3 DZYNKLUGCOSVKS-UHFFFAOYSA-N 0.000 description 1
- 235000010350 erythorbic acid Nutrition 0.000 description 1
- UQPHVQVXLPRNCX-UHFFFAOYSA-N erythrulose Chemical compound OCC(O)C(=O)CO UQPHVQVXLPRNCX-UHFFFAOYSA-N 0.000 description 1
- XYIBRDXRRQCHLP-UHFFFAOYSA-N ethyl acetoacetate Chemical compound CCOC(=O)CC(C)=O XYIBRDXRRQCHLP-UHFFFAOYSA-N 0.000 description 1
- WDKYDMULARNCIS-UHFFFAOYSA-N ethyl caffeoate Natural products CCOC(=O)C=CC1=CC=C(O)C(O)=C1 WDKYDMULARNCIS-UHFFFAOYSA-N 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019277 ethyl gallate Nutrition 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229960002089 ferrous chloride Drugs 0.000 description 1
- 235000013925 ferrous lactate Nutrition 0.000 description 1
- 239000004225 ferrous lactate Substances 0.000 description 1
- 229940037907 ferrous lactate Drugs 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 235000011087 fumaric acid Nutrition 0.000 description 1
- PHMDYZQXPPOZDG-UHFFFAOYSA-N gallane Chemical compound [GaH3] PHMDYZQXPPOZDG-UHFFFAOYSA-N 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000003700 hair damage Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229940051250 hexylene glycol Drugs 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 150000004340 hydroxynaphthoquinones Chemical class 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 230000003752 improving hair Effects 0.000 description 1
- 229940097275 indigo Drugs 0.000 description 1
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- NMCUIPGRVMDVDB-UHFFFAOYSA-L iron dichloride Chemical compound Cl[Fe]Cl NMCUIPGRVMDVDB-UHFFFAOYSA-L 0.000 description 1
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 229940026239 isoascorbic acid Drugs 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- OTCKOJUMXQWKQG-UHFFFAOYSA-L magnesium bromide Chemical compound [Mg+2].[Br-].[Br-] OTCKOJUMXQWKQG-UHFFFAOYSA-L 0.000 description 1
- 229910001623 magnesium bromide Inorganic materials 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 150000005309 metal halides Chemical class 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- FYFFGSSZFBZTAH-UHFFFAOYSA-N methylaminomethanetriol Chemical compound CNC(O)(O)O FYFFGSSZFBZTAH-UHFFFAOYSA-N 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- FAARLWTXUUQFSN-UHFFFAOYSA-N methylellagic acid Natural products O1C(=O)C2=CC(O)=C(O)C3=C2C2=C1C(OC)=C(O)C=C2C(=O)O3 FAARLWTXUUQFSN-UHFFFAOYSA-N 0.000 description 1
- CQDGTJPVBWZJAZ-UHFFFAOYSA-N monoethyl carbonate Chemical compound CCOC(O)=O CQDGTJPVBWZJAZ-UHFFFAOYSA-N 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 229940043348 myristyl alcohol Drugs 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910001453 nickel ion Inorganic materials 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- 239000013110 organic ligand Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000005691 oxidative coupling reaction Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- DCKVFVYPWDKYDN-UHFFFAOYSA-L oxygen(2-);titanium(4+);sulfate Chemical compound [O-2].[Ti+4].[O-]S([O-])(=O)=O DCKVFVYPWDKYDN-UHFFFAOYSA-L 0.000 description 1
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 description 1
- JRKICGRDRMAZLK-UHFFFAOYSA-L peroxydisulfate Chemical compound [O-]S(=O)(=O)OOS([O-])(=O)=O JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 229940067107 phenylethyl alcohol Drugs 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- XPGAWFIWCWKDDL-UHFFFAOYSA-N propan-1-olate;zirconium(4+) Chemical compound [Zr+4].CCC[O-].CCC[O-].CCC[O-].CCC[O-] XPGAWFIWCWKDDL-UHFFFAOYSA-N 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- FOWDZVNRQHPXDO-UHFFFAOYSA-N propyl hydrogen carbonate Chemical compound CCCOC(O)=O FOWDZVNRQHPXDO-UHFFFAOYSA-N 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- NIPZZXUFJPQHNH-UHFFFAOYSA-N pyrazine-2-carboxylic acid Chemical compound OC(=O)C1=CN=CC=N1 NIPZZXUFJPQHNH-UHFFFAOYSA-N 0.000 description 1
- 229940079889 pyrrolidonecarboxylic acid Drugs 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- WPPDXAHGCGPUPK-UHFFFAOYSA-N red 2 Chemical compound C1=CC=CC=C1C(C1=CC=CC=C11)=C(C=2C=3C4=CC=C5C6=CC=C7C8=C(C=9C=CC=CC=9)C9=CC=CC=C9C(C=9C=CC=CC=9)=C8C8=CC=C(C6=C87)C(C=35)=CC=2)C4=C1C1=CC=CC=C1 WPPDXAHGCGPUPK-UHFFFAOYSA-N 0.000 description 1
- 239000001054 red pigment Substances 0.000 description 1
- DOUMFZQKYFQNTF-MRXNPFEDSA-N rosemarinic acid Natural products C([C@H](C(=O)O)OC(=O)C=CC=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 DOUMFZQKYFQNTF-MRXNPFEDSA-N 0.000 description 1
- TVHVQJFBWRLYOD-UHFFFAOYSA-N rosmarinic acid Natural products OC(=O)C(Cc1ccc(O)c(O)c1)OC(=Cc2ccc(O)c(O)c2)C=O TVHVQJFBWRLYOD-UHFFFAOYSA-N 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- VVNRQZDDMYBBJY-UHFFFAOYSA-M sodium 1-[(1-sulfonaphthalen-2-yl)diazenyl]naphthalen-2-olate Chemical compound [Na+].C1=CC=CC2=C(S([O-])(=O)=O)C(N=NC3=C4C=CC=CC4=CC=C3O)=CC=C21 VVNRQZDDMYBBJY-UHFFFAOYSA-M 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229940045920 sodium pyrrolidone carboxylate Drugs 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- HYRLWUFWDYFEES-UHFFFAOYSA-M sodium;2-oxopyrrolidine-1-carboxylate Chemical compound [Na+].[O-]C(=O)N1CCCC1=O HYRLWUFWDYFEES-UHFFFAOYSA-M 0.000 description 1
- CGXSFOUXEQBDCJ-UHFFFAOYSA-N sodium;8-hydroxy-5,7-dinitronaphthalene-2-sulfonic acid Chemical compound [Na+].C1=C(S(O)(=O)=O)C=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 CGXSFOUXEQBDCJ-UHFFFAOYSA-N 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 229940082787 spirulina Drugs 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 229940012831 stearyl alcohol Drugs 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 235000020238 sunflower seed Nutrition 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229910001432 tin ion Inorganic materials 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 229910000348 titanium sulfate Inorganic materials 0.000 description 1
- XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 description 1
- VXYADVIJALMOEQ-UHFFFAOYSA-K tris(lactato)aluminium Chemical compound CC(O)C(=O)O[Al](OC(=O)C(C)O)OC(=O)C(C)O VXYADVIJALMOEQ-UHFFFAOYSA-K 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- 229910001928 zirconium oxide Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/10—Preparations for permanently dyeing the hair
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
本發明提供一種具有優良的染髮性，而且用法簡便，可於短時間內染髮，且對毛髮或頭皮之安全性亦優良的染髮劑。
本發明為一種染髮劑，其係同時或個別包含：成分(1)：選自由具有兒茶酚結構之色素、具有連苯三酚結構之色素、具有α-羥羰基結構之色素、具有β-羥羰基結構之色素及彼等之色素前驅物所成群組的1種或2種以上之色素及/或其色素前驅物；及成分(2)：有機鈦化合物及/或有機鋯化合物。又，本發明為一種染髮方法，其係將上述成分(1)與上述成分(2)同時或個別施用於毛髮。
Description
本發明係有關於一種具有優良的染髮性與便利性，且對毛髮或頭皮之安全性亦優良的染髮劑。
傳統上，使用對苯二胺類之氧化染髮劑經廣泛使用。此染髮劑係由第1液與第2液所構成，該第1液係含有對苯二胺、2,5-二胺基甲苯等氧化染料中間體及氨、乙醇胺等鹼劑；該第2液則含有過氧化氫等氧化劑。週知使用氧化染髮劑之染髮劑，其中氧化染料中間體會滲透至毛髮內部，藉由進行氧化偶合形成色素而將毛髮染色，因而染髮力高，且堅牢性優良，較不會因洗髮精、潤絲精或光而發生褪色。此外，亦可藉由過氧化氫的作用而同時進行黑色素的脫色與染髮，而有可染成明亮的色調之優點。
然而，就如上述之使用氧化染髮劑之染髮劑，有因染髮處理所使用的鹼劑或過氧化氫，而使毛髮或頭皮產生損傷的問題。再者，對苯二胺、2,5-二胺基甲苯等氧化染料中間體被指出會引起皮膚過敏，亦有誘突變性的疑慮。
另外，作為用法簡便的染髮劑，有人提出使酸性染料或鹼性染料吸附於毛髮的表面之染色劑或護髮劑。然而，使用此等進行染髮時，由於染附性與洗髮精耐性不足，而有需頻繁進行染髮處理或皮膚遭染色的問題。再者，亦有染料中所含之硝基或苯二胺結構所引起的安全性風險。
就染髮劑的安全性改良，迄此有人提出各種方式。例如，將自古以來屬源自天然之植物色素的散沫花或靛藍用於染髮。然而，該等染髮性低，要有效地染髮則需要30℃以上且1小時以上的染髮條件，且色調亦極為有限。又，有將自古以來使用於草木染的多種植物色素利用於染髮。然而，此等色素一般而言染髮性極差，而缺乏實用性。從而，作為予以改良之技術，週知有併用金屬離子系媒染劑，或併用硫醇類等還原劑與鹼劑的方法(專利文獻1、2)。
[先前技術文獻]
[專利文獻]
[專利文獻1]日本特開2002-138024號公報
[專利文獻2]日本特開2013-133320號公報
[發明所欲解決之課題]
然而，根據專利文獻1所記載之金屬離子系媒染劑，確實可提升染髮性；而為鐵離子時，有色相僅限於黑色系，且彩度亦低，有鐵離子固有臭味等問題。又，若為銅離子、鋁離子、錫離子、鎳離子、鉛離子、鉻離子等時，則有對人體安全性的疑慮，染髮性仍舊不足，且洗髮精耐性亦有改善的餘地。另一方面，如專利文獻2所記載之併用硫醇類等還原劑與鹼劑的方法則有染髮步驟繁瑣，而且無法避免對毛髮與頭皮造成傷害等問題。
有鑑於上述習知技術，本發明目的在於提供一種具有優良的染髮性，而且用法簡便，可於短時間內染髮，且對毛髮或頭皮之安全性亦優良的染髮劑。
[解決課題之手段]
本案發明人等致力重複多次研究的結果，作為解決上述課題之手段，終至發現組合既定的色素及/或其色素前驅物與有機鈦化合物及/或有機鋯化合物。
亦即，第一，本發明係提供一種染髮劑，其係同時或個別包含下述成分(1)與下述成分(2)：
成分(1)：選自由具有兒茶酚結構之色素、具有連苯三酚結構之色素、具有α-羥羰基結構之色素、具有β-羥羰基結構之色素及彼等之色素前驅物所成群組的1種或2種以上之色素及/或其色素前驅物
成分(2)：有機鈦化合物及/或有機鋯化合物。
上述染髮劑中，前述成分(1)較佳為選自由蘇木因、蘇木精、巴西靈酮、巴西靈、羥基萘醌類化合物、薑黃素、類黃酮類化合物、花青素類化合物、茜素、紫膠色素、胭脂紅色素、咖啡酸衍生物、沒食子酸衍生物及單寧類化合物所成群組的1種或2種以上之源自天然之色素。
又，上述染髮劑中，前述成分(2)較佳為選自由羥基羧酸類化合物、β-二酮類化合物、β-酮酯類化合物、還原酮類化合物、多元醇類化合物、多羧酸類化合物、含氮雜環羧酸類化合物、烷醇胺類化合物及胺基酸所成群組的1種或2種以上之化合物與鈦及/或鋯配位而成的錯合物。
另外，第二，本發明係提供一種染髮方法，其係將下述成分(1)與下述成分(2)同時或個別施用於毛髮：
成分(1)：選自由具有兒茶酚結構之色素、具有連苯三酚結構之色素、具有α-羥羰基結構之色素、具有β-羥羰基結構之色素及彼等之色素前驅物所成群組的1種或2種以上之色素及/或其色素前驅物
成分(2)：有機鈦化合物及/或有機鋯化合物。
上述染髮方法中，前述成分(1)較佳為選自由蘇木因、蘇木精、巴西靈酮、巴西靈、羥基萘醌類化合物、薑黃素、類黃酮類化合物、花青素類化合物、茜素、紫膠色素、胭脂紅色素、咖啡酸衍生物、沒食子酸衍生物及單寧類化合物所成群組的1種或2種以上之源自天然之色素。
又，上述染髮方法中，前述成分(2)較佳為選自由羥基羧酸類化合物、β-二酮類化合物、β-酮酯類化合物、還原酮類化合物、多元醇類化合物、多羧酸類化合物、含氮雜環羧酸類化合物、烷醇胺類化合物及胺基酸所成群組的1種或2種以上之化合物與鈦及/或鋯配位而成的錯合物。
[發明之效果]
根據本發明，由於係與既定的色素及/或其色素前驅物組合有機鈦化合物及/或有機鋯化合物，故可獲得具有優良染髮性的染髮劑。此染髮劑其用法簡便，可於短時間內染髮，且對毛髮或頭皮之安全性亦優良。
[實施發明之形態]
本發明係由以下所構成：
成分(1)：選自由具有兒茶酚結構之色素、具有連苯三酚結構之色素、具有α-羥羰基結構之色素、具有β-羥羰基結構之色素及彼等之色素前驅物所成群組的1種或2種以上之色素及/或其色素前驅物；及
成分(2)：有機鈦化合物及/或有機鋯化合物。
構成上述成分(1)的色素及/或其色素前驅物，實質上係呈淡黃色至紅色，而該色素藉由與構成上述成分(2)的有機鈦化合物及/或有機鋯化合物形成錯合物，便會轉換成濃色且深色(黃色、紫色或黑色)之色素。藉由在毛髮上進行此反應，該有機鈦化合物及/或有機鋯化合物便與上述色素形成錯合物，同時與毛髮表面的羧基、羥基、醯胺基產生交互作用，而使毛髮牢固地染色。由此，可實現高染髮性與優良的洗髮精耐性。而且，構成上述成分(1)或上述成分(2)的化合物其安全性高，不會使頭皮引起發炎或過敏。再者，縱未使用鹼劑亦可將毛髮染色，而無鹼劑所引起的毛髮內部損傷等。
作為上述成分(1)，可舉出蘇木因、屬蘇木因之前驅物的蘇木精、巴西靈酮、屬巴西靈酮前驅物的巴西靈、羥基萘醌類化合物(指甲花醌(lowsone)、胡桃醌、紫草素、紫草紅、醯化紫草素、脫氫紫草素等)、薑黃素、類黃酮類化合物(槲皮素、芸香苷、葉黃酮等)、花青素類化合物、茜素、紫膠色素、胭脂紅色素、咖啡酸衍生物(咖啡酸、咖啡酸乙酯、綠原酸、迷迭香酸、七葉內酯等)、沒食子酸衍生物(沒食子酸乙酯、鞣花酸、二沒食子酸等)、單寧類化合物(五倍子、雲實單寧、白堅木、表沒食子兒茶素、柿子發酵液等)等。此等可單獨使用1種，亦可併用2種以上。
作為上述成分(1)，較佳為源自天然之成分。具體而言，例如蘇木因為含於墨水樹(Haematoxylum campechianum)之色素，巴西靈酮為含於蘇木、指甲花醌為含於散沫花、胡桃醌為含於黑胡桃、紫草素衍生物為含於紫草或紫草烷、薑黃素則為含於薑黃之色素。又，槲皮素、芸香苷、葉黃酮等類黃酮類化合物係含於以使君子科植物(例如訶子等)為首的各種樹木、各種柑橘類、莓類、蔬菜等，沒食子酸衍生物為兒茶素的一種，富含於莓類或單寧類。茜素富含於西洋茜草或茜草，咖啡酸衍生物則富含於咖啡生豆、甘薯莖葉、向日葵種子、果實、艾草等。單寧類化合物含於廣範圍的植物中，可粗分為水解型與縮合型。另一方面，紫膠色素及胭脂紅色素為源自介殼蟲之色素。
上述色素當中，蘇木因與巴西靈酮在基原植物中係與彼等之還原體共存。亦即，在蘇木因之基原植物墨水樹(log wood)中富含還原體之蘇木精，在巴西靈酮之基原植物蘇木中則富含還原體之巴西靈。於本發明中，亦可直接使用共存有此等還原體的植物萃取物，惟，係以預先將萃取物以各種氧化劑(氧、過氧化氫、氧化銀、二氧化錳、過硫酸鹽、過碘酸等)進行處理，將例如蘇木精或巴西靈等的還原體轉換成蘇木因或巴西靈酮等的氧化體而提高其含量後再使用為宜。
作為由植物或昆蟲等天然資源獲得萃取物之方法，一般係採用將該天然資源乾燥、粉碎，並以水、乙醇、異丙醇、丙二醇、1,3-丁二醇或者彼等之混合溶劑進行萃取的方法。
上述萃取物常含有已氧化之色素。含有該等色素的著色萃取物可視需求進一步供予氧化步驟及純化步驟，而得到高純度的含色素物，惟亦可將著色之未純化品直接使用於染髮。
作為上述成分(1)，亦可為非源自天然者。具體而言，可舉出羥基蒽醌系色素(醌茜(1,4-二羥基蒽醌)、1,4,5,8-四羥基蒽醌等)、羥基萘醌系色素(萘茜、萘紫素、2,3-二羥基-1,4-萘醌等)等。此等可單獨使用1種，亦可併用2種以上。又，能以透過與上述源自天然者併用而使染髮的色相多樣化為目的而合宜地使用。
就上述成分(2)而言，係鈦或鋯與有機配基鍵結而成的錯合物，係例如與羥基羧酸類化合物之錯合物、與β-二酮類化合物之錯合物、與β-酮酯類化合物之錯合物、與還原酮類化合物之錯合物、與多元醇類化合物之錯合物、與多羧酸類化合物之錯合物、與含氮雜環羧酸之錯合物、與烷醇胺類化合物之錯合物、與胺基酸之錯合物等。通常，鈦為四價六配位、鋯為四價八配位，多個配基可藉由共價鍵或配位鍵與上述成分(1)及毛髮鍵結，藉此可賦予高染髮性與優良的洗髮精耐性。使用鈦化合物作為媒染劑係向來廣為人知者，惟週知之鈦媒染劑係包含高濃度的硫酸或者鹽酸之強酸性的硫酸鈦水溶液或氯化鈦水溶液，而無法將彼等施用於人類的染髮。構成上述成分(2)的有機鈦化合物實質上為中性化合物，在水溶液中的穩定性亦極高。另一方面，鋯向來則幾乎未作為草木染之媒染劑使用。其化學性質與鈦極為相似。
就鈦及鋯所共有的化學性質，其與鍵結力較弱之不穩定配基形成的錯合物在水中容易水解，而分解成氧化鈦或氧化鋯，因此，要獲得在水中呈穩定的錯合物，則配基的選擇極為重要。較佳羥基羧酸配基，可舉出乙醇酸、乳酸、苦杏仁酸、檸檬酸、酒石酸、蘋果酸、柳酸、磺柳酸等；較佳β-二酮或β-酮酯配基，可舉出乙醯丙酮、苯甲醯丙酮、二苯甲醯基甲烷、乙醯乙酸乙酯等；較佳還原酮配基，可舉出抗壞血酸、異抗壞血酸、二羥基丙酮、赤蘚酮糖等；較佳多元醇配基，可舉出乙二醇、丙二醇、丁二醇、異戊二醇、甘油、兒茶酚、試鈦靈等；較佳多羧酸配基，可舉出草酸、丙二酸、馬來酸、麩胺酸等；較佳含氮雜環羧酸配基，可舉出吡啶-2-羧酸、咪唑-2-羧酸、咪唑-4-羧酸、5-吡咯啶酮-2-羧酸、吡嗪-2-羧酸等；較佳烷醇胺配基，可舉出乙醇胺、二乙醇胺、三乙醇胺等；較佳胺基酸配基，可舉出絲胺酸、甘胺酸、丙胺酸、麩胺酸、離胺酸、組胺酸等。
本發明係提供一種同時或個別包含上述成分(1)與上述成分(2)的染髮劑。以下，方便上將包含上述成分(1)之形態稱為組成物(A)、包含上述成分(2)之形態稱為組成物(B)，或者將包含上述成分(1)及成分(2)此兩成分之形態表示為組成物(C)，茲就彼等以染髮劑提供之樣態更詳細地加以說明。
上述組成物(A)或上述組成物(B)或上述組成物(C)其各自的形態不特別限制，基於容易施用於毛髮之觀點，可較佳例示溶液狀、懸浮液狀、乳液狀、乳脂(cream)狀、泡沫狀、凝膠狀、糊膏狀等形態。用以提供此等形態之溶劑的種類不特別限制，可使用例如水、甲醇、乙醇、異丙醇、乙二醇、二乙二醇、丙二醇、二丙二醇、1,3-丁二醇、異戊二醇、己二醇、乙基卡必醇、甘油、二甘油、聚乙二醇、聚丙二醇等。此等溶劑可單獨使用，亦可組合2種以上使用。較佳為單獨使用水，或使用水與上述有機溶劑的混合物。
惟，基於染髮性與洗髮精耐性觀點，上述成分(1)與上述成分(2)較佳以不同的形態提供。例如，特佳為以將上述形態中為溶液狀等的組成物(A)與溶液狀等的組成物(B)各自填充於不同的容器之形態提供。又，亦能以與推進劑共同在加壓下封入於氣溶膠容器內之形態等提供。
另一方面，就同時包含上述成分(1)與上述成分(2)之形態加以說明，若將上述成分(1)與上述成分(2)混合則會進行錯合物形成，大部分會生成難溶於水或有機溶劑的著色沉澱。一旦生成沉澱，一般而言染髮性會明顯變差，因此需採取不會生成沉澱的方法。具體而言，係應用：將上述成分(1)與上述成分(2)之組合最佳化；併用可使該著色沉澱成為可溶的輔助溶劑；將混合溶劑中的溶劑比率最佳化等對策。同時包含上述成分(1)與上述成分(2)之實施形態由於染髮操作較單純，外出時須於短時間內染髮時尤其可理想地使用。
上述成分(1)的用量不特別限定，調製包含成分(1)之溶液狀等的組成物(A)時，於該組成物中較佳含有0.03質量%～5質量%左右，特佳含有0.1質量%～3質量%左右。而且，例如藉由改變成分(1)之色素的濃度或混合多種色素，可使染髮時的色調大幅變化。
上述成分(2)的用量不特別限定，調製包含成分(2)之溶液狀等的組成物(B)時，成分(2)較佳為對水的溶解度為0.1質量%以上者，特佳為1.0質量%以上者。又，於該組成物中較佳含有0.05質量%～10質量%左右，特佳含有0.1質量%～5質量%左右。而且，例如藉由改變成分(2)之鈦化合物或鋯化合物的配基、濃度、與成分(1)之色素的莫耳比等，可使挑染後之毛髮的色相、明度、彩度等大幅變化。
上述成分(1)及上述成分(2)的pH不特別限定，基於染髮性觀點，調製包含上述成分(1)之溶液狀等的組成物(A)時、調製包含上述成分(2)之溶液狀等的組成物(B)時，或者調製包含上述成分(1)及成分(2)之溶液狀等的組成物(C)時，該等組成物(A)或組成物(B)或組成物(C)的pH較佳為3～10的範圍，特佳為3～8的範圍。基於抑制毛髮損傷之觀點，彼等之pH較佳為9以下，特佳為3.5～6.5的範圍。
上述pH亦可適宜使用由酸或鹼構成的pH調節劑等來調節。
作為pH調節劑使用的酸，可舉出例如乙酸、乳酸、酒石酸、蘋果酸、檸檬酸、乙醇酸、吡咯啶酮羧酸、乙醯丙酸、富馬酸、琥珀酸、草酸、馬來酸、苦杏仁酸、天門冬胺酸、己二酸、菸鹼酸等有機酸、磷酸等。此等當中，較佳使用乙酸、乳酸、酒石酸、蘋果酸、檸檬酸、乙醇酸、富馬酸、琥珀酸、馬來酸、苦杏仁酸、天門冬胺酸、己二酸等有機酸。又，亦可使用此等酸之鹽類(鈉鹽、鉀鹽或銨鹽等)作為pH調節劑。
作為pH調節劑使用的鹼，可舉出例如氨、乙醇胺、二乙醇胺、三乙醇胺、咪唑、氫氧化四甲銨、碳酸氫鈉、乙酸鈉、乳酸鈉等。此等當中，較佳使用乙醇胺、二乙醇胺、三乙醇胺、咪唑等。
上述pH調節劑可單獨使用，或者組合2種以上使用。又，pH調節劑的摻混量不特別限定，例如相對於染髮劑使用時的總質量，較佳以0.01質量%～15質量%的範圍使用，更佳以0.1質量%～10質量%的範圍使用，特佳以0.5質量%～5質量%的範圍使用。
另一方面，為調節pH，較佳使用pH緩衝液。作為pH緩衝液，可舉出例如乙酸緩衝液、磷酸緩衝液、檸檬酸緩衝液、檸檬酸磷酸緩衝液、硼酸緩衝液、酒石酸緩衝液、三羥甲基胺基甲烷緩衝液等。尤以使用乙酸緩衝液、磷酸緩衝液、檸檬酸緩衝液、檸檬酸磷酸緩衝液等為佳。
調製包含上述成分(1)之溶液狀等的組成物(A)時、調製包含上述成分(2)之溶液狀等的組成物(B)時，或者調製包含上述成分(1)及成分(2)之溶液狀等的組成物(C)時，該等組成物(A)或組成物(B)或組成物(C)中亦可視需求摻混界面活性劑。作為界面活性劑，可舉出例如陰離子性界面活性劑、陽離子性界面活性劑、非離子性界面活性劑、兩性界面活性劑等。尤以使用非離子性界面活性劑為佳。
作為非離子性界面活性劑，可舉出脂肪酸烷醇醯胺類、聚乙烯吡咯啶酮類、聚環氧乙烷類、聚環氧乙烷單烷基醚類、聚環氧乙烷二醚類、聚環氧乙烷單苯基醚類、聚環氧丙烷類、聚環氧丙烷單烷基醚類、聚環氧丙烷二烷基醚類、聚環氧乙烷脂肪酸酯類、甘油脂肪酸酯類、甘油單醚類、山梨醇酐脂肪酸酯類等。
上述界面活性劑可單獨使用，或者組合2種以上使用。又，界面活性劑的摻混量不特別限定，例如相對於染髮劑使用時的總質量，較佳以0.01質量%～20質量%的範圍使用，更佳以0.1質量%～5質量%的範圍使用。
調製包含上述成分(1)之溶液狀等的組成物(A)時、調製包含上述成分(2)之溶液狀等的組成物(B)時，或者調製包含上述成分(1)及成分(2)之溶液狀等的組成物(C)時，該等組成物(A)或組成物(B)或組成物(C)中亦可視需求摻混油性成分。就油性成分，只要是可溶解或分散於該等組成物(A)或組成物(B)或組成物(C)中者則不特別限定。藉由摻混油性成分，可抑制染髮後毛髮的傷害，並可具有光澤或滋潤感。作為油性成分，可舉出例如聚矽氧類、烴、油脂、蠟類、高級脂肪酸酯等。
上述油性成分可單獨使用，或者組合2種以上使用。油性成分的摻混量不特別限定，例如相對於染髮劑使用時的總質量，較佳以0.01質量%～5質量%的範圍使用，更佳以0.05質量%～3質量%的範圍使用。
調製包含上述成分(1)之溶液狀等的組成物(A)時、調製包含上述成分(2)之溶液狀等的組成物(B)時，或者調製包含上述成分(1)及成分(2)之溶液狀等的組成物(C)時，該等組成物(A)或組成物(B)或組成物(C)中亦可視需求摻混高級醇。就高級醇，只要是可溶解或分散於該等組成物(A)或組成物(B)或組成物(C)中者則不特別限定。可舉出例如肉豆蔻醇、鯨蠟醇、油醇、硬脂醇等。此等高級醇可單獨使用，或者併用2種以上。高級醇的摻混量不特別限定，例如相對於染髮劑使用時的總質量，較佳以0.01質量%～5質量%的範圍使用，更佳以0.03質量%～3質量%的範圍使用。
調製包含上述成分(1)之溶液狀等的組成物(A)時、調製包含上述成分(2)之溶液狀等的組成物(B)時，或者調製包含上述成分(1)及成分(2)之溶液狀等的組成物(C)時，該等組成物(A)或組成物(B)或組成物(C)中亦可視需求摻混高分子化合物。就高分子化合物，只要是可溶解或分散於該等組成物(A)或組成物(B)或組成物(C)中者則不特別限定。可舉出例如陽離子性高分子化合物、兩性高分子化合物、陰離子性高分子化合物、非離子性高分子化合物等。
陽離子性高分子化合物，可舉出例如陽離子化纖維素(例如氯化O-[2-羥基-3-(三甲銨基)丙基]羥乙基纖維素、氯化O-[2-羥基-3-(月桂基二甲銨基)丙基)羥乙基纖維素)、陽離子性澱粉、陽離子化瓜爾膠、聚二甲基二烯丙基銨鹽等。
陰離子性高分子化合物，可舉出例如丙烯酸或甲基丙烯酸與其他乙烯基單體之共重合高分子、羧甲基纖維素等。
非離子性高分子化合物，可舉出例如聚乙烯醇、聚乙烯吡咯啶酮、纖維素、甲基纖維素、乙基纖維素、羥乙基纖維素、羥丙基纖維素、羥甲基丙基纖維素、瓜爾膠、羥丙基黃原膠、洋菜、澱粉、聚丙烯酸酯、聚甲基丙烯酸酯、聚丙烯醯胺、聚甲基丙烯醯胺、聚乙二醇、聚丙二醇等。
此外，有用的高分子化合物，可舉出例如阿拉伯膠、鹿角菜膠、銀耳多醣體、半乳聚糖、榅桲籽膠、次槐豆膠、黃蓍膠、果膠、甘露聚糖、黃原膠、葡聚糖、卡特蘭多醣、結蘭膠、琥珀醯聚糖、明膠、羅望子膠、酪蛋白等天然高分子化合物。
上述高分子化合物可單獨使用，或者組合2種以上使用。高分子化合物的摻混量不特別限定，例如相對於染髮劑使用時的總質量，較佳以0.01質量%～10質量%的範圍使用，更佳以0.05質量%～5質量%的範圍使用。
調製包含上述成分(1)之溶液狀等的組成物(A)時、調製包含上述成分(2)之溶液狀等的組成物(B)時，或者調製包含上述成分(1)及成分(2)之溶液狀等的組成物(C)時，該等組成物(A)或組成物(B)或組成物(C)中亦可視需求摻混增黏劑。增黏劑可舉出例如海藻酸鈉、阿拉伯膠、經交聯之丙烯酸聚合物、纖維素衍生物、黃原膠等。此等增黏劑可單獨使用，或者組合2種以上使用。增黏劑的摻混量不特別限定，例如相對於染髮劑使用時的總質量，較佳以0.01質量%～5質量%的範圍使用，更佳以0.05質量%～0.5質量%的範圍使用。
調製包含上述成分(1)之溶液狀等的組成物(A)時、調製包含上述成分(2)之溶液狀等的組成物(B)時，或者調製包含上述成分(1)及成分(2)之溶液狀等的組成物(C)時，該等組成物(A)或組成物(B)或組成物(C)中亦可視需求摻混香料。就香料而言，可為合成品或天然品，可任意使用，但特佳使用精油(香精油)。
調製包含上述成分(1)之溶液狀等的組成物(A)時、調製包含上述成分(2)之溶液狀等的組成物(B)時，或者調製包含上述成分(1)及成分(2)之溶液狀等的組成物(C)時，該等組成物(A)或組成物(B)或組成物(C)中，視需求，為調節染髮性，亦可摻混各種添加劑。供調節染髮性之添加劑，可較佳例示例如脂肪族羧酸(例如乙酸、丙酸、乳酸、乙醇酸、乙醯丙酸、富馬酸、馬來酸、琥珀酸、酒石酸、蘋果酸、檸檬酸)或胺基酸(例如甘胺酸、α-丙胺酸、β-丙胺酸、纈胺酸、白胺酸、異白胺酸、苯丙胺酸、脯胺酸、絲胺酸、蘇胺酸、天門冬胺酸、麩胺酸、精胺酸、組胺酸、色胺酸、甲硫胺酸等)。
調製包含上述成分(1)之溶液狀等的組成物(A)時、調製包含上述成分(2)之溶液狀等的組成物(B)時，或者調製包含上述成分(1)及成分(2)之溶液狀等的組成物(C)時，該等組成物(A)或組成物(B)或組成物(C)，尤其是包含該有機鈦化合物及/或有機鋯化合物之組成物(B)中可視需求摻混鈦或者鋯以外的金屬離子作為媒染劑。諸如上述，鐵以外的金屬離子雖有對人體之安全性的疑慮，但為低濃度的話則可摻混之。可使用之金屬離子，可舉出銅離子、鋁離子、鋅離子等。另外，鐵離子雖有待解決之課題，但要染成黑色系時，可與有機鈦化合物及/或有機鋯化合物併用。較佳之鐵離子的原料，可舉出例如乳酸亞鐵、乳酸鐵、乙酸亞鐵、乙酸鐵、硫酸亞鐵、硫酸鐵、氯化亞鐵、氯化鐵等。就摻混鐵離子時的摻混量，較佳以0.001質量%～0.3質量的範圍使用。
於本發明中，可對上述成分添加各種水溶性金屬鹽。藉由添加該金屬鹽，可提升染髮性或洗髮精耐性並微調色相。作為該金屬鹽，較有用的是鹼金屬鹵化物、鹼金屬硫酸鹽、鹼土金屬鹵化物、水溶性鋁鹽、水溶性銅鹽等；就其較佳實例，可舉出氯化鈉、氯化鉀、溴化鈉、氯化鎂、溴化鎂、乙酸鋁、乳酸鋁、硫酸鋁、明礬類、乙酸銅、乳酸銅等。
調製包含上述成分(1)之溶液狀等的組成物(A)時、調製包含上述成分(2)之溶液狀等的組成物(B)時，或者調製包含上述成分(1)及成分(2)之溶液狀等的組成物(C)時，該等組成物(A)或組成物(B)或組成物(C)，尤為包含該色素及/或其色素前驅物的組成物(A)中可視需求，以調整色調為目的而添加週知之色素・染料。作為週知之色素・染料，可舉出例如HC黃1、HC黃2、HC黃3、HC黃4、HC橙1、HC紅1、HC紅2、HC紅3、HC藍1、HC藍2、分散紫1、分散藍3等；直接染料可舉出黑色401號、藍色1號、藍色2號、藍色201號、藍色202號、藍色203號、藍色403號、藍色404號、紫色201號、紫色401號、紅色102號、紅色106號、紅色201號、紅色202號、紅色203號、紅色204號、紅色205號、紅色206號、紅色207號、紅色208號、橙色201號、橙色203號、橙色205號、橙色206號、橙色207號、黃色201號、黃色203號、黃色204號、黃色205號、黃色401號、黃色402號、黃色403號；天然色素可舉出葉綠素色素、螺旋藻色素、梔子黃色素、梔子藍色素、愈創薁、愈創薁磺酸鹽等。
調製包含上述成分(1)之溶液狀等的組成物(A)時、調製包含上述成分(2)之溶液狀等的組成物(B)時，或者調製包含上述成分(1)及成分(2)之溶液狀等的組成物(C)時，該等組成物(A)或組成物(B)或組成物(C)中可進一步添加其他物質。就其他物質，只要是不會使染髮性變差，且可溶解或分散於該等組成物(A)或組成物(B)或組成物(C)中者則不特別限定。作為較佳實例，可舉出膠原蛋白、角蛋白、彈力蛋白、絲纖蛋白、貝殼硬蛋白、吡咯啶酮羧酸鈉、乳酸鈉、山梨糖醇、玻尿酸、苯甲醇、苯乙醇、苄氧基乙醇、N-甲基吡咯啶酮、N-乙基吡咯啶酮、碳酸伸乙酯、尿素、羥乙基尿素、環己烷-1,4-二羧酸雙乙氧基二甘醇、碳酸伸丙酯、對羥基苯甲酸酯、紫外線吸收劑等。
本發明之由上述構成所成之染髮劑可使用於人類或動物的毛，例如毛髮或體毛、動物的體毛等的染色，較佳可使用於人類毛髮的染色、犬或貓等寵物體毛的染色，特佳為人類毛髮的染色。
使用本發明之由上述構成所成之染髮劑進行染髮時，上述成分(1)與上述成分(2)之施用順序不特別限定，能以任意順序施用。例如，可將包含上述成分(1)之溶液狀等的組成物(A)塗佈於毛髮等而施用後，將包含上述成分(2)之溶液狀等的組成物(B)塗佈於該毛髮等而施用，或者亦可將包含上述成分(2)之溶液狀等的組成物(B)塗佈於毛髮等而施用後，將包含上述成分(1)之溶液狀等的組成物(A)塗佈於該毛髮等而施用。或者，可將包含上述成分(1)之溶液狀等的組成物(A)與包含上述成分(2)之溶液狀等的組成物(B)同時塗佈於毛髮等而施用，也可於臨使用前將混合兩者所得之混合物塗佈於毛髮等而施用。再者，亦可調製包含上述成分(1)及成分(2)此兩成分之溶液狀等的組成物(C)，並將其塗佈於毛髮等而施用。
此等當中，特佳為將包含上述成分(2)之溶液狀等的組成物(B)塗佈於毛髮等而施用後，將包含上述成分(1)之溶液狀等的組成物(A)塗佈於該毛髮等而施用的方法。這是因為，由於構成上述成分(2)的有機鈦化合物及/或有機鋯化合物具有與毛髮角蛋白蛋白質等強力進行交互作用的性質，透過先予以施用，一般而言，由此可獲得更高的染髮性。亦即，例如將上述組成物(B)施用於毛髮後，放置片刻後再施用上述組成物(A)。放置時間不特別限定，較佳為例如3～30分鐘，更佳為5～20分鐘。又，施用該組成物(A)後，係以進一步放置片刻為佳。其放置時間不特別限定，較佳為例如5～30分鐘，更佳為10～20分鐘。染髮處理能以例如20℃～40℃左右的溫度進行。包含上述成分(1)之溶液狀等的組成物(A)與包含上述成分(2)之溶液狀等的組成物(B)的用量不特別限定，就兩者的容量比，較佳為3/1～1/3的範圍。上述組成物(A)或上述組成物(B)的施用方法不特別限定，可採用對毛髮等塗佈該組成物，或者將毛髮等浸漬於該組成物中等的任意方法。於染髮後，可使用洗髮精及潤絲精進行處理。其後，較佳以適當的方法加以乾燥。
[實施例]
以下，根據實施例對本發明更具體地加以說明，惟本發明之範圍不受下述實施例任何限定。
＜調製例1＞(溶液A1的製作)
在丁二醇10mL、異丙醇5mL及乳酸2.70g的混合物中，於冰冷卻下滴下四異丙氧基鈦(東京化成製)2.84g，其後於室溫下攪拌1小時。另外，將羥乙基纖維素1.0g溶於純水70mL，將此液逐滴添加於乳酸鈦的溶液中，而得到略帶黏性的無色透明溶液(A1)。
＜調製例2＞(溶液A2的製作)
在丁二醇10mL、正丙醇5mL及乳酸2.70g的混合物中，於冰冷卻下滴下四丙氧基鋯的70%丙醇溶液(東京化成製)5.54g，其後於室溫下攪拌1小時。另外，將羥乙基纖維素1.0g溶於純水70mL，將此液逐滴添加於乳酸鋯的溶液中，而得到略帶黏性的無色透明溶液(A2)。
＜調製例3＞(溶液B1的製作)
將蘇木因0.60g與葉黃酮0.57g添加於丁二醇5g與AMINON C-11S(花王製)10g的混合物中，以50℃使其加熱溶解。接著，添加2%羥乙基纖維素水溶液100g，使用均質機於50℃下劇烈攪拌30分鐘後，放置冷卻而得到橙紅色乳脂狀的溶液(B1)。
＜調製例4＞(植物色素的萃取法1)
將訶子乾燥片(田中染料店製)100g添加於50%乙醇溶液1L，進行回流加熱2小時。放置冷卻後，進行過濾，並由濾液中減壓餾去溶劑而得到包含葉黃酮作為主成分的萃取物6.5g。本方法係最常見的植物色素萃取法。
＜調製例5＞(植物色素的萃取法2)
將墨水樹乾燥片(田中染料店製)100g添加於50%乙醇溶液1L，進行回流加熱2小時。放置冷卻後，進行過濾，對濾液添加氧化銀1.16g並於室溫下攪拌2小時。過濾分離不溶物，並由濾液中減壓餾去溶劑而得到包含蘇木因作為主成分的萃取物8.2g。要由蘇木獲得巴西靈酮時亦較佳採用本方法。
＜調製例6＞(溶液B2的製作)
將調製例4之訶子萃取物1.0g及調製例5之墨水樹萃取物1.2g添加於丁二醇5g、純水5g及AMINON C-11S(花王製)15g的混合物，以60℃使其加熱溶解。接著，添加2%羥乙基纖維素水溶液100g，使用均質機於60℃下劇烈攪拌30分鐘後，放置冷卻而得到暗紅色乳脂狀的溶液(B2)。
＜調製例7＞(植物色素的萃取法3)
將軟紫草乾燥片(中國陝西省產)100g微粉碎，添加95%乙醇溶液1L並於50℃下攪拌2小時。放置冷卻後，進行過濾，由濾液中減壓餾去溶劑。將殘渣溶於乙酸乙酯100mL，以3%碳酸氫鈉水溶液100mL洗淨3次而去除共存的中級脂肪酸類，以1%乳酸水溶液進一步洗淨後，以無水硫酸鎂乾燥，再減壓餾去乙酸乙酯而得到以醯化紫草素為主成分的粗紫草素3.1g。
＜調製例8＞(植物色素的萃取法4)
將乾燥薑黃(印度產)100g微粉碎，添加95%乙醇溶液1L並於50℃下攪拌2小時。放置冷卻後，進行過濾，由濾液中減壓餾去溶劑。將殘渣加熱溶解於乙酸乙酯200mL，過濾分離不溶物。由濾液中減壓餾去乙酸乙酯而得到粗薑黃素6.5g。
[試驗例1](染髮試驗1)
對人髮白髮(100%)束(Beaulax製)2g以毛刷塗敷調製例1之溶液A1、20g，放置10分鐘。接著，以毛刷塗佈調製例3之乳脂狀溶液B1、20g，進一步放置10分鐘。以溫水充分洗淨髮束，進行洗髮及潤髮(rinse)，並使用吹風機加以乾燥。髮束經染成黑褐色。對染髮後的髮束，使用色彩色差計(Konica Minolta Sensing製CR-400)測定染髮濃度(△E：與染髮前比較之色差)，△E為50.2。
[試驗例2](染髮試驗2)
對人髮白髮(100%)束(Beaulax製)2g以毛刷塗敷調製例1之溶液A1、20g，放置10分鐘。接著，以毛刷塗佈調製例6之乳脂狀溶液B2、20g，進一步放置10分鐘。以溫水充分洗淨髮束，進行洗髮及潤髮，並使用吹風機加以乾燥。髮束經染成暗褐色。對染髮後的髮束，使用色彩色差計測定染髮濃度(△E)，△E為48.5。
[試驗例3](染髮試驗3)
對人髮白髮(100%)束(Beaulax製)2g以毛刷塗敷調製例2之溶液A2、20g，放置10分鐘。接著，以毛刷塗佈調製例6之乳脂狀溶液B2、20g，進一步放置10分鐘。以溫水充分洗淨髮束，進行洗髮及潤髮，並使用吹風機加以乾燥。髮束經染成暗褐色。對染髮後的髮束，使用色彩色差計測定染髮濃度(△E)，△E為45.2。
[試驗例4](染髮試驗4)
適宜組合溶液A群與乳脂狀溶液B群，依據試驗例1～3進行染髮試驗。將結果示於表1。此外，就溶液A群，係以依據調製例1或調製例2之方法，具體而言係將鈦或鋯與配基的莫耳比取1：2，並將鈦或鋯之四烷氧化物，於水冷卻下添加於配基與異丙醇或丙醇的混合物中的方法，來調製表1所示配基所成之鈦或鋯的錯合化合物。又，就乳脂狀溶液B群，則以依據調製例4或調製例5之方法，具體而言係將乾燥之被萃取植物粉碎物100g添加於50%或者95%乙醇1L，一邊攪拌一邊進行回流加熱2小時後，過濾分離不溶物，並由濾液中減壓餾去溶劑的方法，由各種植物中萃取出色素，並以依據調製例6之方法來調製乳脂狀的溶液。
[表1]
[試驗例5](染髮試驗5)
對人髮白髮(100%)束(Beaulax製)2g以毛刷塗佈調製例3之乳脂狀溶液B1、20g，放置10分鐘。接著，以毛刷塗敷調製例1之溶液A1、20g，放置10分鐘。以溫水充分洗淨髮束，進行洗髮及潤髮，並使用吹風機加以乾燥。髮束經染成黑褐色。對染髮後的髮束，使用色彩色差計測定染髮濃度(△E)，△E為45.8。由此結果，若為本試驗例時，可知即使改變溶液A與溶液B的塗佈順序，染髮性亦無較大差異。
[試驗例6](染髮試驗6)
將調製例1之溶液A1、20g與調製例3之乳脂狀溶液B1、20g，使用毛刷以在毛髮上混合的方式塗滿人髮白髮(100%)束2g。放置30分鐘後，以溫水充分洗淨髮束，進行洗髮及潤髮，並使用吹風機加以乾燥。髮束經染成褐色。對染髮後的髮束測定染髮濃度(△E)，△E為28.7。由此結果可知，若將溶液A與溶液B同時塗佈於毛髮則染髮性會變差。
[試驗例7](染髮試驗7)
將調製例1之溶液A1、20g與色素溶液B12(粗紫草素1.0g及羥乙基尿素1.0g溶於95%乙醇100mL之溶液)、20g混合，使用毛刷塗滿人髮白髮(100%)束2g。放置30分鐘後，以溫水充分洗淨髮束，進行洗髮及潤髮，並使用吹風機加以乾燥。髮束經染成褐色。對染髮後的髮束測定染髮濃度(△E)，△E為41.7。由此結果可知，藉由溶液A與溶液B之組合，於使用時將兩者混合塗佈於毛髮，染髮性也不會變差。
[試驗例8](染髮試驗8)
將調製例7之粗紫草素50mg、調製例8之粗薑黃素60mg、苯甲醇100mg、羥乙基尿素50mg、純水1.0g及乙醇9.0g的混合物以50℃加熱攪拌而調製成橙紅色的色素溶液。另一方面，在丁二醇5mL、乙醇5mL及乳酸2.70g的混合物中，於冰冷卻下添加四異丙氧基鈦2.84g，其後於室溫下攪拌1小時而調製成乳酸鈦溶液。對上述色素溶液添加乳酸鈦溶液150mg而調製成褐色的色素/鈦錯合物溶液。此溶液經放置一夜後亦未生成沉澱而呈穩定。
使用睫毛膏用迷你刷將上述溶液塗滿人髮白髮(100%)束0.2g。放置於室溫下1小時後，以溫水充分洗淨髮束，進而進行洗髮，並以吹風機乾燥。髮束在剛染髮後經染成濃褐色。此外，溫水洗淨後亦未看出濃度降低。再者，將洗髮後之髮束的染髮濃度與剛染髮後的染髮濃度相比，濃度降低僅止於10%。由此結果可知，藉由適宜組合色素溶液與鈦溶液，可獲得具有高染髮性與洗髮精耐性的穩定的色素/鈦錯合物溶液。
[試驗例9](比較染髮試驗1)
對人髮白髮(100%)束(Beaulax製)2g以毛刷塗佈調製例3之乳脂狀溶液B1、20g並以聚乙烯薄膜包覆後，予以放置於35℃的恆溫槽內30分鐘。以溫水充分洗淨髮束，進行洗髮及潤髮，並使用吹風機加以乾燥。髮束經染成淡紅褐色。對染髮後的髮束，使用色彩色差計測定染髮濃度(△E)，△E為10.3。由此結果可知，若無鈦化合物則染髮性會明顯變差。
[試驗例10](比較染髮試驗2)
對人髮白髮(100%)束(Beaulax製)2g，使用以與調製例4同樣方式由關黃柏萃取之含有未與鈦形成錯合物的黃色色素小蘗鹼之關黃柏萃取物，以與調製例6同樣的方式製作乳脂狀溶液B，以毛刷塗佈其20g，放置30分鐘。以溫水充分洗淨髮束，進行洗髮及潤髮，並使用吹風機加以乾燥。髮束經染成淡黃色。對染髮後的髮束，使用色彩色差計測定染髮濃度(△E)，△E為12.2。
[試驗例11](比較染髮試驗3)
對人髮白髮(100%)束(Beaulax製)2g以毛刷塗敷調製例1之溶液A1、20g並放置10分鐘後，以毛刷塗佈上述關黃柏萃取物的乳脂狀溶液、20g，放置30分鐘。以溫水充分洗淨髮束，進行洗髮及潤髮，並使用吹風機加以乾燥。髮束經染成淡黃色。對染髮後的髮束，使用色彩色差計測定染髮濃度(△E)，△E為11.8。由此結果可知，若為未與鈦形成錯合物的植物色素，即使存在鈦化合物，染髮性仍會明顯變差。
[試驗例12](耐洗髮精性試驗)
對試驗例1～3中所得之染髮試樣，使用含有胺基酸系洗淨劑的廣用洗髮精重複進行5次洗髮，測定洗髮前後的染髮濃度(△E)。將結果示於表2。
[表2]
由表2之結果，可知本發明之染髮劑具有高洗髮精耐性。
[試驗例13](對頭皮的刺激性試驗)
將試驗例2所使用之由溶液A1與乳脂狀溶液B2構成的染髮劑施用於對氧化染髮劑會引起頭皮過敏的10位監測員之染髮。其結果，無任何產生過敏的監測員。此外，1個月後對同一位監測員再度進行染髮試驗，未看出產生過敏。由此結果可知，本發明之染髮劑不會引起頭皮過敏。
Claims (4)
- 一種染髮劑，其係包含下述成分(1)與下述成分(2)：成分(1)：紫草素及/或紫草紅成分(2)：有機鈦化合物及/或有機鋯化合物。
- 如請求項1之染髮劑，其中前述成分(2)為選自由羥基羧酸類化合物及β-二酮類化合物所成群組的1種或2種以上之化合物與鈦及/或鋯配位而成的錯合物。
- 一種染髮方法，其係將下述成分(1)與下述成分(2)施用於毛髮：成分(1)：紫草素及/或紫草紅成分(2)：有機鈦化合物及/或有機鋯化合物。
- 如請求項3之染髮方法，其中前述成分(2)為選自由羥基羧酸類化合物及β-二酮類化合物所成群組的1種或2種以上之化合物與鈦及/或鋯配位而成的錯合物。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018-027508 | 2018-02-20 | ||
| JP2018027508 | 2018-02-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201938224A TW201938224A (zh) | 2019-10-01 |
| TWI839343B true TWI839343B (zh) | 2024-04-21 |
Family
ID=67687077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW108104536A TWI839343B (zh) | 2018-02-20 | 2019-02-12 | 染髮劑 |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP6624628B1 (zh) |
| CN (1) | CN110573135B (zh) |
| TW (1) | TWI839343B (zh) |
| WO (1) | WO2019163497A1 (zh) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021186917A1 (ja) * | 2020-03-17 | 2021-09-23 | 株式会社Ｎｉｌ | 染毛剤 |
| JP2023131240A (ja) * | 2022-03-09 | 2023-09-22 | 株式会社Nil | 染毛剤 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2543434B1 (fr) * | 1983-04-01 | 1986-03-14 | Muller International Sarl Alba | Composition et procede pour la teinture du systeme pileux. |
| JPH04164017A (ja) * | 1990-10-29 | 1992-06-09 | Lion Corp | 染毛剤組成物 |
| JPH0812539A (ja) * | 1994-06-29 | 1996-01-16 | Dai Ichi Seiyaku Co Ltd | 染毛用組成物 |
| JP2003048819A (ja) * | 2001-07-31 | 2003-02-21 | Chuo Aerosol Kagaku Kk | 染毛のための頭髪化粧品 |
| JP2003246716A (ja) * | 2002-02-25 | 2003-09-02 | Picaso Cosmetic Laboratory Ltd | 染毛剤 |
| BRPI0610694A2 (pt) * | 2005-04-06 | 2010-07-20 | Boots Co Plc | corantes de cabelo oxidativos aperfeiçoados e composições tópicas relacionadas |
| US7550014B2 (en) * | 2006-05-01 | 2009-06-23 | Advanced Cosmetic Technologies, Llc | Composition for dyeing keratin fibers and a method of dyeing hair using same |
| JP6169071B2 (ja) * | 2011-06-23 | 2017-07-26 | ロレアル | 少なくとも１種類のオルト−ジフェノールと、マンガン塩または亜鉛塩と、過酸化水素と、（重）炭酸塩と、アルカリ剤と、チタン塩またはスカンジウム塩とを使用する染毛方法 |
| US8828100B1 (en) * | 2013-10-14 | 2014-09-09 | John C. Warner | Formulation and processes for hair coloring |
| FR3014681B1 (fr) * | 2013-12-13 | 2015-12-18 | Oreal | Procede de coloration capillaire mettant en œuvre au moins un orthodiphenol, un sel organique de titane et d'acide carboxylique |
| FR3029406B1 (fr) * | 2014-12-08 | 2016-12-09 | Oreal | Procede de coloration capillaire mettant en œuvre au moins un colorant, un sel de titane, et un polymere epaississant anionique |
| FR3029409B1 (fr) * | 2014-12-08 | 2016-12-09 | Oreal | Procede de coloration capillaire mettant en œuvre au moins un colorant, un sel organique de titane, et un polysaccharide non cellulosique |
| FR3029407B1 (fr) * | 2014-12-08 | 2016-12-09 | Oreal | Procede de coloration capillaire mettant en œuvre au moins un colorant direct et/ou naturel, un sel de titane, un polysaccharide cellulosique et eventuellement un solvant organique particulier |
| FR3029405B1 (fr) * | 2014-12-08 | 2019-08-02 | L'oreal | Procede de coloration capillaire mettant en œuvre au moins un colorant, un sel de titane, et un silicate insoluble |
| FR3037237B1 (fr) * | 2015-06-12 | 2018-11-30 | L'oreal | Procede de coloration capillaire mettant en œuvre une etape de coloration a partir d'un colorant, et d'un sel de titane et une etape de revelation a partir d'agent alcalin comportant au plus une fonction amine |
-
2019
- 2019-02-04 JP JP2019533247A patent/JP6624628B1/ja active Active
- 2019-02-04 WO PCT/JP2019/003830 patent/WO2019163497A1/ja active Application Filing
- 2019-02-04 CN CN201980001978.0A patent/CN110573135B/zh active Active
- 2019-02-12 TW TW108104536A patent/TWI839343B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| JP6624628B1 (ja) | 2019-12-25 |
| JPWO2019163497A1 (ja) | 2020-02-27 |
| WO2019163497A1 (ja) | 2019-08-29 |
| TW201938224A (zh) | 2019-10-01 |
| CN110573135B (zh) | 2022-07-22 |
| CN110573135A (zh) | 2019-12-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101856312B (zh) | 用于染色角蛋白纤维的化妆组合物和使用该组合物的毛发染色方法 | |
| KR101840743B1 (ko) | 모발 염색 제품 | |
| US7749286B2 (en) | Composition for dyeing keratin fibers and a method of dyeing hair using same | |
| KR101621032B1 (ko) | 염료로서 차 폴리페놀 및/또는 차 색소의 용도 및 그의 제품 | |
| JP2017066154A (ja) | 少なくとも１つのオルトジフェノール、１つの金属塩、過酸化水素及び（重）炭酸塩を含む組成物から出発する染髪方法 | |
| JP2001192326A (ja) | 染色毛髪用処理組成物 | |
| WO2002087529A1 (fr) | Compositions pour colorant capillaire utilisees dans la coiffure des cheveux | |
| CN101862270A (zh) | 含有邻-联苯酚、金属盐、过氧化氢、碳酸盐和碱的染发组合物 | |
| EP2633849A1 (en) | Hair dye | |
| TWI839343B (zh) | 染髮劑 | |
| TW201223551A (en) | Hair dye containing one or multiple edible pigments or cosmetic pigments and hair dyeing method using the same | |
| JP2010138175A (ja) | オルトジフェノールから出発し、拭取り、乾燥または無濯ぎ段階を含む染色方法 | |
| WO2012127502A1 (en) | Hair colouring composition using plant dyes | |
| CN108392433B (zh) | 一种复合剂型的染发剂 | |
| KR101510486B1 (ko) | 카테킨을 함유하는 염모제 조성물 | |
| CN115297829A (zh) | 染发剂 | |
| CN107789241B (zh) | 具有养发固色效果的发膜组合物及其制备方法 | |
| KR102442840B1 (ko) | 아민기를 가지는 고분자 및 천연 염료의 혼합물을 이용한 모발의 염색방법 | |
| JPH0987152A (ja) | 頭髪用組成物および染毛方法 | |
| KR20100067604A (ko) | 천연성분을 함유하는 1제형 산화형 염모제 조성물 | |
| KR20100061261A (ko) | 천연성분을 함유하는 산화염색용 염모제 조성물 | |
| WO2014048868A2 (en) | Hair dyeing process using at least one ortho-methoxyphenol, a manganese or zinc salt, hydrogen peroxide and (bi)carbonate | |
| US20230270662A1 (en) | Natural vegetable source based hair colour | |
| CA2549254A1 (en) | Hair dye | |
| KR20190031795A (ko) | 아스코르브산을 유효성분으로 포함하는 천연 염료 발색 강화용 조성물 |