TWI837532B - 治療潰瘍性結腸炎之方法 - Google Patents

治療潰瘍性結腸炎之方法 Download PDF

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Publication number
TWI837532B
TWI837532B TW110139868A TW110139868A TWI837532B TW I837532 B TWI837532 B TW I837532B TW 110139868 A TW110139868 A TW 110139868A TW 110139868 A TW110139868 A TW 110139868A TW I837532 B TWI837532 B TW I837532B
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Taiwan
Prior art keywords
dose
administered
mirikizumab
weeks
maintenance
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TW110139868A
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English (en)
Chinese (zh)
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TW202206104A (zh
Inventor
詹姆士 班那迪 卡納凡
史都華 威廉 菲來得利奇
凱瑟琳 安 庫爵
凱瑟琳 謬琪
杰 勞倫斯 圖透
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美商美國禮來大藥廠
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
TW110139868A 2018-03-30 2019-03-27 治療潰瘍性結腸炎之方法 TWI837532B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862650314P 2018-03-30 2018-03-30
US62/650,314 2018-03-30

Publications (2)

Publication Number Publication Date
TW202206104A TW202206104A (zh) 2022-02-16
TWI837532B true TWI837532B (zh) 2024-04-01

Family

ID=66429483

Family Applications (2)

Application Number Title Priority Date Filing Date
TW110139868A TWI837532B (zh) 2018-03-30 2019-03-27 治療潰瘍性結腸炎之方法
TW108110767A TWI744617B (zh) 2018-03-30 2019-03-27 治療潰瘍性結腸炎之方法

Family Applications After (1)

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TW108110767A TWI744617B (zh) 2018-03-30 2019-03-27 治療潰瘍性結腸炎之方法

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US (2) US12152072B2 (https=)
EP (2) EP4327866B1 (https=)
JP (4) JP7119114B2 (https=)
KR (1) KR102552693B1 (https=)
CN (1) CN111936165A (https=)
AU (2) AU2019243283C1 (https=)
BR (1) BR112020018099A2 (https=)
CA (1) CA3095297A1 (https=)
DK (2) DK3773715T3 (https=)
EA (1) EA202091989A1 (https=)
ES (2) ES3063700T3 (https=)
FI (2) FI3773715T3 (https=)
HR (2) HRP20240904T1 (https=)
HU (1) HUE067445T2 (https=)
IL (2) IL277514B2 (https=)
LT (2) LT4327866T (https=)
MA (2) MA67901B1 (https=)
MD (1) MD3773715T2 (https=)
MX (1) MX2020010269A (https=)
MY (1) MY202368A (https=)
PL (2) PL3773715T3 (https=)
PT (2) PT3773715T (https=)
RS (2) RS67806B1 (https=)
SG (1) SG11202009526RA (https=)
SI (1) SI3773715T1 (https=)
TW (2) TWI837532B (https=)
UA (1) UA128578C2 (https=)
WO (1) WO2019191464A1 (https=)
ZA (1) ZA202005388B (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020234834A1 (en) 2019-05-23 2020-11-26 Janssen Biotech, Inc. Method of treating inflammatory bowel disease with a combination therapy of antibodies to il-23 and tnf alpha
CA3170677A1 (en) * 2020-02-14 2021-08-19 Janssen Biotech, Inc. Safe and effective method of treating ulcerative colitis with anti-il-12/il23 antibody
KR20230023663A (ko) 2020-05-21 2023-02-17 얀센 바이오테크 인코포레이티드 Il-23 및 tnf 알파에 대한 항체의 병용 요법으로 염증성 장질환을 치료하는 방법
JP7423815B2 (ja) * 2020-10-20 2024-01-29 セトラスホールディングス株式会社 治験管理装置、治験管理方法、治験管理プログラム及び治験管理システム
JP2024501900A (ja) * 2021-01-06 2024-01-16 アッヴィ・インコーポレイテッド クローン病及び潰瘍性大腸炎を処置する方法
EP4340875A1 (en) * 2021-05-20 2024-03-27 Janssen Biotech, Inc. Method of treating inflammatory bowel disease with a combination therapy of antibodies to il-23 and tnf alpha
JP2024521748A (ja) * 2021-05-28 2024-06-04 イーライ リリー アンド カンパニー 潰瘍性大腸炎に関与する遺伝子の抗ｉｌ－２３ｐ１９抗体調節
WO2023095000A1 (en) * 2021-11-23 2023-06-01 Janssen Biotech, Inc. Method of treating ulcerative colitis with anti-il23 specific antibody
US20240199734A1 (en) * 2022-11-22 2024-06-20 Janssen Biotech, Inc. Method of Treating Ulcerative Colitis with Anti-IL23 Specific Antibody
KR20250156783A (ko) 2023-03-10 2025-11-03 일라이 릴리 앤드 캄파니 궤양성 결장염을 치료하는 방법
CN121443635A (zh) * 2023-06-16 2026-01-30 信达生物医药科技(杭州)有限公司 重组抗白介素23p19亚基抗体在治疗炎症性肠病中的用途
WO2025170982A2 (en) 2024-02-06 2025-08-14 Paragon Therapeutics, Inc. Il-23 antibody compositions and methods of use
WO2026060205A1 (en) 2024-09-13 2026-03-19 Eli Lilly And Company PAN-ELR+ CXC CHEMOKINE ANTIBODIES AND IL-23p19 ANTIBODIES FOR THE TREATMENT OF ULCERATIVE COLITIS

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070009526A1 (en) * 2005-06-30 2007-01-11 Jacqueline Benson Anti-IL-23 antibodies, compositions, methods and uses
WO2010062663A1 (en) * 2008-11-03 2010-06-03 Schering Corporation Inflammatory bowel disease biomarkers and related methods of treatment
US20120282269A1 (en) * 2010-11-04 2012-11-08 Boehringer Ingelheim International Gmbh Anti-IL-23 Antibodies
US20170002060A1 (en) * 2014-01-08 2017-01-05 Moderna Therapeutics, Inc. Polynucleotides for the in vivo production of antibodies

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1971366T1 (sl) 2005-12-29 2014-10-30 Janssen Biotech, Inc. Humana protitelesa anti-il-23, sestavki, postopki in uporabe
AR065420A1 (es) 2007-02-23 2009-06-03 Schering Corp Anticuerpos anti-il-23 p19 de ingenieria
JO3244B1 (ar) 2009-10-26 2018-03-08 Amgen Inc بروتينات ربط مستضادات il – 23 البشرية
AR094877A1 (es) 2013-03-08 2015-09-02 Lilly Co Eli Anticuerpos que se unen a il-23
CA3092551A1 (en) * 2018-03-05 2019-09-12 Janssen Biotech, Inc. Methods of treating crohn's disease with anti-il23 specific antibody

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070009526A1 (en) * 2005-06-30 2007-01-11 Jacqueline Benson Anti-IL-23 antibodies, compositions, methods and uses
WO2010062663A1 (en) * 2008-11-03 2010-06-03 Schering Corporation Inflammatory bowel disease biomarkers and related methods of treatment
US20120282269A1 (en) * 2010-11-04 2012-11-08 Boehringer Ingelheim International Gmbh Anti-IL-23 Antibodies
US20170002060A1 (en) * 2014-01-08 2017-01-05 Moderna Therapeutics, Inc. Polynucleotides for the in vivo production of antibodies

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
期刊 Mariangela Allocca et al. Evolving strategies and goals of treatment in ulcerative colitis. Best Practice & research. Clinical Gastroenterology. 32-33. 1 Feb 2018. 1-2. *

Also Published As

Publication number Publication date
EP4327866A2 (en) 2024-02-28
JP7331219B2 (ja) 2023-08-22
AU2019243283B2 (en) 2023-07-27
JP2025020134A (ja) 2025-02-12
HUE067445T2 (hu) 2024-10-28
AU2023248103B2 (en) 2026-02-05
IL277514B2 (en) 2024-11-01
JP7119114B2 (ja) 2022-08-16
HRP20260275T1 (hr) 2026-04-10
TWI744617B (zh) 2021-11-01
IL312807B1 (en) 2025-02-01
PT4327866T (pt) 2026-02-17
ES3063700T3 (en) 2026-04-20
TW202206104A (zh) 2022-02-16
SI3773715T1 (sl) 2024-06-28
BR112020018099A2 (pt) 2020-12-22
IL312807B2 (en) 2025-06-01
TW201946657A (zh) 2019-12-16
US20210032325A1 (en) 2021-02-04
IL312807A (en) 2024-07-01
EP4327866A3 (en) 2024-03-20
ES2983809T3 (es) 2024-10-24
CA3095297A1 (en) 2019-10-03
IL277514B1 (en) 2024-07-01
RS67806B1 (sr) 2026-03-31
ZA202005388B (en) 2025-05-28
DK3773715T3 (da) 2024-05-27
PL3773715T3 (pl) 2024-08-19
DK4327866T3 (da) 2026-02-23
HRP20240904T1 (hr) 2024-10-11
KR20200128101A (ko) 2020-11-11
PT3773715T (pt) 2024-05-27
US12152072B2 (en) 2024-11-26
EP4327866B1 (en) 2025-12-10
JP7571225B2 (ja) 2024-10-22
FI3773715T3 (fi) 2024-05-30
JP2023166388A (ja) 2023-11-21
LT3773715T (lt) 2024-06-25
RS65661B1 (sr) 2024-07-31
US20250034243A1 (en) 2025-01-30
MY202368A (en) 2024-04-24
EP3773715B1 (en) 2024-05-08
MA52216A (fr) 2021-02-17
CN111936165A (zh) 2020-11-13
AU2019243283A1 (en) 2020-09-24
UA128578C2 (uk) 2024-08-21
AU2019243283C1 (en) 2024-05-02
AU2023248103A1 (en) 2023-11-09
MA67901B1 (fr) 2026-02-27
WO2019191464A1 (en) 2019-10-03
JP2021517156A (ja) 2021-07-15
SG11202009526RA (en) 2020-10-29
MX2020010269A (es) 2020-11-06
KR102552693B1 (ko) 2023-07-07
LT4327866T (lt) 2026-03-10
FI4327866T3 (fi) 2026-02-18
MD3773715T2 (ro) 2024-10-31
IL277514A (en) 2020-11-30
EA202091989A1 (ru) 2021-01-13
JP2022169562A (ja) 2022-11-09
EP3773715A1 (en) 2021-02-17
PL4327866T3 (pl) 2026-04-20
MA52216B1 (fr) 2024-07-31
NZ767902A (en) 2024-05-31

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