TWI835735B - 減少或預防第ii型糖尿病患者中心血管事件之方法 - Google Patents
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| DK2385374T4 (en) * | 2010-05-05 | 2018-04-30 | Zora Biosciences Oy | LIPIDOMICS BIOMARKERS FOR ATHEROSCLEROSIS AND CARDIOVASCULAR DISEASE |
| CN102985075A (zh) * | 2010-05-11 | 2013-03-20 | 田边三菱制药株式会社 | 含卡纳格列净的片剂 |
| US20160000816A1 (en) * | 2013-04-05 | 2016-01-07 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| CA2812016A1 (en) * | 2013-04-05 | 2014-10-05 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| CA2938406A1 (en) * | 2014-01-31 | 2015-08-06 | Janssen Pharmaceutica Nv | Methods for the treatment and prevention of renal disorders and fatty liver disorders |
| US20170071970A1 (en) * | 2015-09-15 | 2017-03-16 | Janssen Pharmaceutica Nv | Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders |
-
2018
- 2018-06-08 TW TW107119774A patent/TWI835735B/zh active
- 2018-06-11 JP JP2020517619A patent/JP2020523408A/ja active Pending
- 2018-06-11 US US16/004,607 patent/US20180353470A1/en not_active Abandoned
- 2018-06-11 KR KR1020207000103A patent/KR20200014406A/ko not_active Ceased
- 2018-06-11 AU AU2018283781A patent/AU2018283781B2/en active Active
- 2018-06-11 WO PCT/IB2018/054208 patent/WO2018229630A1/en not_active Ceased
- 2018-06-11 CA CA3066874A patent/CA3066874A1/en active Pending
- 2018-06-11 UA UAA202000168A patent/UA127987C2/uk unknown
- 2018-06-11 MX MX2019014988A patent/MX2019014988A/es unknown
- 2018-06-11 CN CN201880039211.2A patent/CN110740735A/zh active Pending
- 2018-06-11 BR BR112019026120-6A patent/BR112019026120A2/pt not_active Application Discontinuation
- 2018-06-11 EA EA202090028A patent/EA202090028A1/ru unknown
- 2018-06-11 EP EP18740894.3A patent/EP3638250A1/en active Pending
-
2019
- 2019-12-02 IL IL271100A patent/IL271100A/en unknown
- 2019-12-11 CO CONC2019/0013940A patent/CO2019013940A2/es unknown
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2020
- 2020-09-15 US US17/021,370 patent/US20210000792A1/en not_active Abandoned
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2023
- 2023-05-10 JP JP2023077544A patent/JP2023113644A/ja not_active Withdrawn
Non-Patent Citations (1)
| Title |
|---|
| 網路文獻 ROSENTHAL N ET AL, "Canagliflozin: a sodium glucose co-transporter 2 inhibitor for the treatment of type 2 diabetes mellitus", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, NEW YORK ACADEMY OF SCIENCES, US, (20150825) vol. 1358, no. 1, pages 28 - 43 |
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| Publication number | Publication date |
|---|---|
| IL271100A (en) | 2020-01-30 |
| KR20200014406A (ko) | 2020-02-10 |
| EP3638250A1 (en) | 2020-04-22 |
| US20210000792A1 (en) | 2021-01-07 |
| US20180353470A1 (en) | 2018-12-13 |
| CO2019013940A2 (es) | 2020-01-17 |
| JP2020523408A (ja) | 2020-08-06 |
| AU2018283781A1 (en) | 2019-12-19 |
| AU2018283781B2 (en) | 2023-09-28 |
| WO2018229630A1 (en) | 2018-12-20 |
| CA3066874A1 (en) | 2018-12-20 |
| CN110740735A (zh) | 2020-01-31 |
| JP2023113644A (ja) | 2023-08-16 |
| UA127987C2 (uk) | 2024-03-06 |
| TW201904584A (zh) | 2019-02-01 |
| EA202090028A1 (ru) | 2020-04-03 |
| BR112019026120A2 (pt) | 2020-07-07 |
| MX2019014988A (es) | 2020-08-06 |
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