TWI835595B - 亞硝酸鈉之透析中用途 - Google Patents
亞硝酸鈉之透析中用途 Download PDFInfo
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- TWI835595B TWI835595B TW112109906A TW112109906A TWI835595B TW I835595 B TWI835595 B TW I835595B TW 112109906 A TW112109906 A TW 112109906A TW 112109906 A TW112109906 A TW 112109906A TW I835595 B TWI835595 B TW I835595B
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- Prior art keywords
- nitrite
- dialysate
- sodium nitrite
- dialyzer
- added
- Prior art date
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- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 title claims abstract description 399
- 235000010288 sodium nitrite Nutrition 0.000 title claims abstract description 198
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 claims abstract description 127
- 238000001631 haemodialysis Methods 0.000 claims abstract description 48
- 230000000322 hemodialysis Effects 0.000 claims abstract description 48
- 239000000243 solution Substances 0.000 claims description 116
- 238000000502 dialysis Methods 0.000 claims description 90
- 239000012528 membrane Substances 0.000 claims description 86
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 59
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- 229940046728 tumor necrosis factor alpha inhibitor Drugs 0.000 description 1
- 239000002452 tumor necrosis factor alpha inhibitor Substances 0.000 description 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 description 1
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- 229960005356 urokinase Drugs 0.000 description 1
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1654—Dialysates therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1654—Dialysates therefor
- A61M1/1656—Apparatus for preparing dialysates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- External Artificial Organs (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US201762468857P | 2017-03-08 | 2017-03-08 | |
| US62/468,857 | 2017-03-08 |
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| TW202325265A TW202325265A (zh) | 2023-07-01 |
| TWI835595B true TWI835595B (zh) | 2024-03-11 |
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| TW107107745A TWI798203B (zh) | 2017-03-08 | 2018-03-07 | 亞硝酸鈉之透析中用途 |
| TW113105276A TWI888012B (zh) | 2017-03-08 | 2018-03-07 | 亞硝酸鈉之透析中用途 |
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| TW107107745A TWI798203B (zh) | 2017-03-08 | 2018-03-07 | 亞硝酸鈉之透析中用途 |
| TW113105276A TWI888012B (zh) | 2017-03-08 | 2018-03-07 | 亞硝酸鈉之透析中用途 |
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| CA (1) | CA3055105A1 (https=) |
| ES (1) | ES2986444T3 (https=) |
| IL (4) | IL312092B2 (https=) |
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| TW (3) | TWI835595B (https=) |
| WO (1) | WO2018165098A1 (https=) |
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| BR112019018861A2 (pt) * | 2017-03-08 | 2023-10-10 | Hope Medical Entpr Inc Dba Hope Pharmaceuticals | Uso de nitrito de sódio, método para manter os níveis fisiológicos de nitrito, prevenir enfarte do miocárdio, prevenir morte súbita cardíaca, prevenir acidente vascular cerebral, doenças cardiovasculares, pressão alta, solução aquosa |
| IL268883B (en) | 2017-03-08 | 2022-09-01 | Hope Medical Entpr Inc Dba Hope Pharmaceuticals | Intradialytic use of sodium thiosulfate |
| EP4005611B1 (en) * | 2019-07-22 | 2025-11-26 | School Juridical Person The Kitasato Institute | Dialysis device |
| US20230149732A1 (en) * | 2021-11-17 | 2023-05-18 | Wake Forest University Health Sciences | Combined nitrite and light treatment to prevent device thrombosis |
| CN120456938A (zh) | 2022-12-16 | 2025-08-08 | 费森尤斯医疗保健控股公司 | 用于在透析中使用一氧化氮的系统和方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP0218900B1 (en) | 1985-09-10 | 1992-01-22 | Research Corporation Technologies, Inc. | Osmotic agents for peritoneal dialysis |
| US6380163B1 (en) | 1992-12-22 | 2002-04-30 | Baxter International Inc. | Peritoneal dialysis solutions with polypeptides |
| FI98538C (fi) | 1993-10-20 | 1997-07-10 | Enso Gutzeit Oy | Menetelmä natriumhydroksidin valmistamiseksi valkolipeästä |
| US6306836B1 (en) | 1994-01-21 | 2001-10-23 | Baxter International Inc. | Peritoneal dialysis solutions containing maltodextrins and amino acids |
| US6436969B1 (en) | 1995-09-12 | 2002-08-20 | Kansas University Medical Center Research Institute Inc. | Dialysis solutions and methods |
| JP4882054B2 (ja) | 2000-09-13 | 2012-02-22 | 独立行政法人科学技術振興機構 | 腹膜透析液およびその調製法 |
| JP5564158B2 (ja) * | 2003-07-09 | 2014-07-30 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 亜硝酸塩によって特定の心臓血管状態を処置する方法 |
| US7362274B1 (en) * | 2004-07-09 | 2008-04-22 | Huan-Cheng Lien | Coupled feed-in butterfly shaped left/right hand circularly polarized microstrip antenna |
| US20070154570A1 (en) * | 2004-09-29 | 2007-07-05 | Miller Christopher C | Use of nitric oxide in the treatment and disinfection of biofilms |
| US7547637B2 (en) * | 2005-06-21 | 2009-06-16 | Intel Corporation | Methods for patterning a semiconductor film |
| US20090304600A1 (en) | 2008-06-09 | 2009-12-10 | Anupkumar Shetty | Intradialytic administration of sodium thiosulfate |
| US8568793B2 (en) | 2009-02-11 | 2013-10-29 | Hope Medical Enterprises, Inc. | Sodium nitrite-containing pharmaceutical compositions |
| AU2010270605B2 (en) | 2009-07-08 | 2014-07-31 | Hope Medical Enterprises, Inc. Dba Hope Pharmaceuticals | Sodium thiosulfate-containing pharmaceutical compositions |
| CA2844759A1 (en) * | 2011-08-11 | 2013-02-14 | Nathan S. Bryan | Method of measuring and monitoring in vivo nitrite levels |
| WO2013112582A1 (en) | 2012-01-23 | 2013-08-01 | Santalis Pharmaceuticals Inc. | Sandalwood oil and its uses related to clostridium infections |
| JP5486069B1 (ja) | 2012-11-05 | 2014-05-07 | 旭 酒井 | 透析装置 |
| US20140350097A1 (en) | 2013-05-23 | 2014-11-27 | Medinox,Inc. | Treatment of hypotension associated with hemodialysis |
| JP6183832B2 (ja) * | 2013-06-19 | 2017-08-23 | 扶桑薬品工業株式会社 | 酸化ストレス抑制型透析用剤およびその調製方法 |
| BR112019018861A2 (pt) * | 2017-03-08 | 2023-10-10 | Hope Medical Entpr Inc Dba Hope Pharmaceuticals | Uso de nitrito de sódio, método para manter os níveis fisiológicos de nitrito, prevenir enfarte do miocárdio, prevenir morte súbita cardíaca, prevenir acidente vascular cerebral, doenças cardiovasculares, pressão alta, solução aquosa |
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Non-Patent Citations (1)
| Title |
|---|
| 期刊 CARLSTRÖM MATTIAS ET AL Peritoneal dialysis impairs nitric oxide homeostasis and may predispose infants with low systolic blood pressure to cerebral ischemia NITRIC OXIDE vol. 58 2016 pages 1-37 |
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