TWI816666B - Monitoring device for the effectiveness of the ketogenic diet and management method for the ketogenic diet intake - Google Patents

Abstract

The object of the present invention is to obtain a ketogenic diet monitoring device that individually manages the effective state of the ketogenic diet of animals. The ketogenic diet monitoring device of the present invention is configured to measure and monitor the amount of metabolites in the gas excreted from the body of an animal whose ketogenic diet is being managed once and/or multiple times over time. The ketogenic diet monitoring device 1 has: an intake information acquisition unit that acquires information on the intake of the ketogenic diet into the animal's body; and an acetone concentration measurement unit that measures the acetone amount in the gas excreted from the animal's body, that is, the acetone concentration. and a determination unit that determines the metabolism of the animal's ketogenic diet based on the information on the intake of the ketogenic diet obtained by the intake information acquisition unit and the information on the acetone concentration measured by the acetone concentration measuring unit. condition.

Description

Monitoring device for the effectiveness of the ketogenic diet and management method for the ketogenic diet intake

The present invention is a monitoring device used to manage the effective status of a ketogenic diet.

Prior to this, it was speculated that ketogenic diet and high-fat diet (especially sugar-restricted high-fat diet) could become one of the treatments for end-stage cancer patients. Therefore, the effectiveness of ketogenic diet on Japanese end-stage lung cancer patients was investigated. Research was conducted and it was found that compositions for treating cancer through a ketogenic diet, such as a high-fat diet including sugar restriction, or a combination thereof, are preferably made by setting the fat to 120g or more, and/or Limiting carbohydrates to less than 30g per day, and/or setting the daily calorie intake to more than 20kcal/kg of body weight, and/or combining medium-chain fatty acid oils (MCT oils), etc., will have unexpectedly significant effects. It is effective in treating cancer and improving quality of life (QOL) (Patent Document 1).

Furthermore, it is known that the ketogenic diet can effectively improve brain function and prevent and treat cognitive dysfunction (Patent Document 2). Furthermore, the ketogenic diet is known to be effective in treating obesity, circulatory disease, type 2 diabetes, epilepsy, acne, cancer, polycystic ovary syndrome, neurological disorders, Alzheimer's disease, Parkinson's disease, and head trauma ( Non-patent literature 1).

Prior to this, intensive research was conducted in order to provide a food or medical agent that suppresses an increase in gastric discharge and delays gastric discharge. In the process, the following method was discovered: by administering The amount of 13CO ₂ exhaled by animals labeled with 13C-labeled various amino acids is monitored, and the amount of amino acid metabolism is measured non-invasively using exhaled breath as a sample (Patent Document 3).

According to general knowledge, the ketogenic diet ingested by animals will be metabolized in the animal's body, and part of it will become acetone, which will be excreted from the body into the body as exhalation or gas excreted from the skin or mucous membranes. As a method for measuring acetone in gas, a multifunctional breath analyzer (Patent Document 4), a breath measurement device (Patent Document 5), and the like are known. In addition, a system for estimating diabetes index values using the amount of exhaled acetone is known (Patent Document 6). [Prior Art Document] [Patent Document] Patent Document 1: International Publication No. 2017/038101 Patent Document 2: International Publication No. 2016/013617 Patent Document 3: Japanese Patent No. 5938219 Patent Document 4: Japanese Patent No. Publication No. 5921562 Patent Document 5: Japanese Patent Publication No. 5139186 Patent Document 6: Japanese Patent Publication No. 2015-102381 [Non-patent Document] Non-Patent Document 1: European Journal of Clinical Nutrition (2013) 67, 789-796

[Problem to be solved by the invention] Until now, it has not been heard that in order to manage the effective state of the ketogenic diet of animals, the gases excreted from the body (exhalation, evaporation from the skin or mucous membranes) A monitoring device for measuring the amount of metabolites. Furthermore, I have not heard of any attempt to manage the effective state of the ketogenic diet while taking the ketogenic diet, or to manage the effective state of the ketogenic diet for patients and/or prospective patients with diseases that can be effectively treated by taking the ketogenic diet. Or as an auxiliary method for consuming a ketogenic diet, or as a method to check or judge whether the body condition or constitution can effectively metabolize the ketogenic diet as a source of ketone bodies, and to remove gases excreted from the body automatically. A monitoring device for measuring the amount of acetone. In the management of the effective state of the ketogenic diet of animals, it is considered that as long as the amount of acetone in the gas excreted from the body can be measured non-invasively in real time or continuously, the ketogenic diet of animals can be monitored as a source of ketone bodies. Metabolic state, the effective state of the ketogenic diet can be managed individually. That is, the development of such a device is the subject. [Technical Means for Solving the Problem] The present inventor, through dedicated efforts, discovered a device and a method of using it to measure and monitor the amount of acetone in the gas discharged from the body once and/or multiple times over time, thereby completing of the present invention. According to the present invention, it provides the following invention. [1] A monitoring device that measures the amount of acetone in the gas excreted from the body once and/or multiple times in order to manage the effective state of the ketogenic diet. [2] The monitoring device as described in [1], which performs one and/or multiple measurements in order to manage the effectiveness of the ketogenic diet, and the above-mentioned animal is a patient with a disease that can be effectively cured by taking the ketogenic diet, and /or prospective patients. [3] The monitoring device according to [1], wherein the management of the effective state of the ketogenic diet is performed once and/or in order to manage the metabolism of the animal's body before and after the ketogenic diet is ingested. Or multiple measurements. [4] The monitoring device according to [1], wherein the management of the effective state of the ketogenic diet is performed once and/or multiple times in order to check the subject's suitability for maintaining and improving the effective state of the ketogenic diet. Determination. Furthermore, the ketogenic diet monitoring device of the present invention is characterized in that it monitors the effectiveness of the ketogenic diet and has an intake information acquisition unit that acquires information on the intake of the ketogenic diet into the animal's body. ; an acetone concentration measurement unit that measures the amount of acetone in the gas excreted from the body of the animal, that is, the acetone concentration; and a determination unit that determines the intake amount of the ketogenic diet based on the intake information acquisition unit Information, and the information of the acetone concentration measured by the acetone concentration measuring unit, determine the metabolic state of the ketogenic diet of the above-mentioned animal. Preferably, the determination unit performs the determination based on an increase or decrease in the acetone concentration before and after ingesting the ketogenic diet. Furthermore, it is preferable that when the acetone concentration shows a tendency to increase compared with before ingesting the ketogenic diet, the determination unit determines that the animal metabolizes the ketogenic diet as a source of ketone bodies, or the above-mentioned The animal is in a physical condition or constitution that can metabolize the above-mentioned ketogenic diet as a source of ketone bodies. [Effects of the Invention] According to the present invention, it is possible to provide a device for measuring and monitoring the amount of metabolites in the gas excreted from the body once and/or multiple times over time and a method of using the same. Furthermore, by providing the monitoring device and its usage method of the present invention, the effective state of the ketogenic diet can be managed while ingesting the ketogenic diet, or patients and/or prospective patients with diseases that can be effectively treated by the ketogenic diet can be treated as The object is to manage the effective status of the ketogenic diet, or as an auxiliary method for consuming the ketogenic diet, to check or judge whether the ketogenic diet is a body condition or constitution that can effectively metabolize the ketogenic diet as a source of ketone bodies. According to the present invention, when an animal consumes a ketogenic diet, it is possible to provide a device for measuring and monitoring the amount of acetone in the gas excreted from the body once and/or multiple times over time and a method of using the same. . According to the present invention, it is possible to provide a method for measuring and monitoring the amount of acetone in the gas excreted from the body of patients and/or prospective patients who have a disease that can be effectively treated by taking a ketogenic diet once and/or multiple times over time. Device and method of use. According to the monitoring device of the present invention, it can measure the amount of metabolites in the gas excreted from the body of the animal (exhalation, evaporation from the skin or mucous membrane), and manage the effective state of the animal's ketogenic diet. According to the monitoring device of the present invention, when an animal ingests a ketogenic diet, it can measure the amount of metabolites in the gas excreted from the body (exhalation, evaporation from the skin or mucous membranes), and manage the animal. The effective state of the ketogenic diet. According to the monitoring device of the present invention, it can target patients and/or prospective patients with diseases that can be effectively treated by taking a ketogenic diet, measure the amount of acetone in the gas excreted from the body, and determine the source of the ketone body. Taking into account the metabolic rate, dietary management is carried out, such as adjusting the balance of carbohydrates and lipids in the diet. Regarding the ketogenic diet, because the taste is not good, it may be difficult to consume a large amount out of love. According to the present invention, it is possible to adjust the intake while monitoring and only eat a sufficient and necessary amount, that is, an appropriate amount, thereby avoiding excessive intake of an unfavorable ketogenic diet. According to the present invention, it has the following effect: by monitoring and adjusting the intake of the ketogenic diet (by clarifying the amount of food intake of the ketogenic diet that can effectively maintain or improve body condition), the feeding animal ( Especially humans) eat consciously or unconsciously. According to the monitoring device of the present invention, it can measure the amount of acetone in the gas excreted from the body, and check or determine whether the body condition or constitution can effectively metabolize the ketogenic diet as a source of ketone bodies. Further features related to the present invention will become clear from the description of this specification and the accompanying drawings. In addition, problems, structures, and effects other than those described above will become clear from the following description of the embodiments.

Preferred embodiments of the present invention will be described in detail below, but the present invention is not limited to each of the following embodiments. Examples of animals that can be used in the present invention include any mammals. Examples include rodents such as mice, rats, hamsters, and guinea pigs; Leporidae such as rabbits; pigs, cattle, goats, horses, and sheep. Isodactylidae, cats such as dogs and cats, humans, apes, rhesus monkeys, cynomolgus monkeys, marmosets, orangutans, chimpanzees and other primates. The mammal is preferably a rodent (mouse, etc.) or a primate (human, etc.), more preferably a primate, and still more preferably a human. In the present invention, the so-called effective state of the ketogenic diet refers to the state in which the animal ingests the ketogenic diet from outside the body, and the ketogenic diet is effectively used for the animal's living maintenance or the animal's life activities. The effectiveness of a ketogenic diet can be judged by the state of effective metabolism of the ketogenic diet as a source of ketone bodies. For example, it can be based on the amount of acetone in the gas excreted from the body (exhalation, evaporation from the skin or mucous membranes) judge the status. The amount of acetone in the gas excreted from the animal body (expiration, evaporation from the skin or mucous membranes) can be managed based on absolute amounts and/or relative amounts. In addition, due to individual differences among animals, the amount of acetone in the gas excreted from the body (exhalation, evaporation from the skin or mucous membranes) can be determined based on the period when the same individual did not take a ketogenic diet and the time when they took a ketogenic diet. It can be judged by the increase, decrease and/or increase in the amount of acetone before or after the ketogenic diet is taken or during the ketogenic diet. If there is a certain increase trend compared to before the ketogenic diet is taken, It can be judged that it has the above effects. For example, the increasing tendency is preferably a statistically significant difference. Furthermore, even if the difference in the amount of acetone between the period of not ingesting the ketogenic diet and the period of ingesting the ketogenic diet is fixed in the same individual, or the difference in the amount of acetone before or after ingestion of the ketogenic diet is constant, it can be judged that the effect is maintained The best. In the present invention, the management of the effective state of the ketogenic diet refers to grasping the state in which the ketogenic diet as a source of ketone bodies is effectively metabolized, and trying to maintain and/or improve the body condition of the animal within the target range. In the present invention, the so-called ketogenic diet refers to a diet or food that can produce ketone bodies in a living animal. Examples include high-fat diets, medium-chain fatty acid diets, ketone body esters, and foods formulated with ketogenic amino acids. In addition, in the present invention, these ketogenic diets may be referred to as ketone body-derived diets. Among them, examples of ketogenic diets or combinations thereof used to treat cancer include ketogenic diets, especially high-fat diets (for example, so-called "carbohydrate-restricted high-fat diets"). Examples of the gas excreted from the body of a cancer patient include exhalation and gas excreted from the skin or mucous membranes. In the present invention, the animals that are managed in an effective state of the ketogenic diet may be patients and/or prospective patients with diseases that can be effectively treated by taking the ketogenic diet. In the present invention, the diseases that can be effectively treated by taking the ketogenic diet can be List obesity, circulatory disease, type 2 diabetes, epilepsy, acne, cancer, polycystic ovary syndrome, neurological disorders, Alzheimer's disease, Parkinson's disease, and head trauma. In the present invention, the so-called patients with diseases that can be effectively treated by taking a ketogenic diet refer to those who have been diagnosed with the above-mentioned diseases, and the so-called prospective patients refer to those who have been diagnosed with the possibility of suffering from the above-mentioned diseases, or those who have the above-mentioned diseases. tendencies and/or symptoms. In addition, the so-called prospective patients further include those who are genetically more likely to suffer from the above-mentioned diseases, and/or those who wish to eat a ketogenic diet to prevent the above-mentioned diseases based on their own wishes. In the present invention, the device of the present invention can be used for monitoring, so as to determine the intake of the ketogenic diet before and after the intake of the ketogenic diet. In addition, monitoring can be performed by the device of the present invention in order to check or determine whether the animal under management of the above-mentioned ketogenic diet is in a body condition that can effectively metabolize the ketogenic diet as a source of ketone bodies after ingesting the ketogenic diet or Physique. 1 and 2 are functional block diagrams showing an example of the monitoring device of this embodiment. For example, as shown in FIG. 1 , the monitoring device 1 includes a monitoring terminal device 2 and a monitoring management device 3 . The monitoring terminal device 2 and the monitoring management device 3 are connected via the communication circuit 4 and can exchange information with each other. The monitoring terminal device 2 has a measurement unit 21 including an acetone concentration measurement unit 21a and a display unit 22 including a determination display unit 22a. Furthermore, the monitoring and management device 3 has a data acquisition unit 31 and a determination unit 32 . The acetone concentration measuring unit 21a of the monitoring terminal device 2 measures the amount of acetone in the gas discharged from the body, that is, the acetone concentration. Moreover, the judgment display part 22a displays the judgment result obtained by the judgment part 32 of the monitoring management apparatus 3. The data acquisition unit 31 of the monitoring and management device 3 acquires the intake information of the ketogenic diet, the information of the acetone concentration, and the individual information of the animals ingesting the ketogenic diet. The intake information of the ketogenic diet includes information on the intake amount of the ketogenic diet ingested into the animal's body, and may further include at least one of the information on the time, period, type, etc. of the ketogenic diet being ingested. Furthermore, the individual information of the animal may include at least one of the animal's species, age, gender, physique, body condition, constitution, disease name, and other information. The intake information of the ketogenic diet and the individual information of the animal are input to the data acquisition unit 31 from an input mechanism (not shown) provided in the monitoring terminal device 2 or the monitoring management device 3 . That is, the data acquisition unit 31 serves as an intake information acquisition unit and acquires intake information on the ketogenic diet. Furthermore, the information on the acetone concentration is obtained from the acetone concentration measuring unit 21a. The determination unit 32 determines the metabolic state of the animal on the ketogenic diet based on the ketogenic diet intake information and the acetone concentration information. The determination unit 32 determines whether the ketogenic diet is efficiently metabolized as a source of ketone bodies, that is, whether ketone bodies are produced in the animal's body. The determination unit 32 determines the metabolic state based on, for example, an increase or decrease in the acetone concentration before and after ingestion of the ketogenic diet. When the acetone concentration after ingestion of the ketogenic diet shows a tendency to increase compared with that before ingestion of the ketogenic diet, the determination unit 32 determines that the animal is in a state of effectively metabolizing the ketogenic diet as a source of ketone bodies, or that the animal is capable of A body condition or constitution that effectively metabolizes the ketogenic diet as a source of ketone bodies. The determination unit 32 calculates the increase rate of the acetone concentration due to the ingestion of the ketogenic diet based on, for example, the ketogenic diet intake (g) per unit body weight (Kg) of the animal and the difference in acetone concentration before and after the ketogenic diet is ingested. Furthermore, when compared with the preset reference value, the acetone concentration tends to increase when it exceeds the reference value. Therefore, it is judged that the animal is in a state of effectively metabolizing the ketogenic diet as a source of ketone bodies, or that the animal is able to A body condition or constitution that effectively metabolizes the ketogenic diet as a source of ketone bodies. On the other hand, the acetone concentration does not show an increasing tendency when it is below the reference value. Therefore, it is judged that the animal is not in a state of effectively metabolizing the ketogenic diet as a source of ketone bodies, or that the animal is not able to use the ketogenic diet as a source of ketone bodies. A body condition or constitution that can efficiently metabolize ketone bodies from a source. Furthermore, for example, it may be determined whether the increase rate of the acetone concentration belongs to one of a plurality of metabolic levels (levels 1 to 5) in which a stepwise range is set. The range of the baseline value or metabolic level can also be corrected based on the individual information of the animal. For example, in the case of larger animals such as adult males, the correction may be made in the direction of increasing the reference value, and in the case of smaller animals such as adult women or children, the correction may be made in the direction of lowering the reference value. The determination result of the determination unit 32 is displayed on the determination display unit 22a of the monitoring terminal device 2. Therefore, by looking at the determination display part 22a, it can be understood whether ingesting the ketogenic diet is effective for the animal. Corrections can be made based on statistical information published by administrative agencies, etc., public information such as paper publications/society publications, and non-public information obtained based on data accumulated by individuals. This correction can be done manually or by using functions such as AI (artificial intelligence). According to the monitoring device 1 having the above-mentioned configuration, the intake amount of the ketogenic diet from the next time can be determined based on the determination result. In addition, it can be determined whether the animal is in a body condition or constitution that can effectively metabolize the ketogenic diet as a source of ketone bodies. Moreover, changes in the animal's physical condition or constitution can also be grasped by continuous recording. According to the monitoring device 1, regarding the ketogenic diet, patients and/or prospective patients with diseases that can be effectively treated by the ketogenic diet can be targeted for dietary management, such as adjusting the balance of sugars and lipids in the diet, etc. However, since the taste is not good, it may be difficult to ingest a large amount out of preference. However, the intake can be adjusted while monitoring by the monitoring device 1. Therefore, only a sufficient and necessary amount, that is, an appropriate amount can be ingested, thereby avoiding excessive consumption. Eat a ketogenic diet you don’t like. According to the monitoring device 1, the food intake of the ketogenic diet that can effectively maintain or improve body condition becomes clear. Therefore, it has the effect of enabling feeding animals (especially humans) to eat consciously or unconsciously. The monitoring device 1 may be a device that directly connects the determination part 32 that displays the determination of the measurement results and the determination display part 22 a that displays the determination to perform monitoring at one place, or may be a device that includes the above-mentioned measurement part 21 and the determination display through the communication circuit 4 The monitoring terminal device 2 of the part 22a is connected to the monitoring management device 3 having a data acquisition part 31 for processing data and a determination part 32 for determining the effectiveness of the ketogenic diet (Fig. 1). Examples of the communication circuit 4 include radio waves, various known wireless communication lines, wired communication lines, and the like. Monitoring can be in real time or with a certain time difference. In addition, monitoring can be performed at one place or at multiple places, such as the patient himself, doctors, nurses, examination technicians, nutritionists, management equipment, ketogenic diet producers, etc. In addition, it may also include a monitoring terminal device and a monitoring management device. The monitoring terminal device includes a measurement unit, a judgment display unit, and a judgment display unit that receives and displays judgments; the monitoring management device includes a data acquisition unit, a judgment unit, and a storage judgment unit. A judgment storage unit for making judgments, and a judgment judgment unit for making judgments based on the stored judgments (Fig. 2). The monitoring terminal device can be shaped like a watch or glasses, or can be in any form that is easy to wear on the body, such as an ornament or a belt. Furthermore, it is also possible to have a monitoring management server that manages a plurality of monitoring terminal devices in a coordinated manner. By monitoring the management server, for example, it can also be used to determine the usually optimal treatment amount based on the treatment results of multiple patients. As a monitoring terminal device or monitoring management device, all digital computers including personal computers and supercomputers can be used, as well as mobile phones, smart phones, tablets, alarm devices, etc. FIG. 3 is a functional block diagram showing the overall structure of the monitoring device of this embodiment. The monitoring terminal device 2 includes an acetone concentration measurement unit that measures the acetone concentration, and a display unit that displays data from a determination and other transmission unit. The display unit includes a determination display unit. Furthermore, it may also have a judgment display part which displays the data from the judgment etc. transmission part. Furthermore, one or a plurality of other measurement units useful for managing the effective state of the ketogenic diet may be included. The monitoring and management device 3 includes a data acquisition unit that acquires measurement data, a recording unit that records the measurement data, and a determination unit that determines the dietary amount of metabolized ketone bodies based on the data. In addition, it may also have a judgment storage part that stores judgments in advance, and a judgment part that checks or judges whether the food intake or fat amount of the diet needs to be adjusted based on the stored judgments, and whether the diet can be adapted to the ketogenic diet. The judgment from the judgment unit and the judgment from the judgment unit are sent to the judgment display unit or the judgment display unit via the judgment transmitting unit and displayed on the monitoring terminal device. The monitoring and management device may also include a data recording unit. FIG. 4 is a functional block diagram showing the structure of the monitoring device of this embodiment. The monitoring device 1 has monitoring terminal devices 2A to 2C, monitoring management devices 3A to 3C, and communication circuits 4A to 4C connecting them. It may have a plurality of monitoring terminal devices, or it may have one and/or a plurality of monitoring management devices that manage a plurality of monitoring terminal devices. Furthermore, it may also have a monitoring and management server for upper-level management of the monitoring and management device. The present invention includes methods of using the monitoring device of the present invention or methods of use, methods of evaluating ketogenic diet, methods of managing ketogenic diet intake, verification of animals that can be effectively treated with ketogenic diet, etc. using the monitoring device of the present invention. All forms and can be applied to all forms. The embodiments of the present invention have been described in detail above. However, the present invention is not limited to the above-described embodiments, and various design changes can be made without departing from the spirit of the present invention described in the claims.

1‧‧‧Monitoring device 2‧‧‧Monitoring terminal device 2A‧‧‧Monitoring terminal device A2B‧‧‧Monitoring terminal device B2C‧‧‧Monitoring terminal device C3‧‧‧Monitoring and management device 3A‧‧‧Monitoring and management device A3B‧ ‧‧Monitoring and management device B3C‧‧‧Monitoring and management device C4‧‧‧Communication circuit 4A‧‧‧Communication circuit A4B‧‧‧Communication circuit B4C‧‧‧Communication circuit C5‧‧‧Monitoring and management server 21‧‧‧Measurement section 21a‧‧‧Acetone concentration measurement part 22‧‧‧Display part 22a‧‧‧Judgment display part 31‧‧‧Data acquisition part 32‧‧‧Judgment part

FIG. 1 is a functional block diagram showing an example of the monitoring device of this embodiment. FIG. 2 is a functional block diagram showing an example of the monitoring device of this embodiment. FIG. 3 is a functional block diagram showing the overall structure of the monitoring device of this embodiment. FIG. 4 is a functional block diagram showing the structure of the monitoring device of this embodiment.

1:Monitoring device

2: Monitoring terminal device

3: Monitoring and management device

4: Communication circuit

21: Measurement Department

21a: Acetone concentration measurement part

22:Display part

22a‧‧‧Judgment display part

31‧‧‧Data Acquisition Department

32‧‧‧Judgment Department

Claims (6)

A ketogenic diet monitoring device, characterized in that it monitors the effectiveness of the ketogenic diet and has: an intake information acquisition unit that acquires information on the intake of the ketogenic diet into the animal's body; acetone concentration a measurement unit that measures the amount of acetone in the gas excreted from the body of the animal, that is, the acetone concentration; and a determination unit that is based on the information on the intake of the ketogenic diet acquired by the intake information acquisition unit, and The metabolic state of the ketogenic diet of the animal is determined based on the information on the acetone concentration measured by the acetone concentration measuring unit. The ketogenic diet monitoring device of claim 1, wherein the determination unit performs the determination based on the increase or decrease in the acetone concentration before and after ingesting the ketogenic diet. The ketogenic diet monitoring device of Claim 2, wherein when the acetone concentration shows a tendency to increase compared with before ingesting the ketogenic diet, the determination unit determines that the animal uses the ketogenic diet as a source of ketone bodies. The metabolic state, or the body condition or constitution of the above-mentioned animal can metabolize the above-mentioned ketogenic diet as a source of ketone bodies. A method for managing ketogenic diet intake, characterized in that it uses a ketogenic diet monitoring device, and the ketogenic diet monitoring device has an intake information acquisition unit that acquires the intake of ketogenic diet into an animal's body. capital information; an acetone concentration measurement unit that measures the amount of acetone in the gas excreted from the body of the animal, that is, the acetone concentration; and a determination unit that is based on the intake of the ketogenic diet acquired by the intake information acquisition unit The information of the above-mentioned acetone concentration measured by the above-mentioned acetone concentration measuring unit is used to determine the metabolic state of the above-mentioned ketogenic diet of the above-mentioned animal; and the management method of the ketogenic diet intake includes the following steps: a measuring step, It measures the above-mentioned acetone concentration; it calculates the increase rate of the above-mentioned acetone concentration; and it adjusts the intake amount of the ketogenic diet for the above-mentioned animal according to the above-mentioned increase rate of the acetone concentration. If the method for managing the intake of the ketogenic diet is requested in item 4, in the above adjustment step, when the increase rate of the acetone concentration is greater than the preset reference value, the intake of the above-mentioned ketogenic diet is increased. When the increase rate is below the above-mentioned reference value, the intake of the above-mentioned ketogenic diet will be reduced. In the method for managing the intake of a ketogenic diet according to claim 5, in the measuring step, the acetone concentration is measured before and after the animal ingests the ketogenic diet, and in the calculating step, the acetone concentration is measured based on the intake of the ketogenic diet. The difference in the acetone concentration before and after the ketogenic diet was used to calculate the increase rate of the acetone concentration.