JP2018179960A - Device for monitoring effective state of ketogenic meal - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a device for measuring and monitoring an acetone amount in a gas discharged from the body of an animal to the outside, one time and/or a plurality of times over time, and a use method thereof.SOLUTION: A device 1 for monitoring effectiveness on a ketogenic meal includes: an ingestion information acquisition unit configured to acquire information on an ingestion amount of a ketogenic meal ingested in the body of an animal; an acetone concentration measurement unit 21a configured to measure acetone concentration which is an acetone amount in a gas discharged from the body of the animal to the outside; and a determination unit 32 configured to determine a metabolic state of the animal on the ketogenic meal, based on the information on the ingestion amount of the ketogenic meal acquired by the ingestion information acquisition unit and the information on the acetone amount measured by the acetone concentration measurement unit.SELECTED DRAWING: Figure 1

Description

  The present invention is a monitoring device used to manage the effectiveness of the ketone diet.

  Until now, assuming that ketone diet and high fat diet (especially carbohydrate limited high fat diet) can be one of the treatment methods for terminal cancer patients, we examine the effectiveness of ketone diet for Japanese terminal lung cancer patients Composition, or a combination thereof, for treating cancer, preferably containing at least 120 g of fat and / or at least 30 g of carbohydrate per day. And / or daily intake of 20 kcal / kg body weight or more, and / or combining medium-chain fatty acid oil (MCT oil) etc., unexpectedly found that treatment of cancer significantly improves QOL (Patent Document 1).

  In addition, it is known that a ketone diet is effective for prevention and treatment of brain function improvement and cognitive dysfunction (Patent Document 2). Furthermore, it is known that ketone diet is effective for obesity, cardiovascular disease, type 2 diabetes, epilepsy, acne, cancer, polycystic ovary syndrome, neuropathy, Alzheimer's disease, Parkinson's disease, head trauma (Non-Patent Document 1).

  Until now, 13 C-labeled various amino acids were administered in the process of intensively studying for the purpose of providing an agent for food or a medicine for delaying gastric emptying and suppressing an increase in gastric emptying. By monitoring the exhaled amount of 13 CO 2 in animals, a method has been found to non-invasively measure the metabolic amount of amino acid as a sample of exhaled breath (Patent Document 3).

  It is general that the ketone diet ingested by the animal is metabolized in the body of the animal and part of it becomes acetone and excreted from the body of the animal as exhaled air or gas released from the skin or mucous membrane outside the body, It is known to.

  As a method of measuring acetone in gas, a multifunction breath analyzer (patent document 4), a breath measuring apparatus (patent document 5), and the like are known.

  There is also known a system for estimating a diabetes index value using the amount of exhaled acetone (Patent Document 6).

International Publication No. 2017/038101 International Publication No. 2016/013617 Patent No. 5938219 gazette Patent No. 5921562 Patent No. 5139186 gazette JP, 2015-102381, A

European Journal of Clinical Nutrition (2013) 67, 789-796

  Until now, there has been no known monitoring device for measuring the amount of metabolite in gas (exhaled breath, transpiration from skin or mucous membrane) discharged from the body of the animal to control the effective state of the ketone diet of the animal. . Furthermore, in order to control the effectiveness of the ketone diet when taking the ketone diet, or to the sick and / or spare patient of the disease for which the intake of the ketone diet is effective, the effectiveness of the ketone diet is As a method to support dietary intake of a ketone diet, or as a method of screening or judging whether a physical condition or constitution capable of effectively metabolizing a ketone diet as a ketone body source, or in a gas excreted from the body of an animal There is no known monitoring device for measuring the amount of acetone.

  In the management of the effective state of the ketone diet of the animal, the amount of acetone in the gas released outside the body is measured non-invasively, immediately and continuously, etc., and the metabolic state as the ketone body source of the ketone diet of the animal is determined. If monitoring was possible, it was thought that the effective state of the ketone diet could be managed individually. That is, the development of such a device has been a challenge.

  The present inventor has made an effort to find an apparatus for measuring and monitoring the amount of acetone in a gas which is excreted from the body of an animal one or more times with time, and a method of using the same. completed.

According to the present invention, the following inventions are provided.
[1] A monitoring device which measures the amount of acetone in a gas which is excreted from the body of an animal once or / or several times in order to control the effective state of a ketone diet.
[2] [1] The animal according to [1] is a sick person and / or a sick person who is a patient with a disease for which the intake of the ketone diet is effective, measurement once and / or multiple times to control the effectiveness of the ketone diet Monitoring device.
[3] The management of the effective state of the ketone diet described in [1] is measured once and / or multiple times to control the intake of the ketone diet in conjunction with the metabolism in the animal body before and after the intake of the ketone diet, Monitoring device.
[4] A monitoring device which measures the management of the effective state of the ketone diet as described in [1] once and / or multiple times in order to screen the subject's suitability for maintenance / improvement of the effective state of the ketone diet.

  Further, the ketone diet monitoring device of the present invention is a ketone diet monitoring device that monitors the effectiveness of the ketone diet, and an intake information acquisition unit that acquires information on the intake amount of the ketone diet ingested into the body of the animal; An acetone concentration measurement unit that measures an acetone concentration, which is the amount of acetone in the gas taken out of the body of the animal from the body, information on the intake amount of the ketone food acquired by the intake information acquisition unit, and the acetone concentration measurement unit A determination unit that determines the metabolic state of the ketone diet by the animal based on the information on the acetone concentration measured by

  It is preferable that the determination unit performs the determination based on increase and decrease of the acetone concentration before and after intake of the ketone diet. And the said determination part is a state which the said animal metabolises the said ketone diet as a ketone body source, or when the said acetone concentration shows a tendency to increase compared with before intake of the said ketone diet, or the said animal It is preferable to determine that the ketone diet is a physical condition or constitution metabolizable as a ketone body source.

  According to the present invention, it is possible to provide an apparatus for measuring and monitoring the amount of metabolite in a gas which is excreted from the body of an animal one time and / or several times, and a method of using the same. And, by being able to provide the monitoring apparatus of the present invention and the method of using the same, the management of the effective state of the ketone diet when taking the ketone diet, and the sick and / or the person whose disease is effective in taking the ketone diet. It is possible to screen and judge the physical condition and constitution that can effectively metabolize ketone diet as a ketone body source as a management method of the effective condition of ketone diet for the patient's spare armed forces, and as a support method of diet intake of ketone diet It becomes.

  According to the present invention, an apparatus and method for measuring and monitoring the amount of acetone in a gas which is taken out from the body of an animal one time and / or a plurality of times when a ketone diet is ingested and the use thereof Can provide

  According to the present invention, the amount of acetone in the gas which is taken out of the body from the body of a patient and / or a preparatory person of a disease for whom the intake of a ketone diet is effective is measured once and / or several times over time Provide monitoring and monitoring devices and methods for their use.

  According to the monitoring device of the present invention, it is possible to manage the effective state of the ketone diet of the animal by measuring the amount of metabolite in the gas (exhaled breath, transpiration from the skin or mucous membrane) which is discharged from the animal body.

  According to the monitoring device of the present invention, when the ketone diet is ingested, the amount of metabolite in the gas (exhaled breath, transpiration from the skin or mucous membrane) which is excreted from the animal body is measured to make the ketone diet effective. Can manage the state.

  According to the monitoring apparatus of the present invention, it is possible to measure the amount of acetone in the gas which is taken out from the body of the animal from the animal body for the sick and / or spare sick for the disease for which the intake of the ketone diet is effective. The diet can be managed by adjusting the balance of carbohydrates and lipids in the diet in consideration of the metabolic rate as a body source. Due to their palatability, it is sometimes difficult to ingest a large amount of ketone diet.

  According to the present invention, by adjusting intake while monitoring, it is possible to feed only a proper amount as a necessary and sufficient amount, and it is possible to avoid excessive intake of a non-preferred ketone diet. According to the present invention, by adjusting the intake of the ketone diet while monitoring (by the fact that the amount of intake of the ketone diet effective for maintenance and improvement of physical condition is clarified), the animals (especially humans) who eat it are conscious Or it also has the effect of being able to eat unconsciously.

  According to the monitoring device of the present invention, it is possible to measure the amount of acetone in the gas which is discharged from the animal body to the outside, and to screen or judge whether it is a physical condition or constitution capable of effectively metabolizing ketone diet as a ketone body source.

  Further features related to the present invention will become apparent from the description of the present specification and the accompanying drawings. Further, problems, configurations and effects other than those described above will be clarified by the description of the following embodiments.

FIG. 2 is a functional block diagram showing an example of a monitoring device according to the present embodiment. FIG. 2 is a functional block diagram showing an example of a monitoring device according to the present embodiment. BRIEF DESCRIPTION OF THE DRAWINGS The functional block diagram which shows the whole structure of the monitoring apparatus concerning this embodiment. FIG. 2 is a functional block diagram showing a configuration of a monitoring device according to the present embodiment.

  Hereinafter, preferred embodiments of the present invention will be described in detail, but the present invention is not limited to the individual forms described below.

  Examples of target animals that can be used in the present invention include any mammals, and examples include rodents such as mice, rats, hamsters and guinea pigs, lagomorphs such as rabbits, pigs, cows, goats and horses. And ovines such as sheep, felines such as dogs and cats, and primates such as humans, monkeys, rhesus monkeys, cynomolgus monkeys, marmosets, orangutans and chimpanzees. The mammal is preferably a rodent (such as mouse) or a primate (such as human), more preferably a primate, and even more preferably a human.

  In the present invention, the effective state of the ketone diet means that the animal ingests the ketone diet from outside the body, and the ketone diet is effectively used for the maintenance of the living body of the animal and the life activity of the animal. The effective state of the ketone diet can be determined from the state in which the ketone diet is effectively metabolized as a ketone body source, for example, the amount of acetone in the gas (breath, transpiration from skin and mucous membranes) released from the body of the animal It can be judged in the state of The amount of acetone in the gas (exhaled breath, transpiration from the skin or mucous membranes) discharged from the body of the animal may be managed in absolute and / or relative amounts. In addition, the amount of acetone in the gas (exhaled breath, transpiration from the skin and mucous membranes) released from the body of the animal from the body is different between animals, so the same individual does not take the ketone diet and the time it is ingested. Or, it may be judged by the increase, decrease and / or increase of the amount of acetone before and after the intake of the ketone food, and if a certain increase tendency is shown as compared to before the intake of the ketone food, It can be judged that those effects are present. For example, it is more preferable that the increase tendency is statistically significant.

  Moreover, even if the difference between the amounts of acetone before and after the intake of the ketone diet is constant, the effect is maintained even when the same individual does not take the ketone diet and when the ketone diet is consumed. It can be judged to be preferable.

  In the present invention, the management of the effective state of the ketone diet means grasping the state where the ketone diet is effectively metabolized as a ketone body source, and maintaining and / or improving the physical condition of the animal within the intended range. It is hard to do.

  In the present invention, the ketone diet is a diet or food that can produce a ketone body in vivo in an animal. For example, it is a food blended with a high-fat diet, a medium-chain fatty acid diet, a ketone ester, and a ketogenic amino acid. Also, in the present invention, these ketones are sometimes referred to as ketone body source food.

  In particular, ketone diets or combinations thereof for treating cancer include, for example, ketone diets, particularly high fat diets (eg, so-called "carbohydrate limited high fat diets"). Examples of the gas that is released from the body of the cancer patient as described above include exhaled air and gases that are released from the skin and mucous membranes.

  In the present invention, the animal whose effective state of ketone diet is controlled may be a sick person and / or a sick person who has a disease for which the intake of ketone diet is effective, and the intake of ketone food according to the present invention is Effective diseases include obesity, cardiovascular disease, type 2 diabetes, epilepsy, acne, cancer, polycystic ovary syndrome, neuropathy, Alzheimer's disease, Parkinson's disease and head trauma.

  In the present invention, a patient suffering from a disease effective to take a ketone diet is one diagnosed with the above disease, and one or more persons with a diseased person have been diagnosed from the possibility of the above disease, or Refers to things that have trends and / or signs. In addition, the patient reserve further includes those who are genetically likely to be affected by the disease and / or those who desire to take the ketone diet for the prevention of the disease at their own will.

  In the present invention, the apparatus may be monitored by the present invention to determine the amount of intake of the ketone diet before and after the intake of the ketone diet. In addition, the device according to the present invention is used to screen or judge whether or not the above-mentioned animal whose controlled condition of the ketone diet can effectively metabolize the ketone diet as a ketone body source after taking the ketone diet. It may be monitored by

  FIG.1 and FIG.2 is a functional block diagram which shows the example of the monitoring apparatus concerning this embodiment.

  For example, as shown in FIG. 1, the monitoring device 1 includes a monitoring terminal device 2 and a monitoring management device 3. The monitoring terminal device 2 and the monitoring management device 3 are connected via the communication circuit 4 and can mutually transmit and receive information. The monitoring terminal device 2 includes a measurement unit 21 including an acetone concentration measurement unit 21 a and a display unit 22 including a determination display unit 22 a. The monitoring management device 3 includes a data acquisition unit 31 and a determination unit 32.

  The acetone concentration measurement unit 21a of the monitoring terminal device 2 measures the acetone concentration which is the amount of acetone in the gas taken out of the body of the animal. Then, the determination display unit 22 a displays the determination result by the determination unit 32 of the monitoring management device 3.

  The data acquisition unit 31 of the monitoring management device 3 acquires the intake information of the ketone diet, the information of the acetone concentration, and the individual information of the animal that ingests the ketone diet. The intake information on the ketone diet includes information on the intake amount of the ketone diet ingested into the body of the animal, and further includes at least one of information on the intake time, intake period, type, etc. of the ketone diet. May be The individual information of the animal may include at least one of information such as the type of animal, age, sex, physical constitution, physical condition, constitution, disease name and the like.

  The intake information of the ketone diet and the individual information of the animal are input to the data acquisition unit 31 from input means (not shown) provided in the monitoring terminal device 2 or the monitoring management device 3. That is, the data acquisition unit 31 acquires the intake information of the ketone food as the intake information acquisition unit. Then, information on the acetone concentration is obtained from the acetone concentration measurement unit 21a.

  The determination unit 32 determines the metabolic state of the ketone diet by the animal based on the intake information on the ketone diet and the information on the acetone concentration. The determination unit 32 determines whether the ketone diet is effectively metabolized as a ketone body source, that is, whether or not a ketone body is produced in the animal. The determination unit 32 determines the metabolic state, for example, based on the increase and decrease of the acetone concentration before and after intake of the ketone diet. When the concentration of acetone after intake shows a tendency to increase as compared with that before intake of the ketone diet, the determination unit 32 indicates that the animal is effectively metabolizing the ketone diet as a ketone body source, or the animal is a ketone The food is determined to be a physical condition or constitution that can be effectively metabolized as a ketone body source.

  The determination unit 32 determines, for example, the rate of increase of the acetone concentration due to the intake of the ketone food based on the ketone food intake (g) per body weight (Kg) of the animal and the difference between the acetone concentrations before and after the intake of the ketone food. calculate. And since the acetone concentration tends to increase when it exceeds the standard value compared with the standard value set in advance, the state in which the ketone diet is effectively metabolized as a ketone body source, or The animal is judged to be in a physical condition or constitution capable of effectively metabolizing a ketone diet as a ketone body source. On the other hand, since the acetone concentration does not show a tendency to increase when below the standard value, a state in which ketone diet is not effectively metabolized as a ketone body source, or an animal can effectively metabolize ketone diet as a ketone body source Judged as having no physical condition or constitution. In addition, for example, it may be determined which of a plurality of metabolic levels (levels 1 to 5) in which the increase rate of acetone concentration is set stepwise.

  Ranges of reference values and metabolic levels may be corrected based on individual information of animals. For example, in the case of an animal with a large physical size such as an adult male, correction may be made to increase the reference value, and in the case of an animal with a small physical size such as an adult woman or a child, correction may be made to decrease the reference value. .

  The determination result of the determination unit 32 is displayed on the determination display unit 22 a of the monitoring terminal device 2. Therefore, by looking at the judgment display portion 22a, it can be recognized whether or not the intake of the ketone diet is effective for the animal. The correction can be performed based on statistical information published by the administrative organization, public information such as dissertation and academic conference presentation, and private information based on data accumulated uniquely. The correction can be made artificially, and functions such as AI (Artificial Intelligence) can also be used.

  According to the monitoring device 1 having the above-described configuration, it is possible to determine the intake from the next time of the ketone diet based on the determination result. In addition, it can be determined whether or not an animal can effectively metabolize ketone diet as a ketone body source. And, by recording continuously, it is possible to grasp changes in the physical condition and constitution of the animal.

  According to the monitoring device 1, it is possible to control the diet such as adjusting the balance of carbohydrates and lipids in the diet for the sick and / or spare sick for the disease for which the intake of the ketone diet is effective Although it may be difficult to ingest a large amount of food depending on preference because of its palatability, it is possible to adjust the intake while monitoring with the monitoring device 1 and therefore only a proper amount as a necessary and sufficient amount is consumed. It is possible to avoid excessive intake of non-preferred ketone diets. According to the monitoring device 1, the amount of intake of ketone food effective for maintenance and improvement of physical condition is clarified. Therefore, the feeding animals (especially humans) also have the effect of consciously or unconsciously feeding.

  The monitoring device 1 may be a device in which the determination unit 32 for displaying the determination of the measurement result and the determination display unit 22a for displaying the determination are directly connected and monitored at one place, or may be determined as the measurement unit 21 The monitoring device 1 (the monitoring management device 3 having the monitoring terminal device 2 including the display portion 22a, the data acquisition portion 31 for handling data, and the determination portion 32 for determining the effective state of ketone corrosion) through the communication circuit 4 It may be as shown in FIG. Examples of the communication circuit 4 include radio waves, various known wireless communication circuits, and wired communication circuits. The monitoring may be real time or may have a fixed time difference. Moreover, monitoring may be performed at one place, or may be multiple places, for example, a sick person, a doctor, a nurse, a laboratory technician, a dietitian, a management facility, a ketone food manufacturer, and the like.

  In addition, a monitoring terminal device including a measurement display unit that receives and displays the measurement unit and the determination display unit and a determination unit, a data acquisition unit and a determination unit, a determination storage unit that stores the determination, and a determination determination determined from the accumulated determination It may be comprised with the monitoring management apparatus (FIG. 2) containing a part.

  The monitoring terminal may have the same shape as a watch or glasses, or any shape that is easy to wear such as accessories and belts. Furthermore, it may have a monitoring management server that manages a plurality of monitoring terminal devices in conjunction. The monitoring management server may generally be used to determine the optimal treatment amount, for example, from the treatment results of multiple patients.

  As a monitoring terminal device or a monitoring management device, any digital computer including a personal computer, a super computer and the like may be used, or a mobile phone, a smartphone, a tablet, an alarm device or the like may be used.

  FIG. 3 is a functional block diagram showing the entire configuration of the monitoring device according to the present embodiment.

  The monitoring terminal device 2 includes an acetone concentration measurement unit that measures the acetone concentration and a display unit that displays data from the determination and transmission unit, and the display unit includes a determination display unit. In addition, it may have a judgment display unit for displaying data from the judgment etc. transmission unit. Furthermore, one or more other measuring units useful for managing the effective state of the ketone food may be included.

  The monitoring management device 3 includes a data acquisition unit that acquires measurement data, a recording unit that records measurement data, and a determination unit that determines the amount of ketone body source food metabolized from the data. Further, it may have a determination storage unit for storing determinations, and a determination and determination unit for adjusting the amount of food intake and fat amount based on the stored determinations and screening and determining the suitability of the ketone diet. The determination from the determination unit and the determination from the determination unit are sent to the determination display unit or the determination display unit via the determination transmission unit and displayed on the monitoring terminal device. The monitoring management device may include a data recording unit.

  FIG. 4 is a functional block diagram showing the configuration of the monitoring device according to the present embodiment.

  The monitoring device 1 includes monitoring terminal devices 2A to 2C, monitoring management devices 3A to 3C, and communication circuits 4A to 4C connecting them. It may have a plurality of monitoring terminal devices, may have one and / or a plurality of monitoring management devices that manage a plurality of monitoring terminal devices, and further monitoring for managing a monitoring management device as a higher rank It may have a management server.

  The present invention uses the monitoring device of the present invention, such as a method and a method of using the monitoring device of the present invention, a method of evaluating a ketone diet, a method of managing a ketone diet intake, screening of animals effective for ketone feeding. It can be applied to all things, including all things done.

  As mentioned above, although the embodiment of the present invention was explained in full detail, the present invention is not limited to the above-mentioned embodiment, and various designs are possible in the range which does not deviate from the spirit of the present invention described in the claim. It is possible to make changes.

1 Monitoring Device 2 Monitoring Terminal Device 2A Monitoring Terminal Device A
2B Monitoring terminal B
2C Monitoring terminal C
3 Monitoring Management Device 3A Monitoring Management Device A
3B Monitoring management device B
3C Monitoring management device C
4 Communication circuit 4A Communication circuit A
4B Communication circuit B
4C Communication circuit C
5 Monitoring management server

Claims (7)

  The monitoring device which measures the amount of acetone in the gas taken out of the animal from the body once and / or multiple times to control the effective state of the ketone diet.   The animal according to claim 1 is a sick person and / or a sick person who is a sick person who is effective in taking a ketone diet, monitoring is performed once and / or a plurality of times to control an effective state of the ketone food apparatus.   A monitoring device, wherein the management of the effective state of the ketone diet according to claim 1 is measured once and / or a plurality of times in order to control the intake of the ketone diet together with the metabolism in the animal before and after the intake of the ketone diet.   The monitoring apparatus which measures management of the effective state of the ketone diet of Claim 1 once and / or multiple times in order to screen a subject's aptitude for maintenance and improvement of the effective state of a ketone diet. A ketone diet monitoring device for monitoring the effectiveness of a ketone diet, comprising:
An intake information acquisition unit for acquiring information on the intake amount of ketone food to be ingested into the body of the animal;
An acetone concentration measuring unit which measures an acetone concentration which is an amount of acetone in a gas which is taken out from the body of the animal;
A determination unit that determines the metabolic state of the ketone diet by the animal based on the information on the intake amount of the ketone diet acquired by the intake information acquisition unit and the information on the acetone concentration measured by the acetone concentration measurement unit When,
The ketone food monitoring device characterized by having.   The ketone diet monitoring apparatus according to claim 5, wherein the determination unit performs the determination based on increase and decrease of the acetone concentration before and after intake of the ketone diet.   The determination unit is a state in which the animal is metabolizing the ketone diet as a ketone body source, or the animal is the ketone when the acetone concentration tends to increase as compared to before intake of the ketone diet. The ketone diet monitoring apparatus according to claim 6, wherein the food is determined to be a metabolizable condition or constitution capable of being metabolized as a ketone body source.

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