CN110506211A - For monitoring the device of the effective status of high fat diet - Google Patents
For monitoring the device of the effective status of high fat diet Download PDFInfo
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- CN110506211A CN110506211A CN201880023394.9A CN201880023394A CN110506211A CN 110506211 A CN110506211 A CN 110506211A CN 201880023394 A CN201880023394 A CN 201880023394A CN 110506211 A CN110506211 A CN 110506211A
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- 235000009200 high fat diet Nutrition 0.000 title claims abstract description 148
- 238000012544 monitoring process Methods 0.000 title claims description 56
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims abstract description 108
- 241001465754 Metazoa Species 0.000 claims abstract description 71
- 238000012806 monitoring device Methods 0.000 claims abstract description 43
- 238000001727 in vivo Methods 0.000 claims abstract description 21
- 230000004060 metabolic process Effects 0.000 claims abstract description 12
- 201000010099 disease Diseases 0.000 claims description 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 17
- 238000005259 measurement Methods 0.000 claims description 12
- 230000006872 improvement Effects 0.000 claims description 2
- 238000012423 maintenance Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 21
- 230000008569 process Effects 0.000 abstract description 5
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- 238000013481 data capture Methods 0.000 description 7
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- 238000001704 evaporation Methods 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 238000012216 screening Methods 0.000 description 5
- 241000288906 Primates Species 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 230000007963 carbohydrate restriction Effects 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- 208000002874 Acne Vulgaris Diseases 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- 206010019196 Head injury Diseases 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 208000012902 Nervous system disease Diseases 0.000 description 2
- 208000008589 Obesity Diseases 0.000 description 2
- 208000018737 Parkinson disease Diseases 0.000 description 2
- 206010036049 Polycystic ovaries Diseases 0.000 description 2
- 241000283984 Rodentia Species 0.000 description 2
- 206010000496 acne Diseases 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
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- 150000004667 medium chain fatty acids Chemical class 0.000 description 2
- 235000020824 obesity Nutrition 0.000 description 2
- 201000010065 polycystic ovary syndrome Diseases 0.000 description 2
- CVOFKRWYWCSDMA-UHFFFAOYSA-N 2-chloro-n-(2,6-diethylphenyl)-n-(methoxymethyl)acetamide;2,6-dinitro-n,n-dipropyl-4-(trifluoromethyl)aniline Chemical compound CCC1=CC=CC(CC)=C1N(COC)C(=O)CCl.CCCN(CCC)C1=C([N+]([O-])=O)C=C(C(F)(F)F)C=C1[N+]([O-])=O CVOFKRWYWCSDMA-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/64—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving ketones
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
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- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/20—Oxygen containing
- Y10T436/200833—Carbonyl, ether, aldehyde or ketone containing
- Y10T436/202499—Formaldehyde or acetone
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25875—Gaseous sample or with change of physical state
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Abstract
It is a kind of for individually managing the high fat diet monitoring device of the effective status of the high fat diet of animal the purpose of the present invention is obtaining.High fat diet monitoring device of the invention has following structure: process once and/or at any time repeatedly measures and monitors the amounts of acetone being discharged in external gas in vivo from the targeted animal of the effective status of positive management high fat diet.High fat diet monitoring device 1 includes: intake information acquisition unit, for obtaining information related with the intake of intracorporal high fat diet of animal is taken in；Acetone concentration measuring unit, for measuring the acetone concentration as the amounts of acetone being discharged in external gas in vivo from animal；And judging unit, for based on the information of acetone concentration measured by the related information of the intake of high fat diet and the acetone concentration measuring unit accessed by the intake information acquisition unit, to determine animal to the metabolism state of high fat diet.
Description
Technical field
The present invention relates to the monitoring devices of the effective status for managing high fat diet.
Background technique
It in the past, will be advanced stage based on high fat diet or high fat diet (the especially high fat diet of carbohydrate restriction)
Cancer patient provide treatment method this it is assumed that having checked high fat diet for the validity of Japanese Patients with Advanced Lung Cancer.
As a result, it was found that pass through the high fat diet (combination for treating cancer of such as high fat diet including carbohydrate restriction
Object or their combination etc.), treating cancer and QOL can be improved unexpectedly significantly, in which: preferably,
Fat is not less than 120g and/or carbohydrate is restricted to be not more than 30g and/or every daily caloric intake daily
Not less than (patent documents 1) such as 20kcal/kg weight, and/or combination medium chain fatty acid oily (miglyol 812).
It it is known that high fat diet is effective (patent in terms of improving brain function and preventing and treating cognition dysfunction
Document 2).Additionally, it is known that high fat diet is comprehensive to obesity, cardiovascular disease, diabetes B, epilepsy, acne, cancer, polycystic ovary
Simulator sickness, neurological disorder, Alzheimer disease, Parkinson's disease and head injury etc. are effectively (non-patent literature 1).
Past, in order to provide the increase for inhibiting gastric emptying amount and food agent or drug for postponing gastric emptying
During the further investigation carried out with agent, it was found that following method: utilizing the various of 13C label by monitoring to be fed with
The expiratory air discharge rate of the 13CO2 of the animal of amino acid, uses expiratory air to carry out non-invasively measuring amino acid as sample
Metabolism amount (patent document 3).
It is well known that high fat diet being metabolized in vivo in animal that animal is taken in, and a part generates acetone,
And the external of animal is discharged by expiratory air or in the form of by skin or mucous membrane being discharged to external gas.
The known method for measuring the acetone in gas includes using multi-functional expired air analysis instrument (patent document 4)
With the method (patent document 5) of expiratory air measuring device.
It it is known that for using exhalation amounts of acetone and estimate the system (patent document 6) of diabetes index value.
Existing technical literature
Patent document
2017/038101 A of patent document 1:WO
2016/013617 A of patent document 2:WO
5938219 B of patent document 3:JP
5921562 B of patent document 4:JP
5139186 B of patent document 5:JP
Patent document 6:JP 2015-102381 A
Non-patent literature
Non-patent literature 1:European Journal of Clinical Nutrition (2013) 67,789-796
Summary of the invention
Problems to be solved by the invention
So far, there is no it is known for measure from animal be discharged in vivo external gas (expiratory air and
Evaporation from skin or mucous membrane) in metabolism object amount to manage the monitoring device of the effective status of the high fat diet of animal.This
Outside, for the management effective status of high fat diet in just intake high fat diet or effective for the intake of high fat diet
The purpose of the effective status of the patient and/or case control's high fat diet early period of disease, or as assisting high fat diet
The intake of diet or for screening or judging it is effective whether physical condition or constitution make high fat diet can be used as ketoboidies source
The method of ground metabolism, the monitoring that there is no known for measuring from the amounts of acetone of animal being discharged in external gas in vivo
Device.
It has been considered, if the management of the effective status of zoologic high fat diet, for example can non-invasively simultaneously
And the amounts of acetone being discharged in external gas immediately or is continuously measured, and if it is possible thereby to monitor the ketone as animal
The metabolism state of the high fat diet in body source then can will individually manage the effective status of high fat diet.Thus, such dress
The exploitation set is a problem.
The solution to the problem
The intensive multiple measurement of process and monitoring for making great efforts to have obtained for once and/or at any time that the present inventor is carried out
Device from the amounts of acetone of animal being discharged in external gas in vivo and the method using the device, this results in
The present invention.
The present invention provides inventions below.
[1] a kind of monitoring device, for primary to being carried out from the amounts of acetone of animal being discharged in external gas in vivo
And/or repeatedly measurement, to manage the effective status of high fat diet.
[2] for managing the monitoring device of the effective status of high fat diet according to [1], wherein the monitoring dress
Set carry out it is primary and/or repeatedly measurement to manage the effective status of high fat diet, wherein the animal according to [1] be for
The patient and/or patient's early period of the effective disease of intake of high fat diet.
[3] for managing the monitoring device of the effective status of high fat diet according to [1], wherein the monitoring dress
It sets that progress is primary and/or repeatedly measurement, is managed with the intracorporal metabolism of the animal before and after the intake according to high fat diet
Manage the intake of high fat diet.
[4] for managing the monitoring device of the effective status of high fat diet according to [1], wherein the monitoring dress
It sets that progress is primary and/or repeatedly measurement, the suitable of object is screened with the maintenance or improvement of the effective status for high fat diet
Property.
A kind of high fat diet monitoring device of the invention, for monitoring the validity of high fat diet, the high fat diet prison
Surveying device includes: intake information acquisition unit, related with the intake of intracorporal high fat diet of animal is taken in for obtaining
Information；Acetone concentration measuring unit, for measuring as the acetone being discharged in external gas in vivo from the animal
The acetone concentration of amount；And judging unit, for based on high fat diet accessed by the intake information acquisition unit
The information of acetone concentration measured by the related information of intake and the acetone concentration measuring unit, to determine the animal
To the metabolism state of high fat diet.
Preferably, increase of the judging unit based on the acetone concentration before and after the intake of high fat diet or
It reduces to carry out the judgement.Preferably, before the intake with high fat diet compared with, the acetone concentration indicate increase trend
In the case where, the judging unit is determined as the state that high fat diet is just being metabolized by the animal as ketoboidies source, or
Person is determined as that the animal has the physical condition or constitution that can be metabolized high fat diet as ketoboidies source.
The effect of invention
According to the present invention it is possible to provide following device and the method using the device, the device for it is primary and/or with
The process of time repeatedly measures and monitors the metabolism object amount being discharged in external gas in vivo from animal.Using according to this hair
Bright monitoring device and the method using the monitoring device, can carry out: the management high fat diet in just intake high fat diet
Effective status；Effective shape of patient and/or case control's high fat diet early period for the effective disease of intake of high fat diet
State；And the method for the intake as auxiliary high fat diet diet, it screens or judges whether physical condition or constitution make raw ketone
Diet can be used as ketoboidies source and is effectively metabolized.
According to the present invention it is possible to the method for providing following device and using the device, which is used to take in raw ketone
In the case where diet, process once and/or at any time repeatedly measurement and monitors and from animal is discharged to external gas in vivo
In amounts of acetone.
According to the present invention it is possible to provide following device and the method using the device, the device for it is primary and/or with
The process of time repeatedly measures and monitors the body of the effective disease of intake of patient and/or patient's early period from to(for) high fat diet
The amounts of acetone being inside discharged in external gas.
Monitoring device according to the present invention, can measure that (expiratory air comes from from the external gas that is discharged in vivo of animal
The evaporation of skin or mucous membrane) in metabolism object amount, and manage the effective status of the high fat diet of animal.
Monitoring device according to the present invention can measure being discharged in vivo from animal in the case where taking in high fat diet
Metabolism object amount in external gas (expiratory air, the evaporation from skin or mucous membrane), and manage the high fat diet of animal
Effective status.
Monitoring device according to the present invention, for the patient and/or patient's early period of the effective disease of intake of high fat diet,
The amounts of acetone being discharged in external gas in vivo from animal can be measured, and in view of the life ketone as ketoboidies source is drunk
The metabolic rate of food can carry out dietary management, adjust the balance etc. between the carbohydrate and fat in diet.According to
Depending on the taste of preference, it is difficult to take in a large amount of high fat diets sometimes.
According to the present invention, it is taken in by being adjusted while being monitored, the suitable of required sufficient amount can be merely provided as
Food ration is measured, and can be to avoid the excessive intake of not preferred high fat diet.The present invention also provides following advantages: by
The intake that high fat diet is adjusted while being monitored is (thus clear for maintaining or improving the effective high fat diet of physical condition
Food ration), the animal (especially people) to ingest can be made to ingest consciously or unconsciously.
Monitoring device according to the present invention can measure the amounts of acetone being discharged in external gas in vivo from animal,
And can carry out whether making with physical condition or constitution high fat diet can be used as ketoboidies source be effectively metabolized it is related
Screening or judgement.
From the following description and attached drawing, supplementary features related to the present invention be will be apparent.In view of below to embodiment
Detailed description, other purposes, feature and effect will be apparent.
Detailed description of the invention
Fig. 1 is the exemplary functional block diagram for showing monitoring device according to the embodiment.
Fig. 2 is the exemplary functional block diagram for showing monitoring device according to the embodiment.
Fig. 3 is the integrally-built functional block diagram for showing monitoring device according to the embodiment.
Fig. 4 is the functional block diagram for showing the structure of monitoring device according to the embodiment.
Specific embodiment
It will be described below the preferred embodiment of the present invention.However, any individual side that the present invention is not limited to will be described below
Face.
In the present invention, arbitrary mammal can be used.Example includes: rodent, such as mouse, rat,
Hamster and cavy etc.；Lagomorph, rabbit etc.；Ungulate, pig, ox, goat, horse and sheep etc.；Carnivore,
Dog and cat etc.；And primate, people, monkey, rhesus macaque, macaque, marmoset, red hair orangutan and chimpanzee etc..
Mammal is preferably rodent (mouse etc.) or primate (people etc.), and more preferably Primates are dynamic
Object, and even more preferably people.
In the present invention, the effective status of high fat diet refers to animal just from external intake high fat diet and effective land productivity
The state of the life of animal or the life activity of animal is maintained with high fat diet.Can be just used as according to high fat diet ketoboidies come
The state that source is effectively metabolized judges the effective status of high fat diet.For example, body can be discharged in vivo according to from animal
The state of amounts of acetone in outer gas (expiratory air and the evaporation from skin or mucous membrane) judges effective status.It can use
Absolute magnitude and/or relative quantity management are discharged to the (expiratory air and from skin or mucous membrane of external gas from animal in vivo
Evaporation) in amounts of acetone.It is discharged to external gas (expiratory air and evaporation) from skin or mucous membrane in vivo from animal
In amounts of acetone for each animal and there are individual differences.Therefore, it for same individual, can be based on not taking in high fat diet
Period and take in high fat diet period between or amounts of acetone before and after the intake of high fat diet it is upper
It rises, reduce and/or increase etc. and judged.If observing that constant increase becomes compared with before the intake of high fat diet
Gesture then may determine that obtain effect.Preferably, for example, increasing trend indicates statistical significant difference.
If for same individual, in period for not taking in high fat diet and take between the period of high fat diet,
Or before and after the intake of high fat diet between the difference of amounts of acetone be in steady state, then may determine that and obtained for effect
To maintaining and be preferred.
In the present invention, the management of the effective status of high fat diet refers to: identifying that high fat diet is just being used as ketoboidies source
The state being effectively metabolized, and attempt to maintain and/or improve the physical condition of the animal in target zone.
In the present invention, high fat diet refers to the diet or food that ketoboidies can be generated in the living body of animal.Example packet
Include high fat diet, medium chain fatty acid diet and the food for having prepared ketoboidies ester or ketogenic amino acid.In the present invention, these life ketone
Diet is referred to alternatively as ketoboidies source diet.
Particularly, for high fat diet for the treatment of cancer or combinations thereof for example including high fat diet, such as high fat diet (institute
" high fat diet of carbohydrate restriction " of meaning) etc..The example for being discharged to the external gas of cancer patient includes expiratory air
And external gas is discharged to by skin or mucous membrane.
In the present invention, the targeted animal of effective status for managing high fat diet may include taking the photograph for high fat diet
Enter the patient and/or patient's early period of effective disease.In the present invention, for the example of the effective disease of intake of high fat diet
Including obesity, cardiovascular disease, diabetes B, epilepsy, acne, cancer, Stein-Leventhal syndrome, neurological disease, A Erci
The silent disease in sea, Parkinson's disease and head injury.
In the present invention, the patient of the effective disease of intake of high fat diet is referred to and is diagnosed with the disease
Patient.Early period, patient referred to a possibility that being diagnosed with the disease or show the disease is susceptible to suffer from tendency and/or morning
The patient of phase symptom.Early period, patient included from the patient for being genetically susceptible to suffer from the disease and/or voluntary intake high fat diet to prevent
The patient of the disease.
In the present invention, the intake of the high fat diet before and after the intake in order to determine high fat diet, can make
It is monitored with the device of the invention.Furthermore it is possible to device through the invention is monitored, with carry out with below in connection with
Screening or judgement: whether the physical condition or constitution of the targeted animal of the effective status of positive management high fat diet taking in
After high fat diet, high fat diet can be used as ketoboidies source and is effectively metabolized.
Fig. 1 and Fig. 2 description shows the exemplary functional block diagram of monitoring device according to the embodiment.
For example, as shown in Figure 1, monitoring device 1 is equipped with monitoring terminal set 2 and monitoring management device 3.Monitor terminal dress
Set 2 and monitoring management device 3 connected via telecommunication circuit 4, and sending and receiving for information can be carried out between each other.Prison
Surveying terminal installation 2 includes the measuring unit 21 comprising acetone concentration measuring unit 21a and the display comprising determining display unit 22a
Unit 22.Monitoring management device 3 includes data capture unit 31 and judging unit 32.
The acetone concentration measuring unit 21a of monitoring terminal set 2 is measured as from animal and is discharged to external gas in vivo
The acetone concentration of amounts of acetone in body.Determine display unit 22a to show made by the judging unit 32 of monitoring management device 3 to sentence
Determine result.
The data capture unit 31 of monitoring management device 3 obtains high fat diet intake information, acetone concentration information and intake
The individual information of the animal of high fat diet.High fat diet intake information includes and takes in taking the photograph to the intracorporal high fat diet of animal
Enter the related information of amount, and can also include for example with the intake moment of high fat diet, intake period and type at least it
One related information.The individual information of animal may include for example with the type of animal, the age, gender, figure, physical condition,
The related information of at least one constitution and name of disease.
The individual information of high fat diet intake information and animal is, for example, from being set to monitoring terminal set 2 or monitoring management
The unshowned input part of device 3 is input to data capture unit 31.That is, data capture unit 31 is as intake
Information acquisition unit obtains high fat diet and takes in information.Acetone concentration information is got from acetone concentration measuring unit 21a.
Judging unit 32 takes in information and acetone concentration information based on high fat diet to determine animal to the generation of high fat diet
Thank to state.Judging unit 32 determines whether high fat diet is just effectively being metabolized as ketoboidies source, i.e., is in vivo in animal
No positive generation ketoboidies.Increasing of the judging unit 32 for example based on the acetone concentration before and after intake of high fat diet adds deduct
It is few to determine metabolism state.Acetone concentration of the judging unit 32 after the intake of high fat diet indicates to increase compared with before intake
In the case where adding trend, it is determined as the state that high fat diet is just effectively being metabolized by animal as ketoboidies source, or be determined as
Animal has the physical condition or constitution that can be effectively metabolized high fat diet as ketoboidies source.
The high fat diet intake (g) of every weight (Kg) of the judging unit 32 based on animal and in the intake of high fat diet
Before and after acetone concentration difference, to calculate the increment rate of the acetone concentration due to caused by the intake of high fat diet.Such as
Fruit compared with pre-set a reference value, be more than a reference value, then acetone concentration indicate increase trend.Therefore, it is judged as the shape
State make high fat diet be just used as ketoboidies source be effectively metabolized or animal have can be using high fat diet as ketoboidies
The physical condition or constitution that source is effectively metabolized.On the other hand, if being less than a reference value, acetone concentration, which does not indicate to increase, to become
Gesture.Therefore, judge are as follows: the state is being metabolized high fat diet just effectively as ketoboidies source；Or the body of animal
Situation or constitution cannot be effectively metabolized using high fat diet as ketoboidies source.For example, it is also possible to determine the increasing of acetone concentration
Rate of acceleration belongs to which metaboilic level in multiple metaboilic levels (level 1~5) with the range being gradually arranged.
Can the individual information based on animal come correction reference value or metaboilic level range.For example, in such as adult male
Deng the big animal of figure in the case where, can be corrected on the direction for increasing a reference value.In such as adult female
Or it in the case where the small animal of children etc., can be corrected on the direction for reducing a reference value.
By judgement made by judging unit 32 as the result is shown on the judgement display unit 22a of monitoring terminal set 2.Cause
This, determines display unit 22a by viewing, can identify whether the intake of high fat diet is effective for animal.It can be according to public affairs
Open information (statistical information, published articles and the conference speed etc. of agency's publication) and based on the number independently accumulated
According to nonpublic information be corrected.Artificial intelligence (AI) function etc. can be used artificially to be corrected.
According to the monitoring device 1 with above-mentioned structure, the life ketone since next time can be determined based on result is determined
The intake of diet.It can also judge whether animal has the body that can be effectively metabolized high fat diet as ketoboidies source
Situation or constitution.By continuously holding the record, the variation of the physical condition or constitution of animal can also be identified.
According to monitoring device 1, for the patient and/or patient's early period of the effective disease of intake of high fat diet, although root
Make to be difficult to the fact that take in a large amount of high fat diets sometimes according to the taste for depending on preference, but the device 1 can also used
Intake is adjusted while being monitored, this allows for dietary management, carbohydrate and rouge in such as adjustment diet
Balance etc. between fat.Therefore, can be merely provided as must the appropriate amount of sufficient amount ingest, and can be to avoid not preferred
The excessive intake of high fat diet.According to monitoring device 1, for maintaining or improving the food ration of the effective high fat diet of physical condition
Become clear.Thus, monitoring device 1 provides the animal (especially people) for allowing to be ingested and takes the photograph consciously or unconsciously
The effect of food.
Monitoring device 1 can be a device which to be directly connected to the judgement for showing the judgement according to measurement result
Unit 32 and for showing the judgement display unit 22a of the judgement to be monitored at a position.Monitoring device 1 can be
Following device (Fig. 1): monitoring terminal set 2 (including measuring unit 21 and determine display unit 22a) via telecommunication circuit 4 with
Monitoring management device 3 (including the data capture unit 31 for handling data and the effective status for determining high fat diet
Judging unit 32) connection.The example of telecommunication circuit 4 includes radio wave, various known wireless communication lines and wire communication
Route.Monitoring can carry out in real time or by specified time interval.Monitoring can be in a position or multiple position (such as patients
He or she oneself, doctor, nurse, laboratory technicians, nutritionist, handling facility and high fat diet manufacturer etc.) at carry out.
Monitoring device 1 can be made of monitoring terminal set and monitoring management device (Fig. 2), which includes
Measuring unit determines display unit and judgement display unit and the monitoring management device for receiving and showing judgement
Including data capture unit, judging unit, for accumulating the judgement cumulative unit determined and for based on the judgement accumulated
Come the judgement judging unit judged.
Monitoring terminal set can be similar in shape to watch or glasses, or can use and be suitable for any of wearing
Shape or form, accessory or belt etc..Monitoring terminal set may include for connecting multiple monitoring terminal sets each other
The monitoring management server managed dynamicly.Monitoring management server can be used for being determined according to the treatment results for multiple patients
General optimal treatment amount.
As monitoring terminal set or monitoring management device, times including personal computer and supercomputer can be used
What digital computer.Cellular phone, smart phone, tablet computer and warning device etc. can also be used.
Fig. 3 is the integrally-built functional block diagram for showing monitoring device according to the embodiment.
Monitoring terminal set 2 includes acetone concentration measuring unit for measuring acetone concentration and comes from for showing
The display unit of the data of transmission units such as judgement.Display unit includes determining whether display unit.It can also include coming for showing
From the judgement display unit of the data of the transmission units such as judgement.In addition, it can include effective shape for managing high fat diet
One or more of the other measuring unit of state.
Monitoring management device 3 include for obtaining the data capture unit of measurement data, the note for recording measurement data
Record the judging unit of the amount of unit and the ketoboidies source diet for determining to be metabolized according to the data.Can also include
For accumulate determine judgements cumulative unit and according to accumulated determine adjust diet food ration and fat mass and
Carry out the judgement judging unit of screening related with the adaptability of high fat diet or judgement.It judgement from judging unit and comes from
Determine that the judgement of judging unit is sent to via transmission units such as judgements to determine display unit or judge display unit, and is shown
Show on monitoring terminal set.Monitoring management device may include data record unit.
Fig. 4 is the functional block diagram for showing the structure of monitoring device according to the embodiment.
Monitoring device 1 includes monitoring terminal set 2A~2C, monitoring management device 3A~3C and connects these devices
Telecommunication circuit 4A~4C.It can also include multiple monitoring terminal sets.It can also include for managing multiple monitoring terminal sets
One and/or multiple monitoring management devices.In addition, it can include for the prison from higher level management monitoring management device
Survey management server.
The present invention includes any and all purposes of monitoring device of the invention, and is suitable for its any application, this packet
Include method and its application method using monitoring device of the invention, the method for evaluating high fat diet, for managing raw ketone
It the method for dietary intake and ingests the screening of effective animal for high fat diet.
Although embodiments of the invention have been described, but the present invention is not limited to the above embodiments, and can not have
Various design modifications are carried out in the range of documented effect of the invention in claims.
Description of symbols
1 monitoring device
2 monitoring terminal sets
2A monitoring terminal set A
2B monitoring terminal set B
2C monitoring terminal set C
3 monitoring management devices
3A monitoring management device A
3B monitoring management device B
3C monitoring management device C
4 telecommunication circuits
4A telecommunication circuit A
4B telecommunication circuit B
4C telecommunication circuit C
5 monitoring management servers
Claims (7)
1. a kind of monitoring device, for from the amounts of acetone of animal being discharged in external gas in vivo carry out it is primary and/or
Repeatedly measurement, to manage the effective status of high fat diet.
2. according to claim 1 for managing the monitoring device of the effective status of high fat diet, wherein the monitoring dress
It sets and carries out primary and/or repeatedly measure to manage the effective status of high fat diet, wherein animal according to claim 1
It is the effective disease of intake of patient and/or patient's early period to(for) high fat diet.
3. according to claim 1 for managing the monitoring device of the effective status of high fat diet, wherein the monitoring dress
It sets that progress is primary and/or repeatedly measurement, is managed with the intracorporal metabolism of the animal before and after the intake according to high fat diet
Manage the intake of high fat diet.
4. according to claim 1 for managing the monitoring device of the effective status of high fat diet, wherein the monitoring dress
It sets that progress is primary and/or repeatedly measurement, the suitable of object is screened with the maintenance or improvement of the effective status for high fat diet
Property.
5. a kind of high fat diet monitoring device, for monitoring the validity of high fat diet, the high fat diet monitoring device includes:
Information acquisition unit is taken in, for obtaining information related with the intake of intracorporal high fat diet of animal is taken in；
Acetone concentration measuring unit, for measuring as the amounts of acetone being discharged in external gas in vivo from the animal
Acetone concentration；And
Judging unit, for based on letter related with the intake of high fat diet accessed by the intake information acquisition unit
The information of acetone concentration measured by breath and the acetone concentration measuring unit, to determine the animal to the generation of high fat diet
Thank to state.
6. high fat diet monitoring device according to claim 5, wherein intake of the judging unit based on high fat diet
Before and after the acetone concentration increase or decrease to carry out the judgement.
7. high fat diet monitoring device according to claim 6, wherein compared with before the intake with high fat diet, institute
In the case where stating acetone concentration expression increase trend, the judging unit is determined as the animal just using high fat diet as ketoboidies
The state that source is metabolized, or be determined as that the animal has and high fat diet can be metabolized as ketoboidies source
Physical condition or constitution.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017076201 | 2017-04-06 | ||
| JP2017-076201 | 2017-04-06 | ||
| JP2017-162775 | 2017-08-25 | ||
| JP2017162775A JP6968624B2 (en) | 2017-04-06 | 2017-08-25 | How to manage ketogenic diet intake |
| PCT/JP2018/014673 WO2018186481A1 (en) | 2017-04-06 | 2018-04-06 | Device for monitoring ketogenic diet efficacy |
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| CN110506211A true CN110506211A (en) | 2019-11-26 |
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| CN201880023394.9A Pending CN110506211A (en) | 2017-04-06 | 2018-04-06 | For monitoring the device of the effective status of high fat diet |
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| Country | Link |
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| JP (1) | JP6968624B2 (en) |
| CN (1) | CN110506211A (en) |
| TW (1) | TWI816666B (en) |
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| JP7361517B2 (en) * | 2018-07-17 | 2023-10-16 | 大阪瓦斯株式会社 | Index value determination system, mitochondrial activity evaluation system, index value determination method, and mitochondrial activity evaluation method |
| CN112752827A (en) | 2018-09-26 | 2021-05-04 | 松下知识产权经营株式会社 | Warm color composite phosphor, wavelength converter, and light-emitting device |
| CN114008452A (en) * | 2019-06-18 | 2022-02-01 | 味之素株式会社 | Method for evaluating food related to cognitive function |
| WO2021140640A1 (en) * | 2020-01-10 | 2021-07-15 | 大阪瓦斯株式会社 | Index value determination system, mitochondrial activiy evaluation system, index value determination method, and mitochondrial activity evaluation method |
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Also Published As
| Publication number | Publication date |
|---|---|
| TWI816666B (en) | 2023-10-01 |
| TW201842316A (en) | 2018-12-01 |
| JP6968624B2 (en) | 2021-11-17 |
| JP2018179960A (en) | 2018-11-15 |
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