TW201842316A - Device for monitoring ketogenic diet efficacy - Google Patents

Abstract

The purpose of the present invention is to obtain a ketogenic diet monitoring device for individually managing ketogenic diet efficacy in animals. This ketogenic diet monitoring device is configured to monitor by measuring, once or multiple times over time, the volume of metabolites in gas expelled from the interior to the exterior of the body of an animal in which ketogenic diet efficacy is being managed. The ketogenic monitoring device 1 comprises: an intake information acquiring unit for acquiring information on the volume of ketogenic diet being taken into the body of the animal; an acetone concentration measuring unit for measuring acetone concentration, which is the volume of acetone in gas expelled from the interior to the exterior of the body of the animal; and an assessing unit for assessing the ketogenic diet metabolic state of the animal on the basis of the ketogenic diet intake volume information acquired by the intake information acquiring unit and the acetone concentration information measured by the acetone concentration measuring unit.

Description

Monitoring device for effective state of ketogenic diet

The invention is a monitoring device for managing the effective state of a ketogenic diet.

Prior to this, it was suspected that ketogenic diets and high-fat diets (especially high-fat diets with limited sugars) could become one of the treatments for patients with end-stage cancer, so the effectiveness of ketogenic diets for Japanese patients with end-stage lung cancer A study was conducted and it was found that a composition for treating cancer by a ketogenic diet, such as a high-fat diet including sugars, or a combination thereof, preferably by setting the fat to 120 g or more, and / Or limit carbohydrates to less than 30 g per day, and / or set daily calories to be above 20 kcal / kg body weight, and / or combine medium chain fatty acid oil (MCT oil), etc. The expected remarkable effect is to treat cancer and improve quality of life (QOL) (Patent Document 1). In addition, it is known that a ketogenic diet can effectively improve brain function and prevent and treat cognitive dysfunction (Patent Document 2). Furthermore, the ketogenic diet is known to be effective for obesity, circulatory organ diseases, type 2 diabetes, epilepsy, acne, cancer, multi-ovarian syndrome, neurological disorders, Alzheimer's disease, Parkinson's disease, and head trauma ( Non-patent literature 1). Prior to this, in order to provide a food or medical agent for suppressing the increase of gastric discharge and delaying gastric discharge, a vigorous research was conducted, and the following methods were found in the process, namely: by administering 13C ₂ animals with various amino acids labeled with 13C are monitored for the amount of 13CO ₂ exhaled air, and the exhaled air is used as a specimen to non-invasively measure the amount of amino acid metabolism (Patent Document 3). According to general knowledge, the ketogenic diet ingested by an animal is metabolized in the animal body, and part of it becomes acetone, which is used as exhalation or gas discharged from the skin or mucous membrane, and is automatically excreted from the body to the body. As a method for measuring acetone in gas, a multi-function breath analyzer (Patent Document 4), a breath measurement device (Patent Document 5), and the like are known. In addition, a system for estimating the diabetes index value using the amount of expiratory acetone is known (Patent Document 6). [Prior Art Literature] [Patent Literature] Patent Literature 1: International Publication No. 2017/038101 Patent Literature 2: International Publication No. 2016/013617 Patent Literature 3: Japanese Patent No. 5938219 Patent Literature 4: Japanese Patent No. 5921562 Patent Document 5: Japanese Patent No. 5139186 Patent Document 6: Japanese Patent Laid-Open No. 2015-102381 [Non-Patent Document] Non-Patent Document 1: European Journal of Clinical Nu trition (2013) 67, 789-796

[Problems to be solved by the invention] Prior to this, I have not heard of any gas (exhalation, evapotranspiration from the skin or mucous membranes) that is expelled from the automatic body in order to manage the effective state of the ketogenic diet of animals Monitoring device for measuring the amount of metabolites. It has never been heard that there is an effective state for managing the ketogenic diet when ingesting the ketogenic diet, or for managing the effective state of the ketogenic diet for patients and / or prospective patients whose diseases can be effectively treated by ingesting the ketogenic diet, Or as an auxiliary method for eating and ingesting a ketogenic diet, or as a method for checking or judging whether the ketogenic diet can be effectively metabolized as a source of ketone bodies, and to expel the gas from the body of the automatic body A monitoring device for measuring the amount of acetone. In the management of the effective state of the animal's ketogenic diet, it is considered that as long as the amount of acetone in the gas discharged from the body can be measured in a non-invasive manner in an immediate or continuous manner, to monitor the animal's ketogenic diet as a source of ketone bodies The metabolic state allows individual management of the effective state of the ketogenic diet. That is, the development of such devices is the subject. [Technical Means for Solving the Problem] The inventor has made strenuous efforts to find a device for measuring and monitoring the amount of acetone in the gas discharged from the automatic body once and / or multiple times and its use method, and completed The present invention. According to the present invention, it provides the following invention. [1] A monitoring device that measures the amount of acetone in the gas discharged from an automatic object in order to manage the effective state of the ketogenic diet, and / or measures the amount of acetone once and / or multiple times. [2] The monitoring device as described in [1], which performs one and / or multiple measurements in order to manage the effective state of the ketogenic diet, and the above-mentioned animals are patients with diseases that can be effectively treated by ingesting the ketogenic diet and / Or prospective patients. [3] The monitoring device according to [1], wherein the management of the effective state of the ketogenic diet described above is performed once to manage the intake of the ketogenic diet together with the metabolism of the animal body before and after ingesting the ketogenic diet and // Or multiple determinations. [4] The monitoring device as described in [1], wherein the management of the effective state of the ketogenic diet is performed once and / or multiple times in order to verify the fitness of the subject to maintain and improve the effective state of the ketogenic diet Determination. In addition, the ketogenic diet monitoring device of the invention of the present invention is characterized in that it monitors the effectiveness of the ketogenic diet, and has: an intake information acquiring section that acquires information on the amount of ketogenic diet ingested into the animal An acetone concentration measuring section, which measures the amount of acetone in the gas discharged from the animal body, that is, the acetone concentration; and a judgment section, which is based on the intake amount of the ketogenic diet obtained by the intake information obtaining section Information and the information on the acetone concentration measured by the acetone concentration measuring section to determine the metabolic state of the ketogenic diet of the animal. Preferably, the determination unit performs the determination based on an increase or decrease in the acetone concentration before and after ingesting the ketogenic diet. Furthermore, it is preferable that the determination unit determines that the animal is metabolizing the ketogenic diet as a source of ketone bodies when the acetone concentration shows an increasing tendency compared to before the intake of the ketogenic diet, or The animal system can use the ketogenic diet as a source of ketone body to metabolize the body condition or constitution. [Effects of the Invention] According to the present invention, it is possible to provide a device for measuring and monitoring the amount of metabolites in the gas discharged from an automatic body once and / or multiple times, and a method of using the same. Moreover, by providing the monitoring device of the present invention and the method of use thereof, the effective state of the ketogenic diet can be managed when ingesting the ketogenic diet, or patients and / or quasi-patients who can effectively treat diseases by ingesting the ketogenic diet can be used The subject manages the effective state of the ketogenic diet, or as an auxiliary method of eating and ingesting the ketogenic diet, checks or judges whether the ketogenic diet can be effectively metabolized as a source of ketone body. According to the present invention, it can provide a device for measuring and monitoring the amount of acetone in the gas discharged from the automatic body once and / or multiple times over time when the animal ingests a ketogenic diet and its use method . According to the present invention, it can provide a method for measuring and monitoring the amount of acetone in the gas discharged from the body of patients and / or quasi-patients who can effectively treat diseases by ingesting the ketogenic diet. Device and method of use. According to the monitoring device of the present invention, it can measure the amount of metabolites in the gas (exhalation, evapotranspiration from the skin or mucous membrane) discharged from the automatic object, and manage the effective state of the animal's ketogenic diet. According to the monitoring device of the present invention, when an animal ingests a ketogenic diet, it can measure the amount of metabolites in the gas (exhalation, evapotranspiration from the skin or mucous membranes) discharged from the automatic body to manage the animal The effective state of the ketogenic diet. According to the monitoring device of the present invention, it can target patients and / or quasi-patients with diseases that can be effectively treated by ingesting a ketogenic diet, and can measure the amount of acetone in the gas discharged from the automatic body and source the ketone body Take into account the metabolic rate, and carry out diet management, such as adjusting the balance of sugars and lipids in the diet. Regarding the ketogenic diet, because of its poor taste, it is difficult to consume a large amount of it out of affection. According to the present invention, it is possible to adjust the intake by monitoring while monitoring the food intake by only the necessary and sufficient amount, thereby avoiding excessive intake of a ketogenic diet that is not favorite. According to the present invention, it has the effect that the intake of the ketogenic diet can be adjusted by monitoring while monitoring (by making the intake of the ketogenic diet effective to maintain or improve the body condition clear), and feeding animals ( Especially people) eat consciously or unconsciously. According to the monitoring device of the present invention, it can measure the amount of acetone in the gas discharged from the automatic body, and check or judge whether it is a body condition or constitution that can effectively metabolize the ketogenic diet as a source of ketone bodies. Further features related to the present invention will be apparent from the description in this specification and the accompanying drawings. In addition, problems, configurations, and effects other than the above can be made clear by the description of the following embodiments.

Hereinafter, preferred embodiments of the present invention will be described in detail, but the present invention is not limited to the following embodiments. Examples of animals that can be used in the present invention include any mammals, and examples include rodents such as mice, rats, hamsters, and guinea pigs, rabbits such as rabbits, pigs, cows, goats, horses, and sheep. Primates such as ungulates, dogs, cats and other cats, humans, apes, rhesus monkeys, cynomolgus monkeys, marmosets, orangutans, chimpanzees, etc. The mammal is preferably a rodent (mouse, etc.) or a primate (human, etc.), more preferably a primate, and even more preferably a human. In the present invention, the effective state of the ketogenic diet refers to a state in which the animal ingests the ketogenic diet from outside the body, and effectively uses the ketogenic diet for the living maintenance of the animal or the life activity of the animal. The effective state of the ketogenic diet can be judged by the state of effectively metabolizing the ketogenic diet as a source of ketone bodies, for example, the amount of acetone in the gas (exhalation, evapotranspiration from the skin or mucous membranes) that is excreted from the automatic body To determine the state of the situation. The amount of acetone in the gas (exhalation, evapotranspiration from the skin or mucous membranes) discharged from the body of the automatic body can be managed in absolute and / or relative amounts. In addition, due to individual animal differences, the amount of acetone in the gas (exhalation, evapotranspiration from the skin or mucous membranes) in the automatic body is based on the time and intake of the ketogenic diet in the same individual. The period of ketone diet, or the increase, decrease, and / or increase in the amount of acetone before or after intake of the ketogenic diet can be judged. If it shows a certain increase tendency compared with before intake of the ketogenic diet, It can be judged that it has the above effect. For example, the tendency to increase is more preferably a statistically significant difference. In addition, even if the difference between the time when the ketogenic diet is not taken and the time when the ketogenic diet is taken, or the amount of acetone before or after the ketogenic diet is fixed in the same individual, the effect is maintained and it can be judged Outstanding. In the present invention, the management of the effective state of the ketogenic diet refers to grasping the state in which the ketogenic diet is effectively metabolized as a source of ketone bodies, and trying to maintain and / or improve the physical condition of the animal within the target range. In the present invention, the ketogenic diet refers to a diet or food that can produce ketone bodies in the living body of an animal. Examples include high-fat diets, medium-chain fatty acid diets, ketone body esters, and foods formulated with ketogenic amino acids. In the present invention, such ketogenic diets are sometimes referred to as ketone-derived diets. Among them, as a ketogenic diet for treating cancer or a combination thereof, for example, a ketogenic diet, especially a high-fat diet (for example, a so-called "sugar-limited high-fat diet") may be mentioned. Examples of the gas discharged from the body of a cancer patient include exhalation and gas discharged from the skin or mucous membrane. In the present invention, the animal whose effective state of the ketogenic diet is managed can be a patient and / or prospective patient who can effectively treat diseases ingested by the ketogenic diet. In the present invention, the diseases effectively treated by ingesting the ketogenic diet can be Examples include obesity, circulatory organ diseases, type 2 diabetes, epilepsy, acne, cancer, polycystic ovarian syndrome, neurological disorders, Alzheimer's disease, Parkinson's disease, and head trauma. In the present invention, a patient who is effectively treated by taking a ketogenic diet refers to a patient diagnosed with the above-mentioned diseases, and a quasi-patient refers to a patient who is diagnosed as having the above-mentioned diseases or is suffering from the above-mentioned diseases. Prone and / or symptoms. In addition, the so-called quasi-patients include those who are genetically more likely to suffer from the above-mentioned diseases, and / or those who wish to ingest a ketogenic diet based on their own wishes to prevent the above-mentioned diseases. In the present invention, the device of the present invention can be used for monitoring to determine the intake of the ketogenic diet before and after ingesting the ketogenic diet. In addition, the device of the present invention can be used for monitoring to check or judge whether the animal whose effective state of the ketogenic diet is managed is a body condition that can be effectively metabolized by taking the ketogenic diet as a source of ketone bodies after ingesting the ketogenic diet constitution. 1 and 2 are functional block diagrams showing an example of the monitoring device of this embodiment. For example, as shown in FIG. 1, the monitoring device 1 includes a monitoring terminal device 2 and a monitoring management device 3. The monitoring terminal device 2 and the monitoring management device 3 are connected via a communication circuit 4 and can exchange information with each other. The monitoring terminal device 2 includes a measurement unit 21 including an acetone concentration measurement unit 21a and a display unit 22 including a determination display unit 22a. In addition, the monitoring management device 3 includes a data acquisition unit 31 and a determination unit 32. The acetone concentration measuring part 21a of the monitoring terminal device 2 measures the acetone concentration, which is the amount of acetone in the gas discharged from the body of the automatic object. In addition, the determination display unit 22a displays the determination result obtained by the determination unit 32 of the monitoring management device 3. The data acquisition part 31 of the monitoring management device 3 acquires the intake information of the ketogenic diet, the information of the acetone concentration, and the individual information of the animals ingesting the ketogenic diet. The intake information of the ketogenic diet includes information on the amount of intake of the ketogenic diet ingested into the animal body, and may further include at least one of information such as intake time, intake period, and type of the ketogenic diet. In addition, the individual information of the animal may include at least one of the information such as the type, age, sex, physique, physical condition, physique, and disease name of the animal. The intake information of the ketogenic diet and the individual information of the animals are input to the data acquisition unit 31 from an input mechanism (not shown) provided in the monitoring terminal device 2 or the monitoring management device 3. That is, the data acquisition unit 31 serves as an intake information acquisition unit to acquire intake information of the ketogenic diet. In addition, the acetone concentration information is obtained from the acetone concentration measuring unit 21a. The determination unit 32 determines the metabolic state of the ketogenic diet of the animal based on the intake information of the ketogenic diet and the information of the acetone concentration. The determination unit 32 determines whether the ketogenic diet is effectively metabolized as a source of ketone bodies, that is, whether ketone bodies are produced in the animal. The determination unit 32 determines the metabolic state based on, for example, the increase or decrease in the acetone concentration before and after ingesting the ketogenic diet. When the acetone concentration after ingestion shows a tendency to increase compared with before the intake of the ketogenic diet, the determination section 32 determines that the animal system is effectively metabolizing the ketogenic diet as a source of ketone bodies, or the animal system may A ketogenic diet as a source of ketone bodies that effectively metabolizes body condition or physique. The determination unit 32 calculates the increase rate of the acetone concentration due to the intake of the ketogenic diet based on, for example, the amount of ketogenic diet intake (g) per unit body weight (Kg) of the animal and the difference between the acetone concentration before and after the ketogenic diet. Furthermore, when compared with a preset reference value, the acetone concentration tends to increase when the reference value is exceeded, so it is determined that the animal system is effectively metabolizing the ketogenic diet as a ketone body source, or the animal system can A ketogenic diet as a source of ketone bodies that effectively metabolizes body condition or physique. On the other hand, when the acetone concentration does not show a tendency to increase when the reference value is less than the reference value, it is judged that the animal system does not use the ketogenic diet as a source of ketone bodies and is effectively metabolized, or the animal does not adopt the ketogenic diet A body condition or constitution that is derived from ketone bodies and efficiently metabolized. In addition, for example, it may be determined whether the increase rate of the acetone concentration belongs to one of a plurality of metabolic levels (levels 1 to 5) set in a stepped range. The reference value or the range of metabolic grade can also be corrected based on the individual information of the animal. For example, it may be corrected in the direction of increasing the reference value in the case of larger animals such as adult males, and in the direction of decreasing the reference value in the case of smaller animals such as adult females or children. The determination result of the determination unit 32 is displayed on the determination display unit 22 a of the monitoring terminal device 2. Therefore, by looking at the judgment display section 22a, it can be understood whether ingesting the ketogenic diet is effective for the animal. Revisions can be made based on statistical information published by administrative agencies, public information such as paper publications / society publications, and non-public information obtained based on personally accumulated data. This correction can be carried out artificially, or it can be realized by using functions such as AI (artificial intelligence). According to the monitoring device 1 having the above configuration, the intake amount of the ketogenic diet from the next time can be determined based on the determination result. In addition, it can be judged whether the animal is a body condition or constitution that can effectively metabolize the ketogenic diet as a source of ketone bodies. In addition, by continuously recording, you can grasp the changes in the animal's physical condition or physique. According to the monitoring device 1, regarding the ketogenic diet, that is, patients and / or quasi-patients who can effectively treat diseases ingested by the ketogenic diet can be targeted for diet management, such as adjusting the balance of sugars and lipids in the diet, etc. In addition, due to poor taste, it is difficult to ingest in large quantities out of affection, but the ingestion can be adjusted while monitoring by the monitoring device 1, so ingestion can be carried out only in a sufficient amount, that is, in an appropriate amount, to avoid excessive Take a ketogenic diet that you do n’t like. According to the monitoring device 1, the intake of the ketogenic diet which can effectively maintain or improve the body condition becomes clear. Therefore, it has the effect of allowing the feeding animals (especially humans) to eat consciously or unconsciously. The monitoring device 1 may be a device that directly connects the determination unit 32 that displays the determination of the measurement result and the determination display unit 22a that displays the determination to monitor at one place, or may include the measurement unit 21 and the determination display via the communication circuit 4 The monitoring terminal device 2 of the unit 22a is connected to the monitoring management device 3 having the data acquisition unit 31 for processing data and the monitoring management device 3 of the determination unit 32 for determining the effective state of the ketogenic diet (FIG. 1). The communication circuit 4 may include radio waves, various well-known wireless communication lines, or wired communication lines. The monitoring can be real-time or have a certain time difference. In addition, the monitoring can be carried out in one place, or in a plurality of places, such as the patient himself, a doctor, a nurse, an inspection technician, a nutritionist, a management device, a ketogenic diet producer, and so on. Furthermore, it may also include a monitoring terminal device and a monitoring management device, wherein the monitoring terminal device includes a measuring unit, a judgment display unit, and a judgment display unit that receives and displays judgments; the monitoring management device includes a data acquisition unit, a judgment unit, and a storage judgment unit The judgment storage unit for the judgment and the judgment judgment unit for judging based on the stored judgment (FIG. 2). The monitoring terminal device may be in a shape like a watch or glasses, or any form that is easy to wear on the body such as an ornament or a belt. Furthermore, there may be a monitoring management server that manages a plurality of monitoring terminal devices in a linked manner. By monitoring the management server, for example, it can also be used to determine the usually optimal amount of treatment based on the treatment results of multiple patients. As the monitoring terminal device or monitoring management device, all digital computers including personal computers, super computers, etc. can be used, as well as mobile phones, smart phones, tablets, alarm devices, etc. FIG. 3 is a functional block diagram showing the overall configuration of the monitoring device of this embodiment. The monitoring terminal device 2 includes an acetone concentration measuring unit that measures the concentration of acetone, and a display unit that displays data from a transmitting unit such as a judgment. The display unit includes a judgment display unit. Furthermore, it may have a judgment display unit that displays data from a transmission unit such as judgment. Furthermore, one or a plurality of other measurement units useful for managing the effective state of the ketogenic diet may be included. The monitoring management device 3 includes a data acquisition unit that acquires measurement data, a recording unit that records measurement data, and a determination unit that determines the amount of ketone body-derived diet that is metabolized based on the data. In addition, a judgment storage section that stores judgments in advance, and a judgment judgment section that checks or judges whether it is necessary to adjust the food intake or fat amount of the diet based on the stored judgments and whether it can adapt to the ketogenic diet. The judgment from the judgment section and the judgment from the judgment judgment section are transmitted to the judgment display section or judgment display section via the judgment transmission section and displayed on the monitoring terminal device. The data management unit may also be included in the monitoring management device. FIG. 4 is a functional block diagram showing the configuration of the monitoring device of this embodiment. The monitoring device 1 includes monitoring terminal devices 2A to 2C, monitoring management devices 3A to 3C, and communication circuits 4A to 4C that connect them. There may be a plurality of monitoring terminal devices, one and / or a plurality of monitoring management devices that manage the plurality of monitoring terminal devices, and furthermore, a monitoring management server for supervising the monitoring management device. The present invention includes the method or method of using the monitoring device of the present invention, the method of evaluating the ketogenic diet, the management method of the intake of the ketogenic diet, the verification of animals that can be effectively treated by the ketogenic diet, etc. All forms, and can be applied to all forms. The embodiments of the present invention have been described in detail above, but the present invention is not limited to the above-mentioned embodiments, and various design changes can be made without departing from the spirit of the invention described in the scope of the patent application.

1‧‧‧Monitoring device

2‧‧‧Monitoring terminal device

2A‧‧‧Monitoring terminal device A

2B‧‧‧Monitoring terminal device B

2C‧‧‧Monitoring terminal device C

3‧‧‧Monitoring management device

3A‧‧‧Monitoring management device A

3B‧‧‧Monitoring management device B

3C‧‧‧Monitoring management device C

4‧‧‧Communication circuit

4A‧‧‧Communication circuit A

4B‧‧‧Communication circuit B

4C‧‧‧Communication circuit C

5‧‧‧Monitoring management server

21‧‧‧Measurement Department

21a‧‧‧Acetone concentration measurement department

22‧‧‧Display

22a‧‧‧judgment display unit

31‧‧‧ Data Acquisition Department

32‧‧‧Judgment Department

FIG. 1 is a functional block diagram showing an example of the monitoring device of this embodiment. FIG. 2 is a functional block diagram showing an example of the monitoring device of this embodiment. FIG. 3 is a functional block diagram showing the overall configuration of the monitoring device of this embodiment. FIG. 4 is a functional block diagram showing the configuration of the monitoring device of this embodiment.

Claims (7)

A monitoring device which measures the amount of acetone in the gas discharged from the automatic body in order to manage the effective state of the ketogenic diet. For the monitoring device according to claim 1, in order to manage the effective state of the ketogenic diet, it is measured once and / or multiple times, and the above-mentioned animals are patients and / or quasi-patients who can effectively treat diseases by ingesting the ketogenic diet. The monitoring device according to claim 1, wherein the management of the effective state of the ketogenic diet is performed once and / or multiple times in order to manage the intake of the ketogenic diet together with the metabolism of the animal body before and after ingesting the ketogenic diet. The monitoring device according to claim 1, wherein the above-mentioned management of the effective state of the ketogenic diet is performed once and / or multiple times in order to check the maintenance and improvement of the effective state of the ketogenic diet by the subject. A ketogenic diet monitoring device, characterized in that: it is a person who monitors the effectiveness of a ketogenic diet, and has: an intake information acquisition section that acquires information on the amount of ketogenic diet ingested into the animal; acetone concentration A measuring section that measures the amount of acetone in the gas discharged from the animal body, that is, the concentration of acetone; and a judging section that is based on information on the intake amount of the ketogenic diet obtained by the intake information obtaining section, and Based on the information of the acetone concentration measured by the acetone concentration measuring section, the metabolic state of the ketogenic diet of the animal is determined. The ketogenic diet monitoring device according to claim 5, wherein the determination unit makes the determination based on an increase or decrease in the acetone concentration before and after ingesting the ketogenic diet. The ketogenic diet monitoring device according to claim 6, wherein the determination unit determines that the animal uses the ketogenic diet as a source of ketone body when the acetone concentration shows a tendency to increase compared to before the intake of the ketogenic diet The metabolic state, or the body condition or physique that the above ketogenic diet can be metabolized by the above ketogenic diet as a source of ketone bodies.