TWI808067B - 作為ehmt2抑制劑之胺取代的雜環化合物及其使用方法 - Google Patents

作為ehmt2抑制劑之胺取代的雜環化合物及其使用方法 Download PDF

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TWI808067B
TWI808067B TW106144660A TW106144660A TWI808067B TW I808067 B TWI808067 B TW I808067B TW 106144660 A TW106144660 A TW 106144660A TW 106144660 A TW106144660 A TW 106144660A TW I808067 B TWI808067 B TW I808067B
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約翰 愛默生 坎培爾
肯尼斯 威廉 鄧肯
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美商雅酶股份有限公司
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
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  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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TW106144660A 2016-12-19 2017-12-19 作為ehmt2抑制劑之胺取代的雜環化合物及其使用方法 TWI808067B (zh)

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US201662436139P 2016-12-19 2016-12-19
US62/436,139 2016-12-19
US201762517840P 2017-06-09 2017-06-09
US62/517,840 2017-06-09

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EA202090959A1 (ru) * 2017-10-18 2020-07-13 Эпизайм, Инк. Аминзамещенные гетероциклические соединения в качестве ингибиторов ehmt2, их соли и способы их синтеза
BR112020007585A2 (pt) * 2017-10-18 2020-09-24 Epizyme, Inc. método para prevenir ou tratar um distúrbio sanguíneo, inibidor de ehmt2 e uso de um inibidor de ehmt2
KR101954370B1 (ko) 2018-07-25 2019-03-05 한미약품 주식회사 피리미딘 화합물 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물
BR112021007745A2 (pt) 2018-10-24 2021-07-27 Effector Therapeutics, Inc. formas cristalinas de inibidores de mnk
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JP7577672B2 (ja) 2019-02-22 2024-11-05 ハンミ ファーマシューティカルズ カンパニー リミテッド Ｆｌｔ３阻害剤及び低メチル化剤を含む急性骨髄性白血病の治療のための薬学的組成物
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CN120904157A (zh) 2020-12-22 2025-11-07 益方生物科技(上海)股份有限公司 杂芳基化合物及其制备方法和用途
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MX2024004416A (es) * 2021-10-15 2024-07-09 Tango Therapeutics Inc Nuevos moduladores de ehmt1 y ehmt2 y uso terapéutico de estos.
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