TWI797116B - 用於治療上皮細胞屏障功能病症的蛋白質 - Google Patents
用於治療上皮細胞屏障功能病症的蛋白質 Download PDFInfo
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- TWI797116B TWI797116B TW107112165A TW107112165A TWI797116B TW I797116 B TWI797116 B TW I797116B TW 107112165 A TW107112165 A TW 107112165A TW 107112165 A TW107112165 A TW 107112165A TW I797116 B TWI797116 B TW I797116B
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| US11666629B2 (en) * | 2020-01-10 | 2023-06-06 | National Taipei University Of Technology | Peptide interacting with toll-like receptor 2 and the composition comprising the same |
| CN113773364B (zh) * | 2021-08-25 | 2023-04-28 | 无锡市儿童医院 | 小分子肽及其制备方法和应用 |
| WO2024098026A2 (en) * | 2022-11-04 | 2024-05-10 | Mink Therapeutics, Inc. | B-cell maturation antigen (bcma) chimeric antigen receptor invariant natural killer t cells and uses thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103930117A (zh) * | 2011-10-07 | 2014-07-16 | Gt生物制剂有限公司 | 用作用于营养和医药应用的益生菌剂的细菌 |
| CN105407908A (zh) * | 2013-04-10 | 2016-03-16 | 4D制药研究有限公司 | 罗斯拜瑞氏菌属鞭毛蛋白和免疫调控 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US5783415A (en) | 1991-03-29 | 1998-07-21 | Genentech, Inc. | Method of producing an IL-8 receptor polypeptide |
| AR053579A1 (es) * | 2005-04-15 | 2007-05-09 | Genentech Inc | Tratamiento de la enfermedad inflamatoria intestinal (eii) |
| ES2568938T3 (es) | 2009-04-28 | 2016-05-05 | Vanderbilt University | Composiciones y procedimientos de tratamiento de trastornos que implican apoptosis de células epiteliales |
| JP2014093482A (ja) | 2012-11-06 | 2014-05-19 | Toshiba Corp | 固体撮像装置の製造方法および固体撮像装置 |
| WO2015014973A2 (en) * | 2013-07-31 | 2015-02-05 | Institut National De La Recherche Agronomique | Use of specific glycoside phosphorylases for the implementation of phosphorolysis or reverse phosphorolysis reactions |
| PT3307288T (pt) * | 2015-06-15 | 2019-10-17 | 4D Pharma Res Ltd | Composições compreendendo estirpes bacterianas |
| US10251933B2 (en) | 2017-04-07 | 2019-04-09 | Second Genome, Inc. | Proteins for the treatment of epithelial barrier function disorders |
| US11666627B2 (en) * | 2017-04-07 | 2023-06-06 | Second Genome, Inc. | Proteins for the treatment of epithelial barrier function disorders |
| WO2018223051A1 (en) | 2017-06-02 | 2018-12-06 | Second Genome, Inc. | Proteins for the treatment of epithelial barrier function disorders |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CN105407908A (zh) * | 2013-04-10 | 2016-03-16 | 4D制药研究有限公司 | 罗斯拜瑞氏菌属鞭毛蛋白和免疫调控 |
Non-Patent Citations (1)
| Title |
|---|
| 網路文獻 UniProtKB G2T1E5 2011/11/16 * |
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| AU2023202844A1 (en) | 2023-07-06 |
| CA3059354A1 (en) | 2018-10-11 |
| KR20200003821A (ko) | 2020-01-10 |
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