CN110769844B - 用于治疗上皮屏障功能紊乱的蛋白质 - Google Patents

用于治疗上皮屏障功能紊乱的蛋白质 Download PDF

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Publication number
CN110769844B
CN110769844B CN201880037987.0A CN201880037987A CN110769844B CN 110769844 B CN110769844 B CN 110769844B CN 201880037987 A CN201880037987 A CN 201880037987A CN 110769844 B CN110769844 B CN 110769844B
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seq
protein
amino acid
therapeutic
proteins
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Chinese (zh)
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CN110769844A (zh
Inventor
A·W·韩
A·W·古德耶
T·古亚
T·Z·德桑蒂斯
K·达巴
T·竹内
Y·金
M·I·威尔科匈
S·巴纳斯
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Geneva Co
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Geneva Co
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Prostheses (AREA)
CN201880037987.0A 2017-04-07 2018-04-06 用于治疗上皮屏障功能紊乱的蛋白质 Active CN110769844B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762482963P 2017-04-07 2017-04-07
US62/482,963 2017-04-07
US201762607706P 2017-12-19 2017-12-19
US62/607,706 2017-12-19
US201762611334P 2017-12-28 2017-12-28
US62/611,334 2017-12-28
PCT/US2018/026447 WO2018187682A1 (en) 2017-04-07 2018-04-06 Proteins for the treatment of epithelial barrier function disorders

Publications (2)

Publication Number Publication Date
CN110769844A CN110769844A (zh) 2020-02-07
CN110769844B true CN110769844B (zh) 2025-01-21

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CN201880037987.0A Active CN110769844B (zh) 2017-04-07 2018-04-06 用于治疗上皮屏障功能紊乱的蛋白质

Country Status (12)

Country Link
US (3) US10251933B2 (cg-RX-API-DMAC7.html)
EP (1) EP3606542A4 (cg-RX-API-DMAC7.html)
JP (2) JP7789303B2 (cg-RX-API-DMAC7.html)
KR (1) KR20200003821A (cg-RX-API-DMAC7.html)
CN (1) CN110769844B (cg-RX-API-DMAC7.html)
AU (2) AU2018248324B2 (cg-RX-API-DMAC7.html)
CA (1) CA3059354A1 (cg-RX-API-DMAC7.html)
IL (1) IL269853A (cg-RX-API-DMAC7.html)
MX (2) MX393998B (cg-RX-API-DMAC7.html)
SG (1) SG11201909334TA (cg-RX-API-DMAC7.html)
TW (1) TWI797116B (cg-RX-API-DMAC7.html)
WO (1) WO2018187682A1 (cg-RX-API-DMAC7.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10251933B2 (en) 2017-04-07 2019-04-09 Second Genome, Inc. Proteins for the treatment of epithelial barrier function disorders
US11666627B2 (en) 2017-04-07 2023-06-06 Second Genome, Inc. Proteins for the treatment of epithelial barrier function disorders
EP3773644A4 (en) * 2018-04-06 2021-06-02 Second Genome, Inc. Proteins for the treatment of epithelial barrier function disorders
JP2022512639A (ja) * 2018-10-09 2022-02-07 セカンド ゲノム インコーポレイテッド 上皮バリア機能障害の治療に有効なタンパク質を送達するためのラクトコッカス・ラクティス発現系
WO2021035129A1 (en) * 2019-08-21 2021-02-25 Astrazeneca Collaboration Ventures, Llc Use of brazikumab to treat crohn's disease
US11666629B2 (en) * 2020-01-10 2023-06-06 National Taipei University Of Technology Peptide interacting with toll-like receptor 2 and the composition comprising the same
CN113773364B (zh) * 2021-08-25 2023-04-28 无锡市儿童医院 小分子肽及其制备方法和应用
WO2024098026A2 (en) * 2022-11-04 2024-05-10 Mink Therapeutics, Inc. B-cell maturation antigen (bcma) chimeric antigen receptor invariant natural killer t cells and uses thereof

Citations (1)

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Publication number Priority date Publication date Assignee Title
CN103930117A (zh) * 2011-10-07 2014-07-16 Gt生物制剂有限公司 用作用于营养和医药应用的益生菌剂的细菌

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US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US5783415A (en) 1991-03-29 1998-07-21 Genentech, Inc. Method of producing an IL-8 receptor polypeptide
AR053579A1 (es) * 2005-04-15 2007-05-09 Genentech Inc Tratamiento de la enfermedad inflamatoria intestinal (eii)
ES2568938T3 (es) 2009-04-28 2016-05-05 Vanderbilt University Composiciones y procedimientos de tratamiento de trastornos que implican apoptosis de células epiteliales
JP2014093482A (ja) 2012-11-06 2014-05-19 Toshiba Corp 固体撮像装置の製造方法および固体撮像装置
GB201306536D0 (en) * 2013-04-10 2013-05-22 Gt Biolog Ltd Polypeptide and immune modulation
WO2015014973A2 (en) * 2013-07-31 2015-02-05 Institut National De La Recherche Agronomique Use of specific glycoside phosphorylases for the implementation of phosphorolysis or reverse phosphorolysis reactions
PT3307288T (pt) * 2015-06-15 2019-10-17 4D Pharma Res Ltd Composições compreendendo estirpes bacterianas
US10251933B2 (en) 2017-04-07 2019-04-09 Second Genome, Inc. Proteins for the treatment of epithelial barrier function disorders
US11666627B2 (en) * 2017-04-07 2023-06-06 Second Genome, Inc. Proteins for the treatment of epithelial barrier function disorders
WO2018223051A1 (en) 2017-06-02 2018-12-06 Second Genome, Inc. Proteins for the treatment of epithelial barrier function disorders

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103930117A (zh) * 2011-10-07 2014-07-16 Gt生物制剂有限公司 用作用于营养和医药应用的益生菌剂的细菌

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
G2T1E5.UniProtKB，https://www.uniprot.org/uniprotkb/G2T1E5/entry#sequences.2011,第1-2页第第25-256个氨基酸. *

Also Published As

Publication number Publication date
US20180289770A1 (en) 2018-10-11
US20200148728A1 (en) 2020-05-14
AU2018248324A1 (en) 2019-10-31
MX2019012051A (es) 2020-02-12
CN110769844A (zh) 2020-02-07
SG11201909334TA (en) 2019-11-28
WO2018187682A1 (en) 2018-10-11
AU2018248324B2 (en) 2023-02-09
MX2022008842A (es) 2022-08-02
TW201841649A (zh) 2018-12-01
JP2020516615A (ja) 2020-06-11
US20240066095A1 (en) 2024-02-29
EP3606542A1 (en) 2020-02-12
US10251933B2 (en) 2019-04-09
US11207376B2 (en) 2021-12-28
IL269853A (en) 2019-11-28
EP3606542A4 (en) 2021-01-20
JP2024037834A (ja) 2024-03-19
MX393998B (es) 2025-03-24
JP7789303B2 (ja) 2025-12-22
TWI797116B (zh) 2023-04-01
KR20230144097A (ko) 2023-10-13
AU2023202844A1 (en) 2023-07-06
CA3059354A1 (en) 2018-10-11
KR20200003821A (ko) 2020-01-10

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