TWI781960B - 腺核苷5'-核苷酸酶之抑制劑及相關用途 - Google Patents
腺核苷5'-核苷酸酶之抑制劑及相關用途 Download PDFInfo
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- TWI781960B TWI781960B TW106134280A TW106134280A TWI781960B TW I781960 B TWI781960 B TW I781960B TW 106134280 A TW106134280 A TW 106134280A TW 106134280 A TW106134280 A TW 106134280A TW I781960 B TWI781960 B TW I781960B
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- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662403598P | 2016-10-03 | 2016-10-03 | |
| US62/403,598 | 2016-10-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201817739A TW201817739A (zh) | 2018-05-16 |
| TWI781960B true TWI781960B (zh) | 2022-11-01 |
Family
ID=61831914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW106134280A TWI781960B (zh) | 2016-10-03 | 2017-10-03 | 腺核苷5'-核苷酸酶之抑制劑及相關用途 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US11058704B2 (OSRAM) |
| EP (1) | EP3518934A4 (OSRAM) |
| JP (2) | JP7184761B2 (OSRAM) |
| CN (1) | CN110049767B (OSRAM) |
| TW (1) | TWI781960B (OSRAM) |
| WO (1) | WO2018067424A1 (OSRAM) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11058704B2 (en) | 2016-10-03 | 2021-07-13 | Arcus Biosciences, Inc. | Inhibitors of adenosine 5′-nucleotidase |
| JP2020515559A (ja) * | 2017-03-31 | 2020-05-28 | ぺロトン セラピューティクス,インク. | Cd73阻害剤とその使用 |
| US11129841B2 (en) | 2017-05-10 | 2021-09-28 | Oric Pharmaceuticals, Inc. | CD73 inhibitors |
| WO2019090111A1 (en) | 2017-11-03 | 2019-05-09 | Oric Pharmaceuticals, Inc. | Cd73 inhibitors |
| CN111094317B (zh) * | 2017-12-29 | 2023-03-31 | 上海和誉生物医药科技有限公司 | 一种具有cd73抑制活性的膦酸衍生物、其制备方法和应用 |
| EP3761993A4 (en) * | 2018-03-09 | 2022-03-09 | Arcus Biosciences, Inc. | PARENTERALLY ADMINISTRATED IMMUNE-ENHANCERING DRUGS |
| IL304348B2 (en) * | 2018-04-30 | 2024-08-01 | Oric Pharmaceuticals Inc | CD73 inhibitors |
| TW202017569A (zh) | 2018-05-31 | 2020-05-16 | 美商佩樂敦治療公司 | 用於抑制cd73之組合物及方法 |
| EP3843742A4 (en) * | 2018-08-28 | 2022-04-20 | Jiangsu Hengrui Medicine Co., Ltd. | CD73 INHIBITORS AND THEIR THERAPEUTIC USES |
| CA3126735A1 (en) | 2019-01-11 | 2020-07-16 | Omeros Corporation | Methods and compositions for treating cancer |
| CN112955444B (zh) * | 2019-01-22 | 2023-12-12 | 江苏恒瑞医药股份有限公司 | 一种新型的小分子cd73抑制剂、其制备方法及其在医药上的应用 |
| AU2020239048B2 (en) | 2019-03-12 | 2025-10-16 | Arcus Biosciences, Inc. | Treatment of oncogene-driven cancers |
| WO2020190073A1 (ko) * | 2019-03-20 | 2020-09-24 | 한국화학연구원 | 신규한 아졸로피리미딘 헤테로고리 화합물을 유효 성분으로 함유하는 약제학적 조성물 |
| KR20210144821A (ko) | 2019-03-29 | 2021-11-30 | 아르커스 바이오사이언시즈 인코포레이티드 | 규명된 아데노신 지문을 이용한 암의 치료방법 |
| WO2020210970A1 (en) * | 2019-04-16 | 2020-10-22 | Bioardis Llc | Imidazotriazine derivatives as cd73 inhibitors |
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| US20220331343A1 (en) * | 2019-07-16 | 2022-10-20 | Oric Pharmaceuticals, Inc. | Cd73 inhibitors |
| WO2021040356A1 (en) * | 2019-08-23 | 2021-03-04 | Kainos Medicine, Inc. | C-nucleosides, c-nucleotides and their analogs, equivalents and prodrugs thereof for ectonucleotidase inhibition |
| CA3159248C (en) * | 2019-10-30 | 2024-05-28 | Oric Pharmaceuticals, Inc. | Cd73 inhibitors |
| KR20220155593A (ko) | 2020-03-19 | 2022-11-23 | 아르커스 바이오사이언시즈 인코포레이티드 | Hif-2알파의 억제제로서의 테트랄린 및 테트라히드로퀴놀린 화합물 |
| CR20220611A (es) | 2020-06-02 | 2023-06-07 | Arcus Biosciences Inc | Anticuerpos anti-tigit |
| CN117337288A (zh) | 2021-05-21 | 2024-01-02 | 艾库斯生物科学有限公司 | Axl抑制剂化合物 |
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Also Published As
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| JP2022173493A (ja) | 2022-11-18 |
| US20250319113A1 (en) | 2025-10-16 |
| EP3518934A4 (en) | 2020-06-24 |
| WO2018067424A1 (en) | 2018-04-12 |
| US11058704B2 (en) | 2021-07-13 |
| TW201817739A (zh) | 2018-05-16 |
| JP7184761B2 (ja) | 2022-12-06 |
| US12168023B2 (en) | 2024-12-17 |
| CN110049767A (zh) | 2019-07-23 |
| US20200222441A1 (en) | 2020-07-16 |
| JP2019529500A (ja) | 2019-10-17 |
| EP3518934A1 (en) | 2019-08-07 |
| US20240285665A1 (en) | 2024-08-29 |
| CN110049767B (zh) | 2023-04-04 |
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