TWI752282B - 苯甲酸或其鹽及衍生物用於預防或治療憂鬱症之用途 - Google Patents

苯甲酸或其鹽及衍生物用於預防或治療憂鬱症之用途 Download PDF

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Publication number
TWI752282B
TWI752282B TW107141674A TW107141674A TWI752282B TW I752282 B TWI752282 B TW I752282B TW 107141674 A TW107141674 A TW 107141674A TW 107141674 A TW107141674 A TW 107141674A TW I752282 B TWI752282 B TW I752282B
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TW
Taiwan
Prior art keywords
day
depression
benzoic acid
salts
derivatives
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TW107141674A
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English (en)
Chinese (zh)
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TW201924667A (zh
Inventor
林潔欣
藍先元
Original Assignee
林潔欣
藍先元
科進製藥科技股份有限公司
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Publication of TW201924667A publication Critical patent/TW201924667A/zh
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Publication of TWI752282B publication Critical patent/TWI752282B/zh

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/192Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014External stimulators, e.g. with patch electrodes
    • A61N1/36025External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36053Implantable neurostimulators for stimulating central or peripheral nerve system adapted for vagal stimulation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36082Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
    • A61N1/36096Mood disorders, e.g. depression, anxiety or panic disorder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00Magnetotherapy
    • A61N2/002Magnetotherapy in combination with another treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0613Apparatus adapted for a specific treatment
    • A61N5/0618Psychological treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/38Applying electric currents by contact electrodes alternating or intermittent currents for producing shock effects
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00Magnetotherapy
    • A61N2/004Magnetotherapy specially adapted for a specific therapy
    • A61N2/006Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Developmental Disabilities (AREA)
  • Child & Adolescent Psychology (AREA)
  • Social Psychology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
TW107141674A 2017-11-22 2018-11-22 苯甲酸或其鹽及衍生物用於預防或治療憂鬱症之用途 TWI752282B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762589933P 2017-11-22 2017-11-22
US62/589,933 2017-11-22

Publications (2)

Publication Number Publication Date
TW201924667A TW201924667A (zh) 2019-07-01
TWI752282B true TWI752282B (zh) 2022-01-11

Family

ID=66631699

Family Applications (2)

Application Number Title Priority Date Filing Date
TW110139097A TW202206061A (zh) 2017-11-22 2018-11-22 苯甲酸或其鹽及衍生物用於預防或治療憂鬱症之用途
TW107141674A TWI752282B (zh) 2017-11-22 2018-11-22 苯甲酸或其鹽及衍生物用於預防或治療憂鬱症之用途

Family Applications Before (1)

Application Number Title Priority Date Filing Date
TW110139097A TW202206061A (zh) 2017-11-22 2018-11-22 苯甲酸或其鹽及衍生物用於預防或治療憂鬱症之用途

Country Status (10)

Country Link
US (1) US11826326B2 (ja)
EP (1) EP3713556A4 (ja)
JP (2) JP7034314B2 (ja)
KR (2) KR20230047509A (ja)
CN (1) CN111491627A (ja)
AU (1) AU2018371628B2 (ja)
CA (1) CA3076180C (ja)
MY (1) MY197404A (ja)
TW (2) TW202206061A (ja)
WO (1) WO2019103597A1 (ja)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102292094A (zh) * 2009-01-20 2011-12-21 洛杉矶生物医学研究所在哈伯-加州大学洛杉矶分校医疗中心 增强神经药方疗效的山梨酸与苯甲酸及其衍生物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8974365B2 (en) * 2012-11-25 2015-03-10 Steven Richard Devore Best Treatment of thalamocortical dysrhythmia
EP2808023A1 (en) * 2013-05-30 2014-12-03 Université Pierre et Marie Curie (Paris 6) New drug for the treatment and/or prevention of depressive disorders
JP6836905B2 (ja) * 2014-01-17 2021-03-03 ラッシュ・ユニバーシティ・メディカル・センター 尿素サイクル障害及び神経変性障害におけるベンゾエート含有組成物の使用
WO2015147742A1 (en) * 2014-03-24 2015-10-01 Kaohsiung Chang Gung Memorial Hospital Use of benzoic acid salt in the manufactue of a composition for preventing or treating dementia or mild cognitive impairment
FI3468944T3 (fi) 2016-06-13 2023-01-31 Natriumbentsoaatin yhteiskiteitä ja niiden käyttöjä
US10336679B2 (en) 2016-10-24 2019-07-02 Syneurx International (Taiwan) Corp. Polymorphic forms of sodium benzoate and uses thereof
CN108553456B (zh) 2016-12-29 2020-09-15 天津中医药大学 苯甲酸及其衍生物的用途
JP6550426B2 (ja) * 2017-07-26 2019-07-24 カオシュン・チャン・グン・メモリアル・ホスピタル 認知症または軽度認知障害を予防または治療する組成物を製造するための安息香酸塩の使用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102292094A (zh) * 2009-01-20 2011-12-21 洛杉矶生物医学研究所在哈伯-加州大学洛杉矶分校医疗中心 增强神经药方疗效的山梨酸与苯甲酸及其衍生物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Chien-Han Lai."Sodium Benzoate, a D-Amino Acid Oxidase Inhibitor,Increased Volumes ofThalamus, Amygdala, and Brainstem in a Drug-Naïve Patient With Major Depression",J Neuropsychiatry Clin Neurosci,25:1,Winter 2013. *

Also Published As

Publication number Publication date
WO2019103597A1 (en) 2019-05-31
EP3713556A1 (en) 2020-09-30
EP3713556A4 (en) 2021-10-20
AU2018371628A1 (en) 2020-04-09
KR20230047509A (ko) 2023-04-07
WO2019103597A8 (en) 2019-11-21
JP2022071083A (ja) 2022-05-13
CA3076180A1 (en) 2019-05-31
AU2018371628B2 (en) 2021-08-12
CA3076180C (en) 2022-05-17
US11826326B2 (en) 2023-11-28
US20200360321A1 (en) 2020-11-19
KR20200088861A (ko) 2020-07-23
JP2021504471A (ja) 2021-02-15
CN111491627A (zh) 2020-08-04
JP7034314B2 (ja) 2022-03-11
TW201924667A (zh) 2019-07-01
TW202206061A (zh) 2022-02-16
JP7312286B2 (ja) 2023-07-20
MY197404A (en) 2023-06-16

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