TWI752147B - [6r]-亞甲基四氫葉酸-在基於5-氟尿嘧啶的化療中有效的葉酸替代物 - Google Patents

[6r]-亞甲基四氫葉酸-在基於5-氟尿嘧啶的化療中有效的葉酸替代物 Download PDF

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TWI752147B
TWI752147B TW107100834A TW107100834A TWI752147B TW I752147 B TWI752147 B TW I752147B TW 107100834 A TW107100834 A TW 107100834A TW 107100834 A TW107100834 A TW 107100834A TW I752147 B TWI752147 B TW I752147B
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methylenetetrahydrofolate
day
minutes
weeks
bolus
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TW107100834A
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TW201912159A (zh
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佩爾 倫納特 林德柏格
安德斯 維丹
貢內爾 伊莉莎白 森頓
班特 古斯塔夫松
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瑞典商伊索弗爾醫藥公司
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators

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TW107100834A 2017-08-24 2018-01-09 [6r]-亞甲基四氫葉酸-在基於5-氟尿嘧啶的化療中有效的葉酸替代物 TWI752147B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17187684.0A EP3446704A1 (en) 2017-08-24 2017-08-24 [6r]-mthf - an efficient folate alternative in 5-fluorouracil based chemotherapy
EP17187684.0 2017-08-24

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TW201912159A TW201912159A (zh) 2019-04-01
TWI752147B true TWI752147B (zh) 2022-01-11

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US (2) US11013744B2 (enExample)
EP (3) EP3446704A1 (enExample)
JP (2) JP7356411B2 (enExample)
KR (1) KR102216031B1 (enExample)
CN (1) CN110290802A (enExample)
AU (1) AU2018320069B2 (enExample)
BR (1) BR112020003585A2 (enExample)
CA (2) CA3073555C (enExample)
DK (1) DK3446705T3 (enExample)
ES (1) ES2901621T3 (enExample)
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IL (1) IL272874B2 (enExample)
MX (1) MX2020002053A (enExample)
PL (1) PL3446705T3 (enExample)
PT (1) PT3446705T (enExample)
RU (1) RU2763934C2 (enExample)
SG (2) SG11202001372TA (enExample)
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WO (1) WO2019037898A1 (enExample)

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EP3446704A1 (en) 2017-08-24 2019-02-27 Isofol Medical AB [6r]-mthf - an efficient folate alternative in 5-fluorouracil based chemotherapy
US20240350495A1 (en) * 2023-04-20 2024-10-24 Isofol Medical Ab [6r]-mthf in b6 enhanced 5-fu based chemotherapy of carcinoma
EP4450071A1 (en) 2023-04-20 2024-10-23 Isofol Medical AB [6r]-mthf in b6 enhanced 5-fu based chemotherapy of pancreatic cancer
US20240350467A1 (en) * 2023-04-20 2024-10-24 Isofol Medical Ab [6r]-mthf in b6 enhanced 5-fu based chemotherapy of pancreatic cancer
EP4534088A1 (en) 2023-10-04 2025-04-09 Isofol Medical AB Arfolitixorin for use in vitamin b6-enhanced, 5-fluorouracil-based chemotherapy of carcinomas

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US20240350495A1 (en) 2023-04-20 2024-10-24 Isofol Medical Ab [6r]-mthf in b6 enhanced 5-fu based chemotherapy of carcinoma
US20240350467A1 (en) 2023-04-20 2024-10-24 Isofol Medical Ab [6r]-mthf in b6 enhanced 5-fu based chemotherapy of pancreatic cancer

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WO2019037898A1 (en) 2019-02-28
EP3446705B1 (en) 2021-09-22
CA3073555A1 (en) 2019-02-28
HUE057332T2 (hu) 2022-05-28
EP3446705A1 (en) 2019-02-27
CA3073555C (en) 2023-01-10
MX2020002053A (es) 2020-12-11
KR20190022270A (ko) 2019-03-06
JP2019038797A (ja) 2019-03-14
SG11202001372TA (en) 2020-03-30
PL3446705T3 (pl) 2022-05-23
AU2018320069B2 (en) 2024-11-21
CN110290802A (zh) 2019-09-27
US20210401842A1 (en) 2021-12-30
JP7356411B2 (ja) 2023-10-04
SG10201800195XA (en) 2019-03-28
US12527796B2 (en) 2026-01-20
EP3446704A1 (en) 2019-02-27
KR102216031B1 (ko) 2021-02-16
RU2763934C2 (ru) 2022-01-11
AU2018320069A1 (en) 2020-03-05
EP3672623A1 (en) 2020-07-01
CA2991357A1 (en) 2019-02-24
RU2020109130A3 (enExample) 2021-09-24
IL272874A (en) 2020-04-30
JP2020531490A (ja) 2020-11-05
ES2901621T3 (es) 2022-03-23
IL272874B1 (en) 2023-12-01
RU2020109130A (ru) 2021-09-24
PT3446705T (pt) 2021-12-29
TW201912159A (zh) 2019-04-01
IL272874B2 (en) 2024-04-01
US20190060316A1 (en) 2019-02-28
US11013744B2 (en) 2021-05-25
BR112020003585A2 (pt) 2020-09-01
DK3446705T3 (da) 2021-12-13

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