TWI749529B - Ribonucleic acid test panel and ribonucleic acid test device - Google Patents

Abstract

A ribonucleic acid test panel and a ribonucleic acid test device. The ribonucleic acid test device includes a control unit and a ribonucleic acid test panel. The ribonucleic acid test panel includes a substrate, multiple sensation electrode layers electrically connected with the control unit, at least one primer layer and multiple electrode wiring layers. The multiple sensation electrode layers are disposed on a first surface of the substrate. The at least one primer layer is disposed on the multiple sensation electrode layers and insulated from each other. The multiple electrode wiring layers are electrically connected with the multiple sensation electrode layers and the control unit. By means of the design of the ribonucleic acid test device, the test time is shortened and the cost is lowered.

Description

Ribonucleic acid detection panel and ribonucleic acid detection device

The present invention relates to a ribonucleic acid detection panel and a ribonucleic acid detection device, in particular to a ribonucleic acid detection panel and a ribonucleic acid detection device that can shorten the detection time and reduce the cost.

Due to the current conditions to be tested for users (such as Kawasaki disease, colorectal cancer, hand-foot-mouth disease, new coronavirus (COVID-19) or other RNA viruses), they must be sent to the measurement platform of the medical institution for labeling (such as aggregation After the enzyme chain reaction (PCR) analysis instrument), the user’s blood is taken, and the miRNA virus is extracted through the RNA extraction instrument, and then the miRNA is added in sequence, the miRNA labeling reagent is added, and the miRNA is dripped onto the miRNA chip for staining and staining. Scan to know whether the user is diagnosed according to the fluorescence brightness change and the comparison data. Therefore, it is known that professional equipment (such as measurement platform, RNA extractor) is required to detect RNA (or miRNA) viruses, so that only specific professions are required. Medical personnel will operate these professional instruments, which leads to the problems of high detection difficulty and high cost. In addition, the conventional procedures for detecting viruses through fluorescent labeling methods are numerous and complicated, which makes it take at least 2 hours or more to detect symptoms, which causes the problem of long detection time.

One purpose of the present invention is to provide a ribonucleic acid detection panel that can shorten the detection time and reduce the cost.

Another object of the present invention is to provide a ribonucleic acid detection panel with simple detection operation and good convenience in detection and use.

One purpose of the present invention is to provide a ribonucleic acid detection device that can shorten the detection time and reduce the cost.

Another object of the present invention is to provide a ribonucleic acid detection device with simple detection operation and good convenience in detection and use.

To achieve the above objective, the present invention provides a ribonucleic acid detection panel including a substrate, a plurality of sensing electrode layers, at least one lead layer and a plurality of electrode wiring layers. The substrate has a first surface and a second surface opposite to the first surface. On the surface, the plurality of sensing electrode layers are disposed on the first surface, the at least one primer layer is disposed on the plurality of sensing electrode layers and insulated from each other, and the at least one primer layer is used for corresponding to a detection body with ribonucleic acid In response to each other, the plurality of electrode wiring layers are arranged on the first surface, and the plurality of electrode wiring layers are electrically connected to the plurality of sensing electrodes.

The present invention also provides a ribonucleic acid detection device including a control unit and a ribonucleic acid detection panel. The ribonucleic acid detection panel includes a substrate, a plurality of sensing electrode layers, at least one primer layer, and a plurality of electrode wiring layers. The substrate has a first A surface and a second surface opposite to the first surface, the plurality of sensing electrode layers are electrically connected to the control unit, the plurality of sensing electrode layers are disposed on the first surface, and the at least one primer layer is disposed on the plurality of sensing electrodes The electrode layers are insulated from each other, the at least one primer layer is used for interacting with a corresponding detection body with ribonucleic acid, the plurality of electrode wiring layers are arranged on the first surface, and the plurality of electrode wiring layers are electrically The plurality of sensing electrode layers and the control unit are connected sexually.

Therefore, through the design of the present invention in the above embodiments, the detection time can be shortened and the cost can be reduced, and the user can also perform rapid detection by himself. The detection operation is simple and the detection operation is also quite convenient.

1: Ribonucleic acid detection panel

11: substrate

111: first surface

112: second surface

1111: induction zone

1112: Surrounding area

113: first sensing electrode layer

1131: first sensing electrode

114: second sensing electrode layer

1141: second sensing electrode

115: primer layer

116: Electrode routing layer

117: first insulating layer

118: second insulating layer

1181: Groove

1182: micro channel

2: Ribonucleic acid detection device

21: control unit

22: circuit board

23: Display components

24: processing unit

25: wireless transceiver unit

26: power supply unit

Figure 1 is an exploded perspective view of the ribonucleic acid detection panel according to the first embodiment of the present invention.

Figure 2A is a three-dimensional schematic diagram of the assembly of the ribonucleic acid detection panel according to the first embodiment of the present invention.

Figure 2B is a cross-section and partial enlarged schematic view of the ribonucleic acid detection panel of the first embodiment of the present invention.

Figure 2C is a cross-sectional and partial enlarged schematic view of an embodiment of the ribonucleic acid detection panel of the first embodiment of the present invention.

Figure 3 is an exploded perspective view of the ribonucleic acid detection device according to the second embodiment of the present invention.

FIG. 4A is a three-dimensional schematic diagram of the first configuration of the ribonucleic acid detection device according to the second embodiment of the present invention.

Fig. 4B is a schematic top view of Fig. 4A of the second embodiment of the present invention.

Figure 5 is a three-dimensional schematic diagram of the second configuration of the ribonucleic acid detection device according to the second embodiment of the present invention.

Figure 6 is a three-dimensional schematic diagram of the third aspect of the ribonucleic acid detection device according to the second embodiment of the present invention.

FIG. 7 is a graph of the detection result of the test body and the corresponding primer layer in the second embodiment of the present invention.

The above-mentioned objects and structural and functional characteristics of the present invention will be described based on the preferred embodiments of the accompanying drawings.

The invention provides a ribonucleic acid detection panel and a ribonucleic acid detection device. Please refer to Figure 1 for an exploded perspective view of the ribonucleic acid detection panel of the first embodiment of the present invention; Figure 2A is a perspective view of the assembly of the ribonucleic acid detection panel of the first embodiment of the present invention; Figure 2B is the present invention The cross-section and partial enlarged schematic diagram of the ribonucleic acid detection panel of the first embodiment; Figure 2C is a cross-sectional and partial enlarged schematic diagram of an embodiment of the ribonucleic acid detection panel of the first embodiment of the present invention. As shown in FIGS. 1, 2A, and 2B, the ribonucleic acid (RNA) detection panel 1 includes a substrate 11, a plurality of sensing electrode layers, at least one primer layer 115, and a plurality of electrode wiring layers 116. The substrate 11 is a Glass substrate 11, a circuit board 22 (such as a flexible circuit board) or a polyethylene terephthalate (PET) substrate 11, the substrate 11 in this embodiment is the glass substrate 11, but is not limited to this The substrate 11 has a first surface 111 and a second surface 112 opposite to the first surface 111. The first surface 111 of the substrate 11 is provided with a sensing area 1111 and a peripheral area 1112 surrounding the sensing area 1111, The plurality of sensing electrode layers are arranged in the sensing area 1111 On the first surface 111 of the, the plurality of electrode wiring layers 116 are provided on the first surface 111 of the peripheral area 1112, and the plurality of electrode wiring layers 116 are electrically connected to the plurality of sensing electrode layers.

The plurality of sensing electrode layers are provided with a transparent or opaque first sensing electrode layer 113 and a transparent or opaque second sensing electrode layer 114, and the first sensing electrode layer 113 is provided with a plurality of first sensing electrodes 1131 (such as X-axis sensing Electrodes) are provided on the first surface 111 in the sensing area 1111, the second sensing electrode layer 114 is provided with a plurality of second sensing electrodes 1141 (such as Y-axis sensing electrodes) are provided on the first sensing electrode layer 113, In addition, the first and second sensing electrodes 1131 and 1141 are respectively denoted as X-axis sensing electrodes and Y-axis sensing electrodes in this embodiment, and they are arranged in a staggered arrangement. The plurality of sensing electrode layers and the plurality of electrode wiring layers 116 are made of metal material, such as tin oxide (ITO), indium zinc oxide (IZO), antimony tin oxide Oxide (ATO) or a combination thereof, but not limited to this, in specific implementation, the metal material can also be aluminum (Al), gold (Au), copper, silver (Ag) or other metals Material (such as nickel (Ni), chromium (Cr) or the aforementioned metals and their alloys). The form of the plurality of first and second sensing electrodes 1131 and 1141 is a rhombus in this embodiment, but is not limited to this. In one embodiment, the form of the plurality of first and second sensing electrodes 1131 and 1141 may be one Band, strip, wide band or rectangle. In another embodiment, the plurality of first sensing electrodes 1131 are arranged on the first surface 111 in the sensing area 1111 in a matrix array (such as an M×N array), and the plurality of second sensing electrodes 1141 are in a matrix array ( Such as M×N array) are arranged on the first sensing electrode layer 113, and the first and second sensing electrodes 1131 and 1141 are insulated from each other.

In an alternative embodiment, the plurality of first and second sensing electrodes 1131 and 1141 of the first and second sensing electrode layers 113, 114 are arranged on the first surface 111 of the substrate 11 in parallel to each other, and the primer layer 115 is provided with They are on the first and second sensing electrode layers 113 and 114 and are insulated from each other.

A first insulating layer 117 is provided between the first and second sensing electrode layers 113 and 114, and the material of the first insulating layer 117 is, for example, silicon dioxide (SiO2). The at least one lead layer 115 is formed on the plurality of sensing electrode layers by printing or coating, and the lead layer 115 and the plurality of sensing electrode layers are insulated from each other. The primer layer 115 in this embodiment is represented as a plurality of primer layers 115 arranged on the second sensing electrode layer 114 at intervals, and the primer layer 115 is made of polymer material for supplying and corresponding to a ribonucleic acid (or micro-ribonucleic acid micro). RNA) detection body (such as the user's saliva) reacts with each other, for example, when the user's saliva (that is, the RNA detection body) does not contain RNA virus and the primer layer 115 that does not meet the corresponding specificity reacts with each other, it is non-electrical. The change (such as no change in capacitance or change in dielectric coefficient) is formed as if the user's finger does not touch the touch sensing area 1111, so that the first and second sensing electrodes of the first and second sensing electrode layers 113, 114 are There will be a fixed coupling capacitance between 1131 and 1141. At this time, the electric field (line of power) between the plurality of first and second sensing electrodes 1131 and 1141 is fixed; when the user’s saliva (that is, the RNA detection body) The RNA virus and the primer layer 115 conforming to the corresponding specificity react with each other to produce an obvious electrical change (such as a change in capacitance or a change in dielectric coefficient) after the interaction is formed, as if the user's finger touches the touch sensing area 1111, for example , So that a capacitor is formed between the primer layer 115 and the second sensing electrode layer 114. At this time, the first and second sensing electrodes 1131 and 1141 are originally fixedly distributed on the first and second sensing electrode layers 113 and 114. The electric field (line of power) between the power lines will change because part of the power line is connected to the corresponding primer layer 115 (that is, the electric field changes), which in turn changes the capacitance of the coupling capacitor between the first and second sensing electrodes 1131 and 1141 (That is, the capacitance value changes).

In addition, the aforementioned primer layer 115 is a primer that only reacts with viruses that meet the specific specificity of the corresponding (such as Kawasaki disease, colorectal cancer, hand-foot-mouth disease, new coronavirus (COVID-19) or other viruses with RNA) to generate binding. (Primers), for example, pre-designed specific specific primers are used to detect the virus as a new type of coronavirus (COVID-19), if the user’s saliva (i.e. test body) contains RNA new type of coronavirus (COVID-19) 19) It will react with the primer layer 115 corresponding to the corresponding detection of the new coronavirus, and there will be obvious electrical changes after it is combined, and it means that the user has confirmed the diagnosis (if positive) and has obtained the new coronavirus (COVID-19) (that is, there is Infected with virus); if the user’s saliva (i.e. the test body) does not contain the virus or other viruses (such as Kawasaki disease), the primer layer 115 corresponding to the detection of the new coronavirus is not compatible with each other, and there is no electrical change. It means that the user has not been diagnosed (if negative) and has not received the new coronavirus (that is, not infected) Virus). Among them, the aforementioned primer (or primer, primer) is a small piece of single-stranded DNA or RNA, as the starting point of DNA replication, which exists in the DNA replication (RNA primer) and polymerase chain reaction (PCR) of natural organisms. Synthetic primers (usually DNA primers), composed of nucleotides.

A second insulating layer 118 is provided between the plurality of primer layers 115 and the second sensing electrode layer 114, a third insulating layer 119 is provided between the first sensing electrode layer 113 and the substrate 11, and the second and third insulating layers The layers 118 and 119 are made of silicon dioxide (SiO2). In an alternative embodiment, the third insulating layer 119 can be omitted and not provided, so that the first sensing electrode layer 113 is provided on the substrate 11 (such as a glass substrate). Or PET substrate) on the first surface 111.

The plurality of primer layers 115 are arranged in a strip shape in the sensing area 1111 at intervals in the X-axis direction (or Y-axis direction). On the second insulating layer 118. In one embodiment, referring to FIG. 2C, the second insulating layer 118 is provided with a plurality of grooves 1181 at positions corresponding to the plurality of primer layers 115, and the plurality of primer layers 115 are accommodated in the plurality of grooves of the second insulating layer 118 Within 1181, and between each primer layer 115 and the inner wall of each groove 1181, a micro channel 1182 is defined. The micro channel 1182 is used to collect the test body (such as saliva), thereby increasing the test body The contact area with the corresponding primer layer 115 can effectively improve the detection accuracy and shorten the detection time.

Therefore, through the design of the ribonucleic acid detection panel 1 of the present invention, the detection time can be shortened and the cost can be reduced, and it can also allow users to quickly and instantly detect their physical condition through their own saliva, which not only achieves simple detection operations And it is also quite convenient in detection and use.

Please refer to Figure 3 for an exploded perspective view of the ribonucleic acid detection device of the second embodiment of the present invention; Figure 4A is a perspective view of the first configuration of the ribonucleic acid detection device of the second embodiment of the present invention; page 4B Figure is a schematic top view of Figure 4A of the second embodiment of the present invention; Figure 5 is a three-dimensional schematic view of the second configuration of the ribonucleic acid detection device of the second embodiment of the present invention; Figure 6 is the second embodiment of the present invention A three-dimensional schematic diagram of the third aspect of the ribonucleic acid detection device of the embodiment is combined with reference to Fig. 1. This embodiment mainly applies the ribonucleic acid detection panel 1 of the aforementioned first embodiment to a ribonucleic acid detection (Ribonucleic acid, RNA) device 2, that is, the ribonucleic acid detection device 2 of this embodiment includes a control unit 21 and a ribonucleic acid detection panel 1. The structure and connection relationship of the ribonucleic acid (RNA) detection panel 1 and The effect is the same as the structure, connection relationship and effect of the ribonucleic acid (RNA) detection panel 1 of the aforementioned first embodiment, so it will not be repeated here. The control unit 21 is a central processing unit (CPU), a microcontroller (MCU) or a digital signal processor (DSP), and the control unit 21 is electrically connected to the plurality of electrode wiring layers 116 and the plurality of sensors The electrode layer, the control unit 21 determines whether there is an electrical change between the detection body and the primer layer 115 according to the signal of the capacitance change transmitted by the plurality of sensing electrode layers (i.e., the first and second sensing electrodes 1131 and 1141), and A detection result is generated. The detection result is the result of if there is an electrical change (such as a change in capacitance value) between the detection body and the primer layer 115, or if there is no electrical change (such as no change in capacitance value) between the detection body and the primer layer 115 )the result of.

The control unit 21 in this embodiment has three configurations as follows: the first configuration is shown in FIGS. 3, 4A, and 4B, and the control unit 21 is disposed on the substrate 11 (such as the glass substrate 11 or the PET substrate 11). On the first surface 111 of the peripheral area 1112, and the control unit 21 is combined with the first surface 111 of the substrate 11 by means of chip-on-glass (COG), the control unit 21 is electrically Connected to a circuit board 22 (such as a flexible circuit board 22, FPC), and the circuit board 22 is combined with the substrate 11 by thermal compression bonding to form an integrated body. The circuit board 22 is provided with a display element 23, a processing unit 24, A wireless transceiver unit 25 and a power supply unit 26. The processing unit 24 is electrically connected to the control unit 21 and the display element 23 and the wireless transceiver unit 25. The processing unit 24 is, for example, a central processing unit (CPU) and a digital signal. The processor (DSP) or a controller (MCU) is used to process and execute the signal. For example, the processing unit 24 processes the electrical changes according to the detection result sent by the control unit 21, and generates a detection result information , The detection result information is displayed through the display element 23 (if it shows that it is positive and the diagnosis is confirmed), if the processing unit 24 processes according to the detection result sent by the control unit 21 that there is no electrical change and generates the detection result information, through The display element 23 displays the test result information (for example, it is negative and undiagnosed), so that the user can know from the display element 23 whether he is infected with a virus or not.

The display element 23 is represented in this embodiment as a display for displaying the detection result information, but it is not limited to this. In other embodiments, the display element 23 may be a plurality of light emitting diodes (LED), that is, through Multiple lights indicate the test result. For example, a bright red LED light indicates a positive diagnosis, and a bright blue LED light indicates a negative diagnosis. The power supply unit 26 is a battery in this embodiment, and the power supply unit 26 is used to provide power to the display element 23, the processing unit 24, the wireless transceiver unit 25 and the ribonucleic acid detection panel 1. In one embodiment, the power supply unit 26 may be a rechargeable battery, and the circuit board 22 is provided with a connection port (such as a Micro USB port) for charging the power supply unit 26.

The wireless transceiver unit 25 is a Bluetooth unit (such as a Bluetooth transceiver) in this embodiment, and the Bluetooth unit is used to interact with an electronic device (such as a smart phone, a smart watch, a computer, a laptop, or a tablet). (Not shown in the figure) is wirelessly connected, so that the processing unit 24 wirelessly transmits the detection result information to the electronic device for display through the Bluetooth unit. In specific implementation, the wireless transceiver unit 25 is a Wi-Fi unit or an RF (radio frequency) unit.

The second aspect is shown in FIG. 5. The difference between the second aspect and the aforementioned first aspect is that the control unit 21 is provided on the circuit board 22, and the control unit 21 is packaged by a flip chip film. (COF) is combined on the circuit board 22. The third aspect is shown in FIG. 6, and the difference between the third aspect and the foregoing second aspect is that the substrate 11 is a circuit board (or a PET substrate) instead of the circuit board 22 externally bonded to the second aspect, so that the The control unit 21, the processing unit 24, the display element 23, the wireless transceiver unit 25, and the power supply unit 26 are arranged together in the peripheral area 1112 on the same substrate 11 (or PET substrate 11), and the sensing area 1111 on the substrate 11 is located Approaching the center position of the substrate 11.

When the user wants to detect Kawasaki disease (or Mucocutaneous Lymph Node Syndrome) virus, the user can drop his saliva (ie the test body) onto the sensing area 1111 to make the saliva in The miRNA with miRNA Kawasaki disease virus is selected from miR-30e-3P and the primer layer 115 corresponding to the corresponding detection of Kawasaki disease virus will react with each other to produce a significant electrical change (such as a change in capacitance), so that the control unit 21 according to The capacitance value transmitted by the first and second sensing electrodes 1131 and 1141 The signal of the change determines that there is an electrical change between the test body and the primer layer 115, and generates the detection result and transmits it to the processing unit 24, so that the processing unit 24 performs processing according to the detection result as an electrical change, and transmits the detection result The information is given to the display element 23, so that the user can know the detection result information displayed by the display element 23 (as shown in FIG. 7). If the miRNA in the user’s saliva is miR-223-3P (without miRNA Kawasaki disease virus) and the primer layer 115 corresponding to the Kawasaki disease virus detection fails to interact with each other, there will be no electrical changes, so that the processing unit 24 will respond according to the control unit. The detection result sent by 21 is processed for the non-electricity change, and the detection result information is sent, so that the user can know the detection result information displayed by the display element 23 (as shown in FIG. 7). Among them, as shown in Figure 7 is the test result chart of the test body and the corresponding primer layer. In the chart, the test result value corresponding to the test body miR-30e-3P (such as 32.5) is greater than the test result corresponding to the test body miR-223-3P Value (such as 6.2), the default value of the detection result value in this embodiment is such as 15, that is, the detection result value is equal to or greater than 15 to indicate a diagnosis, and the larger the detection result value, the number of days the user has the virus in the body The longer the time, and the more severe the symptoms, if the test result is less than 15, it means that the diagnosis is not confirmed.

Therefore, the ribonucleic acid detection device 2 of the present invention is designed to detect diseases through electrical measurement, so that the detection time can be effectively shortened, such as detecting diseases (such as disease viruses) within 15 minutes, and reducing costs. And it also allows any user to perform real-time detection at home by himself, which not only achieves simple detection operation, but also quite convenient in detection use.

1: Ribonucleic acid detection panel

11: substrate

111: first surface

112: second surface

113: first sensing electrode layer

1131: first sensing electrode

114: second sensing electrode layer

1141: second sensing electrode

115: primer layer

116: Electrode routing layer

117: first insulating layer

118: second insulating layer

Claims (19)

A ribonucleic acid detection panel, comprising: a substrate having a first surface and a second surface opposite to the first surface; a plurality of sensing electrode layers, provided with a first sensing electrode layer and a second sensing electrode layer, the first A sensing electrode layer is provided on the first surface, the second sensing electrode layer is provided on the first sensing electrode layer, and a first insulating layer is provided between the first and second sensing electrode layers; at least one primer layer , Arranged on the second sensing electrode layer and insulated from each other, the at least one primer layer is used for interacting with a corresponding detection body with ribonucleic acid; and a plurality of electrode wiring layers are arranged on the first surface , The plurality of electrode wiring layers are electrically connected to the plurality of sensing electrode layers. The ribonucleic acid detection panel according to claim 1, wherein the first surface of the substrate is provided with a sensing area and a peripheral area surrounding the sensing area, and the plurality of sensing electrode layers are provided on the first surface of the sensing area , The plurality of electrode wiring layers are arranged on the first surface of the peripheral area. The ribonucleic acid detection panel according to claim 2, wherein the at least one primer layer is formed on the second sensing electrode layer by printing or coating, and the first sensing electrode layer is provided on the first surface in the sensing area superior. The ribonucleic acid detection panel according to claim 3, wherein the plurality of primer layers are arranged on the second sensing electrode layer at intervals, and a second insulating layer is provided between the plurality of primer layers and the second sensing electrode layer. The ribonucleic acid detection panel according to claim 4, wherein a plurality of grooves are provided on the second insulating layer corresponding to the plurality of primer layers, the plurality of primer layers are accommodated in the plurality of grooves, and each primer A micro channel is defined between the layer and the inner wall of each groove. The ribonucleic acid detection panel according to claim 1, wherein the substrate is a glass substrate, a circuit board or a polyethylene terephthalate substrate. The ribonucleic acid detection panel according to claim 1, wherein the materials of the plurality of sensing electrode layers and the plurality of electrode wiring layers are tin oxide (ITO), indium zinc oxide (IZO), antimony tin oxide (ATO) ), the material of the at least one primer layer is a polymer material. The ribonucleic acid detection panel according to claim 1, wherein the plurality of sensing electrode layers and the plurality of electrode wiring layers are made of metal material, and the metal material is aluminum, gold, copper or silver. A ribonucleic acid detection device, comprising: a control unit; and a ribonucleic acid detection panel, comprising: a substrate having a first surface and a second surface opposite to the first surface; a plurality of sensing electrode layers, which are electrically connected In the control unit, the plurality of sensing electrode layers are provided with a first sensing electrode layer and a second sensing electrode layer, the first sensing electrode layer is provided on the first surface, and the second sensing electrode layer is provided on the first sensing electrode. On the electrode layer, a first insulating layer is provided between the first and second sensing electrode layers; at least one lead layer is provided on the second sensing electrode layer and insulated from each other, and the at least one lead layer is used for Corresponding to a detection body with ribonucleic acid reacting with each other; and a plurality of electrode wiring layers are arranged on the first surface, and the plurality of electrode wiring layers are electrically connected to the plurality of sensing electrode layers and the control unit. The ribonucleic acid detection device according to claim 9, wherein the control unit is electrically connected to a circuit board, and the circuit board is provided with a display element, a processing unit, a wireless transceiver unit and a power supply unit, and the processing unit is electrically connected The control unit is connected with the display element and the wireless transceiving unit, and the power supply unit is used to provide power to the display element, the processing unit, the wireless transceiving unit and the ribonucleic acid detection panel. The ribonucleic acid detection device according to claim 10, wherein the wireless transceiver unit is a Bluetooth unit, a Wi-Fi unit, and an RF unit. The ribonucleic acid detection device according to claim 10, wherein the display element is a plurality of light-emitting diodes or a display, and the control unit is a central processing unit, a microcontroller or a digital signal processor. The ribonucleic acid detection device according to claim 10, wherein the control unit is provided on the first surface of the substrate or on the circuit board. The ribonucleic acid detection device according to claim 9, wherein the first surface of the substrate is provided with a sensing area and a peripheral area surrounding the sensing area, and the plurality of sensing electrode layers are provided on the first surface of the sensing area , The plurality of electrode wiring layers are arranged on the first surface of the peripheral area. The ribonucleic acid detection device according to claim 14, wherein the at least one primer layer is formed on the second sensing electrode layer by printing or coating, and the first sensing electrode layer is provided on the first surface in the sensing area superior. The ribonucleic acid detection device according to claim 15, wherein the plurality of primer layers are arranged on the second sensing electrode layer at intervals, and a second insulating layer is provided between the plurality of primer layers and the second sensing electrode layer. The ribonucleic acid detection device according to claim 16, wherein the second insulating layer is provided with a plurality of grooves corresponding to the plurality of primer layers, and the plurality of primer layers are accommodated in the plurality of grooves of the second insulating layer And a micro channel is defined between each primer layer and the inner wall of each groove. The ribonucleic acid detection device according to claim 9, wherein the substrate is a glass substrate, a circuit board or a polyethylene terephthalate substrate, and the plurality of sensing electrode layers and the plurality of electrode wiring layers are made of Metal material, the metal material is tin oxide (ITO), indium zinc oxide (IZO) or antimony tin oxide (ATO), aluminum, gold, copper or silver, and the material of the at least one primer layer is polymer Material. A ribonucleic acid detection panel, including: A substrate having a first surface and a second surface opposite to the first surface; a plurality of sensing electrode layers are provided with a first sensing electrode layer and a second sensing electrode layer, the first and second sensing electrode layers are parallel to each other Correspondingly disposed on the first surface; at least one primer layer is provided on one or both of the first and second sensing electrode layers and insulated from each other, and the at least one primer layer is used for supplying and corresponding one with ribose The detection body of the nucleic acid reacts with each other; and a plurality of electrode wiring layers are arranged on the first surface, and the plurality of electrode wiring layers are electrically connected to the plurality of sensing electrode layers.

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