TWI747885B - 用於治療類風濕性關節炎之組成物及方法 - Google Patents

用於治療類風濕性關節炎之組成物及方法 Download PDF

Info

Publication number
TWI747885B
TWI747885B TW106107363A TW106107363A TWI747885B TW I747885 B TWI747885 B TW I747885B TW 106107363 A TW106107363 A TW 106107363A TW 106107363 A TW106107363 A TW 106107363A TW I747885 B TWI747885 B TW I747885B
Authority
TW
Taiwan
Prior art keywords
antibody
individual
administered
weeks
score
Prior art date
Application number
TW106107363A
Other languages
English (en)
Chinese (zh)
Other versions
TW201808993A (zh
Inventor
迪波拉 包爾
亞歷山大 勃狄
尼爾 格林漢
永 林
賈尼 帕里諾
拉胡 帕特爾
珍奈特 汎阿德勒斯伯格
胡貝特 汎霍赫斯特拉騰
Original Assignee
法商賽諾菲生物技術公司
美商再生元醫藥公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP16305253.3A external-priority patent/EP3216461A1/en
Application filed by 法商賽諾菲生物技術公司, 美商再生元醫藥公司 filed Critical 法商賽諾菲生物技術公司
Publication of TW201808993A publication Critical patent/TW201808993A/zh
Application granted granted Critical
Publication of TWI747885B publication Critical patent/TWI747885B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW106107363A 2016-03-07 2017-03-07 用於治療類風濕性關節炎之組成物及方法 TWI747885B (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
??16305253.3 2016-03-07
EP16305253.3 2016-03-07
EP16305253.3A EP3216461A1 (en) 2016-03-07 2016-03-07 Compositions and methods for treating rheumatoid arthritis
EP16170664 2016-05-20
EP16170664.3 2016-05-20
??16170664.3 2016-05-20
??16306111.2 2016-09-05
EP16306111 2016-09-05
EP16306111.2 2016-09-05

Publications (2)

Publication Number Publication Date
TW201808993A TW201808993A (zh) 2018-03-16
TWI747885B true TWI747885B (zh) 2021-12-01

Family

ID=58387910

Family Applications (3)

Application Number Title Priority Date Filing Date
TW106107363A TWI747885B (zh) 2016-03-07 2017-03-07 用於治療類風濕性關節炎之組成物及方法
TW110146922A TWI819435B (zh) 2016-03-07 2017-03-07 用於治療類風濕性關節炎之組成物及方法
TW112135625A TW202419103A (zh) 2016-03-07 2017-03-07 用於治療類風濕性關節炎之組成物及方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
TW110146922A TWI819435B (zh) 2016-03-07 2017-03-07 用於治療類風濕性關節炎之組成物及方法
TW112135625A TW202419103A (zh) 2016-03-07 2017-03-07 用於治療類風濕性關節炎之組成物及方法

Country Status (18)

Country Link
US (1) US20190100585A1 (enExample)
EP (1) EP3426295A1 (enExample)
JP (2) JP7166925B2 (enExample)
KR (3) KR20230093522A (enExample)
CN (1) CN109069642A (enExample)
AU (2) AU2017229364A1 (enExample)
BR (1) BR112018067851A2 (enExample)
CA (1) CA3016880A1 (enExample)
CL (1) CL2018002559A1 (enExample)
CR (1) CR20180465A (enExample)
EA (1) EA201892005A1 (enExample)
IL (2) IL308539A (enExample)
MX (2) MX2018010815A (enExample)
PH (1) PH12018501894A1 (enExample)
SG (2) SG10202012182YA (enExample)
TN (1) TN2018000312A1 (enExample)
TW (3) TWI747885B (enExample)
WO (1) WO2017155990A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3417B1 (ar) 2010-01-08 2019-10-20 Regeneron Pharma الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
MX2020005630A (es) * 2017-11-30 2020-08-20 Bio Thera Solutions Ltd Formulacion liquida de anticuerpos humanizados para el tratamiento de enfermedades relacionadas con il-6.
KR20260109977A (ko) 2018-08-29 2026-07-13 리제너론 파아마슈티컬스, 인크. 류마티스성 관절염을 갖는 대상체를 치료하기 위한 방법 및 조성물
JP7542543B2 (ja) 2019-01-31 2024-08-30 サノフィ・バイオテクノロジー 若年性特発性関節炎を治療するための抗ｉｌ－６受容体抗体
JP2022545312A (ja) 2019-04-24 2022-10-27 サノフィ・バイオテクノロジー 関節リウマチの診断及び処置の方法
CA3142710A1 (en) * 2019-06-04 2020-12-10 Sanofi Biotechnology Compositions and methods for treating pain in subjects with rheumatoid arthritis
WO2023020563A1 (en) * 2021-08-18 2023-02-23 Bio-Thera Solutions, Ltd. Liquid formulations comprising high concentrations humanized antibodies for treating il-6 related diseases
WO2026047197A1 (en) 2024-08-30 2026-03-05 Sanofi Biotechnology Differential biomarkers for anti-interleukin-6 and anti-tumor necrosis factor-α treatment response in rheumatoid arthritis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201321017A (zh) * 2011-10-11 2013-06-01 再生元醫藥公司 用於治療類風濕性關節炎之組成物及其使用方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5215534A (en) 1991-12-02 1993-06-01 Lawrence De Harde Safety syringe system
CA2817619A1 (en) * 2001-06-08 2002-12-08 Abbott Laboratories (Bermuda) Ltd. Methods of administering anti-tnf.alpha. antibodies
US20080131374A1 (en) * 2006-04-19 2008-06-05 Medich John R Uses and compositions for treatment of rheumatoid arthritis
ATE537190T1 (de) 2006-06-02 2011-12-15 Regeneron Pharma Hochaffine antikörper gegen den humanen il-6- rezeptor
GB0718684D0 (en) * 2007-09-24 2007-10-31 Roche Products Ltd Treatment method
JO3417B1 (ar) * 2010-01-08 2019-10-20 Regeneron Pharma الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
US9427531B2 (en) 2010-06-28 2016-08-30 Sanofi-Aventis Deutschland Gmbh Auto-injector
US9248242B2 (en) 2012-04-20 2016-02-02 Safety Syringes, Inc. Anti-needle stick safety device for injection device
US20140155827A1 (en) 2012-12-03 2014-06-05 Mylan, Inc. Medicament information system and method
KR20230155586A (ko) * 2013-11-22 2023-11-10 사노피 바이오테크놀로지 류마티스 관절염 치료를 위한 조성물 및 이의 이용방법

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201321017A (zh) * 2011-10-11 2013-06-01 再生元醫藥公司 用於治療類風濕性關節炎之組成物及其使用方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ClinicalTrials.gov Identifier: NCT02332590. First Posted : January 7, 2015. [online] https://clinicaltrials.gov/ct2/show/NCT02332590 *

Also Published As

Publication number Publication date
KR20180114955A (ko) 2018-10-19
MX2023014841A (es) 2024-01-15
TWI819435B (zh) 2023-10-21
WO2017155990A1 (en) 2017-09-14
TW202239767A (zh) 2022-10-16
KR20230093522A (ko) 2023-06-27
IL308539A (en) 2024-01-01
AU2017229364A1 (en) 2018-10-25
SG11201807614SA (en) 2018-10-30
NZ746988A (en) 2023-10-27
TW201808993A (zh) 2018-03-16
JP2023011711A (ja) 2023-01-24
AU2024203011A1 (en) 2024-07-11
JP2019507775A (ja) 2019-03-22
KR20260049875A (ko) 2026-04-14
CL2018002559A1 (es) 2019-03-01
IL261515B2 (en) 2024-04-01
CR20180465A (es) 2019-03-04
IL261515B1 (en) 2023-12-01
EP3426295A1 (en) 2019-01-16
EA201892005A1 (ru) 2019-02-28
MX2018010815A (es) 2019-01-10
CA3016880A1 (en) 2017-09-14
JP7166925B2 (ja) 2022-11-08
US20190100585A1 (en) 2019-04-04
TN2018000312A1 (en) 2020-01-16
SG10202012182YA (en) 2021-01-28
JP7745529B2 (ja) 2025-09-29
CN109069642A (zh) 2018-12-21
TW202419103A (zh) 2024-05-16
PH12018501894A1 (en) 2019-05-15
IL261515A (en) 2018-10-31
BR112018067851A2 (pt) 2019-02-05

Similar Documents

Publication Publication Date Title
JP7745529B2 (ja) 関節リウマチを処置するための組成物及び方法
JP6877357B2 (ja) Ｇｄｆ８阻害剤を用いて、強度及び機能を増加させる方法
DK2892927T3 (en) METHODS OF TREATING ATOPIC DERMATITIS BY ADMINISTRATION OF AN IL-4R ANTAGONIST
US20230127528A1 (en) Compositions and methods for treating juvenile idiopathic arthritis
JP2025134086A (ja) 関節リウマチを有する対象における疼痛を治療するための組成物および方法
US20230174657A1 (en) Compositions comprising an antibody against interleukin-6 receptor for the treatment of rheumatoid arthritis and methods of using same
AU2017366870B2 (en) A pharmaceutical composition for averting opioid addiction
RU2822089C2 (ru) Антитело к рецептору il-6 для лечения ювенильного идиопатического артрита
NZ746988B2 (en) Compositions and methods for treating rheumatoid arthritis
EP4157872A1 (en) Compositions comprising an antibody against interleukin-6 receptor for the treatment of rheumatoid arthritis and methods of using same