TWI729039B - 用於預防及治療眼疼痛之氨基膦衍生物 - Google Patents

用於預防及治療眼疼痛之氨基膦衍生物 Download PDF

Info

Publication number
TWI729039B
TWI729039B TW105139517A TW105139517A TWI729039B TW I729039 B TWI729039 B TW I729039B TW 105139517 A TW105139517 A TW 105139517A TW 105139517 A TW105139517 A TW 105139517A TW I729039 B TWI729039 B TW I729039B
Authority
TW
Taiwan
Prior art keywords
group
ethyl
hydroxy
compound
propionic acid
Prior art date
Application number
TW105139517A
Other languages
English (en)
Chinese (zh)
Other versions
TW201726146A (zh
Inventor
哈維 博拉斯
米契爾 渥姆
史帝芬 梅里克帕莎堤年茲
安娜貝爾 瑞克斯雷果力果
Original Assignee
法商領先藥物公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 法商領先藥物公司 filed Critical 法商領先藥物公司
Publication of TW201726146A publication Critical patent/TW201726146A/zh
Application granted granted Critical
Publication of TWI729039B publication Critical patent/TWI729039B/zh

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Biochemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW105139517A 2015-11-30 2016-11-30 用於預防及治療眼疼痛之氨基膦衍生物 TWI729039B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1561598A FR3044227B1 (fr) 2015-11-30 2015-11-30 Derives aminophosphiniques pour la prevention et le traitement des douleurs oculaires
FR1561598 2015-11-30

Publications (2)

Publication Number Publication Date
TW201726146A TW201726146A (zh) 2017-08-01
TWI729039B true TWI729039B (zh) 2021-06-01

Family

ID=55346018

Family Applications (1)

Application Number Title Priority Date Filing Date
TW105139517A TWI729039B (zh) 2015-11-30 2016-11-30 用於預防及治療眼疼痛之氨基膦衍生物

Country Status (15)

Country Link
US (2) US20180344753A1 (enExample)
EP (1) EP3383403B1 (enExample)
JP (1) JP6889176B2 (enExample)
KR (1) KR102657652B1 (enExample)
CN (2) CN112121008A (enExample)
BR (1) BR112018010007A2 (enExample)
CA (1) CA3006365A1 (enExample)
DK (1) DK3383403T3 (enExample)
ES (1) ES2773148T3 (enExample)
FR (1) FR3044227B1 (enExample)
IL (1) IL259562B (enExample)
MX (1) MX382921B (enExample)
TW (1) TWI729039B (enExample)
WO (1) WO2017093322A1 (enExample)
ZA (1) ZA201804037B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9993427B2 (en) * 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture
US11090317B2 (en) * 2017-03-09 2021-08-17 Pharmaleads Aminophosphinic derivatives for preventing and treating eye inflammation
FR3063635B1 (fr) * 2017-03-09 2019-06-07 Pharmaleads Derives aminophosphiniques pour la prevention et le traitement de l'inflammation oculaire
FR3104581B1 (fr) * 2019-12-11 2021-11-26 Pharmaleads Procédé de préparation industrielle du sel disodique de ((2S)-3-([1,1'-biphenyl]-4-yl)-2-((hydroxy((1R)-1-(((1-(isobutyryloxy)ethoxy)carbonyl)amino)ethyl)phosphoryl) methyl)propanoyl)-L-alanine

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0987291A (ja) * 1995-09-26 1997-03-31 Wakamoto Pharmaceut Co Ltd 新規なアラニン誘導体
FR2755135B1 (fr) * 1996-10-25 2002-12-27 Inst Nat Sante Rech Med Nouveaux derives d'(alpha-aminophosphino)peptides, leur procede de preparation et les compositions qui les contiennent
JP2001506652A (ja) * 1996-12-16 2001-05-22 アルコン ラボラトリーズ，インコーポレイテッド 眼の痛みを治療するためのκオピオイド・アゴニストの局所使用
FR2777780B1 (fr) * 1998-04-22 2001-05-04 Inst Nat Sante Rech Med Derives d'(alpha-aminophosphino) peptides, leur procede de preparation et les compositions qui les contiennent
FR2934267B1 (fr) * 2008-07-23 2010-08-13 Pharmaleads Derives aminophosphiniques utiles dans le traitement de la douleur
FR2934627B1 (fr) 2008-07-29 2010-08-13 Paul Marie Bernard Dispositif de positionnement et de calage d'un garde corps escamotable sur plateforme support de banches
CA2901208A1 (en) * 2013-02-13 2014-08-21 Novartis Ag Topical ocular analgesic agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Roques et al.:"Inhibition the breakdown of Endogenous Opioids and Cannbinoids to Alleviate Pain";Nature Review Drug Discovery,vol.11,2012-04,pages 292-310 *

Also Published As

Publication number Publication date
MX2018006580A (es) 2018-08-01
CN112121008A (zh) 2020-12-25
EP3383403B1 (fr) 2019-12-25
BR112018010007A2 (pt) 2018-11-21
JP6889176B2 (ja) 2021-06-18
IL259562B (en) 2020-08-31
US10688113B2 (en) 2020-06-23
FR3044227B1 (fr) 2017-11-24
TW201726146A (zh) 2017-08-01
KR20180095555A (ko) 2018-08-27
FR3044227A1 (fr) 2017-06-02
CN108289901B (zh) 2021-05-04
WO2017093322A1 (fr) 2017-06-08
ZA201804037B (en) 2020-07-29
DK3383403T3 (da) 2020-03-16
IL259562A (en) 2018-07-31
MX382921B (es) 2025-03-13
KR102657652B1 (ko) 2024-04-15
HK1259181A1 (zh) 2019-11-29
US20180344753A1 (en) 2018-12-06
CA3006365A1 (fr) 2017-06-08
CN108289901A (zh) 2018-07-17
US20190167701A1 (en) 2019-06-06
EP3383403A1 (fr) 2018-10-10
ES2773148T3 (es) 2020-07-09
JP2018536714A (ja) 2018-12-13

Similar Documents

Publication Publication Date Title
US6294553B1 (en) Method for treating ocular pain
ES2204879T3 (es) Neuroprotector para el ojo de mamiferos mediante administracion de bloqueadores del canal de potasio.
JP2001509780A (ja) 緑内障および眼虚血の治療のための特定のイソキノリンスルホニル化合物の使用
AU2001238313A1 (en) Method for treating ocular pain
US10688113B2 (en) Methods of treating eye pain with aminophosphinic derivatives
WO2019131901A1 (ja) ピリジルアミノ酢酸化合物を含有する医薬製剤
JP2023067982A (ja) 眼の炎症を予防及び治療するためのアミノホスフィン誘導体
HK40042434A (en) Aminophosphinic derivatives for preventing and treating eye pain
HK1259181B (en) Aminophosphinic derivatives for preventing and treating eye pain
FR3063635B1 (fr) Derives aminophosphiniques pour la prevention et le traitement de l'inflammation oculaire
HK40016589B (en) Aminophosphinic derivatives for preventing and treating ocular inflammation
HK40016589A (en) Aminophosphinic derivatives for preventing and treating ocular inflammation
HK1051499B (en) Method for treating ocular pain