TWI729039B - 用於預防及治療眼疼痛之氨基膦衍生物 - Google Patents

用於預防及治療眼疼痛之氨基膦衍生物 Download PDF

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Publication number
TWI729039B
TWI729039B TW105139517A TW105139517A TWI729039B TW I729039 B TWI729039 B TW I729039B TW 105139517 A TW105139517 A TW 105139517A TW 105139517 A TW105139517 A TW 105139517A TW I729039 B TWI729039 B TW I729039B
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TW
Taiwan
Prior art keywords
group
ethyl
hydroxy
compound
propionic acid
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TW105139517A
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English (en)
Chinese (zh)
Other versions
TW201726146A (zh
Inventor
哈維 博拉斯
米契爾 渥姆
史帝芬 梅里克帕莎堤年茲
安娜貝爾 瑞克斯雷果力果
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法商領先藥物公司
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Publication of TW201726146A publication Critical patent/TW201726146A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Biochemistry (AREA)
TW105139517A 2015-11-30 2016-11-30 用於預防及治療眼疼痛之氨基膦衍生物 TWI729039B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1561598 2015-11-30
FR1561598A FR3044227B1 (fr) 2015-11-30 2015-11-30 Derives aminophosphiniques pour la prevention et le traitement des douleurs oculaires

Publications (2)

Publication Number Publication Date
TW201726146A TW201726146A (zh) 2017-08-01
TWI729039B true TWI729039B (zh) 2021-06-01

Family

ID=55346018

Family Applications (1)

Application Number Title Priority Date Filing Date
TW105139517A TWI729039B (zh) 2015-11-30 2016-11-30 用於預防及治療眼疼痛之氨基膦衍生物

Country Status (15)

Country Link
US (2) US20180344753A1 (enExample)
EP (1) EP3383403B1 (enExample)
JP (1) JP6889176B2 (enExample)
KR (1) KR102657652B1 (enExample)
CN (2) CN112121008A (enExample)
BR (1) BR112018010007A2 (enExample)
CA (1) CA3006365A1 (enExample)
DK (1) DK3383403T3 (enExample)
ES (1) ES2773148T3 (enExample)
FR (1) FR3044227B1 (enExample)
IL (1) IL259562B (enExample)
MX (1) MX382921B (enExample)
TW (1) TWI729039B (enExample)
WO (1) WO2017093322A1 (enExample)
ZA (1) ZA201804037B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9993427B2 (en) * 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture
EP3592361B1 (fr) * 2017-03-09 2023-09-13 IACTA Pharmaceuticals, Inc. Dérivés aminophosphiniques pour la prévention et le traitement de l'inflammation oculaire
FR3063635B1 (fr) * 2017-03-09 2019-06-07 Pharmaleads Derives aminophosphiniques pour la prevention et le traitement de l'inflammation oculaire
FR3104581B1 (fr) * 2019-12-11 2021-11-26 Pharmaleads Procédé de préparation industrielle du sel disodique de ((2S)-3-([1,1'-biphenyl]-4-yl)-2-((hydroxy((1R)-1-(((1-(isobutyryloxy)ethoxy)carbonyl)amino)ethyl)phosphoryl) methyl)propanoyl)-L-alanine

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0987291A (ja) * 1995-09-26 1997-03-31 Wakamoto Pharmaceut Co Ltd 新規なアラニン誘導体
FR2755135B1 (fr) * 1996-10-25 2002-12-27 Inst Nat Sante Rech Med Nouveaux derives d'(alpha-aminophosphino)peptides, leur procede de preparation et les compositions qui les contiennent
CA2275167C (en) * 1996-12-16 2008-10-28 Alcon Laboratories, Inc. The topical use of kappa opioid agonists to treat ocular pain
FR2777780B1 (fr) * 1998-04-22 2001-05-04 Inst Nat Sante Rech Med Derives d'(alpha-aminophosphino) peptides, leur procede de preparation et les compositions qui les contiennent
FR2934267B1 (fr) * 2008-07-23 2010-08-13 Pharmaleads Derives aminophosphiniques utiles dans le traitement de la douleur
FR2934627B1 (fr) 2008-07-29 2010-08-13 Paul Marie Bernard Dispositif de positionnement et de calage d'un garde corps escamotable sur plateforme support de banches
KR20150119082A (ko) * 2013-02-13 2015-10-23 노파르티스 아게 국소 안구 진통제

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Roques et al.:"Inhibition the breakdown of Endogenous Opioids and Cannbinoids to Alleviate Pain";Nature Review Drug Discovery,vol.11,2012-04,pages 292-310 *

Also Published As

Publication number Publication date
WO2017093322A1 (fr) 2017-06-08
FR3044227B1 (fr) 2017-11-24
IL259562A (en) 2018-07-31
EP3383403B1 (fr) 2019-12-25
JP6889176B2 (ja) 2021-06-18
CA3006365A1 (fr) 2017-06-08
MX2018006580A (es) 2018-08-01
ES2773148T3 (es) 2020-07-09
CN108289901A (zh) 2018-07-17
KR20180095555A (ko) 2018-08-27
IL259562B (en) 2020-08-31
US20190167701A1 (en) 2019-06-06
BR112018010007A2 (pt) 2018-11-21
ZA201804037B (en) 2020-07-29
FR3044227A1 (fr) 2017-06-02
CN112121008A (zh) 2020-12-25
KR102657652B1 (ko) 2024-04-15
MX382921B (es) 2025-03-13
DK3383403T3 (da) 2020-03-16
JP2018536714A (ja) 2018-12-13
HK1259181A1 (zh) 2019-11-29
US20180344753A1 (en) 2018-12-06
TW201726146A (zh) 2017-08-01
EP3383403A1 (fr) 2018-10-10
US10688113B2 (en) 2020-06-23
CN108289901B (zh) 2021-05-04

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