FR3044227B1 - Derives aminophosphiniques pour la prevention et le traitement des douleurs oculaires - Google Patents

Derives aminophosphiniques pour la prevention et le traitement des douleurs oculaires

Info

Publication number
FR3044227B1
FR3044227B1 FR1561598A FR1561598A FR3044227B1 FR 3044227 B1 FR3044227 B1 FR 3044227B1 FR 1561598 A FR1561598 A FR 1561598A FR 1561598 A FR1561598 A FR 1561598A FR 3044227 B1 FR3044227 B1 FR 3044227B1
Authority
FR
France
Prior art keywords
prevention
treatment
eye pain
aminophosphine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR1561598A
Other languages
English (en)
French (fr)
Other versions
FR3044227A1 (fr
Inventor
Herve Poras
Michel Wurm
Parsadaniantz Stephane Melik
Le Goazigo Annabelle Reaux
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmaleads SA
Original Assignee
Pharmaleads SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR1561598A priority Critical patent/FR3044227B1/fr
Application filed by Pharmaleads SA filed Critical Pharmaleads SA
Priority to PCT/EP2016/079285 priority patent/WO2017093322A1/fr
Priority to HK19101231.6A priority patent/HK1259181B/xx
Priority to ES16809676T priority patent/ES2773148T3/es
Priority to JP2018546763A priority patent/JP6889176B2/ja
Priority to US15/779,220 priority patent/US20180344753A1/en
Priority to MX2018006580A priority patent/MX382921B/es
Priority to CN202010893476.8A priority patent/CN112121008A/zh
Priority to CA3006365A priority patent/CA3006365A1/fr
Priority to DK16809676.6T priority patent/DK3383403T3/da
Priority to CN201680070092.8A priority patent/CN108289901B/zh
Priority to BR112018010007-2A priority patent/BR112018010007A2/pt
Priority to EP16809676.6A priority patent/EP3383403B1/fr
Priority to TW105139517A priority patent/TWI729039B/zh
Priority to KR1020187018504A priority patent/KR102657652B1/ko
Publication of FR3044227A1 publication Critical patent/FR3044227A1/fr
Application granted granted Critical
Publication of FR3044227B1 publication Critical patent/FR3044227B1/fr
Priority to IL259562A priority patent/IL259562B/en
Priority to ZA2018/04037A priority patent/ZA201804037B/en
Priority to US16/272,573 priority patent/US10688113B2/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Biochemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR1561598A 2015-11-30 2015-11-30 Derives aminophosphiniques pour la prevention et le traitement des douleurs oculaires Expired - Fee Related FR3044227B1 (fr)

Priority Applications (18)

Application Number Priority Date Filing Date Title
FR1561598A FR3044227B1 (fr) 2015-11-30 2015-11-30 Derives aminophosphiniques pour la prevention et le traitement des douleurs oculaires
BR112018010007-2A BR112018010007A2 (pt) 2015-11-30 2016-11-30 derivados aminofosfínicos para prevenção e tratamento das dores oculares
ES16809676T ES2773148T3 (es) 2015-11-30 2016-11-30 Derivados aminofosfínicos para la prevención y el tratamiento de los dolores oculares
JP2018546763A JP6889176B2 (ja) 2015-11-30 2016-11-30 眼痛を予防及び治療するためのアミノホスフィン酸誘導体
US15/779,220 US20180344753A1 (en) 2015-11-30 2016-11-30 Aminophosphinic derivatives for preventing and treating eye pain
MX2018006580A MX382921B (es) 2015-11-30 2016-11-30 Derivados aminofosfínicos para prevenir y tratar dolor ocular.
CN202010893476.8A CN112121008A (zh) 2015-11-30 2016-11-30 用于预防和治疗眼痛的氨基次膦酸衍生物
CA3006365A CA3006365A1 (fr) 2015-11-30 2016-11-30 Derives aminophosphiniques pour la prevention et le traitement des douleurs oculaires
DK16809676.6T DK3383403T3 (da) 2015-11-30 2016-11-30 Aminofosfonisk derivat til forebyggelse og behandling af øjesmerter
TW105139517A TWI729039B (zh) 2015-11-30 2016-11-30 用於預防及治療眼疼痛之氨基膦衍生物
PCT/EP2016/079285 WO2017093322A1 (fr) 2015-11-30 2016-11-30 Dérivés aminophosphiniques pour la prévention et le traitement des douleurs oculaires
HK19101231.6A HK1259181B (en) 2015-11-30 2016-11-30 Aminophosphinic derivatives for preventing and treating eye pain
CN201680070092.8A CN108289901B (zh) 2015-11-30 2016-11-30 用于预防和治疗眼痛的氨基次膦酸衍生物
KR1020187018504A KR102657652B1 (ko) 2015-11-30 2016-11-30 눈 통증의 예방 및 치료를 위한 아미노포스핀산 유도체
EP16809676.6A EP3383403B1 (fr) 2015-11-30 2016-11-30 Dérivés aminophosphiniques pour la prévention et le traitement des douleurs oculaires
IL259562A IL259562B (en) 2015-11-30 2018-05-23 Aminophosphine derivatives for the prevention and treatment of eye pain
ZA2018/04037A ZA201804037B (en) 2015-11-30 2018-06-15 Aminophosphinic derivatives for preventing and treating eye pain
US16/272,573 US10688113B2 (en) 2015-11-30 2019-02-11 Methods of treating eye pain with aminophosphinic derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1561598A FR3044227B1 (fr) 2015-11-30 2015-11-30 Derives aminophosphiniques pour la prevention et le traitement des douleurs oculaires

Publications (2)

Publication Number Publication Date
FR3044227A1 FR3044227A1 (fr) 2017-06-02
FR3044227B1 true FR3044227B1 (fr) 2017-11-24

Family

ID=55346018

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1561598A Expired - Fee Related FR3044227B1 (fr) 2015-11-30 2015-11-30 Derives aminophosphiniques pour la prevention et le traitement des douleurs oculaires

Country Status (15)

Country Link
US (2) US20180344753A1 (enExample)
EP (1) EP3383403B1 (enExample)
JP (1) JP6889176B2 (enExample)
KR (1) KR102657652B1 (enExample)
CN (2) CN112121008A (enExample)
BR (1) BR112018010007A2 (enExample)
CA (1) CA3006365A1 (enExample)
DK (1) DK3383403T3 (enExample)
ES (1) ES2773148T3 (enExample)
FR (1) FR3044227B1 (enExample)
IL (1) IL259562B (enExample)
MX (1) MX382921B (enExample)
TW (1) TWI729039B (enExample)
WO (1) WO2017093322A1 (enExample)
ZA (1) ZA201804037B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9993427B2 (en) * 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture
US11090317B2 (en) * 2017-03-09 2021-08-17 Pharmaleads Aminophosphinic derivatives for preventing and treating eye inflammation
FR3063635B1 (fr) * 2017-03-09 2019-06-07 Pharmaleads Derives aminophosphiniques pour la prevention et le traitement de l'inflammation oculaire
FR3104581B1 (fr) * 2019-12-11 2021-11-26 Pharmaleads Procédé de préparation industrielle du sel disodique de ((2S)-3-([1,1'-biphenyl]-4-yl)-2-((hydroxy((1R)-1-(((1-(isobutyryloxy)ethoxy)carbonyl)amino)ethyl)phosphoryl) methyl)propanoyl)-L-alanine

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0987291A (ja) * 1995-09-26 1997-03-31 Wakamoto Pharmaceut Co Ltd 新規なアラニン誘導体
FR2755135B1 (fr) * 1996-10-25 2002-12-27 Inst Nat Sante Rech Med Nouveaux derives d'(alpha-aminophosphino)peptides, leur procede de preparation et les compositions qui les contiennent
JP2001506652A (ja) * 1996-12-16 2001-05-22 アルコン ラボラトリーズ，インコーポレイテッド 眼の痛みを治療するためのκオピオイド・アゴニストの局所使用
FR2777780B1 (fr) * 1998-04-22 2001-05-04 Inst Nat Sante Rech Med Derives d'(alpha-aminophosphino) peptides, leur procede de preparation et les compositions qui les contiennent
FR2934267B1 (fr) * 2008-07-23 2010-08-13 Pharmaleads Derives aminophosphiniques utiles dans le traitement de la douleur
FR2934627B1 (fr) 2008-07-29 2010-08-13 Paul Marie Bernard Dispositif de positionnement et de calage d'un garde corps escamotable sur plateforme support de banches
CA2901208A1 (en) * 2013-02-13 2014-08-21 Novartis Ag Topical ocular analgesic agents

Also Published As

Publication number Publication date
MX2018006580A (es) 2018-08-01
CN112121008A (zh) 2020-12-25
EP3383403B1 (fr) 2019-12-25
BR112018010007A2 (pt) 2018-11-21
JP6889176B2 (ja) 2021-06-18
IL259562B (en) 2020-08-31
US10688113B2 (en) 2020-06-23
TW201726146A (zh) 2017-08-01
TWI729039B (zh) 2021-06-01
KR20180095555A (ko) 2018-08-27
FR3044227A1 (fr) 2017-06-02
CN108289901B (zh) 2021-05-04
WO2017093322A1 (fr) 2017-06-08
ZA201804037B (en) 2020-07-29
DK3383403T3 (da) 2020-03-16
IL259562A (en) 2018-07-31
MX382921B (es) 2025-03-13
KR102657652B1 (ko) 2024-04-15
HK1259181A1 (zh) 2019-11-29
US20180344753A1 (en) 2018-12-06
CA3006365A1 (fr) 2017-06-08
CN108289901A (zh) 2018-07-17
US20190167701A1 (en) 2019-06-06
EP3383403A1 (fr) 2018-10-10
ES2773148T3 (es) 2020-07-09
JP2018536714A (ja) 2018-12-13

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