TWI723967B - 用於組織自修復及再生之經取代芳族化合物及醫藥組合物 - Google Patents

用於組織自修復及再生之經取代芳族化合物及醫藥組合物 Download PDF

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TWI723967B
TWI723967B TW104137375A TW104137375A TWI723967B TW I723967 B TWI723967 B TW I723967B TW 104137375 A TW104137375 A TW 104137375A TW 104137375 A TW104137375 A TW 104137375A TW I723967 B TWI723967 B TW I723967B
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compound
nmr
tissue
damaged
pharmaceutically acceptable
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TW104137375A
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English (en)
Chinese (zh)
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TW201618764A (zh
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萊恩 加格諾
皮爾瑞 拉瑞琳
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英商邊緣生物科技有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/32—Phenylacetic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/52—Unsaturated compounds containing hydroxy or O-metal groups a hydroxy or O-metal group being bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW104137375A 2014-11-12 2015-11-12 用於組織自修復及再生之經取代芳族化合物及醫藥組合物 TWI723967B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462078704P 2014-11-12 2014-11-12
US62/078,704 2014-11-12

Publications (2)

Publication Number Publication Date
TW201618764A TW201618764A (zh) 2016-06-01
TWI723967B true TWI723967B (zh) 2021-04-11

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TW104137375A TWI723967B (zh) 2014-11-12 2015-11-12 用於組織自修復及再生之經取代芳族化合物及醫藥組合物

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US (3) US10391073B2 (cg-RX-API-DMAC7.html)
EP (1) EP3217968A4 (cg-RX-API-DMAC7.html)
JP (1) JP6720169B2 (cg-RX-API-DMAC7.html)
KR (1) KR20170072352A (cg-RX-API-DMAC7.html)
CN (1) CN107106526B (cg-RX-API-DMAC7.html)
AR (1) AR102634A1 (cg-RX-API-DMAC7.html)
AU (2) AU2015345943B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017009899A2 (cg-RX-API-DMAC7.html)
CA (1) CA2967499C (cg-RX-API-DMAC7.html)
IL (1) IL252221B (cg-RX-API-DMAC7.html)
MX (1) MX381687B (cg-RX-API-DMAC7.html)
MY (1) MY187515A (cg-RX-API-DMAC7.html)
PH (1) PH12017500856A1 (cg-RX-API-DMAC7.html)
RU (1) RU2728782C2 (cg-RX-API-DMAC7.html)
SG (1) SG11201703741TA (cg-RX-API-DMAC7.html)
TW (1) TWI723967B (cg-RX-API-DMAC7.html)
UY (1) UY36399A (cg-RX-API-DMAC7.html)
WO (1) WO2016074068A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201703579B (cg-RX-API-DMAC7.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI742541B (zh) * 2013-03-15 2021-10-11 英商邊緣生物科技有限公司 用於治療肺纖維化、肝纖維化、皮膚纖維化及心臟纖維化之經取代之芳族化合物
EP3217968A4 (en) * 2014-11-12 2018-06-20 Prometic Pharma Smt Limited Substituted aromatic compounds and pharmaceutical compositions for tissue self-repair and regeneration

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2289417C1 (ru) * 2005-04-15 2006-12-20 Равиль Шамилевич Мирхайдаров Способ биологического омоложения кожи
EP1953222A1 (en) * 2007-01-24 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Improvement of cell growth
BRPI1015124B8 (pt) 2009-05-04 2021-05-25 Prometic Biosciences Inc compostos aromáticos substituídos para a prevenção ou tratamento de distúrbios sanguíneos; distúrbios renais, nefropatias e/ou complicações do distúrbio renal; doenças relacionadas com inflamação; e distúrbios relacionados ao estresse oxidativo, usos farmacêuticos dos mesmos e composição farmacêutica comprendendo ditos compostos
JP5844251B2 (ja) * 2009-05-04 2016-01-13 プロメティック・バイオサイエンシーズ・インコーポレイテッドＰｒｏＭｅｔｉｃ ＢｉｏＳｃｉｅｎｃｅｓ Ｉｎｃ． ３−ペンチルフェニル酢酸の塩およびその薬学的使用
ES2351005B1 (es) * 2009-07-10 2011-11-18 Consejo Superior De Investigaciones Científicas (Csic) Uso de anhidrasa carbónica ii para la elaboración de un medicamento.
PT2632885T (pt) 2010-10-27 2018-04-04 Prometic Pharma Smt Ltd Compostos carboxilatos de fenilcetona e usos farmacêuticos destes
WO2012097428A1 (en) * 2010-10-27 2012-07-26 Prometic Biosciences Inc. Compounds and pharmaceutical compositions for uses in diabetes
KR101821646B1 (ko) 2010-10-27 2018-01-25 프로메틱 파마 에스엠티 리미티드 암을 치료하기 위한 화합물 및 조성물
JP5388233B2 (ja) * 2011-01-19 2014-01-15 富士ソフト株式会社 再生軟骨の軟骨特性を評価する方法
CA2844792A1 (en) * 2011-08-10 2013-02-14 Digna Biotech, S.L. Use of cardiotrophin-1 for the treatment of kidney diseases
TWI689490B (zh) * 2013-03-15 2020-04-01 英商邊緣生物科技有限公司 用於治療纖維化之經取代之芳族化合物及相關方法
TWI742541B (zh) 2013-03-15 2021-10-11 英商邊緣生物科技有限公司 用於治療肺纖維化、肝纖維化、皮膚纖維化及心臟纖維化之經取代之芳族化合物
PH12017500662B1 (en) 2014-10-10 2022-08-19 Liminal Biosciences Ltd Substituted aromatic compounds and pharmaceutical compositions for the prevention and treatment of diabetes
MY194308A (en) 2014-10-10 2022-11-27 Prometic Pharma Smt Ltd Substituted aromatic compounds and pharmaceutical compostions for the prevention and treatment of osteoporosis
EP3217968A4 (en) * 2014-11-12 2018-06-20 Prometic Pharma Smt Limited Substituted aromatic compounds and pharmaceutical compositions for tissue self-repair and regeneration

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Publication number Publication date
AU2015345943A1 (en) 2017-06-01
PH12017500856A1 (en) 2017-11-06
CN107106526B (zh) 2021-05-28
US10869849B2 (en) 2020-12-22
AU2015345943B2 (en) 2020-03-19
RU2728782C2 (ru) 2020-07-31
JP2017533928A (ja) 2017-11-16
TW201618764A (zh) 2016-06-01
MX381687B (es) 2025-03-13
WO2016074068A1 (en) 2016-05-19
MY187515A (en) 2021-09-24
AU2020204112A1 (en) 2020-07-09
US10391073B2 (en) 2019-08-27
IL252221A0 (en) 2017-07-31
RU2017120401A3 (cg-RX-API-DMAC7.html) 2019-06-06
US20170312237A1 (en) 2017-11-02
IL252221B (en) 2022-04-01
SG11201703741TA (en) 2017-06-29
KR20170072352A (ko) 2017-06-26
MX2017006281A (es) 2017-08-14
US20210085626A1 (en) 2021-03-25
ZA201703579B (en) 2018-08-29
CA2967499A1 (en) 2016-05-19
UY36399A (es) 2016-06-30
EP3217968A1 (en) 2017-09-20
BR112017009899A2 (pt) 2018-01-16
US20200078324A1 (en) 2020-03-12
AU2020204112B2 (en) 2021-10-21
EP3217968A4 (en) 2018-06-20
CA2967499C (en) 2023-01-17
CN107106526A (zh) 2017-08-29
JP6720169B2 (ja) 2020-07-08
AR102634A1 (es) 2017-03-15
RU2017120401A (ru) 2018-12-13

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