TWI723962B - 用於預防及治療骨質疏鬆症之苯基酮羧酸鹽化合物及醫藥組合物 - Google Patents

用於預防及治療骨質疏鬆症之苯基酮羧酸鹽化合物及醫藥組合物 Download PDF

Info

Publication number
TWI723962B
TWI723962B TW104133246A TW104133246A TWI723962B TW I723962 B TWI723962 B TW I723962B TW 104133246 A TW104133246 A TW 104133246A TW 104133246 A TW104133246 A TW 104133246A TW I723962 B TWI723962 B TW I723962B
Authority
TW
Taiwan
Prior art keywords
compound
osteoporosis
pharmaceutically acceptable
bone
salt
Prior art date
Application number
TW104133246A
Other languages
English (en)
Chinese (zh)
Other versions
TW201618761A (zh
Inventor
萊恩 加格諾
布萊吉特 格洛克斯
Original Assignee
英商邊緣生物科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 英商邊緣生物科技有限公司 filed Critical 英商邊緣生物科技有限公司
Publication of TW201618761A publication Critical patent/TW201618761A/zh
Application granted granted Critical
Publication of TWI723962B publication Critical patent/TWI723962B/zh

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/86—Unsaturated compounds containing keto groups containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW104133246A 2014-10-10 2015-10-08 用於預防及治療骨質疏鬆症之苯基酮羧酸鹽化合物及醫藥組合物 TWI723962B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462062660P 2014-10-10 2014-10-10
US62/062,660 2014-10-10

Publications (2)

Publication Number Publication Date
TW201618761A TW201618761A (zh) 2016-06-01
TWI723962B true TWI723962B (zh) 2021-04-11

Family

ID=55652426

Family Applications (1)

Application Number Title Priority Date Filing Date
TW104133246A TWI723962B (zh) 2014-10-10 2015-10-08 用於預防及治療骨質疏鬆症之苯基酮羧酸鹽化合物及醫藥組合物

Country Status (22)

Country Link
US (1) US10925846B2 (enExample)
EP (1) EP3204000B1 (enExample)
JP (1) JP6700638B2 (enExample)
KR (1) KR20170066613A (enExample)
CN (1) CN106999459B (enExample)
AR (1) AR102247A1 (enExample)
AU (1) AU2015330642B2 (enExample)
BR (1) BR112017007386A2 (enExample)
CA (1) CA2963358C (enExample)
DK (1) DK3204000T3 (enExample)
ES (1) ES2794782T3 (enExample)
IL (1) IL251409B (enExample)
MX (1) MX376880B (enExample)
MY (1) MY187511A (enExample)
PH (1) PH12017500636A1 (enExample)
PL (1) PL3204000T3 (enExample)
PT (1) PT3204000T (enExample)
RU (1) RU2712027C2 (enExample)
SG (1) SG11201702810TA (enExample)
TW (1) TWI723962B (enExample)
UY (1) UY36355A (enExample)
WO (1) WO2016054725A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3203999T3 (pl) * 2014-10-10 2020-07-27 Liminal Biosciences Limited Podstawione związki aromatyczne i kompozycje farmaceutyczne do zapobiegania i leczenia osteoporozy

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012055014A1 (en) * 2010-10-27 2012-05-03 Prometic Biosciences Inc. Phenylketone carboxylate compounds and pharmaceutical uses thereof
WO2012097428A1 (en) * 2010-10-27 2012-07-26 Prometic Biosciences Inc. Compounds and pharmaceutical compositions for uses in diabetes
WO2012097427A1 (en) * 2010-10-27 2012-07-26 Prometic Biosciences Inc. Compounds and compositions for the treatment of cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200720256A (en) * 2005-05-13 2007-06-01 Synta Pharmaceuticals Corp IL-12 modulatory compounds
CA2777629C (en) * 2009-10-14 2018-02-13 The Governors Of The University Of Alberta Compounds having peptides conjugated to bone targeting moieties and methods of making and using thereof
WO2014138372A1 (en) * 2013-03-06 2014-09-12 Primavera Biosciences, Inc. Composition and method for treating osteoarthritis
PL3203999T3 (pl) * 2014-10-10 2020-07-27 Liminal Biosciences Limited Podstawione związki aromatyczne i kompozycje farmaceutyczne do zapobiegania i leczenia osteoporozy

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012055014A1 (en) * 2010-10-27 2012-05-03 Prometic Biosciences Inc. Phenylketone carboxylate compounds and pharmaceutical uses thereof
WO2012097428A1 (en) * 2010-10-27 2012-07-26 Prometic Biosciences Inc. Compounds and pharmaceutical compositions for uses in diabetes
WO2012097427A1 (en) * 2010-10-27 2012-07-26 Prometic Biosciences Inc. Compounds and compositions for the treatment of cancer

Also Published As

Publication number Publication date
CA2963358A1 (en) 2016-04-14
TW201618761A (zh) 2016-06-01
SG11201702810TA (en) 2017-05-30
IL251409B (en) 2020-08-31
UY36355A (es) 2016-06-01
CN106999459B (zh) 2020-07-10
PT3204000T (pt) 2020-05-06
RU2017116154A (ru) 2018-11-12
AU2015330642A1 (en) 2017-05-11
BR112017007386A2 (pt) 2018-01-23
PH12017500636A1 (en) 2017-09-25
ES2794782T3 (es) 2020-11-19
CN106999459A (zh) 2017-08-01
EP3204000B1 (en) 2020-01-08
DK3204000T3 (da) 2020-04-06
WO2016054725A1 (en) 2016-04-14
IL251409A0 (en) 2017-05-29
EP3204000A1 (en) 2017-08-16
AR102247A1 (es) 2017-02-15
JP6700638B2 (ja) 2020-05-27
US20190038580A1 (en) 2019-02-07
CA2963358C (en) 2023-03-07
RU2712027C2 (ru) 2020-01-27
MX376880B (es) 2025-03-07
PL3204000T3 (pl) 2020-07-27
KR20170066613A (ko) 2017-06-14
JP2017530179A (ja) 2017-10-12
MY187511A (en) 2021-09-24
US10925846B2 (en) 2021-02-23
AU2015330642B2 (en) 2019-07-04
EP3204000A4 (en) 2018-06-20
RU2017116154A3 (enExample) 2019-05-06
MX2017004735A (es) 2017-11-17

Similar Documents

Publication Publication Date Title
TWI699200B (zh) 用於預防及治療骨質疏鬆症之經取代之芳族化合物及醫藥組合物
EP2632452B1 (en) Compounds and compositions for the treatment of cancer
BR112020013694A2 (pt) derivados de ácido 3-fenil-4-hexinôico como agonistas gpr40
CN1131669A (zh) 光学活性苯并硫杂庚英衍生物，其制备方法和用途
WO2005102381A1 (ja) カテプシンｋ阻害薬およびpth類を併用することを特徴とする骨密度増加剤
CN106999459B (zh) 用于预防和治疗骨质疏松症的苯基酮羧酸盐化合物和药物组合物
PT91006B (pt) Processo para a preparacao de um novo sal de estroncio
CN108473518B (zh) 双膦酸化合物
JP2005035895A (ja) 高カルシウム血症および骨疾患治療剤
HK1236420A1 (en) Substituted aromatic compounds and pharmaceutical compositions for the prevention and treatment of osteoporosis
HK1257616B (en) Bisphosphonic acid compound

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees