TWI723065B - 羥基嘌呤類化合物的醫藥用途 - Google Patents

羥基嘌呤類化合物的醫藥用途 Download PDF

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Publication number
TWI723065B
TWI723065B TW105135042A TW105135042A TWI723065B TW I723065 B TWI723065 B TW I723065B TW 105135042 A TW105135042 A TW 105135042A TW 105135042 A TW105135042 A TW 105135042A TW I723065 B TWI723065 B TW I723065B
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TW
Taiwan
Prior art keywords
methyl
purine
dimethyl
dione
ethyl
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Application number
TW105135042A
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English (en)
Chinese (zh)
Other versions
TW201717956A (zh
Inventor
吳凌云
張鵬
張麗
誌中 陳
曙輝 陳
Original Assignee
大陸商廣東衆生睿創生物科技有限公司
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Publication of TW201717956A publication Critical patent/TW201717956A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW105135042A 2015-10-29 2016-10-28 羥基嘌呤類化合物的醫藥用途 TWI723065B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN201510719640.2 2015-10-29
CN201510719640 2015-10-29
CN201610913215.1 2016-10-19
CN201610913215 2016-10-19

Publications (2)

Publication Number Publication Date
TW201717956A TW201717956A (zh) 2017-06-01
TWI723065B true TWI723065B (zh) 2021-04-01

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ID=58629867

Family Applications (1)

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TW105135042A TWI723065B (zh) 2015-10-29 2016-10-28 羥基嘌呤類化合物的醫藥用途

Country Status (3)

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CN (1) CN108348525B (fr)
TW (1) TWI723065B (fr)
WO (1) WO2017071606A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022042390A1 (fr) * 2020-08-25 2022-03-03 广东众生睿创生物科技有限公司 Utilisation de composés d'hydroxypurine pour le traitement de maladies de la peau

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201107326A (en) * 2009-08-26 2011-03-01 Concert Pharmaceuticals Inc Substituted xanthine derivatives
WO2014205081A1 (fr) * 2013-06-18 2014-12-24 Imprimis Pharmaceuticals Inc. Préparations pharmaceutiques de xanthine ou de dérivés de xanthine, et leur utilisation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985592A (en) * 1997-06-05 1999-11-16 Dalhousie University Uses for pentoxifylline or functional derivatives/metabolites thereof
EP2265334A2 (fr) * 2008-02-29 2010-12-29 Concert Pharmaceuticals, Inc. Dérivés de xanthine substitués

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201107326A (en) * 2009-08-26 2011-03-01 Concert Pharmaceuticals Inc Substituted xanthine derivatives
WO2014205081A1 (fr) * 2013-06-18 2014-12-24 Imprimis Pharmaceuticals Inc. Préparations pharmaceutiques de xanthine ou de dérivés de xanthine, et leur utilisation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Han, Ze, Susan L. Bonnet, and Jan H. van der Westhuizen. "Photochemistry synthesis. Part 1: Syntheses of xanthine derivatives by photolysis of 1-(5′-oxohexyl)-3, 7-dimethyl-3, 7-dihydro-1H-purine-2, 6-dione (pentoxifylline): an ambident chromophore." Tetrahedron 64.11 (2008): 2619-2625. *

Also Published As

Publication number Publication date
CN108348525B (zh) 2021-09-10
TW201717956A (zh) 2017-06-01
CN108348525A (zh) 2018-07-31
WO2017071606A1 (fr) 2017-05-04

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