TWI717859B - 一種鴉片類物質受體激動劑的結晶形式及製備方法 - Google Patents
一種鴉片類物質受體激動劑的結晶形式及製備方法 Download PDFInfo
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- DYHSDKLCOJIUFX-UHFFFAOYSA-N tert-butoxycarbonyl anhydride Chemical compound CC(C)(C)OC(=O)OC(=O)OC(C)(C)C DYHSDKLCOJIUFX-UHFFFAOYSA-N 0.000 description 1
- AAYQBJCHFNRLII-UEWDXFNNSA-N tert-butyl N-[(1S)-4-hydroxy-1,2,3,4-tetrahydronaphthalen-1-yl]carbamate Chemical compound C(C)(C)(C)OC(N[C@H]1CCC(C2=CC=CC=C12)O)=O AAYQBJCHFNRLII-UEWDXFNNSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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|---|---|---|---|
| CN201811186743.7 | 2018-10-12 | ||
| CN201811186743 | 2018-10-12 |
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| TW202016099A TW202016099A (zh) | 2020-05-01 |
| TWI717859B true TWI717859B (zh) | 2021-02-01 |
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| Country | Link |
|---|---|
| CN (1) | CN112638907B (fr) |
| TW (1) | TWI717859B (fr) |
| WO (1) | WO2020073985A1 (fr) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| TW201718558A (zh) * | 2015-10-15 | 2017-06-01 | 江蘇恆瑞醫藥股份有限公司 | 氧雜螺環類衍生物、其製備方法及其在醫藥上的應用 |
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| SI2688403T1 (sl) * | 2011-03-23 | 2017-08-31 | Trevena, Inc. | Ligandi opioidnih receptorjev in metode uporabe in izdelave istega |
| UA124400C2 (uk) * | 2017-04-14 | 2021-09-08 | Цзянсу Хенжуй Медісін Ко., Лтд. | Сіль агоніста опіоїдного рецептора (mor), кристалічна форма i його фумаратної солі та спосіб їх одержання |
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2019
- 2019-10-11 CN CN201980053697.XA patent/CN112638907B/zh active Active
- 2019-10-11 WO PCT/CN2019/110563 patent/WO2020073985A1/fr active Application Filing
- 2019-10-14 TW TW108136888A patent/TWI717859B/zh not_active IP Right Cessation
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| Publication number | Priority date | Publication date | Assignee | Title |
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| TW201718558A (zh) * | 2015-10-15 | 2017-06-01 | 江蘇恆瑞醫藥股份有限公司 | 氧雜螺環類衍生物、其製備方法及其在醫藥上的應用 |
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| Publication number | Publication date |
|---|---|
| CN112638907A (zh) | 2021-04-09 |
| TW202016099A (zh) | 2020-05-01 |
| CN112638907B (zh) | 2022-04-12 |
| WO2020073985A1 (fr) | 2020-04-16 |
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