TWI716758B - 初代細胞基因編輯 - Google Patents

初代細胞基因編輯 Download PDF

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TWI716758B
TWI716758B TW107138453A TW107138453A TWI716758B TW I716758 B TWI716758 B TW I716758B TW 107138453 A TW107138453 A TW 107138453A TW 107138453 A TW107138453 A TW 107138453A TW I716758 B TWI716758 B TW I716758B
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cells
nucleotide sequence
tcr
cell
gene
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TW107138453A
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Chinese (zh)
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TW201934754A (zh
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凱爾 馬汀 賈可比
艾利西斯 法蘭蘇索夫
凱須曼 史戴芬尼 曼德爾
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美商Ｐａｃｔ製藥公司
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/32—T-cell receptors [TCR]
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0634—Cells from the blood or the immune system
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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TW107138453A 2017-10-30 2018-10-30 初代細胞基因編輯 TWI716758B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762579114P 2017-10-30 2017-10-30
US201762579113P 2017-10-30 2017-10-30
US62/579,114 2017-10-30
US62/579,113 2017-10-30

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TW201934754A TW201934754A (zh) 2019-09-01
TWI716758B true TWI716758B (zh) 2021-01-21

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US (7) US10584357B2 (https=)
EP (1) EP3703712A4 (https=)
JP (2) JP7397791B2 (https=)
CN (2) CN117904055A (https=)
AU (1) AU2018357861B2 (https=)
BR (1) BR112020008704A2 (https=)
CA (1) CA3081320A1 (https=)
IL (1) IL274351B2 (https=)
MX (1) MX2020004541A (https=)
RU (1) RU2020116585A (https=)
SG (1) SG11202004026QA (https=)
TW (1) TWI716758B (https=)
WO (1) WO2019089610A1 (https=)

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JP7101419B2 (ja) 2017-10-27 2022-07-15 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 内因性ｔ細胞受容体の標的置換
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SG11202111865UA (en) 2019-05-01 2021-11-29 Pact Pharma Inc Compositions and methods for the treatment of cancer using a tet2 engineered t cell therapy
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IL291935A (en) * 2019-10-08 2022-06-01 Pact Pharma Inc Methods for immunotherapy of genetically modified autologous t cells
EP4041293A1 (en) * 2019-10-10 2022-08-17 PACT Pharma, Inc. Method of treating immunotherapy non-responders with an autologous cell therapy
EP4110356A4 (en) * 2020-02-28 2024-03-27 Wisconsin Alumni Research Foundation NON-VIRAL GENERATION OF CHIMERIC ANTIGEN RECEPTOR T CELLS OBTAINED BY GENE EDITING
WO2021216993A1 (en) * 2020-04-24 2021-10-28 Pact Pharma, Inc. Methods of determining gene editing efficiencies in cells
CA3181117A1 (en) * 2020-06-12 2021-12-16 Ines MENDE Compositions and methods of manufacturing autologous t cell therapies
MX2023002455A (es) * 2020-08-28 2023-05-16 Arsenal Biosciences Inc Células inmunitarias modificadas con receptores cebadores.
AU2021368557A1 (en) * 2020-10-27 2023-06-08 Adoc Ssf, Llc Compositions and methods for the treatment of cancer using next generation engineered t cell therapy
JP2024512608A (ja) * 2021-03-24 2024-03-19 ジェネンテック， インコーポレイテッド Ｔリンパ球における効率的なｔｃｒ遺伝子編集
WO2022242644A1 (zh) * 2021-05-18 2022-11-24 赛斯尔擎生物技术（上海）有限公司 修饰细胞的方法
EP4352508A1 (en) 2021-06-11 2024-04-17 Adoc Ssf, Llc Method of assessing cell products
AU2024228388A1 (en) 2023-02-27 2025-10-02 Adaptive Biotechnologies Corp. Therapeutic t cell receptors targeting kras g12d

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